Endophytic fungi enhance drought tolerance in Fagopyrum tataricum: Insights into flavonoid biosynthesis and photosynthetic pathways by Yujie Jia, Qiqi Xie, Jiwen Tao, Yixin Chen, Yixuan Qi, Hongying Zhu, Tongliang Bu, Xinyu Zhang, Yirong Xiao, Zhao Chen, Qingfeng Li, Zizhong Tang, Ming Yuan

“…Metabolite analysis revealed elevated levels of osmotic regulatory substances and antioxidants, while photosynthetic inhibition caused by drought stress was effectively alleviated upon fungal inoculation. …”
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Dose-dependent dual effects of HDAC inhibitors on glial inflammatory response by Samantha Mancino, Mariaserena Boraso, Andrea Galmozzi, Melania Maria Serafini, Emma De Fabiani, Maurizio Crestani, Barbara Viviani

“…Class-selective inhibitors highlighted distinct HDAC roles on LPS modulation: MS-275 reduced, while MC1568 enhanced, TNF-α release, alongside varied IL-1β and IL-10 modulation. …”
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Ferroptosis is important for Toxoplasma gondii replication and virulence in vitro and in vivo by Ling-Yu Li, Chun-Xue Zhou, Bing Han, Hany M. Elsheikha, Hui-Jie Qiu, Xu-Dian An, Ting Zeng, Dai-Ang Liu, Qing Yang, Xing-Quan Zhu, Huai-Yu Zhou

“…The protozoan parasite T. gondii employs intricate mechanisms to exploit host cells while sustaining their viability, yet its interaction with ferroptosis – an iron-dependent cell death driven by lipid peroxidation – remains poorly defined. …”
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The role of multiomics in revealing the mechanism of skin repair and regeneration by Shaoyan Shi, Xuehai Ou, Jafeng Long, Xiqin Lu, Siqi Xu, Gang Li

“…This review explores the transformative role of multiomics in elucidating the mechanisms of skin repair and regeneration. While genomic studies identify the genetic basis of wound healing, transcriptomics and proteomics uncover the dynamic changes in gene and protein expression, and metabolomics provides a snapshot of metabolic alterations associated with wound healing. …”
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In silico analysis of the oncogenic role of myoferlin (MYOF) and suggestion of folate as a potential therapeutic for brain cancer in the Caucasian population by Saanvi Muthuchetty

“…Abstract Background Myoferlin (MYOF), a key gene in endocytosis, is known to be crucial for metastasis in cancer. While the involvement of MYOF as a biomarker is documented in cancer, a comprehensive study on its knockdown for targeted therapy via folate is a novel approach. …”
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A LINC00472-encoded polypeptide impedes migration and proliferation through modulation of the HDAC2/SP1 axis in non-small cell lung cancer cells by Lei Xu, Haoyong Kuang, Haodong Peng, Sen Wu, Yu Bai, Xiangbo Jia, Wenjian Yao

“…Abstract Objective While long non-coding RNAs (lncRNAs) are increasingly recognized as sources of functional micropeptides, their roles in non-small cell lung cancer (NSCLC) remain poorly characterized. …”
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Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages by Adrián Cortés-Martín, Colin Buttimer, Jessie L. Maier, Ciara A. Tobin, Lorraine A. Draper, R. Paul Ross, Manuel Kleiner, Colin Hill, Andrey N. Shkoporov

“…These interactions are driven by eco-evolutionary dynamics, where bacteria employ a variety of mechanisms to evade phage infection, while phages rely on counterstrategies to overcome these defenses. …”
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Single-cell sequencing combined with urinary multi-omics analysis reveals that the non-invasive biomarker PRDX5 regulates bladder cancer progression through ferroptosis signaling by Shun Wan, Kun-peng Li, Si-yu Chen, Chen-yang Wang, Kun Cheng, Jian-wei Yang, Li-yun Ding, Tuan-jie Che, Shan-hui Liu, Li Yang

“…We conducted in vitro experiments to analyze the impact of PRDX5 on BC cell proliferation, migration, and invasion, while exploring its mechanisms of modulating ROS levels and ferroptosis. …”
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Vitamin C potentiates the killing of Mycobacterium tuberculosis by bedaquiline through metabolic disruption by Catherine Vilchèze, Saranathan Rajagopalan, Raja Sab Kalluru, Niaz Banaei, William R. Jacobs

“…This study found that the combination of vitamin C and bedaquiline sterilizes Mycobacterium tuberculosis cultures in vitro while potentiating bedaquiline activity in infected human macrophage cells. …”
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Investigation of granuloma-targeted host-pathogen interactions identify vaccine correlates of immune protection associated with control of M. tuberculosis replication by David Forrest Ackart, Dr. Faye Lanni, Victoria Mitcham, Dr. G. Brooke Anderson, Dr. Michael Lyons, Dr. Marcela Henao-Tamayo, Dr Brendan Podell

