Omics insights into Bacillus velezensis LMY3-5 defense against Botryosphaeria dothidea in kiwifruit by Chunguang Ren, Yu Liu, Wenwen Su, Zhengcheng Han, Di Wu, Weijie Li

“…Botryosphaeria dothidea is the main cause of soft rot in kiwifruit, significantly reducing both yield and quality. While chemical treatments are commonly used, their effectiveness is limited and they may pose environmental risks. …”
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Fish MicroRNA Responses to Thermal Stress: Insights and Implications for Aquaculture and Conservation Amid Global Warming by Ting Lin, Madhava Meegaskumbura

“…In the context of global warming, heat tolerance is becoming a crucial physiological trait influencing fish species’ distribution and survival. While our understanding of fish heat tolerance and stress has expanded from behavioral studies to transcriptomic analyses, knowledge at the transcriptomic level is still limited. …”
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A prognostic PET radiomic model for risk stratification in non-small cell lung cancer: integrating radiogenomics and clinical features to predict survival and uncover tumor biology... by Parisa Taheri, Aaron Golden

“…Radiogenomic analysis revealed that while the low-risk group indicated anti-tumor immunity, the high-risk group exhibited transcriptomic characteristics associated with enhanced tumor aggressiveness, with consistent correlations between risk group membership, oncogenic pathways, immune cell types, and critical gene alterations. …”
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Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer by Hélène Burckel, Anaïs Nicol, Carole Mura, Marc Rousseau, Jolie Bou-Gharios, Lisa Froidurot, Corentin Richard, Véronique Morgand, Pierre-Antoine Laurent, Emeric Limagne, Romain Boidot, Georges Noël, Céline Mirjolet

“…Immunosuppressive cell populations were induced by PT, including MDSCs, while Tregs infiltrated both RT and PT treated tumors. …”
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Effect of dietary replacement of fish meal by poultry by-product meal on the growth and hepatic health in loach (Paramisgurnus dabryanus) by Yongan Li, Chuanqi Yu, Shuyao Li, Youjie Li, Zhiwen Yuan, Jie Pan, Qi Chen, Yaping Li, Qiubai Zhou, Zirui Wang

“…Moreover, primary bile acid biosynthesis was the only one pathway enriched in top 20 significant pathways by transcriptomic and metabolomic analysis. Specifically, the key bile acid synthesis gene CYP7a1 was down-regulated, while CYP7b1 evinced an up-regulated pattern in PBM50 group compared to PBM0 group. …”
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Pseudogene AC106872.1 is involved in maintaining the self-renewal capacity of human embryonic stem cells by JIANG Zhengyang, SUN Mengyao, HE Liu, YU Jia, MA Yanni

“…The expression level of pluripotency marker genes was significantly reduced (P＜0.000 1), while the expression of differentiation marker genes was markedly increased (P＜0.000 1). …”
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Flavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling by Nan Jiang, Tatiana García Navarrete, Yun Sun Lee, Emily G. Pawlowski, Sunyoung Park, Erich Grotewold

“…Abstract Plants integrate light signals to regulate development and produce protective compounds such as flavonoids under excessive light stress. While these metabolites protect against light damage, their roles in modulating photoreceptor responses remain unclear. …”
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Identification and characterization of cell niches in tissue from spatial omics data at single-cell resolution by Jingyang Qian, Xin Shao, Hudong Bao, Yin Fang, Wenbo Guo, Chengyu Li, Anyao Li, Hua Hua, Xiaohui Fan

“…By analyzing mouse liver spatial transcriptomics data across normal and early-onset liver failure donors, scNiche uncovers disease-specific liver injury niches, and further delineates the niche remodeling from normal liver to liver failure. …”
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A novel pilus-associated gene cluster is implicated in Streptococcus agalactiae virulence by Wanyou Xu, Qiangsheng Lu, Meijuan Tian, Lvfeng Yuan, Yangming Song, Qiaoying Zeng, Jie Peng

“…Our results revealed a gene cluster containing BP, AP1, and SrtC. While these genes did not affect the basic biological characteristics of the bacteria, they significantly influenced the adhesion rate to cells and the virulence of A909 in mice. …”
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Oral exposure to PET microplastics induces the pancreatic immune response and oxidative stress in immature pigs by Karol Mierzejewski, Aleksandra Kurzyńska, Monika Golubska, Ismena Gałęcka, Jarosław Całka, Iwona Bogacka

