The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis

The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis

Abstract The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer‐permissive functions. Moreover, brain metastases induce the recruitment of lymphocytes. Despite their presence, T‐cell‐directed therapies fail to elicit...

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Main Authors: Katja Niesel, Michael Schulz, Julian Anthes, Tijna Alekseeva, Jadranka Macas, Anna Salamero‐Boix, Aylin Möckl, Timm Oberwahrenbrock, Marco Lolies, Stefan Stein, Karl H Plate, Yvonne Reiss, Franz Rödel, Lisa Sevenich
Format: Article
Language:English
Published: Springer Nature 2021-03-01
Series:EMBO Molecular Medicine
Subjects:
brain cancer
checkpoint inhibitors
microglia
tumor microenvironment
tumor‐associated macrophages
Online Access:https://doi.org/10.15252/emmm.202013412
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https://doi.org/10.15252/emmm.202013412

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