Seasonal anti-androgen activity in the brackish Baltic waters in relation to the gene expression profiles of the blue mussel Mytilus trossulus by Paulina Goździk, Katarzyna Smolarz, Magda Caban, Anna Hallmann

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Characterizing age-related features for assessing biological age and characteristics in Xinjiang Brown cattle by Jiahao Wang, Menghua Zhang, Qingyao Zhao, Siqian Chen, Yongjie Tang, Quanzhen Chen, Lei Xu, Dan Wang, Xiaoping Guo, Kai Xing, Yachun Wang, ChuduanWang, Xixia Huang, Ying Yu

“…Results A total of 1140 genes were identified as exhibiting a linear change in expression with age, while 697 genes showed non-linear changes, mainly enriched in immune and disease-related pathways. …”
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Functional omics of ORP7 in primary endothelial cells by Juuso H. Taskinen, Minna Holopainen, Hanna Ruhanen, Miesje van der Stoel, Reijo Käkelä, Elina Ikonen, Salla Keskitalo, Markku Varjosalo, Vesa M. Olkkonen

“…We performed a hypothesis-free multi-omics analysis of chemical ORP7 inhibition utilizing transcriptomics and lipidomics as well as proximity biotinylation interactomics to characterize ORP7 functions in a primary cell type, human umbilical vein endothelial cells (HUVECs). …”
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Overexpression of Lol-miR11467 negatively affects osmotic resistance in Larix kaempferi 3 × L. gmelinii 9 by Sufang Zhang, Shanshan Yan, Li Zhang, Pingyu Yan, Hanguo Zhang, Lei Zhang

“…Transcriptome analysis showed that genes associated with phenylpropanoid metabolism, transcription factors, oxidoreductase, plant hormone signal transduction, glucose metabolism and bioprotective macromolecules were mainly downregulated in Lol-miR11467 cell lines. …”
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The transcription factor PoMbp1 promotes the growth and development of Pleurotus ostreatus by regulating polysaccharide utilisation by Lijiao Zhang, Yingjie Zhang, Zeyin Wu, Mengran Zhao, Xiangli Wu, Chenyang Huang

“…The expression pattern analysis showed that PoMbp1 was expressed more in the caps of the fruiting body than in other stages. …”
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Shanling Jiangzhi Tea treats hyperuricemia by inhibition of COMT/MAOA signaling pathway and p53/SERPINE1/NLRP3 signaling pathway by Hao-nan Chen, Hao-nan Chen, He-zhen Wu, He-zhen Wu, He-zhen Wu, Yan-fang Yang, Yan-fang Yang, Yan-fang Yang

“…Kit-based assays indicate that SLJZ increases dopamine (DA) levels in the kidneys of mice while reducing the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). …”
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New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels by Huan Zhao, Huan Zhao, Xu Dong, Xu Dong, Dazuo Yang, Dazuo Yang, Qingchao Ge, Qingchao Ge, Peng Lu, Peng Lu, Chang Liu, Chang Liu

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Identification of regulatory loci and candidate genes related to body weight traits in broilers based on different models by Na Luo, Keqi Cai, Limin Wei, Huanxian Cui, Jie Wen, Bingxing An, Guiping Zhao

“…The study was performed on the BW trait at five developmental stages (72, 81, 89, 113, and 120 days) and mid-test metabolic weight (MWT) across four growth cycles. Transcriptome sequencing analysis was also included to investigate the differential expression of candidate genes identified through the GWAS models, particularly linked to BW and MWT traits. …”
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Identification of key modules and genes in response to high-temperature stress in Platostoma palustre based on WGCNA by Xiufang Li, Fan Wei, Changqian Quan, Meihua Xu, Danfeng Tang

“…Further weighted gene co-expression network analysis (WGCNA) identified 14 modules and 61 hub genes closely related to the response to HTS in P. palustre. …”
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Toxicity of Flonicamid to <i>Diaphorina citri</i> (Hemiptera: Liviidae) and Its Identification and Expression of Kir Channel Genes by Jiangyue Zhu, Xinjing Wang, Yunfei Mo, Beibei Wu, Tuyong Yi, Zhongxia Yang

“…To explore the relevant mechanisms, the treatments with acetone and with 20 mg AI L⁻¹ flonicamid for 96 h were collected as samples for RNA-Seq. The analysis of the transcriptomes revealed 345 differentially expressed genes (DEGs) in <i>D. citri</i> adults subjected to different treatments. …”
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Torreya grandis nut peptides regulate lipid-II inhibitors in high-fat diet-fed mice by Rabia Durrani, Sun Yutian, Hou Bowen, Hammad Ullah, Erwann Durand, Yang Meiyun, Long Yiyang, André Delavault, Muhammad Yasir, Huan Weiwei, Gao Fei, Song Lili

“…Lipid droplets in liver, muscles, and blood vessels were highly reduced, evoked by the high peptide group. Transcriptome analysis highlighted lipid regulation via the PPAR-α pathway, with molecular docking revealing 4 potential lipid II inhibitory peptides. …”
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Enterobacterales use capsules, transporters, mobile genetic elements, and other evolutionary adaptations to survive antibiotics exposure in the absence of resistance genes by Masego Mmatli, Nontombi Marylucy Mbelle, Bernard Fourie, John Osei Sekyere

