Loss of function of MusaPUB genes in banana can provide enhanced resistance to bacterial wilt disease by Leena Tripathi, Valentine Otang Ntui, Samwel Muiruri, Trushar Shah, Jaindra Nath Tripathi

“…Several edited lines displayed complete resistance to Xvm infection, while others showed partial resistance, in contrast to the full susceptibility of wild-type controls. …”
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Evolutionary dynamics of Orchid DL paralogs: gene duplication, functional divergence, and expression patterns across Orchid subfamilies by Francesca Lucibelli, Angela Carfora, Annette Becker, Katrin Ehlers, Serena Aceto

“…Results Through genomic and transcriptomic analyses, we identified 25 full-length DL genes in orchids, with two paralogs (DL1 and DL2-like genes) observed in Epidendroideae, Orchidoideae, Cypripedioideae, and Vanilloideae, while the most ancestral Apostasioideae retained a single-copy gene. …”
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Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. by Elliott D SoRelle, Lauren E Haynes, Katherine A Willard, Beth Chang, James Ch'ng, Heather Christofk, Micah A Luftig

“…Viral infection leads to heterogeneous cellular outcomes ranging from refractory to abortive and fully productive states. Single cell transcriptomics enables a high resolution view of these distinct post-infection states. …”
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Ageless harmony: decoding the microbiome–stem cell nexus in aging by Swarup K. Chakrabarti, Dhrubajyoti Chattopadhyay

“…While therapeutics targeting the microbiome hold promise in keeping stem cell homeostasis and tissue repair capacities, the primary focus remains on deepening our understanding of the interplay between the microbiota and stem cells. …”
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Transcriptional time-course analysis during ash dieback infection revealed different responses in tolerant and susceptible Fraxinus excelsior genotypes by Víctor Chano, Renata Callegari Ferrari, Tania Domínguez-Flores, Karuna Shrestha, Barbara Fussi, Hannes Seidel, Oliver Gailing, Katharina B. Budde

“…Moreover, we identified an earlier expression of genes involved in both pattern- and effector-triggered immunity (PTI and ETI) in ADB-tolerant genotypes, while in ADB-susceptible genotypes both responses were delayed (late response). …”
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Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression by Dong Wang, Yunlong Li, Xiaoyu Peng, Lulu Zhang, Ying Zhang, Xue Guan, Xiao Liang, Songbin Fu, Jingcui Yu

“…Functional validation through in vitro and in vivo models demonstrated PVT1’s oncogenic role, while transcriptomic profiling further decoded neutrophil activation mechanisms regulated by PVT1. …”
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Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1 by Sha Xiao, Tianjing Wei, Mingyang Xiao, Mingming Shan, Ziqi An, Na Li, Jing Zhou, Shuang Zhao, Xiaobo Lu

“…Nicotine-induced oxidative stress contributes significantly to vascular endothelial dysfunction. While negative air ions (NAIs) demonstrate potential blood-pressure-regulating and antioxidant properties, their mechanistic role remains unclear. …”
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Unveiling the mechanisms of ultrasonic radiation-induced free radical stress on algal communities: Insights into growth inhibition, photosynthetic disruption, and antioxidant defen... by Xiaoge Wu, Tingting Shen, Xiaoyang Liu, Guangming Zhang, Xiaoqing Qian, Wenlan Yang

“…Stress response genes, particularly those involved in antioxidant defense, were upregulated, while photosynthesis-related genes were downregulated. …”
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Comprehensive bioinformatics analysis of the common mechanism of atherosclerosis and atrial fibrillation: emphasizing mitochondrial metabolic disorder and immune inflammation by Rui Dai, Xiaotong Lei, Xiaojun Liu, Chen Bian

“…Its decline in AS suggests a potential role in mitochondrial ribosomal integrity loss driving metabolic stress, while immune-microenvironment interactions highlight its pleiotropic impacts on inflammatory cascades. …”
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Cancer-specific senescence signature promotes malignant phenotypes and immunotherapy resistance in colorectal cancer by Wei Wang, Wei Wang, Fengyu Ling, Fengyu Ling, Dong Huang, Guomin Luo, Guomin Luo, Bixia Duan, Bixia Duan

