Genetic adaptation to amoxicillin in Escherichia coli: The limited role of dinB and katE. by Lisa Teichmann, Marcus Wenne, Sam Luitwieler, Gaurav Dugar, Johan Bengtsson-Palme, Benno Ter Kuile

“…While all strains exhibited similar adaptation rates and mutations in the frdD gene and ampC operon, several unique mutations were acquired in the ΔkatE and ΔdinB strains. …”
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Identification of STAT3 signaling as a shared pathogenic signature in systemic lupus erythematosus, chronic obstructive pulmonary disease, and asthma by Arman Mokaram Doust Delkhah

“…Abstract While patients with systemic lupus erythematosus (SLE) have a higher risk of developing chronic obstructive pulmonary disease (COPD) and asthma, the underlying mechanisms have yet to be elucidated. …”
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Developments in Toxicity Testing with Duckweeds by Paul Ziegler

“…Biomarkers of toxic effect have long been determined concomitantly with testing for toxicity itself, and their potential for the assessment of toxicity has recently been greatly expanded by transcriptomic, proteomic and metabolomic techniques complemented by FITR spectroscopy, transformation and genotoxicity and timescale toxicity testing. …”
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Frizzled receptors: gatekeepers of Wnt signaling in development and disease by Dalia Martinez-Marin, Grace C. Stroman, Camryn J. Fulton, Kevin Pruitt

“…Recent advances in structural biology, transcriptomics, and functional genomics are beginning to address these gaps, while emerging therapeutic approaches—such as small-molecule modulators and antibodies—highlight the potential of FZDs as drug targets. …”
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Developing risk stratification strategies and biomarkers for recurrent hepatocellular carcinoma by Jia‐Hao Law, Huilin Shao, Ramanuj DasGupta, Daniel Q. Huang

“…Early recurrence is largely driven by aggressive tumor biology, while late recurrence reflects de novo carcinogenesis in a cirrhotic liver. …”
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KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients by Ao Wang, Xiao-Fei Zhang, Cong-Jian Luo, Yu-Dong Liu, Pei-Ru Chen, An-Lan Wang, Jun Zhang, Song-Yu Huang, Xin-Yi Huang, Shi-Ling Chen, Xing-Yu Zhou

“…In our previous microarray analysis of granulosa cells (GCs), Lysine Acetyltransferase 2B (KAT2B) was significantly highly expressed in GCs of PCOS patients. While KAT2B has been documented to participate in various biological processes, its specific role and mechanism in the pathogenesis of PCOS remain largely unknown. …”
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Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors by Marine J. Petit, Charlotte Flory, Quan Gu, Mazigh Fares, Douglas Lamont, Alan Score, Kelsey Davies, Lesley Bell-Sakyi, Pietro Scaturro, Benjamin Brennan, Alain Kohl

“…Collectively, our results provide insights into the antiviral responses of R. microplus vector cells and highlight critical SFTSV restriction factors, while enriching transcriptomic and proteomic resources for future research.…”
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The salivary gland mRNA and protein datasets after diapause of the soybean hawkmoth, Clanis bilineata tsingtauica by Yehua Li, Feiyang Ji, Pengjun Zhang, Tingting Xiao

“…Here, we analyzed salivary gland mRNA and protein profiles of fifth instar larvae during feeding (gluttonous) and diapause stages. Transcriptomics revealed 2,194 differentially expressed genes (DEGs), while proteomics identified 1,746 proteins in diapause larvae. …”
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Immunomodulatory effects of intratumoral cowpea mosaic virus and calreticulin nanoparticles in canine tumors: early results by Akansha Singh, Jessica Fernanda Affonso de Oliveira, Jessica Fernanda Affonso de Oliveira, Jessica Fernanda Affonso de Oliveira, Jessica Schrader, Deepan Kishore, Sri Vidhya Chandrasekar, Steven Fiering, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Ashish Ranjan

“…Endpoints included serum cytokine analysis, tumor transcriptomics via NanoString, immune cell profiling in blood and tumor biopsies, and efficacy assessment using RECIST criteria.ResultCPMV exhibited an icosahedral shape (~30 nm), while CRT-NP were spherical (~300 nm). …”
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Detecting global and local hierarchical structures in cell-cell communication using CrossChat by Xinyi Wang, Axel A. Almet, Qing Nie

“…Globally, CCC may exist between clusters or only subgroups of a cluster with varying size, while locally, a group of cells as sender or receiver may exhibit distinct signaling properties. …”
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Trimetallic Pt-Pd-Au alloy nanozymes for multimodal synergistic therapy to overcome deep-seated drug-resistant infections via ROS cascade by Xiaojun He, Zijian Wang, Bangxun Mao, Hao Lin, Xuru Jin, Mengxuan Du, Binge Huang, Songlin Xin, Jinmiao Qu, Yun Feng