“…Phenotypic assays were used to evaluate the effects of various inhibitors on antibiotic susceptibility, while bioinformatic pipelines were used to characterize resistance determinants, virulence factors, and mobile genetic elements (MGEs).Results Phylogenetic analysis revealed widespread carriage of diverse resistance genes, particularly on plasmids of K. pneumoniae, while Enterobacter species possessed fewer known ARGs. …”
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Reference genome provide insights into sex determination of silver aworana (Osteoglossum bicirrhosum) by Yi Liu, Chao Bian, Ka Yan Ma, Yexin Yang, Yuanyuan Wang, Chao Liu, Guochang Ouyang, Meng Xu, Jinhui Sun, Changwei Shao, Jiehu Chen, Qiong Shi, Xidong Mu

“…Abstract Background Silver arowana (Osteoglossum bicirrhosum) is a basal fish species with sexual monomorphism, while its sex determination mechanism has been poorly understood, posing a significant challenge to its captive breeding efforts. …”
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Multi-omics exploration of the factors influencing feather coverage in laying hens by Xin Li, Xiaohui Shen, Xiaoliang Wang, Yao Yan, Wei Liu, Kai Zhan, Daqian He, Changsuo Yang, Huaxiang Yan, Junfeng Yao

“…Transcriptomic profiling of cecal tissue was performed via RNA sequencing, while gut microbiota composition was analyzed using 16S rRNA amplicon sequencing. …”
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Assessing the Tolerance of Spotted Longbarbel Catfish as a Candidate Species for Aquaculture to Ammonia Nitrogen Exposure by Song Guo, Linwei Yang, Xiaopeng Xu

“…We demonstrate that ammonia-N stress significantly decreases the survival rate of spotted longbarbel catfish and induces tissue damage, including gill lamella proliferation, hepatocyte blurring, and renal necrosis. Transcriptomic analysis revealed that ammonia-N stress promotes the expression of genes related to endoplasmic reticulum stress, heat-shock proteins, immune response, and apoptosis, while inhibiting antioxidant-related genes and Wnt-related genes. …”
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Research on the Degradation Efficacy and Mechanism of Zearalenone by Tibetan Yeast Meyerozyma caribbica by Zhiliang XU, Yingbo CHEN, Keliang MENG, Chenxiaoye YANG, Dandan JIANG, Disha JIANG, Yulin WANG, Hao HU

“…Mechanistic studies revealed that ZEN degradation by strain 68 primarily involved initial adsorption followed by intracellular biodegradation.Transcriptomic analysis demonstrated that differentially expressed genes were significantly enriched in oxidoreductase activity and oxidoreductase activity, acting on the aldehyde or oxo group of donors.KEGG enrichment highlighted 13 sub-pathways in glycolysis/gluconeogenesis, with redox-associated pathways showing marked upregulation, confirming the critical role of oxidoreduction mechanisms in ZEN detoxification.…”
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Time-dependent cortical responses to siesta disruption in male mice by Jingwei Ding, Shigenobu Shibata, Shigenobu Shibata, Tatsuhiko Kubo, Yu Tahara

“…Transcriptomic analysis at ZT0 and ZT12 revealed distinct time dependent responses: ZT0 was associated with the activation of stress-related and homeostatic pathways, whereas ZT12 showed enrichment of genes related to neuronal structure and intracellular transport.DiscussionThese findings suggest that even short-term siesta disruption induces mild but phase-specific cortical adaptations, involving early stress mitigation at ZT0 followed by synaptic remodeling at ZT12.…”
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Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella by Ti Lu, Skyler T. Kramer, Mary A. York, Mst Nusrat Zahan, Debaki R. Howlader, Zackary K. Dietz, Sean K. Whittier, Nathan J. Bivens, Alexander Jurkevich, Lyndon M. Coghill, Lyndon M. Coghill, William D. Picking, Wendy L. Picking

“…Our analysis also revealed significant reprogramming of fibroblasts and cardiomyocytes, showing that fibroblasts are shifted from extracellular matrix production to immune modulation, while cardiomyocytes enhanced the signaling for immune cell recruitment and vascular stability. …”
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Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in Pseudomonas aeruginosa clinical isolates by Bartosz J. Bartmanski, Anja Bösch, Steven Schmitt, Niranjan R. Ireddy, Qun Ren, Jacqueline Findlay, Adrian Egli, Maria Zimmermann-Kogadeeva, Baharak Babouee Flury

“…Whole-genome sequencing revealed strain heterogeneity and different evolutionary paths, with three genes mutated in three or more strains: dacB in CZA-treated strains and oprD and ftsI in MEM-treated strains. Transcriptomic and proteomic analysis underlined heterogeneous strain response to antibiotic treatment with few commonly regulated genes and proteins. …”
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Exploring transcriptomic databases to identify and experimentally validate tissue-specific consensus reference gene for gene expression normalization in BALB/c mice acutely exposed... by Nour Hammoudeh, Reem Hasan, Mohammad Deeb, Zuher Radwan, Omar Ayoubi, Roaa Alendary, Mouayad Youssef, Abdulfattah Kazan, Rasil Alsahli, Walaa Faiad, Nour Aldeli, Abdulsamie Hanano

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