Transcriptional dynamics and functions of WUSCHEL-related homeobox (WOX) genes from Ginkgo biloba in tissue culture by Wei Xu, Ang Xu, Pingjun Xu, Jiaqi Li, Chao Luo, Xiaoming Yang, Meiling Ming, Yuhua Liu, Guibin Wang, Liangjiao Xue, Fuliang Cao, Gaiping Wang, Fangfang Fu

“…Further investigation through Ginkgo tissue culture indicated that GbWOX2 was specifically expressed in embryos and facilitated callus induction, while GbWOX3A showed preferential expression during the early stages of embryo and callus development. …”
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The EGR1-mediated lncRNA TENM3-AS1 potentiates gastric cancer metastasis via reprogramming fatty acid metabolism by Yuhui Tang, Baiwei Zhao, Wanchuan Wang, Haoming Chen, Junsheng Zhang, Yi Xie, Yongming Chen, Feizhi Lin, Yuanfang Li, Xiaohui Zhai, Wen Zhou

“…Abstract Background Long non-coding RNAs (lncRNAs) are essential modulators in tumor progression. While fatty acid (FA) metabolism can potentiate tumorigenesis, colonization, and metastasis, the roles of lncRNAs in reprograming FA metabolism and regulating gastric cancer (GC) metastasis remain elusive. …”
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How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation by Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma

“…Here, based on integrated omics including anthocyanin, flavonoid metabolome, and transcriptome, the substances basis and metabolic mechanisms regulating gradient coloration were thoroughly resolved. …”
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Antibacterial and antibiofilm activities and mechanisms of Toona sinensis extracts against Bacillus cereus and its application in milk by Yuru Wei, Lei Lei, Honglin Jiang, Qingquan Du, Decheng Liu, Lu Chen, Xiaoshan Shi, Yanxiang Wang, Jingjing Li, Yuanliang Hu, Xian Xia, Junming Tu

“…This report provides the first evidence of both antibacterial and antibiofilm activities in T. sinensis extract against B. cereus, while also elucidating the associated mechanisms.…”
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Modulation of virulence and metabolic profiles in Klebsiella pneumoniae under indole-mediated stress response by Xueyao Fang, Yanhui Chen, Longhua Hu, Shumin Gu, Junqi Zhu, Yaping Hang, Xingwei Cao, Yanping Xiao, Hong Luo, Chuwen Zhao, Lianhua Xiao, Qiaoshi Zhong

“…To elucidate the underlying molecular mechanisms, transcriptome analysis revealed that indole exposure in K. pneumoniae led to the upregulation of genes associated with pili formation and iron acquisition systems, while simultaneously inducing oxidative stress responses. …”
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Glucosylceramides containing very long-acyl-chain fatty acid are critical for cotton fiber elongation by influencing brassinosteroid synthesis and signaling by Qiaoling Wang, Xingying Yan, Qi Niu, Hongju Zhang, Huidan Tian, Zheng Chen, Fan Xu, Yu You, Yinghui Gao, Zhiqing Qiao, Ming Luo

“…Furthermore, we found that PDMP treatment blocked BR synthesis and signal transduction, while exogenous application of GluCer could enhance BR synthesis and signaling. …”
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DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients’ airway epithelial cells by Marey Messingschlager, Sebastian D Mackowiak, Maria Theresa Voelker, Matthias Bieg, Jennifer Loske, Robert Lorenz Chua, Johannes Liebig, Sören Lukassen, Loreen Thürmann, Anke Seegebarth, Sven Twardziok, Daria Doncevic, Carl Herrmann, Stephan Lorenz, Sven Klages, Fridolin Steinbeis, Martin Witzenrath, Florian Kurth, Christian Conrad, Leif E Sander, Naveed Ishaque, Roland Eils, Irina Lehmann, Sven Laudi, Saskia Trump

“…Hypomethylated regions affected immune regulatory genes, while hypermethylated regions were associated with genes governing ciliary function. …”
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The Puccinia triticina effector Pt3372 suppresses wheat innate immunity by targeting wheat TaERP3 in TcLr2a and TcLr18 by Xiaolei Wen, Hao Li, Jianyuan Li, Johannes Mapuranga, Na Zhang, Lulu Song, Jiaying Chang, Ruolin Li, Yue Zhang, Daqun Liu, Wenxiang Yang

“…Here, we identify an effector protein Pt3372 from the transcriptome data of interaction between the Pt race JHKT and the susceptible wheat cultivar Thatcher. …”
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Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma by Hong-Shuai Li, Ruo Tang, Hua-Shan Shi, Zi-Jian Qin, Xiao-Yang Zhang, Yun-Fei Sun, Zhi-Gong Wei, Chao-Fan Ma, Liu Yang, Ye Chen, Zhe-Ran Liu, Li-Li Zhu, Wen Yang, Li Yang, Ai-Ning Xu, Zhuo Zhang, Shu-Qing Liao, Jin-Shui Shi, Jian-Jun Deng, Xiao-Zhong He, Xing-Chen Peng

“…In vitro experiments indicated that UHDR-RT suppressed radioresistant cell proliferation and invasion, while promoting apoptosis and exacerbating DNA damage. …”
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RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy by Jianxuan Gao, Jiali Jin, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song, Jianru Xiao, Ping Wang, Tong Meng

