Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis

Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis

BackgroundHydrogen gas (H2), which is the lightest and diffusible gas molecule, has strong abilities to alleviate excessive oxidative stress, inflammation, and apoptosis. Inhalation of H2 is beneficial for preventing the damage of the lung, heart, brain, liver, kidneys, and many other organs. Howeve...

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Main Authors: Yun Chen, Kangrong Wang, Wenhai Guo, Chengqin Lu, Wenting Suo, Qiuling Li, Yao Deng, Xinling Chen, Min Dai, Xiaodong Zhang, Jiean Xu, Wen Su, Shuangling Yang, Hongzhi Yang, Fuman Yan, Haimei Liu, Yaxing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
intraperitoneal injection
MCD
TLR4
NLRP3
GSDMD
GSDME
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1575106/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1575106/full

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