Photothermal therapy improves the efficacy of topical immunotherapy against melanoma by Lei Shi, Fuhe Zhang, Jia Yan, Min Luo, Kaili Liu, Pei Liu, Guorong Yan, Chunxiao Li, Yutong Yang, Qingyu Zeng, Guolong Zhang, Wei R. Chen, Xiuli Wang

“…Additionally, the population of mature dendritic cells, CD4+ T cells, and CD8+ T cells were increased, while myeloid-derived suppressor cells were downregulated after LIT. …”
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Investigation of the Effects of Salinity Exposure on Immune Defense, Morphology, and Gene Expression in the Gills of <i>Macrobrachium nipponense</i> by Shubo Jin, Rong Zhou, Hongtuo Fu, Wenyi Zhang, Hui Qiao, Yiwei Xiong, Sufei Jiang

“…In addition, we found no obvious morphological changes in the gills, indicating that <i>M. nipponense</i> can adapt well to water environments with such salinity. Transcriptome profiling analysis identified 168, 434, and 944 differentially expressed genes (DEGs) when comparing S0 vs. …”
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Dietary effects of astaxanthin on gonadal development in female broodstock of Macrobrachium rosenbergii by Mingwei Tao, Jie Wei, Clement de Cruz, Junyi Wang, Houkuan Du, Hangxian Zhou, Qiyou Xu

“…Oxidative stress indicators showed lower malondialdehyde levels and higher superoxide dismutase activity in AS62, with total antioxidant capacity peaking in AS140 (P < 0.05). Transcriptome analysis revealed upregulation of genes involved in the pentose phosphate pathway, glutathione metabolism, and ubiquinone/terpenoid-quinone biosynthesis in AS140. …”
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Decreased expression of cell adhesion genes in cancer stem-like cells isolated from primary oral squamous cell carcinomas by Amrendra Mishra, Harshini Sriram, Pinal Chandarana, Vivek Tanavde, Rekha V Kumar, Ashok Gopinath, Raman Govindarajan, S. Ramaswamy, Subhashini Sadasivam

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Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model by Zachary C. E. Hawley, Xueying Li, Dora Bodnar, Yuanzheng Gu, Yi Luo, Daniel Ferretti, Adam Sheehy, Rachelle Driscoll, Maria I. Zavodszky, Shaolong Cao, Isabel Isaza, Luke Jandreski, Yuqing Liu, Thomas Carlile, Shih-Ching Lo, Anna Grimard, Shawn Bourque, Aditya Utturkar, Samantha Desmarais, H. Moore Arnold, Dann Huh, Edward Guilmette, Deborah Y. Kwon

“…Notably, impaired regulation of the PFN1C71G skeletal muscle transcriptome exceeds that of the spinal cord and is also improved by Atxn2 reduction in the CNS. …”
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Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity by Xuyu Gu, Chanchan Gao, Xiangyu Su, Yaoyao Zhu, Qiyu Fang, Jia Yu, Ziming Wang, Deping Zhao, Wentian Zhang

“…Methods Single-cell transcriptome-based analysis was performed to identify CD8+ T-cell profiles and regulatory factors in six LC patients receiving neoadjuvant PD-1 blockade therapy. …”
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Decoding the epigenetic-immune nexus in hepatocellular carcinoma: a Mendelian randomization study reveals BTN3A2, S100A12 and TRIM27 as white blood cell regulators by Yang Qiu, Haiyan Zhang, Xiao Yu, Jielu Pan, Dinghong Xiao, Hongyu Miao, Ruiqing Wang, Nan Shen, Peimin Pu, Yinling Zhou, Zhidong Liu, Lin He, Lianjun Xing

“…The robustness of our findings was established through stringent criteria, comprehensive sensitivity analyses, and Bayesian colocalization, followed by functional validation with TCGA data and a transcriptome-wide association study (TWAS). Results Our analysis identified 26 HCC-specific CpG sites with causal effects on white blood cell counts. …”
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Putative function and prognostic molecular marker of mast cells in colorectal cancer by Jiani Guo, Jie Chen, Yiting Wang, Xiaoming Bai, Haimei Feng, Siqi Sheng, Hongyu Wang, Ke Xu, Mengxi Huang, Zengjie Lei, Xiaoyuan Chu

“…Methods Single-cell transcriptome data of CRC patients were extracted from GSE146771 for cell classification and annotation. …”
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Lnc-MEG8 regulates yak myoblast differentiation via the miR-22-3p/RTL1 axis by Xiaoming Ma, Yongfu La, Tong Wang, Chun Huang, Fen Feng, Xian Guo, Pengjia Bao, Xiaoyun Wu, Min Chu, Chunnian Liang, Ping Yan

“…Functional experiments showed that Lnc-MEG8 promotes cell proliferation and inhibits differentiation, while its silencing had the opposite effect. Further analysis revealed that both Lnc-MEG8 and the gene RTL1 share miR-22-3p as a common target. …”
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A Monocyte-Driven Prognostic Model for Multiple Myeloma: Multi-Omics and Machine Learning Insights by Xie L, Gao M, Tan S, Zhou Y, Liu J, Wang L, Li X

“…Flow cytometry analysis confirmed that the MFI of CD14 (p&lt; 0.01) and HLA-DR (p&lt; 0.05) on CD14+ monocytes was significantly elevated in early-stage MM. …”
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Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice by Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi

