Molecular Interactions of Renin with Chikusetsusaponin IV and Momordin IIc by Hai-Ling Zhang, Gui-Lan Zhu, Xiao-Tian Chen

“…As shown by LigPlot + software analyzing the hydrogen bonding and hydrophobic effect between renin and the saponins, the amino acid residues such as Ser230, Tyr85, and Tyr201 form the hydrogen bonds, with S3sp, S3, and S2′ being the active pockets. In addition, there are relatively strong hydrophobic interactions of renin with saponins in S3sp, S3, S2, S1, S1′, and S2′, with Gly228, Val36, Ala229, Gln19, Met303, Gln135, Ser41, Ile137, Asp38, Arg82, and Tyr83 being the key amino acids. …”
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Carbamazepine-Mediated Adverse Drug Reactions: CBZ-10,11-epoxide but Not Carbamazepine Induces the Alteration of Peptides Presented by HLA-B∗15:02 by Gwendolin S. Simper, Gia-Gia T. Hò, Alexander A. Celik, Trevor Huyton, Joachim Kuhn, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding

“…This observation could be explained through structural insight; EPX binds to the peptide-binding region and alters the biochemical features of the F pocket and thus the peptide motif. Understanding the nature of immunogenic interactions between CBZ and EPX with the HLA immune complex will guide towards effective and safe medications.…”
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A RESEARCH ON SOCIAL MEDIA ADDICTION AND DOPAMINE DRIVEN FEEDBACK by Gamze Macit, Hüseyin Bilal Macit, Orhan Güngör

“…The great technological developments coming up to date and began with the invention of the transistor in the mid-20th century allowed the technological communication tools to enter through our pockets and caused great changes in the way of communication of the societies. …”
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Chip Design of PTP Time Synchronization for Industrial IoT by Yee-Shao Chen, Yuan-Sun Chu, da-Wei Lo, Yen-Ting Chiang, Ting-Chao Hou

“…After a detailed study of the IEEE 1588 protocol, this paper found that the main sources of time errors are frequency changes caused by the temperature characteristics and aging of the crystal oscillator, the uncertainty of network protocol stacking delay, and the queuing delay caused by packets. In order to improve time accuracy and reduce delays caused by network protocol stacking, this study designed the chip on the data link layer and optimized the original IEEE 1588 protocol. …”
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The effect of high temperature deformation on the austenite reversion transformation and η-Ni3Ti precipitation behavior in a Ti–Mo maraging steel by Chih-Yuan Chen, Iting Chiang, Yung-Chang Kang

“…The above metallurgical phenomenon was further verified by Vickers hardness measurement. For example, under the fixed ageing temperature of 520 °C, the distributions of HV0.1 values were 480–680 and 370–660, respectively, for Ti–Mo PHSSs subjected to hot deformation strains of 35 % and 70 %, respectively. …”
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Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…Crystallography analysis revealed that DW18343 binds more deeply into the ligand binding domain (LBD) pocket of STING‐H232 compared to other agonists such as MSA‐2, SR‐717, or cGAMP, which likely contributes to its high potency. …”
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Observed Performance and FEM-Based Parametric Analysis of a Top-Down Deep Excavation in Soil-Rock Composite Stratum by Gang Lei, Panpan Guo, Fucai Hua, Xiaonan Gong, Lina Luo

“…Two-dimensional finite element simulations were carried out to further explore the deformation and internal force responses of end-suspended piles and to capture the effects of pile diameter, embedded depth, and rock-socketed depth on the horizontal displacement and bending moment distributions along the pile shaft. …”
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Pengaruh Aplikasi Bahan Pemutih Gigi Karbamid Peroksida 10% dan Hidrogen Peroksida 6% secara Home Bleaching terhadap Kekerasan Permukaan Email Gigi by Meiyestri Dwi Riani, Fadil Oenzil, Nila Kasuma

“…Kekerasan permukaan email gigi diukur dengan alat Vickers Harndness Tester. Analisis data yang digunakan adalah uji t independen dan uji t dependen (p<0,05). …”
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Transfer functions of a time-varying control system by Volt Avdieiev

“…The task is to show the possibility of obtaining a second-order transfer function, which is equivalent to the LTV on a certain trajectory section, using the example of the system for controlling the rotational motion of a rocket in one plane. The concept of a transfer function is based on the integral Laplace transform, which maps the time function to complex argument function. …”
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Seismic Evaluation and Retrofit of Reinforced Concrete Buildings with Masonry Infills Based on Material Strain Limit Approach by Mangeshkumar R. Shendkar, Denise-Penelope N. Kontoni, Sasankasekhar Mandal, Pabitra Ranjan Maiti, Omid Tavasoli

