Molecular pathways associated with blood pressure and hexadecanedioate levels. by Cristina Menni, Sarah J Metrustry, Georg Ehret, Anna F Dominiczak, Phil Chowienczyk, Tim D Spector, Sandosh Padmanabhan, Ana M Valdes

“…Transcriptomic analyses correlating hexadecanedioate with gene expression levels in adipose tissue in 740 TwinsUK participants were further performed. …”
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Combining explainable machine learning, demographic and multi-omic data to inform precision medicine strategies for inflammatory bowel disease. by Laura-Jayne Gardiner, Anna Paola Carrieri, Karen Bingham, Graeme Macluskie, David Bunton, Marian McNeil, Edward O Pyzer-Knapp

“…Our approach models IBD drug response while also identifying its most predictive features as part of a transparent ML precision medicine strategy.…”
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The gut-liver axis plays a limited role in mediating the liver’s heat susceptibility of Chinese giant salamander by Runliang Zhai, Chunlin Zhao, Liming Chang, Jiongyu Liu, Tian Zhao, Jianping Jiang, Wei Zhu

“…While heat stress altered the gut microbiota’s community structure, their functional profiles, especially in nutrient absorption and transformation, remained stable. …”
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Computational Insights into the Polypharmacological Landscape of BCR-ABL Inhibitors: Emphasis on Imatinib and Nilotinib by Rima Hajjo, Dima A. Sabbah, Raghad Alhaded, Aye Alquabe’h, Sanaa K. Bardaweel

“…<b>Conclusions:</b> These findings highlight the importance of integrating structure–activity relationships and transcriptomic signatures to guide rational repurposing. …”
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Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility by Ranjha Khan, Muhammad Azhar, Muhammad Umair

“…For instance, transcriptomics can uncover gene expression profiles during gamete maturation, while proteomics identifies key protein interactions critical for processes such as capacitation and the acrosome reaction. …”
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Single-Cell RNA Sequencing Identifies Crucial Genes Influencing the Polarization of Tumor-Associated Macrophages in Liver Cancer by Kedong Xu, Mingyi Dong, Zhengqiang Wu, Linfei Luo, Fei Xie, Fan Li, Hongyan Huang, Fenfen Wang, Xiaofeng Xiong, Zhili Wen

“…To examine cellular interactions, CellChat was utilized, while single-cell regulatory network inference and clustering (SCENIC) was applied to deduce transcription factors (TFs) and their associated targets. …”
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Omics-driven insights into plant growth-promoting microorganisms for sustainable agriculture by Abhishek Sahoo, Garima Yadav, Tushar Mehta, Mukesh Meena, Prashant Swapnil

“…At the same time, transcriptomic profiling has illuminated plant immune priming and hormonal modulation under microbial influence. …”
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Exogenous citric acid-mediated modification of metabolism, transport and signal transduction of non-structural carbohydrates in rice under hexavalent chromium stress by Yi Kang, Yu-Juan Lin, Cheng-Zhi Li, Hao Zhan, Xiao-Zhang Yu

“…Tissue-specific transcriptomic shifts revealed CA-mediated modulation of NSC metabolic genes, transporters, and signaling components. …”
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Epimedium-Derived Exosome-Loaded GelMA Hydrogel Enhances MC3T3-E1 Osteogenesis via PI3K/Akt Pathway by Weijian Hu, Xin Xie, Jiabin Xu

“…Underlying mechanisms were examined at transcriptomic and protein levels to elucidate GelMA@Exo’s therapeutic osteogenesis actions. …”
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Machine learning on multiple epigenetic features reveals H3K27Ac as a driver of gene expression prediction across patients with glioblastoma. by Yusuke Suita, Hardy Bright, Yuan Pu, Merih Deniz Toruner, Jordan Idehen, Nikos Tapinos, Ritambhara Singh

