Comparison of the effects and mechanisms of astaxanthin, astaxanthin esters and astacene on high-fat diet-induced NAFLD by Chunhao Gao, Fangtian Chen, Nengyun Gong, Shiran Hu, Mengjia Zhu, Qingxin Zhou, Xiang Gao

“…Moreover, transcriptome sequencing analysis indicated that AX primarily regulates gene transcription in adipose tissue and AC exhibited the most potent regulatory impact on gene transcription in liver. …”
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Claroideglomus etunicatum enhances Pteris vittata L. arsenic resistance and accumulation by mediating the rapid reduction and transport of arsenic in roots by Guofei Pan, YueZhen Xu, WeiZhen Li, Linyan Zan, Xueli Wang

“…To understand how AMF mediate P. vittata arsenic metabolism under arsenic stress, we performed P. vittata root transcriptome analysis before and after Claroideglomus etunicatum (C. etunicatum) colonization. …”
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Effects of Haematococcus pluvialis on growth performance, hepatopancreatic transcriptome and resistance to ammonia-nitrogen stress of pacific white shrimp (Litopenaeus vannamei) by Baoyang Chen, Anqi Chen, Haiqi Pu, Wei Zhao, Yongkang Chen, Yanmei Li, Peinan Zhang, Xingyan Hou, Liuya Feng, Beiping Tan, Jin Niu

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Transcriptomic Insights into Adaptive Strategies of Klebsiella pneumoniae Co-Producing KPC-2 and NDM-5 Carbapenemases Under Meropenem Stress by Dai L, Zhang H, Cao Y, Ding J, Tang J, Xiao Z, Chen Z, Ling J, Zou M, Cao X, Lin L, Xu Z, Liu W, Chen D, Yuan P

“…Transcriptomic analysis mapped stress-responsive pathways and DEGs, whereas qPCR validated carbapenemase gene expression and plasmid copy number variation. …”
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Physiological, transcriptomic and metabolomic analyses reveal the mechanism of CuO and silicon nanoparticles involved in Polygonatum kingianum response to root rot by Xi Xu, Jinpeng Wan, Guizhou Liu, Chengkai Lu, Xinyu Mao, Jinglin Wu, Hanying Liu, Yong Ding, Peng Xu

“…A Pearson coefficient analysis showed that 22 genes were positively correlated with the disease index under CuNP treatment, while 27 genes were positively correlated under SiNP treatment. …”
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Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury by Zhang C, Chen F, Jiang Y, Deng J, Yan X, Yin X, Su B, Liu W

“…The pharmacological mechanisms of CHQF were explored using network pharmacology, transcriptomics, and metabolomics, which enabled the identification of potential therapeutic targets and pathways, as further validated by in vivo and in vitro experiments.Results: CHQF administration significantly improved the survival rates, reduced systemic inflammation, and restored liver function in CLP-induced sepsis mice, while also mitigating liver tissue injury. …”
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Transcriptome and Metabolome Analyses Reveal the Mechanism of Color Differences in Pomegranate (<i>Punica granatum</i> L.) Red and White Petals by Yong Zhang, Peng Han, Ruijie Zhao, Shuhan Yu, Hang Liu, Shuren Ji, Wei Chen

“…The results showed that compared to White petals, the contents of anthocyanin, carotenoid, and sucrose in Tunisia petals were significantly increased, while the flavonoid content was significantly decreased. …”
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Lipidomics and Transcriptomics Revealed Dietary Complex Plant Extracts Improve Lipid Composition of <i>Longissimus dorsi Muscle</i> in Sheep by Hui Guo, Ruixue Nie, Wenwen Wang, Tao Guo, Chang Gao, Jinju Mao, Yuchao Hu, Na Liu, Xiaoping An, Yang Jia, Jingwei Qi, Yuan Wang

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Association of alterations in transcriptomics and intestinal immune responses with Bifidobacterium longum BAA2573 in improving dextran sulfate sodium-induced colitis by Wujuan Hao, Lan Gu, Renmin Zhou, Cuilan Huang, Xuyang Wang, Yanshan Liu, Qiong Lin

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Molecular Mechanisms Underlying Sweet Potato (<i>Ipomoea batatas</i> L.) Responses to Phosphorus Deficiency by Zhufang Yao, Zhongxia Luo, Hongda Zou, Yiling Yang, Bingzhi Jiang, Lifei Huang, Zhangying Wang

“…Transcriptomic analysis identified a total of 6324 differentially expressed genes (DEGs) at 60 days, with significant enrichment in pathways related to stress response and phosphorus utilization (PAPs and PHO1). …”
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Novel metabolic subtypes in IDH-mutant gliomas: implications for prognosis and therapy by Peng Wang, Jiayi Wang, Zheng Fang, Qiaodong Chen, Ying Zhang, Xiaoguang Qiu, Zhaoshi Bao

“…Current study has primarily focused on the different IDH statuses or grades, while the metabolic heterogeneity within IDH-mutant gliomas remains insufficiently characterized. …”
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Integrated physiological and transcriptomic analyses reveal the mechanism of reduction in wheat fertile floret number under spring low-temperature stress by Ying Weng, Zhiwei Tang, Weixiang Huang, Rui Wang, Feifei Wang, Hongmei Cai, Hao Wang, Zehao Liu, Baoqiang Zheng, Jincai Li, Xiang Chen

