Sulfasalzine in the management of pure axial spondyloarthritis: Need to have a relook! by Subramanian Shankar, Arun Hegde

“…Considering that in a country with a per Capita GDP of just Rs 1.44 lakhs/ year, where 80% of people have to meet their medical expenses out of pocket and the cheapest anti TNFs cost over Rs 2 lakhs per annum, the western guidelines are clearly impractical in Indian context. …”
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First molecules to reactivate RASG12V GTPase activity by Aneta Wlodarczyk, Cezary Treda, Marcin Pacholczyk, Adrianna Rutkowska, Marta Wegierska, Amelia Kierasinska-Kalka, Katarzyna Wasiak, Damian Ciunowicz, Dagmara Grot, Pawel Glowacki, Ewelina Stoczynska-Fidelus, Piotr Rieske

“…Methods The compounds were initially identified through virtual screening, and their optimal binding conformation in the RAS SW-II pocket was determined using the flexible docking technique. …”
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Temperature influence on the repair of a hardfacing coating using laser metal deposition and assessment of the repair innocuity by Wilfried Pacquentin, Pierre Wident, Jérôme Varlet, Thomas Cailloux, Hicham Maskrot

“…Local characterization using non-destructive testing, Vickers hardness measurements and microstructural examinations by scanning electron microscopy (SEM) show an excellent metallurgical quality of the repair and its interface with the original part. …”
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Salivary Biomarkers in Periodontitis Patients: A Pilot Study by Sarah Reddahi, Amal Bouziane, Sana Rida, Houssain Tligui, Oumkeltoum Ennibi

“…The concentration of these proteins in saliva showed a significant association with gingival index and pocket depth measurements and may reflect the clinical status of healthy and diseased periodontium. …”
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Screening and Characterizing Tyrosinase Inhibitors from Salvia miltiorrhiza and Carthamus tinctorius by Spectrum-Effect Relationship Analysis and Molecular Docking by Ya-Li Wang, Guang Hu, Qian Zhang, Yu-Xiu Yang, Qiao-Qiao Li, Yuan-Jia Hu, Hua Chen, Feng-Qing Yang

“…Among them, three compounds including protocatechuic aldehyde, hydroxysafflor yellow A, and tanshinone IIA were verified to have high TYR inhibitory activity (IC50 value of 455, 498, and 1214 μM, resp.) and bind to the same amino acid residues in TYR catalytic pocket according to the results of the molecular docking test. …”
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Mechanism of Cordyceps Cicadae in Treating Diabetic Nephropathy Based on Network Pharmacology and Molecular Docking Analysis by Yi Qian, Xin Sun, Xin Wang, Xin Yang, Mengyao Fan, Jiao Zhong, Zejun Pei, Junping Guo

“…Docking studies suggested that myriocin can fit in the binding pocket of two target proteins (AKT1 and MAPK8). Conclusion. …”
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Growth response of Douglas fir to the first early and delayed thinning by Dušek David, Novák Jiří

“…The result confirms the necessity of initiating thinning for DF stands at the stage of thickets. The thinning should ideally begin when the dominant tree height is between 4 to 5 meters. …”
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Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation by Chandrabhan Seniya, Ghulam Jilani Khan, Kuldeep Uchadia

“…Further, molecular dynamics simulations for 1000 ps suggest that ligand interaction with the residues Asp72, Tyr70-121-334, and Phe288 of AChE, all of which fall under active site/subsite or binding pocket, might be critical for the inhibitory activity of AChE. …”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Structurally, bozitinib is optimally embedded in the ATP pocket of c-Met and firmly binds via an extensive interaction network. …”
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Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein by N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik

“…We presume that further optimization of the structures of chemical compounds that can bind with the hydrophobic pocket next to the residue Y25 of FA DD will allow for the creation of the new perspective inhibitors of the programmed cell death.…”
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Densification of hydroxyapatite/zirconia nanocomposites fabricated via low-temperature mineralization sintering process and their mechanical properties by Yeongjun Seo, Shiori Nawa, Tomoyo Goto, Sunghun Cho, Tohru Sekino

