FGF7 secreted from dermal papillae cell regulates the proliferation and differentiation of hair follicle stem cell by Niu Wang, Weidong Zhang, Zhenyu Zhong, Xiongbo Zhou, Xinran Shi, Xin Wang

“…FGF7 functions as a paracrine protein regulating epithelial proliferation, differentiation and migration. The single-cell transcriptome profiling and immunofluorescence analysis demonstrated that FGF7 localizes at DPC, while FGF7 receptor (FGFR2) expresses in both DPC and HFSC. …”
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PRDX1 knockdown promotes erastin-induced ferroptosis and impedes diffuse large B-cell lymphoma development by inhibiting the MAPK/ERK pathway by Chuanming Lin, Shuiling Xie, Menger Wang, Jianzhen Shen

“…Methods The expression of PRDX1 in DLBCL tissues and cells was detected using bioinformatics analysis and reverse transcription quantitative PCR. …”
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Global changes in gene expression of Barrett's esophagus compared to normal squamous esophagus and gastric cardia tissues. by Paula L Hyland, Nan Hu, Melissa Rotunno, Hua Su, Chaoyu Wang, Lemin Wang, Ruth M Pfeiffer, Barbara Gherman, Carol Giffen, Cathy Dykes, Sanford M Dawsey, Christian C Abnet, Kathryn M Johnson, Ruben D Acosta, Patrick E Young, Brooks D Cash, Philip R Taylor

“…<h4>Background</h4>Barrett's esophagus (BE) is a metaplastic precursor lesion of esophageal adenocarcinoma (EA), the most rapidly increasing cancer in western societies. While the prevalence of BE is increasing, the vast majority of EA occurs in patients with undiagnosed BE. …”
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Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis by Le Xu, Jian Xu, Wanting Shi, Sa Zhang, Ting Guo, Shien Zou

“…In vitro, 17β-estradiol (E2) upregulated PRKRA expression, while follicle-stimulating hormone (FSH) downregulated it in HepG2 and HuH7 cells. …”
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Optimizing rabies mRNA vaccine efficacy via RABV-G structural domain screening and heterologous prime-boost immunization by Dongdong Li, Xuan Wang, Gaotian Li, Jingying Zhou, Lijun Bian, Xiaoyan Zhao, Liao Xing, Juanmei Zeng, Jiaxing Cui, Lili Cui, Yong Zhang, Yan Chen

“…Heterologous immunization results revealed that mRNA-primed strategies yielded higher long-lasting VNTs, but lower early VNTs than inactivated rabies virus (IRV)-primed strategies. 2×RABV-Full and IRV > RABV-Full provided 100% protection, while that of RABV-Full>IRV was 90%. Transcriptome analysis showed that rabies mRNA vaccine induced both MHCI and MHCII antigen presentation, as well as B/T cell activation. …”
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Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions. by Karen Campos-León, Jack Ferguson, Thomas Günther, C David Wood, Steven W Wingett, Selin Pekel, Christy S Varghese, Leanne S Jones, Joanne D Stockton, Csilla Várnai, Michelle J West, Andrew Beggs, Adam Grundhoff, Boris Noyvert, Sally Roberts, Joanna L Parish

“…Since CTCF is an important regulator of host cell transcription via coordination of epigenetic boundaries and long-range chromosomal interactions, we hypothesised that HPV18 may also manipulate CTCF to contribute to host transcription reprogramming. Analysis of CTCF binding in the host cell genome by ChIP-Seq revealed that while the total number of CTCF binding sites is not altered by the virus, there are a sub-set of CTCF binding sites that are either enriched or depleted of CTCF. …”
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Multi-omics profiling reveals single-seed mutants of Ephedra saxatilis as dominant variants in high-altitude Xizang by Mengnan Lu, Shiyan Wang, Yonghong Zhou, Xiaona Wang, Hao Su, Yanbing Gong, Ji De

“…Co-expression network analysis integrating transcriptome and hormone data predicted 23 key genes regulating seed germination adaptation. …”
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Human hepatoma Huh-7 cell culture models deficient in apolipoprotein B secretion by Swati Valmiki, Sara Rosario, Ashley Mooring, Chandana Prakashmurthy, Florencia Schlamp, Binu Prakash, Atrayee Chattopadhyay, Abulaish Ansari, José O. Alemán, Nathalie Pamir, M. Mahmood Hussain

“…Total RNA transcriptome analysis identified DNA replication and complement and coagulation pathways as the most upregulated pathways in Ako cells. …”
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Smoking-Associated Changes in Gene Expression in Coronary Artery Disease Patients Using Matched Samples by Mohammed Merzah, Szilárd Póliska, László Balogh, János Sándor, Szilvia Fiatal

“…Differential gene expression analysis identified 58 DEGs, with 38 upregulated in smokers. …”
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Downregulation of hsa-miR-135b-5p Inhibits Cell Proliferation, Migration, and Invasion in Colon Adenocarcinoma by Yunxin Zhang, Wentao Zhang, Wenlong Xia, Junwei Xia, Haishan Zhang

