Therapeutic potential of a choline-zinc-vitamin E nutraceutical complex in ameliorating thioacetamide-induced nonalcoholic fatty liver pathology in zebrafish. by Bingbing Cao, Jiali Zhou, Bo Xia, Xiaoqing Li, Rui Wang, Yiqiao Xu, Chunqi Li

“…The intervention was administered to the zebrafish in a water-soluble form, while the positive control group received polyene phosphatidylcholine at a concentration of 50.0 μg/mL. …”
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Gene Ranking of RNA-Seq Data via Discriminant Non-Negative Matrix Factorization. by Zhilong Jia, Xiang Zhang, Naiyang Guan, Xiaochen Bo, Michael R Barnes, Zhigang Luo

“…RNA-sequencing is rapidly becoming the method of choice for studying the full complexity of transcriptomes, however with increasing dimensionality, accurate gene ranking is becoming increasingly challenging. …”
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Non-reciprocal Interspecies Hybridization Barriers in the Capsella Genus Are Established in the Endosperm. by Carolin A Rebernig, Clément Lafon-Placette, Marcelinus R Hatorangan, Tanja Slotte, Claudia Köhler

“…Strikingly, the transcriptomic response of both hybridizations mimicked respectively the response of paternal and maternal excess hybridizations in Arabidopsis thaliana, suggesting unbalanced genome strength causes hybridization failure in both species. …”
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Data-driven model discovery and model selection for noisy biological systems. by Xiaojun Wu, MeiLu McDermott, Adam L MacLean

“…Neural networks are used to approximate the unknown dynamics of a system, enabling the denoising of the data while simultaneously learning the latent dynamics. …”
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Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy. by Mayank Verma, Yuko Shimizu-Motohashi, Yoko Asakura, James P Ennen, Jennifer Bosco, Zhiwei Zhou, Guo-Hua Fong, Serene Josiah, Dennis Keefe, Atsushi Asakura

“…Recently, the vasculature has also shown to be perturbed in DMD and DMD model mdx mice. Recent DMD transcriptomics revealed the defects were correlated to a vascular endothelial growth factor (VEGF) signaling pathway. …”
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Trajectory inference from single-cell genomics data with a process time model. by Meichen Fang, Gennady Gorin, Lior Pachter

“…Single-cell transcriptomics experiments provide gene expression snapshots of heterogeneous cell populations across cell states. …”
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Residual cell types, molecular expression profiles and quality assessment of in vitro cultured human thymic slices by GUAN Wanqing, LUO Guihua, HAN Jingxuan

“…Objective‍　‍‍To analyze the composition and function of residual cells in pre-transplantation human thymic slices by single-cell transcriptomics sequencing (scRNA-seq), and established a quality assessment method for thymic slices based on the expression levels of molecular markers in the culture supernatant. …”
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Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway by Lingling Bao, Yuefei Wu, Zhengting Ren, Yi Huang, Yue Jiang, Kailang Li, Xin Xu, Yingquan Ye, Zhongxuan Gui

“…Abstract Background UCHL5 was initially recognized as a multifunctional molecule. While recent research has highlighted its involvement in tumor malignant biological behaviors, its specific role in promoting tumor cell apoptosis has drawn particular attention. …”
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IGF2BP3 enhances ferroptosis resistance in colon cancer by stabilizing SLC7A11 and is regulated by miR-98-5p by Yaya Sun, Qingwei Liu, Junjie Wu, Guangqing Jiang, Hongzhou Shi, Yihong Zhang, Yanxuan Ling, Weimin Sun, Xin Shi, Congxing Liu

“…IGF2BP3, an oncogenic RNA-binding protein, is implicated in colon cancer progression, while its role in ferroptosis regulation remains unclear. …”
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Exploring the effects of feeding methods on the growth and meat flavor of Wenchang chicken by Tieshan Xu, Qicheng Jiang, Chaohua Xu, Zhepeng Xiao, Xinli Zheng, Lihong Gu

“…CR chickens had higher IMP, threonine (Thr), and pentadecanoic, oleic, and linoleic acids, while glutamate (Glu) and alpha-linolenic acid were lower compared to FR. …”
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The effect of prolonged G-quadruplex stabilization on the functions of human cells by Nargis Karatayeva, Lili Hegedus, Arindam Bhattacharjee, Eszter Nemeth, Adam Poti, Lorinc Pongor, Gabor Juhasz, David Szuts, Peter Burkovics

