Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPARγ by Yuting Bai, Mingjing Jiang, Xiaojie Chen, Gang Zhou

“…Coimmunoprecipitation assessed CAV2 and NCOR1 binding with PPARγ, while the PPARγ inverse agonist T0070907 was used to enhance NCOR1-mediated repression of CAV2. …”
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Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction by Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng

“…Functional enrichment analyses delineated the dysregulation of pathways, while weighted gene co-expression network analysis identified hub genes within ribosome biogenesis-associated modules. …”
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Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning by Sonu Peedikayil-Kurien, Rizwanul Haque, Asaf Gat, Meital Oren-Suissa

“…Notably, neuronal activity following pathogen exposure was dimorphic: hermaphrodites generate robust representations, while males, in line with their behavior, exhibit contrasting representations. …”
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Cooling Blood and Detoxicating Formula Treats Psoriasis Through RHCG-Related Mechanisms by Qian Zhang, Juan Huang, Cheng-cheng Feng, Yuan-jie Liu, Ning Yang, Xi Zou, Chen Ji, Shun Guo, Hui Shen

“…These findings suggest that CBDF exerts its effects through a multifaceted approach, with RHCG identified as a pivotal target. While the results are promising, further clinical validation and mechanistic research are needed. …”
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Sublethal THPS accelerates Pseudomonas-associated steel corrosion by stimulating biofilm development and microbial electron uptake by Xin Shi, Yimeng Zhang, Ruiyong Zhang, Chengpeng Li, Can Wang, Xiao Wang, Wolfgang Sand, Jizhou Duan

“…While THPS inhibited the growth of planktonic cells, it promoted biofilm formation on the X70 steel surface. …”
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Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus by Diana F. Alzamareh, Nida Meednu, Neha Nandedkar-Kulkarni, Daria Krenitsky, Jennifer Barnard, Ken Yasaka, Wesley Durrett, Juilee Thakar, Juilee Thakar, Javier Rangel-Moreno, Jennifer H. Anolik, Jennifer L. Barnas

“…While durable antibody responses from long-lived plasma cell (LLPC) populations are important for protection against pathogens, LLPC may be harmful if they produce antibodies against self-proteins or self-nuclear antigens as occurs in autoimmune diseases such as systemic lupus erythematosus (SLE). …”
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Dynamic metabolic regulation of histone modifications during the yeast metabolic cycle. by Bárbara Guzmán-Dinamarca, Raúl Conejeros, Marcelo Rivas-Astroza

“…We developed a novel approach integrating flux analysis with transcriptomic data to investigate the production fluxes of acetyl-CoA and SAM and their influence on histone marks H3K9Ac and H3K4me3. …”
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Berberine as a Bioactive Alkaloid: Multi-Omics Perspectives on Its Role in Obesity Management by Bartłomiej Zieniuk, Magdalena Pawełkowicz

“…While promising, further studies are needed to validate these findings in humans and translate them into effective clinical strategies.…”
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Microglial colonization routes and their impacts on cellular diversity by Yuki Hattori

“…While various functions and subtypes of microglia are being uncovered, the mechanisms underlying their diversity remain largely unknown. …”
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Comparison of saliva and blood derived cell free RNAs for detecting oral squamous cell carcinoma by Yuan Hu, Manbin Xu, Muyuan Liu, Hanwei Peng

“…Our transcriptomic profiling revealed that in the saliva group, CLEC2B was notably upregulated in the OSCC group compared to others, while DAZL, F9, and AC008735.2 were markedly downregulated. …”
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Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging by Alejandro Sola-García, María Ángeles Cáliz-Molina, Isabel Espadas, Michael Petr, Concepción Panadero-Morón, Daniel González-Morán, María Eugenia Martín-Vázquez, Álvaro Jesús Narbona-Pérez, Livia López-Noriega, Guillermo Martínez-Corrales, Raúl López-Fernández-Sobrino, Alejandro Castillo-Peña, Lina M. Carmona-Marin, Enrique Martínez-Force, Oscar Yanes, Maria Vinaixa, Daniel López-López, José Carlos Reyes, Joaquín Dopazo, Franz Martín, Benoit R. Gauthier, Morten Scheibye-Knudsen, Vivian Capilla-González, Alejandro Martín-Montalvo

“…By applying a multiomic approach using untargeted metabolomics, transcriptomics, and proteomics, we determined that, in vivo, SB-204990 plays a role in the regulation of molecular mechanisms associated with aging, such as energy metabolism, mitochondrial function, mTOR signaling, and folate cycle, while global alterations on histone acetylation are absent. …”
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Astragaloside IV accelerates hematopoietic reconstruction by improving the AMPK/PGC1α-mediated mitochondrial function in hematopoietic stem cells by Ling Zhang, Wanqi Xu, Yueying Zeng, Long Wang, Jiesi Luo, Xiaogang Zhou, Qibing Mei, Dalian Qin, Anguo Wu, Jianming Wu, Feihong Huang