“…To obtain the target genes of hsa-miR-135b-5p, transcriptome sequencing of the SW480 cells was performed, followed by protein-protein interaction (PPI) network and hsa-miR-135b-5p-target gene regulatory network construction and prognostic analysis. …”
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Co-exposure to ozone and polystyrene nanoplastic exacerbates cognitive impairment and anxiety-like behavior by regulating neuronal pyroptosis in mice by Anqi Dai, Xudong Liu, Yinuo Chen, Yougang Wang, Haomin Qi, Yan Zeng, Jinquan Li

“…Ozone (O3) and nanoplastics (NPs) are pervasive environmental pollutants that frequently co-occur in our heavily industrialized era. While it has been documented that exposure to O3 or NPs individually has neurotoxic effects, studies investigating their combined impact and the hazardous mechanisms resulting from co-exposure are limited. …”
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Genetic prioritisation of candidate drug targets for glaucoma through multi-trait and multi-omics integration by Jianqi Chen, Yangjiani Li, Yingting Zhu, Zhidong Li, Shitong Huang, Wenzhi Huang, Yuyao Ling, Jingying Liang, Yunxia Leng, Yehong Zhuo

“…Methods We sourced druggable gene expression and protein abundance summary-level data from quantitative trait loci studies, and genetic associations with glaucoma from a large-scale multi-trait analysis. We employed proteome and transcriptome Mendelian randomization (MR) and colocalisation to identify potential therapeutic targets, glaucoma endophenotype MR to explore the potential mechanisms of identified associations, and phenome-wide MR to investigate possible adverse effects of candidate targets. …”
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Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for Endometriosis by Mingrui Zou, Mingmei Lin, Kai-Lun Hu, Rong Li

“…Endometriosis (EMT) is a common gynecological disease with a strong genetic component, while its precise etiology remains elusive. This study aims to integrate transcriptome-wide association study (TWAS), Mendelian randomization (MR), and bioinformatics analyses to reveal novel putatively causal genes and potential mechanisms. …”
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Identification and Validation of NK Marker Genes in Ovarian Cancer by scRNA-seq Combined with WGCNA Algorithm by Xin He, Weiwei Feng

“…Weighted gene coexpression network analysis (WGCNA) identified core modules and central genes associated with NK cells. …”
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Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China by Peishan Cong, Biao Wang, Hong He, Xiaoying Li, Lijing Peng, Ji Liu, Hui Guo, Guirong Sun

“…Results A total of 106 C. glabrata strains were isolated from blood cultures of 103 candidemia patients across three medical centers in eastern China. Transcriptome sequencing and whole-genome sequence analysis were used to explore the genomic characteristics of echinocandin-resistant strains. …”
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<i>Saussurea involucrata CML6</i> Enhances Freezing Tolerance by Activating Antioxidant Defense and the CBF-COR Pathway in Plants by Mengjuan Hou, Hui Kong, Jin Li, Wenwen Xia, Jianbo Zhu

“…Calmodulin-like (CML) proteins are crucial calcium sensors in plant cold responses. Transcriptome analysis of cold-stressed <i>Saussurea involucrata</i> identified seven differentially expressed <i>CML</i> genes. qRT-PCR confirmed <i>that SiCML6</i> was strongly induced at 4 °C and −2 °C. …”
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Human lung organoids reveal conserved CYP1A1 and metallothionein activation in response to particulate matter exposure by Seri Choi, Seung-Yeon Kim, Ji Won Baek, Won Keun Oh, Kee K. Kim, Eun-Mi Kim

“…ERM exposure dose-dependently upregulated CYP1A1 expression and enzymatic activity while enhancing reactive oxygen species production. …”
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Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc by Changli Zhang, Martha Elena Diaz-Hernandez, Takanori Fukunaga, Sreekala Shenoy, Sangwook Tim Yoon, Lisbet Haglund, Hicham Drissi

“…Network analysis revealed that PDGFRA and IL6 were the top hub genes in treated NP cells. …”
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Unraveling the role of HIF2α in melanoma progression and epithelial–mesenchymal transition by Zhao Han, Yanling Gao, Zhifeng Li, Zhao Liu, Jianzhong Zhang, Tingting Jing, Yanyan Xv, Guoying Miao, Xiaojing Li, Aijun Chen

“…However, the role of hypoxia-inducible factor 2α (HIF2α), a key transcription factor, in melanoma remains poorly understood. In this study, transcriptome analysis compared HIF2α expression between melanoma patient and control samples. …”
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Histological morphology and gene expression in the digestive system of Procambarus clarkii by Zonglin Yang, Jingjing Hao, Yufei Liu, Xugan Wu, Xiaowu Chen

“…To unravel the intricate morphological structure and functional aspects of the digestive system in Procambarus clarkii, this study employed histology and transcriptome sequencing techniques for a comprehensive analysis of its digestive system. …”
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