METTL14 and WTAP play a crucial role in the regulation of bovine preadipocyte differentiation by Jia Liu, Chicheng Ma, Yu Cheng, Minzhi Wang, Guoqing Zhao, Liwei Huang, Ruigao Song, Xi Wang, Hongxia Li

“…This study investigated their effects on bovine preadipocyte differentiation using siRNA-mediated knockdown combined with transcriptomic analysis. Silencing METTL14 and WTAP significantly impaired lipid droplet formation and revealed distinct regulatory pathways: METTL14 knockdown affected genes like JAK2 and STAT3, while WTAP suppression down-regulated PPARγ/FABP4 signalling pathway components. …”
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Phenotypic and transcriptional fidelity of patient-derived colon cancer xenografts in immune-deficient mice. by Jeffrey Chou, Matthew P Fitzgibbon, Christie-Lynn L Mortales, Andrea M H Towlerton, Melissa P Upton, Raymond S Yeung, Martin W McIntosh, Edus H Warren

“…In most but not all cases, the human stroma, vasculature, and hematopoietic elements were systematically replaced by murine analogues while the carcinoma component persisted. Once established as xenografts, human CRC cells that could be propagated by serial transplantation remained transcriptionally stable. …”
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Lineage trajectories and fate determinants of postnatal neural stem cells and ependymal cells in the developing ventricular zone. by Jianqun Zheng, Yawen Chen, Yukun Hu, Yujian Zhu, Jie Lin, Manlin Xu, Yunlong Zhang, Weihong Song, Xi Chen

“…Previous lineage tracing studies showed that both NSCs and EPCs were derived from radial glial cells (RGCs). However, the transcriptomic dynamics and the molecular mechanisms guiding the cell fate commitment during the differentiation remain poorly understood. …”
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LDHB silencing enhances the effects of radiotherapy by impairing nucleotide metabolism and promoting persistent DNA damage by Haibin Deng, Fatlind Malsiu, Huixiang Ge, Tereza Losmanova, Michaela Medová, Nicola Zamboni, Wenxiang Wang, Ren-Wang Peng, Jinming Tang, Patrick Dorn, Thomas Michael Marti

“…In this study, a re-analysis of our previous transcriptomic data revealed that LDHB silencing in the NSCLC cell lines A549 and H358 dysregulated 1789 genes, including gene sets associated with cell cycle and DNA repair pathways. …”
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Preparation of Trop2-targeted chimeric antigen receptor T cells and study of their exhaustion status in vitro by LIU Xiuying, LI Xinzhan, ZHU Jingjing, ZHU Jingjing

“…Transcriptomic analysis identified multiple differentially expressed genes in the exhausted CAR-T cells. …”
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Exploring the role of EBV in multiple sclerosis pathogenesis through EBV interactome by Chiara Ballerini, Roberta Amoriello, Olfa Maghrebi, Gianmarco Bellucci, Ilaria Addazio, Matteo Betti, Maria Grazia Aprea, Camilla Masciulli, Arianna Caporali, Valeria Penati, Clara Ballerini, Ermelinda De Meo, Emilio Portaccio, Marco Salvetti, Marco Salvetti, Maria Pia Amato, Maria Pia Amato

“…Metascape and GTEx analyzed biological pathways and brain-level gene expression; transcriptomic analysis was performed on glial cells and peripheral blood in MS and controls. …”
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LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy by Pin Li, Qin Li, Nilima Biswas, Hong Xin, Tanja Diemer, Lixian Liu, Lorena Perez Gutierrez, Giovanni Paternostro, Carlo Piermarocchi, Sergii Domanskyi, Ruikang K Wang, Napoleone Ferrara

“…LIF also had protective effects on the choriocapillaris in a model of oxidative retinal injury. Analysis of available single‐cell transcriptomic datasets shows strong expression of the specific LIF receptor in mouse and human choroidal EC. …”
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Integrated Multi-Omics Profiling Reveals That Highly Pyroptotic MDMs Contribute to Psoriasis Progression Through CXCL16 by Liping Jin, Xiaowen Xie, Mi Zhang, Wu Zhu, Guanxiong Zhang, Wangqing Chen

“…<b>Methods:</b> We integrated 21 transcriptomic datasets (from 2007 to 2020) obtained from the GEO database and two single-cell RNA sequencing datasets to quantify pyroptotic activity using Gene Set Variation Analysis and AUCell algorithms. …”
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USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway by Ni Xiong, Yue Wang, Junhong Jiang

“…Materials & Methods This work utilized single‐cell transcriptomic analysis with the Scissor algorithm to identify distinct epithelial subpopulations, particularly focusing on the Stress subpopulation that exhibited significant upregulation of USP5. …”
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Exploring the effects of feeding methods on the growth and meat flavor of Wenchang chicken by Tieshan Xu, Qicheng Jiang, Chaohua Xu, Zhepeng Xiao, Xinli Zheng, Lihong Gu

“…CR chickens had higher IMP, threonine (Thr), and pentadecanoic, oleic, and linoleic acids, while glutamate (Glu) and alpha-linolenic acid were lower compared to FR. …”
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From Multi‐Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR‐T Cell Therapy by Yuting Gong, Peng Fei, Yicheng Zhang, Yang Xu, Jia Wei