“…Animal models illustrate the capability of PPA to accelerate deep infection wound healing while reducing inflammatory cytokine levels, alongside exhibiting excellent biocompatibility. …”
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Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions by Xiuxiu Qiu, Ao Wang, Jiahui Wang, Zhanxia Zhang, Li Tao

“…Mitochondrial metabolic reprogramming has emerged as a central adaptive mechanism that enables CRC cells to withstand hypoxia and therapeutic pressure, while concurrently driving resistance to chemotherapy, targeted agents, and immunotherapy. …”
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Detecting Predicted Cancer-Testis Antigens in Proteomics Datasets of Healthy and Tumoral Samples by Karla Cristina Tabosa Machado, Tayna da Silva Fiuza, Sandro Jose de Souza, Gustavo Antonio de Souza

“…Mass spectrometry-based proteomics allows the characterization of many cellular types and the production of large amounts of data while computational tools allow the comparison of multiple datasets, and together those may corroborate insights obtained at the transcriptomic level. …”
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Probiotic <i>Lactobacillus johnsonii</i> Reduces Intestinal Inflammation and Rebalances Splenic Treg/Th17 Responses in Dextran Sulfate Sodium-Induced Colitis by Hao-Yu Liu, Shicheng Li, Kennedy Jerry Ogamune, Peng Yuan, Xinyu Shi, Wael Ennab, Abdelkareem A. Ahmed, In Ho Kim, Ping Hu, Demin Cai

“…N5 suppressed colonic pro-inflammatory factors such as TNF-α, Il-1b, Il-6, and CXCL1, while elevating anti-inflammatory IL-10 at both mRNA and protein levels. …”
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Autoencoder techniques for survival analysis on renal cell carcinoma. by Iñigo Sanz Ilundain, Laura Hernández-Lorenzo, Cristina Rodríguez-Antona, Jesús García-Donas, José L Ayala

“…Thus, identifying molecular predictors of survival (like genetic alterations or transcriptomic patterns of gene expression) is one of the most relevant fields in current research. …”
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Phylogenomics of East Asian lineage within subgenus Anguinum (Allium, Amaryllidaceae): insights into its taxonomic puzzles and phylogenetic conflicts by Rui-Yu Cheng, Yuan Wang, Bo-Ni Song, Jin-Bo Tan, Jia-Hui Sun, Song-Dong Zhou, Xing-Jin He, Deng-Feng Xie

“…In this study, we collected 102 samples, including 45 transcriptomes and 57 plastid genomes, covering multiple populations of all currently recognized taxa within the EAL and relatives. …”
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Pre-immunotherapy alters stereotactic ablative radiotherapy-induced systemic T cell responses in early-stage NSCLC by Chao Liu, Yanjuan Chen, Xiaohui Li, Zhijie Bai, Meilin Jiang, Dongsheng Sheng, Wenxue Zou, Rui Huang, Qingyu Huang, Fuhao Wang, Jingyang Zhu, Huiru Sun, Bing Liu, Zongcheng Li, Bing Sun

“…Here, we aimed to provide a high-resolution transcriptomic profiling of the systemic T cell response following SABR, with or without preceding immunotherapy/chemotherapy. …”
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Enhancement of direct interspecies electron transfer and methane production by co-culture of dual Methanosarcina species and Geobacter metallireducens by Lu Liu, Pengsong Li, He Dong, Chuanqi Liu, Haoyong Li, Zihao Ma, Ruoyu Li, Ruoyu Li, Yan Dang

“…This corresponds to a 3.8-fold increase over the SM-G co-culture system with M. barkeri and G. metallireducens, and a 3.0-fold increase over that with M. acetivorans and G. metallireducens. Transcriptomic analysis showed that in the DM-G co-culture system, M. barkeri up-regulated key genes related to methane metabolism and acetate utilization, while the core methanogenic pathway of M. acetivorans was down-regulated, but it could still effectively utilize the electron transfer pathway, indicating metabolic complementarity. …”
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Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef... by Jiaqi Wang, Chun Shen, Guangyong Zhao, Mark D. Hanigan, Mengmeng Li

“…Protein restriction decreased average daily gain (ADG; P < 0.05), while protein re-alimentation increased ADG relative to the CON (P < 0.05). …”
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Transcript profiling of plastid ferrochelatase two mutants reveals that chloroplast singlet oxygen signals lead to global changes in RNA profiles and are mediated by Plant U-Box 4 by Snigdha Rai, Matthew D. Lemke, Anika M. Arias, María F. Gómez Méndez, Katayoon Dehesh, Jesse D. Woodson

“…Results To gain mechanistic insights into 1O2 signaling pathways, we compared transcriptomes of adult wt, fc2, and fc2 pub4 plants. …”
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