“…Further investigation revealed that AS-IV increased the proportion of HSC in both bone marrow and spleen while improving their mitochondrial function. Transcriptomic sequencing and Western blot analysis identified the AMPK/PGC1α signaling pathway as the key mechanism underlying AS-IV-mediated mitochondrial enhancement. …”
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Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model by Zohreh Sharafian, Zohreh Sharafian, Paula T. Littlejohn, Paula T. Littlejohn, Paula T. Littlejohn, Christina Michalski, Christina Michalski, James A. Sousa, James A. Sousa, Janelle Cheung, Mariana Hill, Mariana Hill, Hannah Piper, Kevan Jacobson, Kevan Jacobson, Pascal M. Lavoie, Pascal M. Lavoie, Joannie M. Allaire, Bruce A. Vallance, Bruce A. Vallance

“…These effects were ablated when an IL-22 neutralizing antibody was used, while conversely, supplementing with recombinant IL-22 mimicked the Th17 effects, increasing intestinal epithelial cell proliferation and inducing marked differentiation of secretory cells. …”
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Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation by Qing Xu, Rui Wang, Ke Sui, Yuxi Xu, Ya Zhou, Yuxuan He, Ziyi Hu, Qi Wang, Xiaodong Xie, Xiaoqi Wang, Shijie Yang, Lingyu Zeng, Jiang F. Zhong, Zheng Wang, Qingxiao Song, Xi Zhang

“…Targeting CRISPLD2 is a promising strategy to improve the therapeutic efficacy of HUC-MSCs in aGVHD while maintaining GVL activity. Graphical abstract…”
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Temporal analysis of doxorubicin-induced cardiac toxicity and hypertrophy by Yu-Te Lin, Yi-Ju Lee, Wen-Wei Tseng, Zih-Hua Chen, Huai-Ching Hsieh, Ko-Hong Lin, Jin-Yu Su, An-Chi Wei

“…In this study, we collected time-course transcriptomics and metabolomics data from the human cardiomyocyte cell line AC16, which we analyzed along with curated public transcriptomics data on DOX-induced toxicity. …”
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Horizontal gene transfer-mediated enhancement of gut antifungal defense facilitates host plant adaptation in an invasive pest by Shouke Zhang, Xiayu Li, Zikun Li, Yuxin Zhang, Yiping Wang, Letian Xu

“…RNAi knockdown of HcuChiA increased the larval mortality on M. glyptostroboides, while recombinant HcuChiA displayed chitinase activity and broad-spectrum antifungal effects against entomopathogens. …”
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Calcium Release-Activated Calcium Modulator ORAI1-Sensitive Serine Dehydratase Regulates Fatty Acid-Induced CD4⁺ Th17/Treg Imbalance in Dairy Cows by Bingbing Zhang, Jingjing Wang, Ming Li, Jianan Wen, Juan J. Loor, Shuang Wang, Ziwei Ji, Xinquan Lv, Guihua Wang, Cheng Xia, Wei Yang, Chuang Xu

“…Moreover, ORAI1 and SDS abundance was elevated in dairy cows with high FFAs by transcriptomics, QPCR, and Western blot. Knockdown of SDS (siSDS) did not alter <i>ORAI1</i> expression in CD4⁺ T cells from high-FFA cows, while it decreased the expression of inflammatory factors. …”
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Re-evaluating evidence for giant genomes in amoebae by Daniel Barzilay, João P. B. Alcino, Giulia M. Ribeiro, Alfredo L. P. Sousa, Daniel J. G. Lahr

“…Fully sequenced amoebozoa genomes range from 14.4 to 52.37 mega basepairs, well within the typical single-celled eukaryote expectation. While the whole genome of the historically relevant Amoeba proteus has not yet been fully sequenced, we provide here a statistical analysis using protein-coding genes from transcriptomic data, suggesting that the genome size is consistent with this range, far smaller than previously claimed. …”
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Mogat1 drives metabolic adaptations to evade immune surveillance by Huan Wei, Congyi Niu, Yue Shi, Yingfei Fang, Chengheng Yang, Jian Liu, Zhenjie Xu

“…Abstract Immune checkpoint blockade (ICB) therapies for solid tumors often fail due to resistance, necessitating new strategies. While efforts target IFNγ signaling or antigen presentation, other immune evasion mechanisms are unclear. …”
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Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation by Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen

“…Abstract In ever‐increasing numbers, patients are treated with biodegradable magnesium implants. While gas bubbles frequently arise in soft tissue overlying magnesium implants, their biological implications remain uncertain. …”
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