“…The two models of the four-storey RC building have been retrofitted with local and global strengthening techniques (RC-jacketing method and incorporation of infills) as per the requirements of the structure to evaluate their effect on the response reduction factor (R) because the R-factor is an important design tool that shows the level of inelasticity in a structure. …”
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Mechanical Properties of Multi-Layer Woven E-Glass/Epoxy in Variable Fiber-Mat Directions by Saif Aldeen Ghafel H., Nasri Salh M. Namer, Abdul Jabbar H. Ali

“…The tensile test was used to determine the strength of a material ratio to the fiber's direction and by using Vickers hardness to determine the hardness of composite and pure epoxy. …”
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Patterns and Reasons for Junk Food Consumption among Young Adults: A Mixed Methods Study from a Medical College in South India by Poonam Ramesh Naik, S. Vineetha, Nagendra Navya

“…Participants were aware that junk food is unhealthy but consume it because it is delicious while being pocket friendly.…”
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Effect of antacid gastric syrups on surface properties of dental restorative materials: an in vitro analysis of roughness and microhardness by Fikri Öcal, Burak Dayi

“…Surface roughness was measured at the beginning, on the 7th, 15th and 28th days using a mechanical profilometer, AFM, and SEM and microhardness was measured using a Vickers device. Shapiro-Wilk, Repeated Measures ANOVA, One-Way ANOVA, Tukey and Games-Howell tests were applied for statistical analysis. …”
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The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target by Reem Alharthi, Monica Sueiro-Olivares, Isabelle Storer, Hajer Bin Shuraym, Jennifer Scott, Reem Al-Shidhani, Rachael Fortune-Grant, Elaine Bignell, Lydia Tabernero, Michael Bromley, Can Zhao, Jorge Amich

“…We further showed that the structure of the ligand-binding pocket of the fungal enzyme differs significantly from its human counterpart, suggesting that specific inhibitors can be designed. …”
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Microstructural, mechanical and thermodynamic properties ınvestigation of the novel rare earth-free multicomponent Mg-15Al-8Ca-3Zn-2Ba alloy by Türe Y.

“…The general hardness analysis results of the alloy, measured by Brinell and Vickers tests, were determined to be ~77 and ~82, respectively. …”
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The Microbiota Profile Analysis of Combined Periodontal-Endodontic Lesions Using 16S rRNA Next-Generation Sequencing by Ping Sun, Zhiyong Guo, Daiping Guo, Jian Wang, Tingting Wu, Tingjun Li, Jiannan Liu, Xinhua Liu

“…By linear discriminant analysis effect size, Kingella and Barnesiella were significantly increased in the periodontal pocket of retrograde pulpitis (RE-PE), compared with PE. …”
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Determinants of Deescalation Failure in Critically Ill Patients with Sepsis: A Prospective Cohort Study by Nawal Salahuddin, Lama Amer, Mini Joseph, Alya El Hazmi, Hassan Hawa, Khalid Maghrabi

“…Current deescalation practices reflect physician reluctance when dealing with complicated, sicker patients or with drug-resistance or fungal sepsis. …”
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Topical Application of Orabase Bromelain Gel Reduces Inflammatory Process, Bone Loss and Steatosis in Experimental Periodontitis by Even Herlany Pereira Alves, Hélio Mateus Silva Nascimento, Luiz Felipe de Carvalho França, Any Carolina Cardoso Guimarães Vasconcelos, Larissa dos Santos Pessoa, Felipe Rodolfo Pereira da Silva, John Arlley Sousa Pinho de Lira, Paulo Roberto Carneiro Gomes, André dos Santos Carvalho, André Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos

“…The clinical parameters of tooth mobility (TM), gingival bleeding index (GBI) and probing pocket depth (PPD) were evaluated and, after euthanasia, gingival and liver tissue were collected by biopsy for biochemical evaluation of myeloperoxidase (MPO), malonaldehyde (MDA), glutathione (GSH) and from the jaws for morphometric analysis of alveolar bone height. …”
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Therapeutic potential of boric acid as a local drug delivery agent in periodontitis: a comprehensive systematic review and meta-analysis by Reham Abdel-Fatah, Ghada A. Elhusseiny, Wafaa Saleh

“…At 1-month, boric acid demonstrated significant improvements in probing pocket depth (PPD), but insignificant differences were observed in clinical attachment level (CAL), and gingival index (GI). …”
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Curcumin as a potential inhibitor of TGFβ3 computational insights for breast cancer therapy by Ali G. Alkhathami, Mohammad Y. Alshahrani, Saad Ali Alshehri, Nazim Nasir, Shadma Wahab

“…Through molecular docking analyses, curcumin displayed favourable binding affinities at the TGFβ3 binding pocket, forming key interactions such as hydrogen bonds with residues like ASP323, ARG325, VAL333, HIS334, PRO336, LYS337, GLY393, and ARG394. 500 ns molecular dynamic simulations examined docking interactions. …”
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