“…However, it can induce persistent alterations in the transcriptomic profile of human cells, including genes encoded on the mitochondrial genome. …”
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Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia by Huagang Lin, Linjing Nie, Deping Wu, Dexian Zhang, Rui Peng, Sijie Tao, Zhibin Ye, Sibo Zhu, Maoqing Ye, Jing Xiao

“…In CTSBtecKOmice, the expression of reabsorptive urate transporters URAT1 and GLUT9 was decreased, while the secretory transporter ABCG2 was upregulated, leading to enhanced renal uric acid excretion and reduced serum uric acid (SUA). …”
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METTL14 and WTAP play a crucial role in the regulation of bovine preadipocyte differentiation by Jia Liu, Chicheng Ma, Yu Cheng, Minzhi Wang, Guoqing Zhao, Liwei Huang, Ruigao Song, Xi Wang, Hongxia Li

“…This study investigated their effects on bovine preadipocyte differentiation using siRNA-mediated knockdown combined with transcriptomic analysis. Silencing METTL14 and WTAP significantly impaired lipid droplet formation and revealed distinct regulatory pathways: METTL14 knockdown affected genes like JAK2 and STAT3, while WTAP suppression down-regulated PPARγ/FABP4 signalling pathway components. …”
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Exploring the additive antibacterial potential of Cinnamomum cassia volatile oil and imipenem against Acinetobacter baumannii: a multi-omics investigation by Youyuan Lu, Youyuan Lu, Wanlin Xu, Jiahui Xue, Mingxia Xie, Haotian Liu, Ruilin Wang, Gang Li, Hanqing Wang, Hanqing Wang

“…CBV primarily influenced the ribosome pathway, while IPM mainly influenced oxidative phosphorylation. …”
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Chitosan-grape seed oil nanoemulsion enriched diet promotes performance, antioxidant-immune metrics and modifies immune- gene action and morphological architecture in Nile tilapia... by Shaimaa A.A. Ahmed, Fatma Mahsoub, Samar A. El Gamal, Tarek Khamis, Khaled Yehia Faroh, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Mai F. Saad, Hanaa S. Ali, Simon J. Davies, Adham Al-Sagheer, Walaa El-Houseiny

“…In fish fed 40 mg/kg CGON, total protein, globulin, and albumin levels increased, while markers of hepato-renal stress were reduced. …”
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Dehydroleucodine exerts an antiproliferative effect on human Burkitt’s lymphoma Daudi cells via SLC7A11-mediated ferroptosis by Rui Shen, Fang Cheng, Rui Guo, Wenjing Wang, Xiaolong Yang, Yemiao Chen, Yaokai Chen

“…We evaluated DhL’s effects on cell cycle progression, apoptosis, and ferroptosis pathways using cell viability assays, flow cytometry, transcriptomic analysis, and validation experiments.ResultsDhL demonstrated robust and specific anti-proliferative effects against BL Daudi cells. …”
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Harnessing multi-omics and artificial intelligence: revolutionizing prognosis and treatment in hepatocellular carcinoma by Zhen Wang, Zhen Wang, Zhen Wang, Gangchen Zhou, Gangchen Zhou, Rongchuan Cao, Rongchuan Cao, Guolin Zhang, Guolin Zhang, Yongxu Zhang, Yongxu Zhang, Mingyue Xiao, Longbi Liu, Longbi Liu, Xuesong Zhang

“…CS1 was associated with better overall survival, while CS2 exhibited higher mutation burden and immune suppression. …”
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Network spreading and local biological vulnerability in amyotrophic lateral sclerosis by Asa Farahani, Justine Y. Hansen, Vincent Bazinet, Golia Shafiei, D. Louis Collins, Mahsa Dadar, Sanjay Kalra, Alain Dagher, Bratislav Misic

“…Namely, molecular and cellular features may confer vulnerability to specific neuronal populations, while synaptic contacts may also increase exposure to pathology in connected neuronal populations. …”
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Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells by Ines Sturmlechner, Abhinav Jain, Bin Hu, Rohit R. Jadhav, Wenqiang Cao, Hirohisa Okuyama, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy

“…In older adults (>65-years), antigen-specific cells show largely distinct phenotypic and transcriptomic aging trajectories. Common to many albeit not all antigen-specific populations are maintained TCR diversity, gained natural killer cell-like, innate signatures and lost stem-like features while no evidence is seen for cellular senescence or exhaustion. …”
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Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache by Gurueswar Nagarajan, Yumin Zhang

“…RNA sequencing revealed mTBI induced distinct transcriptomic profiles in the peripheral TG and central Sp5C and PAG. …”
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