“…Introduction: Immune correlates of protection to guide vaccine development for tuberculosis (TB) have remained elusive. While a number of blood transcriptomic signatures have been shown to predict clinical states of TB in human subjects, no correlates exist to indicate immune signatures that control bacterial growth, which would inform improved vaccine design. …”
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Watkins wheat landraces decode nitrogen-driven biomass trade-offs: GWAS exposes root-shoot dialectics and elite landraces for resilient agriculture by Abdul Waheed, Muhammad Shahid Iqbal, Zareen Sarfraz, Junliang Hou, Yanping Wei, Bo Song, Shifeng Cheng

“…Adaptive alleles of RALF33 in European landraces optimized root proliferation under LN, while Eurasian landraces exhibited shoot-root coordination under NN through TaNAR1 variants. …”
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Comprehensive analysis of the microbial consortium in the culture of flagellate Monocercomonoides exilis by Alejandro Jiménez-González, Sebastian Cristian Treitli, Priscila Peña-Diaz, Anna Janovská, Vladimír Beneš, Petr Žáček, Vladimír Hampl

“…M. exilis accounted for less than 1.5% of the DNA reads, while bacterial species dominated the sequence data and shifted in abundance over time. …”
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ZC3H12D gene expression exhibits dual effects on the development and progression of lung adenocarcinoma by Yuansi Zheng, Yuhuan Zhang, Jieyi Li, Ying Su

“…Abstract While precision oncology requires robust biomarkers, current predictors for lung adenocarcinoma (LUAD) often show limited clinical utility. …”
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In silico analysis reveals distinct changes in markers of epithelial to mesenchymal transition in glioma subtypes by Nives Pećina-Šlaus, Alja Zottel, Željko Škripek, Borna Puljko, Fran Dumančić, Anja Bukovac, Ivana Jovčevska, Anja Kafka

“…The virtual study showed that alterations in NOTCH1 and LEF1 were associated with LGG, while alterations in CDH1, CTNNB1, TJP1, TWIST1, SOX2, VIM, ZEB1, and ZEB2 were associated with HGG. …”
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Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy by Alessandra Ferraresi, Andrea Esposito, Carlo Girone, Letizia Vallino, Amreen Salwa, Ian Ghezzi, Suyanee Thongchot, Chiara Vidoni, Danny N. Dhanasekaran, Ciro Isidoro

“…<b>Results</b>: LPA stimulated while RV inhibited ovarian cancer cell migration. …”
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Rapid DNA and RNA isolation from few or single cells using low-cost NAxtra magnetic nanoparticles by Eirin Johannessen Starheim, Adeel Manaf, Adnan Hashim, Niklas Nonboe Andersen, Erlend Ravlo, Wei Wang, Vidar Langseth Saasen, Nina-Beate Liabakk, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Magnar Bjørås

“…This method achieves comparable yields to existing isolation kits while offering significant improvements in cost and processing speed. …”
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Exercise-mobilized donor lymphocyte infusions enhanced with cytokine stimulation for the prevention and treatment of leukemic relapse after allogeneic hematopoietic cell transplant... by London M. McDougal, Forrest L. Baker, Forrest L. Baker, Forrest L. Baker, Michael P. Gustafson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson

“…We also discuss how DLI-X and DLI-XS, can be leveraged in combination with other post-transplant interventions to maximize GvL effects while minimizing GvHD risks. Finally, we explore the critical role of donor fitness (e.g. …”
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Antagonistic manipulation of ER-protein quality control between biotrophic pathogenic fungi and host induced defense by Theoni Margaritopoulou, Konstantinos Kotsaridis, Martina Samiotaki, Spyridon Nastos, Marinos Maratos, Ieronymos Zoidakis, Despoina Tsiriva, Stergios Pispas, Emilia Markellou

“…Examination of P. xanthii during infection at control conditions, identified ribosomal, hydrolase-related, putative secreted and effector proteins, while nanoparticle application significantly downregulated their expression. …”
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Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity by Hope A. Townsend, Hope A. Townsend, Kaylee J. Rosenberger, Kaylee J. Rosenberger, Lauren A. Vanderlinden, Lauren A. Vanderlinden, Jun Inamo, Jun Inamo, Fan Zhang, Fan Zhang, Fan Zhang

“…Indeed, we identified supported and novel genetic-phenotype linkages separating RA and ankylosing spondylitis, and UC and crohn’s disease. Overall, while noting evolving single-cell technologies, our study provides key findings for integrating expanding fine-grained scRNA-seq, GWAS, and noncoding SNP resources to unravel the complexities of inflammatory diseases.…”
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Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? by José María Salazar Campos, Lena F Burbulla, Sarah Jäkel

“…Despite decades of research, the molecular mechanisms of the origin of the disease remain unknown. While the disease was initially viewed as a purely neuronal disorder, results from single-cell transcriptomics have suggested that oligodendrocytes may play an important role in the early stages of Parkinson's. …”
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