Proteogenomic characterization of invasive breast tumors in young women by Praveen-Kumar Raj-Kumar, Jianfang Liu, Anthony R. Soltis, Nicholas W. Bateman, Qingrong Chen, Lori A. Sturtz, Brenda Deyarmin, Mariaelena Pierobon, Tamara A. Abulez, Anupama Praveen-Kumar, Xijun Zhang, Trinh Nguyen, Chunhua Yan, Ying Hu, Kate Guion, Jeffrey A. Hooke, Albert J. Kovatich, Leigh Fantacone-Campbell, Brad Mostoller, Leonid Kvecher, Stella Somiari, Patricia S. Steeg, Padma Sheila Rajagopal, Kathleen M. Darcy, Jerry S. H. Lee, Clifton L. Dalgard, Thomas P. Conrads, Emanuel F. Petricoin, Daoud Meerzaman, Matthew D. Wilkerson, APOLLO Research Network, Xiaoying Lin, Craig D. Shriver, Stanley Lipkowitz, Hai Hu

“…Notably, GATA3 mutations were enriched in luminal tumors from young women while TP53 and PIK3CA mutations were more common in luminal tumors from older women. …”
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A Series of Novel Alleles of <i>Ehd2</i> Modulating Heading and Salt Tolerance in Rice by Peng Xu, Shulei Hao, Xiaoxia Wen, Guifang Ma, Qinqin Yang, Ling Liu, Galal Bakr Anis, Yingxin Zhang, Lianping Sun, Xihong Shen, Qunen Liu, Daibo Chen, Yongbo Hong, Yuyu Chen, Xiaodeng Zhan, Shihua Cheng, Liyong Cao, Weixun Wu

“…Salinity stress significantly hampers rice growth and productivity. Transcriptomic analysis of <i>elh10</i> and ZH8015 seedlings exposed to salt stress for 24 h identified 5150 differentially expressed genes (DEGs) at the seedling stage, predominantly linked to stress response pathways. …”
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Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages by Upneet K Sokhi, Ruoxi Yuan, Bikash Mishra, Yurii Chinenov, Anvita Singaraju, Karmela K Chan, Anne Bass, Richard D Bell, Laura Donlin, Lionel B Ivashkiv

“…We used an integrated transcriptomic and epigenomic analysis in primary human monocytes to study PGE2-TNF crosstalk, and how it is regulated by IFN-γ, as occurs in RA synovial macrophages. …”
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Bruton tyrosine kinase covalent inhibition shapes the immune microenvironment in chronic lymphocytic leukemia by Daniel Medina-Gil, Laura Palomo, Víctor Navarro, Gonzalo Lázaro, Beatriz Martín-Mur, Cristina Hernández, Oriol Castells, Belén Sánchez, Pau Marc Muñoz-Torres, Carlota Pagès, Gemma Pujadas, Anna Esteve-Codina, Alba Cabirta, Christelle Ferrà, Miguel Alcoceba, Maria José Terol, Rafael Andreu, Mercè Martí, Pau Abrisqueta, Francesc Bosch, Marta Crespo, Spanish Group of Chronic Lymphocytic Leukemia - GELLC

“…These CLL cells with potential migrative capacity under ibrutinib also exhibited a distinct transcriptomic profile including upregulation of mTOR-AKT and MYC pathways. …”
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Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism by Ielizaveta Gorodetska, Vasyl Lukiyanchuk, Marta Gawin, Myroslava Sliusar, Annett Linge, Fabian Lohaus, Tobias Hölscher, Kati Erdmann, Susanne Fuessel, Angelika Borkowetz, Anna Wojakowska, Daniel Fochtman, Mark Reardon, Ananya Choudhury, Yasmin Antonelli, Aldo Leal-Egaña, Ayse Sedef Köseer, Uğur Kahya, Jakob Püschel, Andrea Petzold, Daria Klusa, Claudia Peitzsch, Romy Kronstein-Wiedemann, Torsten Tonn, Lukasz Marczak, Christian Thomas, Piotr Widłak, Monika Pietrowska, Mechthild Krause, Anna Dubrovska

“…The level of MMP11 protein was analysed by enzyme-linked immunosorbent assay (ELISA) in independent cohorts of plasma samples from patients with primary or metastatic PCa and healthy donors, while plasma proteome profiles were obtained for selected subsets of PCa patients. …”
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Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling by Lun Hua, Wenxue Shen, Dengfeng Gao, Yi Yang, Xiaohan Yang, Haoqi Zhang, Siyuan Liu, Luting Liu, Yaxue Cao, Xuemei Jiang, Xingfa Han, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Jian Li, Zhengfeng Fang, Ting Luo, Mingzhou Li, De Wu, Yong Zhuo

“…Our single-nucleus transcriptomic analysis revealed dynamic changes in cell heterogeneity within the fetal interscapular BAT (iBAT) from obese dams, leading to compromised thermogenesis in their offspring. …”
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Screening of reference genes in Callosobruchus maculatus (Coleoptera: Bruchidae) fourth-instar larvae under high-temperature and antibiotic treatments(高温及抗生素处理下四纹豆象四龄幼虫内参基因的筛选)... by 耿加美(GENG Jiamei), 何云川(HE Yunchuan), 陈秋霖(CHEN Qiulin), 高扬(GAO Yang), 周瀛(ZHOU Ying), 祝增荣(ZHU Zengrong)

“…The results demonstrated that RpL39_1 exhibited the highest stability across all the treatment groups, while the combination of RpL39_1 and RpL39_2 also met the normalization requirements. …”
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