Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors by Jing Jin, Zheng Jiang, Jun Liu, Hui Yang, Long Xu, Weiwei Zhang, Xingchen Peng, Nian Yang, Zongliang Zhang, Liangxue Zhou, Aiping Tong, Huaqing Lu, Yongdong Chen, Liyuan Jin

“…Primary endpoints were safety and tolerability, while secondary endpoints were antitumor response and changes in the tumor microenvironment (TME), assessed by RECIST v1.1 criteria and multiplex immunohistochemistry and single-cell transcriptome analysis.Results SKV-012-infected tumor cells secreted high levels of IL-12 and exhibited increased ICP34.5 expression. …”
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Genome-wide identification and gene expression analysis of the malate dehydrogenase (MDH) gene family in Eucalyptus grandis by Yifan Xing, Yifan Xing, Huiming Xu, Deming Yang, Lichuan Deng, Guolong Li, Guolong Li, Zhixin Zhao, Zhixin Zhao, Zhaohua Lu, Liuyin Ma, Guangyou Li

“…Phylogenetics analysis with model plants revealed that Eucalyptus lacked Group III MDHs, while Poplar lacked Group II members, indicating lineage-specific gene loss in woody angiosperms. …”
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LincRNA-MSTRG.673.2 Promotes Chicken Intramuscular Adipocyte Differentiation by Sponging miR-128-3p by Binbin Zhang, Shuaipeng Zhu, Yuehua He, Wenjie Liang, Tingqi Zhu, Ruili Han, Donghua Li, Yanbin Wang, Yadong Tian, Guoxi Li, Xiangtao Kang, Wenting Li, Guirong Sun

“…Increasing the intramuscular fat (IMF) content of chickens while increasing their growth rate has become a hot topic in molecular breeding. …”
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Complete genomic characterization of global pathogens respiratory syntical virus and human norovirus using probe based capture enrichment by Sravya V Bhamidipati, Anil Surathu, Hsu Chao, Daniel P. Agustinho, Qin Xiang, Kavya Kottapalli, Abirami Santhanam, Zeineen Momin, Kimberly Walker, Vipin K. Menon, George Weissenberger, Nathanael Emerick, Faria Mahjabeen, Qingchang Meng, Jianhong Hu, Richard Sucgang, David Henke, Fritz J. Sedlazeck, Ziad M. Khan, Ginger A. Metcalf, Vasanthi Avadhanula, Pedro A. Piedra, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Joseph F. Petrosino, Richard A. Gibbs, Donna M. Muzny, Sara Cregeen Javornik, Harsha Doddapaneni

“…Abstract Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in children worldwide, while human noroviruses (HuNoV) are a leading cause of epidemic and sporadic acute gastroenteritis. …”
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Unraveling the genetic landscape of susceptibility to multiple primary cancers by Pooja Middha, Linda Kachuri, Jovia L. Nierenberg, Rebecca E. Graff, Taylor B. Cavazos, Thomas J. Hoffmann, Jie Zhang, Stacey Alexeeff, Laurel Habel, Douglas A. Corley, Stephen Van Den Eeden, Lawrence H. Kushi, Elad Ziv, Lori C. Sakoda, John S. Witte

“…Summary: With advances in cancer screening and treatment, there is a growing population of cancer survivors who may develop subsequent primary cancers. While hereditary cancer syndromes account for only a portion of multiple cancer cases, we sought to explore the role of common genetic variation in susceptibility to multiple primary tumors. …”
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Metabolomic and evolutionary integration unveils medicinal potential in six Corydalis species by Yun Gao, Xiangyu Zhou, Mengxiao Yan, Zhengwei Wang, Xin Zhong, Xiaochen Li, Junjie Zhu, Yu Kong, Wanrong Zhu, Ruolin Geng, Yaping Zhou, Qing Zhao, Yonghong Hu, Ping Xu

“…Additionally, transcriptome-metabolome correlation analyses pinpointed several critical genes involved in protopine biosynthesis, particularly emphasizing the TNMT gene family. …”
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Co-culture dynamics between Lachancea cidri and Saccharomyces cerevisiae impact fermentative aroma profile by Vasni Zavaleta, Diego Valderrama-Soto, Luis A. Saona, Romain Minebois, Amparo Querol, Francisco A. Cubillos, Pablo Villarreal