“…These findings suggest that GSCs share a common distributional pattern of enhancer activity characterized by H3K27Ac, which can be utilized to predict gene expression in GSCs across patients. In summary, while GSCs are known for their transcriptomic and phenotypic heterogeneity, we propose that they share a common epigenetic pattern of enhancer activation that defines their underlying transcriptomic expression pattern. …”
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Advances in the application of multi-omics analysis in skin aging by Boquan Long, Boquan Long, Weitian Pan, Shuozhong Wu, Qianye Nong, Wenhui Li, Siqi Chen, Siqi Chen, Hongwei Guo

“…Multi-omics approaches—including macro-genomics, epigenetics, transcriptomics, proteomics, and metabolomics—offer valuable insights into the mechanisms and pathogenesis of skin aging while aiding in the identification of biomarkers and potential therapeutic targets. …”
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To verify the biological characteristics of disulfidptosis associated gene ADORA2B in esophageal cancer by Yixiao Cui, Yuhan Deng, Zhenhua Wu, Xiaohong Sun

“…Utilizing integrated transcriptomics and single-cell proteomics, the involvement of immune cells in the tumor microenvironment was examined, while bioinformatics was used to investigate the expression, function, and survival data of ADORA2B. …”
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The multi-omics analysis identifies a novel endoplasmic reticulum stress and immune related genes signature in lung adenocarcinoma by Danhe Huang, Yuying Liu, Mingyu Yuan, Xiongwei Wang, Lianqing Hong

“…Abstract Background Lung adenocarcinoma (LUAD), a prevalent and aggressive malignancy, necessitates improved prognostic tools and therapeutic insights. While endoplasmic reticulum stress (ERS) and tumor-immune interactions are recognized as key cancer hallmarks, their combined prognostic potential in LUAD remains insufficiently explored. …”
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Optimized Protocol for Linear RNA Amplification and Application to Gene Expression Profiling of Human Renal Biopsies by A. Scherer, A. Krause, J.R. Walker, S.E. Sutton, D. Serón, F. Raulf, M.P. Cooke

“…Gene expression analysis using high-density cDNA or oligonucleotide arrays is a rapidly emerging tool for transcriptomics, the analysis of the transcriptional state of a cell or organ. …”
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Addressing the tissue specificity of U5 snRNP spliceosomopathies by Rahmat Azhari Kemal, Rahmat Azhari Kemal, Raymond T. O’Keefe

“…Variants in TXNL4A and EFTUD2 manifest in craniofacial malformations while variants in PRPF8 and SNRNP200 manifest in retinitis pigmentosa. …”
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Histone Signatures Predict Therapeutic Efficacy in Breast Cancer by Shamim A. Mollah, Shankar Subramaniam

“…<italic>Objective:</italic> Regulatory abnormalities caused by chromatin modifications are being increasingly recognized as contributors to cancer. While many molecularly targeted drugs have the potential to revert these modifications, their precise mechanism of action in cellular reprogramming is not known. …”
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Plant–Microbe Interactions for Improving Postharvest Shelf Life and Quality of Fresh Produce Through Protective Mechanisms by Wajid Zaman, Adnan Amin, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Sajid Ali

“…Advancements in omics technologies, such as metabolomics, transcriptomics, and microbiomics, have provided deeper insights into plant–microbe interactions, facilitating more targeted and effective microbial treatments. …”
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Single-cell sequencing reveals the role of SALL4 in cervical cancer development by Bao Tonghui, Li Wufen, Qi Lin

“…Conclusion High expression of SALL4 promotes cervical cancer progression, while inhibition of SALL4 expression effectively suppresses cancer development. …”
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Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak. by Kenzo Ivanovitch, Pablo Soro-Barrio, Probir Chakravarty, Rebecca A Jones, Donald M Bell, S Neda Mousavy Gharavy, Despina Stamataki, Julien Delile, James C Smith, James Briscoe

“…Outflow tract cells originate from distal locations in the primitive streak while atrial progenitors are positioned more proximally. …”
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Oxidative Stress, Parity History, and Remnant Follicles in the Aged Ovary: Insights on Ovarian Cancer Risk and Protection by Ulises Urzúa, Arnaldo Marín, Enrique A. Castellón

“…Its incidence and mortality consistently rise after menopause. While parity reduces the risk of OC, nulliparity during a woman’s fertile years increases it. …”
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