“…Pharmacological targeting mTORC1 pathway dramatically impeded the RAB3B‐induced stemness regulation, protein translation, and chordoma tumorigenicity, while RAB3B knockdown desensitized mTORC1 inhibition. …”
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Liver transplant-facilitated CD161+Vα7.2+ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients by Wei Wang, Chen Dai, Peng Zhu, Mi Wu, Haoquan Zhang, Qing Wei, Ting Zhou, Xiaosheng Tan, Ying Jiang, Xue Cheng, Zhihui Liang, Xiongwen Wu, Zhishui Chen, Xiufang Weng

“…Liver transplantation facilitates a gradual recovery of recipient-originated MAIT cells. Transcriptome analysis reveals enhanced MAIT cell activation, while TCR mining demonstrates clonotype overlap between circulating and hepatic MAIT cells during significant liver injury. …”
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Cow Placenta Peptides Ameliorate D-Galactose-Induced Intestinal Barrier Damage by Regulating TLR/NF-κB Pathway by Yuquan Zhao, Zhi Zeng, Weijian Zheng, Zeru Zhang, Hanwen Zhang, Yuxin Luo, Kunshan Zhao, Yuyan Ding, Wei Lu, Fuxing Hao, Yixin Huang, Liuhong Shen

“…Groups T and P received oral administration of CPP (2000 mg/kg/day) and vitamin C (100 mg/kg/day), respectively, while groups M, T, and P were subjected to intraperitoneal injections of D-galactose (D-gal) (300 mg/kg/day). …”
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The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts by Ilenia Masi, Flavia Ottavi, Valentina Caprara, Danila Del Rio, Martina Kunkl, Francesca Spadaro, Valerio Licursi, Loretta Tuosto, Anna Bagnato, Laura Rosano’

“…The expression of Col1 (COL1A1) and FN (FN1) were detected by western blotting (WB), quantitative real time-polymerase chain reaction (qRT-PCR), immunofluorescence (IF), and confocal laser scanning microscopy (CLSM) in cells and tumor tissue sections from mice xenografts, while the transcription of COL1A1 was detected by luciferase reporter gene assay. …”
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Type I-E* CRISPR-Cas of Klebsiella pneumoniae upregulates bacterial virulence by targeting endogenous histidine utilization system by Jieying Li, Yuxiao Liu, Jingsi Jiang, Fang Chen, Nan Zhang, Xun Kang, Lin Liu, Yingjuan Wang, Qianfeng Xia, Chuanlong Zhu, Dai Kuang

“…Furthermore, the overexpression of hutT mitigated CRISPR-Cas-mediated repression of the Hut operon, as observed in virulence assays, while simultaneous deletion of hutH and casABECD restored the reduced virulence in the ΔcasABECD strain. …”
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Next-Generation Sequencing–Based Molecular Profiling of Conjunctival Squamous Cell Carcinoma and Its Potential Application for Therapy by Hakan Demirci, MD, Josh N. Vo, PhD, Yi-Mi Wu, PhD, Victor Elner, MD, Arul M. Chinnaiyan, MD, PhD, Dan Robinson, PhD, F. Yesim Demirci, MD

“…Methods: Integrative exome and transcriptome analysis of fresh-frozen tumor and matching normal samples. …”
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MicroRNA-27b alleviates septic cardiomyopathy by targeting the Mff/MAVS axis by Xincai Wang, Long Huang, Jingqing Xu, Min Li, Hongxuan Zhang, Yuqing Yao, Yaqing Liu, Xingsheng Lin, Xiuling Shang

“…ObjectiveTo investigate the protective role of microRNA-27b (miR-27b) in septic cardiomyopathy (SCM) and its regulatory mechanism on the mitochondrial fission factor (Mff)/mitochondrial antiviral signaling protein (MAVS) axis.MethodsTranscriptome data from septic patients’ cardiac tissues (GSE79962) were analyzed. …”
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Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility by Careen A. Schroeter, Anna Gorlova, Michael Sicker, Aleksei Umriukhin, Alisa Burova, Boris Shulgin, Sergey Morozov, Joao P. Costa-Nunes, Tatyana Strekalova

“…We found that chronic stress lowered sucrose preference in a subgroup of mice that also exhibited prolonged floating behavior, behavioral invigoration, and impaired contextual fear conditioning, while auditory conditioning was unaltered. At the remission phase, no changes in the sucrose test were found, and the acquisition of the Morris water maze was unchanged in all groups. …”
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Multigeneration Sublethal Chlorantraniliprole Treatment Disrupts Nutritional Metabolism and Inhibits Growth, Development, and Reproduction of <i>Phthorimaea absoluta</i> by Lun Li, Zunzun Jia, Kaiyun Fu, Xinhua Ding, Weihua Jiang, Xiaowu Wang, Tursun. Ahmat, Jiahe Wu, Yutong Wen, Xiaoqin Ye, Wenchao Guo, Hongying Hu

“…The age-stage, two-sex life table analysis revealed that the preadult development time and mean generation time were significantly prolonged, while population reproduction and pupal weight were reduced. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…Additionally, a dual-luciferase reporter gene assay was conducted to validate the binding effect of SERPINE1 and GATA2.ResultsTranscriptome Analysis revealed that genes including GATA2 and SERPINE1 were downregulated in HK-2 cells following tocilizumab treatment. …”
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Identification of <i>Peroxiredoxin</i> (<i>PRX</i>) Genes from Pepper Fruits: Involvement in Ripening and Modulation by Nitric Oxide (NO) by Fátima Ramírez-Mellado, Salvador González-Gordo, José M. Palma, Francisco J. Corpas

“…Among these, only CaPRX1-Cys was not detected in the transcriptome (RNA-Seq) of sweet pepper fruits reported previously. …”
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