“…Additionally, it exhibited the highest values of mechanical properties such as the Vickers hardness (3.68 ± 0.18 GPa), fracture toughness (1.11 ± 0.10 MPa·m1/2), biaxial flexural strength (63.72 ± 2.35 MPa), and Young’s modulus (83.91 ± 1.93 GPa) among the composite samples. …”
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Population genetics of Glossina fuscipes fuscipes from southern Chad by Ravel, Sophie, Mahamat, Mahamat Hissène, Ségard, Adeline, Argilés-Herrero, Rafael, Bouyer, Jérémy, Rayaisse, Jean-Baptiste, Solano, Philippe, Guihini Mollo, Brahim, Pèka, Mallaye, Darnas, Justin, Belem, Adrien Marie Gaston, Yoni, Wilfrid, Noûs, Camille, De Meeûs, Thierry

“…The genetic signature of a population bottleneck was found in the Mandoul and Timbéri area, suggesting a large ancient interconnected metapopulation that underwent genetic subdivision into small, isolated pockets due to adverse environmental conditions. The long-range dispersal and the existence of genetic outliers suggest a possibility of migration from remote sites such as the Central African Republic in the south (although the fly situation remains unknown there) and/or a genetic signature of recent exchanges. …”
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Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy by Marcelo Matos Rocha, Valesca Sander Koth, Marcela Wiltgen Jeffman, Fernanda Gonçalves Salum, Josiane de Almeida, Karina Cesca, Karen Cherubini

“…<b>Methods</b>: Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups according to the material inserted in the post-extraction socket: (1) BNC (<i>n</i> = 10); (2) BNC/Iodine (<i>n</i> = 10); (3) BNC/Chlorhex (<i>n</i> = 10); (4) Control (<i>n</i> = 10). …”
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Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus by Yue Guo, Lin-Na Guo, Jun-Fei Zhu, Chen-Yi Tang, Yun-Zhi Feng, Hou-De Zhou

“…We also detected full-mouth clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), bleeding index (BI), and plaque index (PLI). …”
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Effects of screw configuration and interfacial properties on oil incorporation in high moisture extrusion by Shuzo Hashimoto, Naoya Ikenaga, Atze Jan van der Goot, Leonard M.C. Sagis

“…Less deformation of the air pockets between protein structures could be seen in the screw with fewer kneading discs in multiphoton microscopy. …”
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SUSTAINABLE CHEMISTRY FOR SUSTAINABLE INDUSTRY by G. Rizzuto, F. Bucelli, M. Sciaccaluga, O. Avataneo

“…For what concern the technological properties, Ecosafe Plus has been tested by accredited laboratories with tribological trials (4 Ball wear test ASTM D 4172, Ball on disc test ASTM 6425, Brugger test DIN 51347, Vickers test ASTM D 2882), with elastomer compatibility test (ASTM D 471) and biodegradability test (OECD 310 F).…”
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The healthcare burden of isolated aortic valve insufficiency by Ibrahim Sultan, Michael Ryan, Candace Gunnarsson, Natalie Heidrich, Prashanth Vallabhajosyula

“…Of 249,660 patients, 58.23% were symptomatic; they were generally older and sicker than the AAI cohort, and less than 1% received AVR. …”
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Soft Tissue Stability around Single Implants Inserted to Replace Maxillary Lateral Incisors: A 3D Evaluation by F. G. Mangano, F. Luongo, G. Picciocchi, C. Mortellaro, K. B. Park, C. Mangano

“…Twenty patients (8 males, 12 females) were selected, 10 with a failing/nonrestorable lateral incisor (test group: immediate placement in postextraction socket) and 10 with a missing lateral incisor (control group: conventional placement in healed ridge). …”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Molecular dynamics simulations and experimental findings reveal that the R configuration of WN2 (WN2-R) is the preferred form (IC50 = 24.7 ± 9.4 nM) within the VSDIV pocket of Nav1.7. WN2-R exhibits impressive analgesic effects in acute and chronic inflammatory pain, as well as neuropathic pain models in mice. …”
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Fast Task Scheduling With Model Predictive Control Integrating a Priority-Based Heuristic by Francesco Liberati, Manuel Donsante, Chiara Maria Francesca Cirino, Andrea Tortorelli

“…The use case motivating the work is given by the problem of managing the integration activities involved in the final assembly of the Vega rocket at the European space center in Kourou, French Guiana. …”
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