“…A low dose changed the expression of one gene, while a high dose affected the expression of 86 genes. …”
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Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons by Nimmy Varghese, Leonora Szabo, M. Zameel Cader, Imane Lejri, Amandine Grimm, Anne Eckert

“…This research addresses the uncertainty around whether aged iPSCsNs retain aging-associated mitochondrial impairments upon transitioning through pluripotency while direct conversion maintains these impairments. …”
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C-terminal binding protein-2 triggers CYR61-induced metastatic dissemination of osteosarcoma in a non-hypoxic microenvironment by Laura Di Patria, Nadia Habel, Robert Olaso, Romain Fernandes, Catherine Brenner, Bojana Stefanovska, Olivia Fromigue

“…Moreover, we demonstrate that while CtBP2 is a downstream transcriptional target of CYR61 signaling cascade, it occurs only under non-hypoxic conditions. …”
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PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy by Rimvile Prokarenkaite, Karolina Kuodyte, Greta Gudoityte, Elzbieta Budginaite, Daniel Naumovas, Egle Strainiene, Kristijonas Velickevicius, Audrius Dulskas, Ernestas Sileika, Jonas Venius, Virginijus Tunaitis, Augustas Pivoriunas, Vytaute Starkuviene, Vaidotas Stankevicius, Kestutis Suziedelis

“…Finally, chemoradiotherapy significantly elevated the expression of PARP9, PARP12, PARP13 and PARP14 in rectal tumors, while having no effect on adjacent normal colon tissues. …”
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The effect of dietary chitin on Atlantic salmon (Salmo salar) chitinase activity, gene expression, and microbial composition by Matilde Mengkrog Holen, Simen Rød Sandve, Thomas Nelson Harvey, Yang Jin, Inga Leena Angell, Knut Rudi, Matthew Peter Kent

“…Chitin is a common component in the natural diet of many fish. While a range of chitin-degrading chitinases have been identified, it is unclear whether chitin is metabolized in fish. …”
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The Application of Single-Cell Technologies for Vaccine Development Against Viral Infections by Hong Nhi Nguyen, Isabel O. Vanderzee, Fei Wen

“…These advances have expanded the range of vaccine platforms beyond live-attenuated and inactivated vaccines to include recombinant platforms, such as subunit proteins and virus-like particles (VLPs), and more recently, mRNA-based vaccines, while also enhancing methods for evaluating vaccine performance. …”
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PTEN as a prognostic factor for radiotherapy plus immunotherapy response in nasopharyngeal carcinoma by Jiaxing Guo, Ming Zhang, Xiaoli Li, Jiashuo Wang

“…In vitro experiments using C666-1 cells and their Exos explored various cellular responses, while a murine subcutaneous NPC model investigated the impact of PTEN modulation on tumor growth and the immune microenvironment. …”
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Polygenic insight identifies precision biomarkers decoding protein catabolism and autophagy pathways in obstructive sleep apnea by Xiaoying Ke, Min Huang, Yingying Zheng, Guohao Chen

“…Gene Ontology and KEGG analyses linked these genes to protein catabolism and autophagy pathways, while immune-cell infiltration profiling associated them with specific leukocyte subsets. …”
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A novel system to culture human intestinal organoids under physiological oxygen content to study microbial-host interaction. by Tatiana Y Fofanova, Umesh C Karandikar, Jennifer M Auchtung, Reid L Wilson, Antonio J Valentin, Robert A Britton, K Jane Grande-Allen, Mary K Estes, Kristi Hoffman, Sashirekha Ramani, Christopher J Stewart, Joseph F Petrosino

“…On one hand the gut bacteria are a mix of facultative, aerotolerant or obligate anaerobes, while the intestinal epithelium requires oxygen for growth and function. …”
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OperonSEQer: A set of machine-learning algorithms with threshold voting for detection of operon pairs using short-read RNA-sequencing data. by Raga Krishnakumar, Anne M Ruffing

“…A number of methods have used transcriptomics data to predict operons, based on the premise that contiguous genes in an operon will be expressed at similar levels. …”
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The quagga mussel, Dreissena rostriformis: a novel model for EcoEvoDevo, environmental research, and the applied sciences by Andreas Wanninger, Gudrun Schwarze

“…Bivalve mollusks are globally distributed in marine and freshwater habitats. While exhibiting a relatively uniform bodyplan that is characterized by their eponymous bivalved shell that houses the soft-bodied animal, many lineages have acquired unique morphological, physiological, and molecular innovations that account for their high adaptability to the various properties of aquatic environments such as salinity, flow conditions, or substrate composition. …”
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