“…Transcriptome analysis shows that PGC1α (the regulator of FNDC5) is regulated by PC treatment, and the results of knocking out PGC1α and FNDC5/irisin are consistent. …”
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The Mechanism of Aniline Blue Degradation by Short-Chain Dehydrogenase (<i>SDRz</i>) in <i>Comamonas testosteroni</i> by Chuanzhi Zhang, Yong Huang, Jiaxin He, Lei He, Jinyuan Zhang, Lijing Yu, Elshan Musazade, Edmund Maser, Guangming Xiong, Miao Xu, Liquan Guo

“…Through prokaryotic transcriptome analysis, we identified a significantly upregulated short-chain dehydrogenase (<i>SDRz</i>) gene (log₂FC = 2.11, <i>p</i> < 0.05) that plays a crucial role in the degradation process. …”
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Investigation of the physiological and molecular regulatory mechanism of soluble sugar metabolism in Lavandula angustifolia Mill. under cold stress by Yuchen Liang, Yuchen Liang, Yuchen Liang, Yuchen Liang, Yinan Liu, Yinan Liu, Yu Wang, Yu Wang, Ruijiao Yang, Ruijiao Yang, Zening Yuan, Zening Yuan, Hui Li, Hui Li

“…To investigate the mechanisms underlying cold tolerance in L. angustifolia and support economic development, we measured the sugar content and performed transcriptome analysis at temperatures of 30°C (control), 20°C, 10°C, and 0°C. …”
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Transcriptional dynamics and functions of WUSCHEL-related homeobox (WOX) genes from Ginkgo biloba in tissue culture by Wei Xu, Ang Xu, Pingjun Xu, Jiaqi Li, Chao Luo, Xiaoming Yang, Meiling Ming, Yuhua Liu, Guibin Wang, Liangjiao Xue, Fuliang Cao, Gaiping Wang, Fangfang Fu

“…Transcriptome analysis indicated tissue-specific expression of seven GbWOXs, with two gymnosperm-specific GbWOXs characterized by extra-long introns exhibiting constitutive expression. …”
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LincRNA-MSTRG.673.2 Promotes Chicken Intramuscular Adipocyte Differentiation by Sponging miR-128-3p by Binbin Zhang, Shuaipeng Zhu, Yuehua He, Wenjie Liang, Tingqi Zhu, Ruili Han, Donghua Li, Yanbin Wang, Yadong Tian, Guoxi Li, Xiangtao Kang, Wenting Li, Guirong Sun

“…In this study, we investigated the mechanism of miR-128-3p regulation of chicken intramuscular adipocyte differentiation and deposition. <b>Results:</b> Transcriptome data analysis of differential LincRNAs indicated that, compared to the NC group, the mimics-treated group had seventeen significantly differentially expressed LincRNAs (<i>p</i> < 0.05), including six upregulated and eleven downregulated ones; the inhibitor-treated group had seventeen differentially expressed LincRNAs (<i>p</i> < 0.05), including eight upregulated and nine downregulated ones; and twenty-four differentially expressed LincRNAs (<i>p</i> < 0.05) were observed when comparing the mimics-treated group to the inhibitor-treated group, with fourteen upregulated and ten downregulated ones. …”
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Effect of polystyrene micro/nanoplastics on mesenchymal phenotypic transformation in testicular Sertoli cells by CAI Jing, WEN Yixian, ZHANG Huilian

“…Cell viability and proliferative capacity were evaluated using CCK-8 assay and EdU incorporation, while cell migration was assessed using transwell and cell scratch assays. …”
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Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper by Hongji Yang, Guorong Yu, Zhidong Lv, Tonghui Li, Xi Wang, Ying Fu, Zhangsheng Zhu, Guangjun Guo, Hang He, Ming Wang, Guochen Qin, Feng Liu, Zhenhui Zhong, Yan Xue

“…Abstract Background Pepper (Capsicum annuum) is one of the earliest and most widely cultivated vegetable crops worldwide. While the large and complex genome of pepper severely hampered the understanding of its functional genome, it also indicates a rich yet unexplored reservoir of regulatory elements (REs). …”
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Chloroplast positioning affects Hexokinase 1-mediated plant immunity under combined low temperature and high light by Sophia Bianca Bagshaw, Anastasia Kitashova, Beyza Özmen, Chun Kwan Yip, Bianca Emily Süling, Laura Schröder, Tatjana Kleine, Thomas Nägele

“…In a double mutant, combining deficiencies in Chloroplast Unusual Positioning 1 (CHUP1)-mediated chloroplast positioning and HXK1 (hxk1 x chup1), this growth phenotype vanished resulting in wild type-like plants. Transcriptome analysis revealed a significantly affected immune response of hxk1 plants, which was suppressed in the double mutants. …”
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Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission by Sun Y, Jin S, Chen J, Zhang J, Lu Y, Gu Q, Yan Z, Chen W, Chen A, Fang Y, Geng W, Xu X, Song N

“…Immunofluorescence and in vitro experiments further elucidated the therapeutic mechanism of cordycepin.Results: In vivo experiments showed that intraperitoneal injection of cordycepin significantly reduced renal inflammation and fibrosis, lowered serum creatinine levels, and decreased collagen deposition. Transcriptome analysis revealed that cordycepin treatment downregulated the mitochondrial fission pathway and upregulated the mitochondrial fusion pathway. …”
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Genetic variants influencing liver fat in normal-weight individuals of European ancestry by Ignazio S. Piras, Janith Don, Nicholas J. Schork, Johanna K. DiStefano

“…Gene-level associations were evaluated using multi-marker analysis of genomic annotation (MAGMA), and liver-specific gene expression was imputed for transcriptome-wide association studies (TWAS). …”
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