Exploring Emerging and Innovative Biomarkers for the Assessment and Monitoring of Cardiovascular Disease Risk and Treatment Efficacy in Patients by Omar Elsaka

“…The current research examines the creation of biomarkers for measuring cardiovascular disease (CVD) risk and tracking therapy effectiveness. While current biomarkers like cholesterol levels and troponins are useful, developing and innovating new biomarkers gives fresh insights into CVD etiology and drug response. …”
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Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo. by Sara Formichetti, Agnieszka Sadowska, Michela Ascolani, Julia Hansen, Kerstin Ganter, Christophe Lancrin, Neil Humphreys, Mathieu Boulard

“…We identified hypomorphic Ogt alleles that perturb O-GlcNAc homeostasis while being compatible with embryogenesis. The analysis of the transcriptomes of the mutant embryos at different developmental stages suggested a sexually-dimorphic developmental delay caused by the decrease in O-GlcNAc. …”
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Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infection. by Jinyuan Yan, Henri Estanbouli, Chen Liao, Wook Kim, Jonathan M Monk, Rayees Rahman, Mini Kamboj, Bernhard O Palsson, Weigang Qiu, Joao B Xavier

“…A detailed analysis of one patient's timeline shows how this mutation can emerge in vivo and drive rapid evolution of resistance while the patient received cancer treatment, a bone marrow transplantation, and antibiotics up to the point of causing the patient's death. …”
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PSD3 as a context-dependent modulator of immune landscape and tumor aggressiveness in esophageal squamous cell carcinoma by Shujuan Luo, Huifang Li, Bangwu Cai, Aididar Nurbahati, Hong Cui, Tianyuan Peng, Wei Wang, Qing Liu, Xiaomei Lu, Shutao Zheng

“…In this study, we investigated PSD3, CD274 (PD-L1), and TNFSF18 as potential immune-related biomarkers in esophageal squamous cell carcinoma (ESCC) using integrative transcriptomic and experimental approaches. CD274 and TNFSF18 were consistently up-regulated in ESCC across both TCGA and GEO datasets, while PSD3 showed significantly higher expression in TCGA but no significant difference in the GEO cohort. …”
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Live Malassezia strains from the mucosa of patients with ulcerative colitis: pathogenic potential and environmental adaptations by Yong-Joon Cho, Seung Yong Shin, Juan Yang, Hyo Keun Kim, Piyapat Rintarhat, Minji Park, Muhyeon Sung, Kate Lagree, David M. Underhill, Dong-Woo Lee, Sohyeong Choi, Chang Hwan Choi, Chul-Su Yang, Won Hee Jung

“…While both gut and skin isolates of M. globosa shared high genomic similarity, transcriptomic analysis revealed distinct responses to oxygen levels, suggesting niche-specific adaptation. …”
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Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension by Francesco Paolo Lo Muzio, Alessia Caputo, Rosario Statello, Mirko Hu, Roberta Maestri, Giovanna Pelà, Aderville Cabassi, Margherita Burattini, Giacomo Rozzi, Silvia Berrettoni, Barbara Montanini, Stefano Rossi, Lorenzo Fassina, Giovanni Battista Luciani, Gianluigi Condorelli, Michele Miragoli

“…In the LV, PAH also results in increased refractoriness from 95.4 ± 3.0 ms to 140.0 ± 11.5 ms and reduced transverse conduction velocity by 14%, despite preserved EF. Transcriptomic analysis indicates that while both ventricles exhibit upregulation of extracellular matrix remodeling-related genes, the RV primarily shows downregulation of electromechanical-related genes. …”
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Preparation of Trop2-targeted chimeric antigen receptor T cells and study of their exhaustion status in vitro by LIU Xiuying, LI Xinzhan, ZHU Jingjing, ZHU Jingjing

“…Pathways related to immune response and T cell receptor signaling were down-regulated, while apoptosis-related pathways were activated. …”
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A pluripotent stem cell atlas of multilineage differentiation by Sophie Shen, Tessa Werner, Han Sheng Chiu, Xiaoli Chen, Quan Nguyen, Nathan J. Palpant

“…While in vivo development has been extensively characterised using these technologies, there remains a need for comprehensive single-cell transcriptomic profiling of stem cell differentiation from pluripotency. …”
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Tolerance and heteroresistance to echinocandins in Candida auris: conceptual issues, clinical implications, and outstanding questions by Erika Shor, David S. Perlin, Dimitrios P. Kontoyiannis

“…Echinocandin tolerance involves reduced drug-mediated killing, while heteroresistance is the ability of a small cell subset to grow at high drug concentrations. …”
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Transcriptions of ACO and ACS genes are involved in nitrate-dependent root growth of maize seedlings by Guoqi Yao, Zhenwei Yan, Shijun Ma, Xia Liu, Juan Shan, Bing Cao, Xiaole Chen, Bingying Leng, Chunhua Mu