“…The integration of genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics enables a comprehensive understanding of the intrinsic mechanisms underlying CAR‐T therapy, while single‐cell and spatial omics significantly improve data resolution and analytical depth. …”
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The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors by Imad Soukar, Robert J. Fisher, Sanjana Bhagavatula, Marianne Collard, Philip A. Cole, Rhoda M. Alani

“…Our findings demonstrate that the LHC small molecule inhibitor, corin, induces apoptosis and significantly inhibits proliferation in MPNST cells. Transcriptomic analysis of corin-treated MPNST cells demonstrates specific increases in genes associated with axonogenesis and neuronal differentiation as well as altered extracellular matrix; additionally, corin treatment is shown to inhibit MPNST invasion in vitro. …”
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Chromogranin A deficiency attenuates tauopathy by altering epinephrine–alpha-adrenergic receptor signaling in PS19 mice by Suborno Jati, Daniel Munoz-Mayorga, Shandy Shahabi, Kechun Tang, Yuren Tao, Dennis W. Dickson, Irene Litvan, Gourisankar Ghosh, Sushil K. Mahata, Xu Chen

“…CgA ablation in Tauopathy mice (PS19) (CgA-KO/PS19) reduced pathological Tau aggregation and spreading, extended lifespan, and improved cognitive function. Transcriptomic and metabolite analysis of mouse cortices revealed elevated alpha-1-adrenergic receptors (Adra1) expression and high Epinephrine (EPI) levels in PS19 mice compared to WT mice, mirroring observations in AD and CBD patients. …”
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance by Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. vanLiere, Bart Westendorp

“…Understanding drug tolerance mechanisms is impeded by analysis of bulk samples, which neglect tumor heterogeneity and often fail to accurately interpret cell cycle‐mediated resistance. …”
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Omics-driven insights into plant growth-promoting microorganisms for sustainable agriculture by Abhishek Sahoo, Garima Yadav, Tushar Mehta, Mukesh Meena, Prashant Swapnil

“…At the same time, transcriptomic profiling has illuminated plant immune priming and hormonal modulation under microbial influence. …”
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Exogenous citric acid-mediated modification of metabolism, transport and signal transduction of non-structural carbohydrates in rice under hexavalent chromium stress by Yi Kang, Yu-Juan Lin, Cheng-Zhi Li, Hao Zhan, Xiao-Zhang Yu

“…Tissue-specific transcriptomic shifts revealed CA-mediated modulation of NSC metabolic genes, transporters, and signaling components. …”
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Epigenetic determinants of an immune-evasive phenotype in HER2-low triple-negative breast cancer by Andrés F. Bedoya-López, Sookyung Ahn, Miquel Ensenyat-Mendez, Javier I. J. Orozco, Sandra Iñiguez-Muñoz, Pere Llinàs-Arias, Samantha M. Thomas, Jennifer L. Baker, Peggy S. Sullivan, Jitin Makker, Julie B. Steele, Sunil M. Kurian, Diego M. Marzese, Maggie L. DiNome

“…We performed a comprehensive multi-omics analysis, integrating genomic, epigenomic, transcriptomic, and proteomic profiling to characterize HER2-low TNBC. …”
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GPATCH11 variants cause mis-splicing and early-onset retinal dystrophy with neurological impairment by Andrea Zanetti, Gwendal Dujardin, Lucas Fares-Taie, Jeanne Amiel, Jérôme E. Roger, Isabelle Audo, Matthieu P. Robert, Pierre David, Vincent Jung, Nicolas Goudin, Ida Chiara Guerrera, Stéphanie Moriceau, Danielle Amana, Nurit Assia Batzir, Anat Bachar-Zipori, Lina Basel Salmon, Nathalie Boddaert, Sylvain Briault, Ange-Line Bruel, Christine Costet-Fighiera, Luisa Coutinho Santos, Cyril Gitiaux, Karolina Kaminska, Paul Kuentz, Naama Orenstein, Nicole Philip-Sarles, Morgane Plutino, Mathieu Quinodoz, Cristina Santos, Sabine Sigaudy, Mariana Soeiro e Sá, Efrat Sofrin, Ana Berta Sousa, Rui Sousa-Luis, Christel Thauvin-Robinet, Erwin L. van Dijk, Khaoula Zaafrane-Khachnaoui, Dinah Zur, Josseline Kaplan, Carlo Rivolta, Jean-Michel Rozet, Isabelle Perrault

“…Proteomic analysis of mouse retina confirms the roles GPATCH11 plays in RNA processing, splicing, and transcription regulation, while also suggesting additional functions in synaptic plasticity and nuclear stress response. …”
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Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPARγ by Yuting Bai, Mingjing Jiang, Xiaojie Chen, Gang Zhou

“…The regulatory role of PPARγ on CAV2 was explored through bioinformatics, correlation analysis, and dual-luciferase assays. Coimmunoprecipitation assessed CAV2 and NCOR1 binding with PPARγ, while the PPARγ inverse agonist T0070907 was used to enhance NCOR1-mediated repression of CAV2. …”
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Investigation of the Roles of Phosphatidylinositol 4-Phosphate 5-Kinases 7,9 and Wall-Associated Kinases 1–3 in Responses to Indole-3-Carbinol and Biotic Stress in Arabidopsis Thal... by Hala Khamesa-Israelov, Alin Finkelstein, Eilon Shani, Daniel A. Chamovitz

“…Physiological, metabolomic, and transcriptomic analysis reveal that these kinases mediate numerous developmental processes and are involved in abiotic and biotic stress responses.…”
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