“…We analyzed the L. cidri's transcriptome after 16 h of fermentation, which remained stable when comparing 180 and 60 mg/L SWM YANs, while S. cerevisiae exhibited changes in the expression of 1,704 genes, many of them related with energy precursor metabolites, highlighting its sensitivity to low nitrogen conditions. …”
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Adaptable and comprehensive approaches for long-read nanopore sequencing of polyadenylated and non-polyadenylated RNAs by Simon Haile, Richard D. Corbett, Kieran O’Neill, Jing Xu, Duane E. Smailus, Pawan K. Pandoh, Anthony Bayega, Miruna Bala, Eric Chuah, Robin J. N. Coope, Richard A. Moore, Karen L. Mungall, Yongjun Zhao, Yussanne Ma, Marco A. Marra, Marco A. Marra, Steven J. M. Jones, Steven J. M. Jones, Andrew J. Mungall

“…Thus, these approaches do not allow comprehensive interrogation of the transcriptome due to their exclusion of non-polyadenylated (polyA-) RNAs. …”
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Diversity of Gibberellin 2-oxidase genes in the barley genome offers opportunities for genetic improvement by Jingye Cheng, Yong Jia, Camilla Hill, Tianhua He, Ke Wang, Ganggang Guo, Sergey Shabala, Meixue Zhou, Yong Han, Chengdao Li

“…Knockdown of HvGA2ox9 did not affect plant height, while ga2ox8a mutants generated by CRISPR/Cas9 increased plant height and significantly altered seed width and weight due to the increased bioactive GA4 level. …”
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Dissecting the genetic architecture of yield-related traits by QTL mapping in maize by Hao Zhang, Hao Zhang, Ting Li, Zhenyu Zhang, Jie Wang, Haoxiang Yang, Jiachen Liu, Wanchao Zhu, Wanchao Zhu, Jiquan Xue, Jiquan Xue, Shutu Xu, Shutu Xu

“…Through integrated transcriptome data and interaction networks, 20 genes located in these QTLs were investigated as candidate genes. …”
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Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model by Sjoerd H van der Burg, Thorbald van Hall, Heleen Vroman, Menno van Nimwegen, Christianne Groeneveldt, Priscilla Kinderman, Dana A M Mustafa, Nadine van Montfoort, Joachim Aerts, Melanie Lukkes, Sai Ping Lau, Casper H J van Eijck, Larissa Klaase, Mandy van Gulijk, Jasper Dumas, Sanne L A Lievense, Ralph Stadhouders, Yunlei Li, Andrew Stubbs, Koen A Marijt, Floris Dammeijer

“…In established disease, combination with stimulating CD40 antibody was necessary to improve survival, while anti-CD40 alone was ineffective. Extensive analysis of the TME showed that anti-CD40 monotherapy did improve CD8 +T cell infiltration, but these essential effector cells displayed hallmarks of exhaustion, including PD-1, TIM-3 and NKG2A. …”
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Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications by Yu He, Susu Jiang, Fang Wang, Junwu Bi, Siting Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

“…These findings provide critical insights into the molecular arms race between phages and prokaryotic hosts while expanding the toolkit for developing phage-based biotechnological applications.…”
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The Chinese Herbal TiaoGanXiaoZhi Formula Alleviates the Progression of Metabolic‐Associated Fatty Liver Disease by Regulating the Gut Microbiota by Wenying Qi, Xu Cao, Yue Chen, Hening Chen, Xiaoke Li, Ningyi Zhang, Ruijia Liu, Wei Wang, Shihao Zheng, Size Li, Qiyao Liu, Xiaobin Zao, Yong‐An Ye

“…TGXZ (or placebo) was administered at a clinical equivalent dose of 7.699 g/(kg·d) to the respective groups, while NFD and HFD groups received distilled water. …”
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Characterization of full-length long noncoding RNAs and identification of virus-responsive lncRNAs in Sogatella furcifera by Yawen Ban, Yawen Ban, Ting Cui, Ting Cui, Lifei Zhao, Lifei Zhao, Xue Li, Xue Li, Qing Bai, Qing Bai, Qingfa Wu, Qingfa Wu