“…In this research, we performed Gene Set Enrichment Analysis (GSEA) of maize transcriptomes in response to nitrate and found that the ethylene action pathway might participate in nitrate signaling. …”
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Immunogenic cell death-related genes as prognostic biomarkers and therapeutic insights in uterine corpus endometrial carcinoma: an integrative bioinformatics analysis by Tianfei Yi, Zhenglun Yang, Peng Shen, Yan Huang

“…Differentially expressed genes (DEGs) were identified from transcriptomic data processed with the "DESeq2" R package. …”
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Identification and Characterization of SQUAMOSA Promoter Binding Protein-like Transcription Factor Family Members in <i>Zanthoxylum bungeanum</i> and Their Expression Profiles in R... by Shengshu Wang, Weiming Hu, Xueli Zhang, Yulin Liu, Fen Liu

“…This study used transcriptomic and bioinformatics data to conduct a thorough genomic identification and expression investigation of the <i>ZbSPL</i> gene family. …”
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Kynu inhibition mitigates bile duct ischemic injury by rewiring tryptophan metabolism to restore tight junction integrity by Guoqing Bao, Siliang Zhang, Zhengchen Ye, Ding Luo, Pinduan Bi, Bin Yang

“…Gene expression was quantified using RT-qPCR and Western blotting, while metabolites were analyzed via liquid chromatography-tandem mass spectrometry (LC–MS/MS). …”
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RNAseq and targeted metabolomics implicate RIC8 in regulation of energy homeostasis, amino acid compartmentation, and asexual development in Neurospora crassa by Monique Quinn, Alexander J. Carrillo, Lida Halilovic, Katherine A. Borkovich

“…RNAseq analysis showed that the Δgna-1 mutant possesses 159 mis-regulated genes, while Δgna-3 and Δric8 strains have more than 1,000 each. …”
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Ferroptosis-related hub genes and immune cell dynamics as diagnostic biomarkers in age-related macular degeneration by Jinquan Chen, Zhao Long, Dandan Shi, Qian Zhang, H. Peng

“…Results In the macula of patients with AMD, 452 DEGs were identified, while in the peripheral retina, 222 DEGs were discovered. …”
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Ketomimetic nutrients remodel the glycocalyx and trigger a metabolic defense in breast cancer cells by Mohini Kamra, Yuan-I Chen, Paula C. Delgado, Erin H. Seeley, Stephanie K. Seidlits, Hsin-Chih Yeh, Amy Brock, Sapun H. Parekh

“…Abstract Background While the triggers for the metastatic transformation of breast cancer (BC) cells remain unknown, recent evidence suggests that intrinsic cellular metabolism could be a crucial driver of migratory disposition and chemoresistance. …”
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Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genes by Shoupeng Ding, Chunxiao Huang, Jinghua Gao, Chun Bi, Yuyang Zhou, Zihan Cai

“…The TB cohort exhibited increased inflammatory T-cell populations, while CD8+ T-cell-mediated MHC-I and BTLA signaling pathways were identified as key regulators of immune clearance and modulation. …”
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Elevated serum levels of monocyte chemoattractant protein-1 in 71 patients 3 months after elective cardiac surgery suggest a potential link to persistent inflammation but not an in... by Krzysztof Laudanski, Mohamed Antar, Hossam Gad, Daniel A. Diedrich

“…MCP-4 levels were unchanged, while Regulated on Activation Normal T Cell Expressed and Secreted cytokine (RANTES) was significantly depleted after surgery. …”
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Genome-Wide Identification of Superoxide Dismutase (<i>SOD</i>) Gene Family in <i>Cymbidium</i> Species and Functional Analysis of <i>CsSOD</i>s Under Salt Stress in <i>Cymbidium s... by Ruyi Li, Songkun Lin, Yin Yan, Yuming Chen, Linying Wang, Yuzhen Zhou, Shuling Tang, Ning Liu

“…<i>Cis</i>-element prediction showed that stress-responsive elements were identified in most <i>SOD</i>s. Transcriptomic data revealed that seven <i>CsSOD</i>s exhibited a border expression in all sequenced tissues, while two exhibited undetectable expression levels. …”
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Endothelial cell proliferation and extracellular matrix-related pathways regulate pulmonary arterial hypertension in rat models by LU Xiaoxuan, GUO Lina, ZHANG Hong, SONG Wanlu, HU Yufei, YANG Peiran

“…Methods Rat PAH models were established using subcutaneous monocrotaline (MCT) injection and the SU5416/hypoxia (SU/Hx) method. Transcriptomic sequencing of lung tissues was performed to identify gene expression and pathway alterations in PAH rats, followed by a comparative analysis with transcriptomic data of patients with idiopathic pulmonary arterial hypertension (IPAH) in NCBI database. …”
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