“…BackgroundWhile cellular senescence in colorectal cancer (CRC) exhibits strong correlations with immunotherapy response and clinical prognosis, its mechanistic basis remains elusive, and validated predictive biomarkers are currently unavailable.MethodsIn this study, we integrated single-cell and bulk transcriptomic data to establish a cancer-specific senescence signature (CSS). …”
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Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations by Sohei Ito, David B. Graf, Yuriko Katsumata, Jessica J. Moorleghen, Chen Zhang, Yanming Li, Scott A. LeMaire, Ying H. Shen, Hong S. Lu, Alan Daugherty, Hisashi Sawada

“…These findings suggest that while fibroblasts in the new subcluster exhibit lineage-specific extracellular matrix-related differences, overall transcriptomic variations between SHF- and nSHF-derived cells in response to AngII remain modest during the prepathological phase of AngII-induced thoracic aortopathy.…”
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The seminal vesicle is a juvenile hormone-responsive tissue in adult male Drosophila melanogaster by Yoshitomo Kurogi, Yosuke Mizuno, Ryosuke Hayashi, Krystal Goyins, Naoki Okamoto, Lacy Barton, Ryusuke Niwa

“…Juvenile hormone (JH) is one of the most essential hormones controlling insect metamorphosis and physiology. While it is well known that JH affects many tissues throughout the insect life cycle, the difference in JH responsiveness and the repertoire of JH-inducible genes among different tissues has not been fully investigated. …”
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Shared and distinct peripheral blood immune cell landscape in MCTD, SLE, and pSS by Yanling Cui, Huina Zhang, Yaxuan Deng, Orion Fan, Junbang Wang, Zhonggang Xing, Jianping Tang, Wenmin Zhu, Bangdong Gong, Yi Eve Sun

“…Furthermore, we offer insights into the transcriptomic similarities and heterogeneity across different autoimmune diseases, while highlighting prospective therapeutic targets.…”
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Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux by Jarmon G. Lees, Timothy S. Cliff, Amanda Gammilonghi, James G. Ryall, Stephen Dalton, David K. Gardner, Alexandra J. Harvey

“…In this study, we integrated metabolic, transcriptomic, and epigenetic data to elucidate the impact of oxygen on hPSC. …”
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Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer by Zhihang Jiang, Zhihang Jiang, Xiaoqing Li, Xiaoqing Li, Long Hu, Zheng Jiang

“…A systematic pan-cancer analysis of succinylation-related molecular activities is needed.MethodsBulk transcriptomic, single-cell RNA sequencing, and spatial transcriptomic data across pan-cancer from TCGA, GEO, TISCH, and multiple other databases were analyzed. …”
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Deoxynucleosides as promising antimicrobial agents against foodborne pathogens and their applications in food and contact material surfaces by Olajide Sunday Faleye, Jin-Hyung Lee, Jintae Lee

“…FdCyd exhibited low minimum inhibitory concentration (MIC) of 30, 40 and 10 μg/mL against V. parahaemolyticus, V. harveyi and Salmonella typhimurium while ddA had MICs 40, 40 and >500 μg/mL, respectively. …”
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Revealing pathogenesis-associated metabolites in Histoplasma capsulatum through comprehensive metabolic profiling by Adrian Heckart, Jean-Christophe Cocuron, Stephanie C. Ray, Chad A. Rappleye, Ana P. Alonso

“…While Histoplasma is a unique example of a true intra-phagosomal pathogen, insights into its pathogenesis may still inform the study of other intracellular pathogens.…”
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Effect of age and sex differences on the abundances of neuronal, glial, and endothelial cells in non-diseased brain tissue. by Arttu Autio-Kimura, Tapio Nevalainen, Mikko Hurme

“…An age-associated decrease in neuronal proportions was only observed in male donors, while no significant change was found in females. …”
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Single-cell RNAseq and longitudinal proteomic analysis of a novel semi-spontaneous urothelial cancer model reveals tumor cell heterogeneity and pretumoral urine protein alterations... by Iliana K Kerzeli, Martin Lord, Milena Doroszko, Ramy Elgendy, Aikaterini Chourlia, Ivan Stepanek, Elinor Larsson, Luuk van Hooren, Sven Nelander, Per-Uno Malmstrom, Anca Dragomir, Ulrika Segersten, Sara M Mangsbo

“…The profiling of the model was performed by histology grading, single cell transcriptomic and proteomic analysis, while the derivation of a tumorigenic cell line was validated and used to assess in vivo anti-tumor effects in response to immunotherapy. …”
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Molecular mechanisms of ageing in cancer development and therapeutic response: Translational implications for precision oncology by Laiba Husain

“…These age‐related changes create a permissive environment for oncogenesis while simultaneously affecting therapeutic efficacy and treatment tolerance. …”
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