“…SLTS altered key enzyme activities, enhancing sucrose synthase and sucrose phosphate synthase but suppressing nitrate reductase and glutamine synthetase. Transcriptomic analysis revealed that SLTS perturbed starch and sucrose metabolism, carbon and nitrogen metabolism, and amino sugar pathways, altering soluble sugars, sucrose, fructose, and protein levels. …”
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48-Hour and 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms in Arabidopsis by Yuwei Qin, Zhijian Liu, Shiqi Gao, Carlos Martínez-Vasallo, Yanping Long, Xinlong Zhu, Bin Liu, Ya Gao, Xiaodong Xu, Maria A. Nohales, Qiguang Xie, Jixian Zhai

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Cesium Accumulation Patterns and Stress Response in Hydroponic Radish (<i>Raphanus sativus</i> L.): A Physiological–Transcriptomic Study by Yu-Han Wen, Xi Chen, Ming Sun, Chao-Hui Yang, Meng-Yuan Xu, Feng-Xiang Lai, Si-Qi Fu, Yu-Meng Fan, Xin-Peng Guo, Qun Li, Guo Wu

“…The superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) activities, reactive oxygen species (ROS), and malondialdehyde (MDA) content increased under the different Cs treatments, which indicated that Cs exposure induced oxidative stress response in radish seedlings. Transcriptome analysis detected a total of 4326 differentially expressed genes (DEGs), in which altered expression patterns in genes associated with mineral transport, antioxidant systems, and carotenoid biosynthesis pathways in radish under 2 mM Cs treatment were observed. …”
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Pharmacological Effects of Antioxidant Mycosporine-Glycine in Alleviating Ultraviolet B-Induced Skin Photodamage: Insights from Metabolomic and Transcriptomic Analyses by Kai Wang, Ling Qin, Huan Lin, Mengke Yao, Junhan Cao, Qing Zhang, Changfeng Qu, Yingying He, Jinlai Miao, Ming Liu

“…Skin metabolomic profiling identified 34 differentially abundant metabolites, and transcriptomic analysis revealed 752 differentially expressed genes. …”
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Decoding submergence tolerance in Prunus persica: Integrated transcriptomic and metabolomic acclimations of antioxidant system, cell wall dynamics, and hormonal signaling by Muhammad Ateeq, Dongmei Zhang, Jinping Xiao, Huiqin Zhang, Xingyi Shen, Jian Meng, Jinzhi Yang, Shariq Mahmood Alam, Muhammad Mohsin Kaleem, Muhammad Abbas Khan, Kaijie Zhu, Guohuai Li, Junwei Liu

“…DX leaves also showed enhanced antioxidant activities of ROS scavengers and reduced levels of H2O2 and MDA, correlating with improved tolerance. Transcriptomic analysis revealed significant alterations in the expression of genes involved in photosynthesis, glycan biosynthesis, and α-linolenic acid metabolism between the two cultivars. …”
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Oligochitosan Mitigates <i>Vibrio harveyi</i> Infection in Hybrid Groupers (<i>Epinephelus lanceolatus</i> ♂ × <i>Epinephelus fuscoguttatus</i> ♀) by Modulating Immune Responses an... by Fei Shi, Lixin Ma, Zhilong Chen, Hao Zhao, Cuiyun Zou, Li Lin, Zhendong Qin

“…Transcriptome analysis was used to identify differentially expressed genes in the disease-related and immune system pathways that significantly accumulated in the treatment groups. …”
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Detection of Different Patterns of Genome-Wide Gene Expression Disturbance in Three Nullisomy Lines in Allotetraploid <i>Brassica napus</i> by Shaolin Lei, Bo Wei, Qi Hu, Lang Liu, Feng Yu, Tuo Zeng, Xuye Du, Lei Gu, Hongcheng Wang

“…Significant phenotypic variations were observed, with the most notable being a marked dwarfing phenotype in the aneuploid materials compared to the euploid Oro. Transcriptomic analysis revealed widespread alterations in gene expression across the entire genome in the deficient variants. …”
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Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice by Xinyu Sun, Long Yun, Keming Xie, Renhui Liu, Xinyue Ren, Bokun Zeng, Xudong Cao, Zhi Li, Guihao Zhou, Bang Liu, Luo Peng, Lihong Yuan

“…LV149 further modulated the gut microbiota, increasing beneficial bacteria and reducing pathogenic populations. Transcriptomic analysis indicated that LV149-L may exert gut repair effects via the IL-17 signaling pathway, whereas LV149-H appears to act through the JAK-STAT signaling pathway.ConclusionThis study demonstrated that LV149, particularly at a higher dose, effectively mitigated DSS-induced colonic injury by modulating gut microbiota, enhancing gut barrier integrity, and reducing inflammation. …”
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Integrated ultrasensitive metabolomics and single-cell transcriptomics identify crucial regulators of sheep oocyte maturation and early embryo development in vitro by Bo Pan, JianPeng Qin, KunLin Du, LuYao Zhang, GongXue Jia, JiangFeng Ye, QiuXia Liang, QiEn Yang, GuangBin Zhou

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