“…Stage-specific lncRNAs were predominantly expressed during embryogenesis (e.g., 93 transcripts between 0 and 72 h post-oviposition) and molting (e.g., 16 in pre-ecdysis), while sex-biased expression patterns emerged after 24 h. …”
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Genome-Wide Identification and Expression Analysis of the <i>PsTPS</i> Gene Family in <i>Pisum sativum</i> by Hao Yuan, Baoxia Liu, Guwen Zhang, Zhijuan Feng, Bin Wang, Yuanpeng Bu, Yu Xu, Zhihong Sun, Na Liu, Yaming Gong

“…Phylogenetic analysis delineated evolutionary relationships, while gene structure analysis revealed compositional insights, and motif analysis provided functional insights. …”
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Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver by Vanessa Dubois, Céline Gheeraert, Wouter Vankrunkelsven, Julie Dubois‐Chevalier, Hélène Dehondt, Marie Bobowski‐Gerard, Manjula Vinod, Francesco Paolo Zummo, Fabian Güiza, Maheul Ploton, Emilie Dorchies, Laurent Pineau, Alexis Boulinguiez, Emmanuelle Vallez, Eloise Woitrain, Eric Baugé, Fanny Lalloyer, Christian Duhem, Nabil Rabhi, Ronald E van Kesteren, Cheng‐Ming Chiang, Steve Lancel, Hélène Duez, Jean‐Sébastien Annicotte, Réjane Paumelle, Ilse Vanhorebeek, Greet Van den Berghe, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute

“…Abstract Liver injury triggers adaptive remodeling of the hepatic transcriptome for repair/regeneration. We demonstrate that this involves particularly profound transcriptomic alterations where acute induction of genes involved in handling of endoplasmic reticulum stress (ERS) is accompanied by partial hepatic dedifferentiation. …”
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The VDAC3/DHODH Axis Ameliorates Sepsis-induced Myocardial Injury by Regulating Ferroptosis by Jiali Wang, Fan Zhang, Chaoqing Tan, Nana Wang, Xuexia Xia, Yun Ye, Yue Cao, Xin Huang, Zhenjiang Bai, He Zhao, Ling Sun, Qiuqin Xu, Huiting Zhou, Jie Huang

“…Transmission electron microscopy (TEM) was employed to evaluate the mitochondrial ultrastructure in cardiac tissues, while hematoxylin-eosin (H&E) staining was used to assess histopathological alterations. …”
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Functional analysis of lncRNAs in lipid metabolism of fat and lean line broiler embryonic livers by Huili Zhang, Xuanming Cao, Youdong Wang, Bohan Cheng, Li Leng, Peng Luan, Zhiping Cao, Yumao Li, Xue Bai

“…Lipid metabolism during the broiler embryo stage may significantly affect post-hatch growth performance, yet research on this subject remains limited. While long non-coding RNAs (lncRNAs) have been found to regulate liver lipid metabolism in post-hatch chickens, their functions during the embryonic stage remains unclear. …”
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Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization t... by Yunzhuo Xin, Yunzhuo Xin, Rou Wen, Rou Wen, Rou Wen, Dong Song, Jing Xiao, Jing Xiao, Xiaoping Gao, Mei Yin, Yanli Bai, Jie Wang, Jie Wang, Xiangyu Zhou, Jiaqing Zhao, Jiaqing Zhao, Jiaqing Zhao

“…The gene expression changes in MH-S cells after transfect with emu-miR-10a-5p mimics was analyzed through transcriptome sequencing. We established a mouse model of ovalbumin (OVA)-induced allergic asthma. …”
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Bridging the Gap: Biofilm-mediated establishment of Bacillus velezensis on Trichoderma guizhouense mycelia by Jiyu Xie, Xinli Sun, Yanwei Xia, Lili Tao, Taimeng Tan, Nan Zhang, Weibing Xun, Ruifu Zhang, Ákos T. Kovács, Zhihui Xu, Qirong Shen

“…We firstly demonstrate that while co-inoculation of B. velezensis and T. guizhouense could promote tomato growth, these two microorganisms display mutual antagonism on agar solidified medium. …”
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