Prognostic risk model of six m7 g-related lncRNAs in lung adenocarcinoma by Kaijun Long, Kai Wang, Manjun Gao, Yao Wang, Yang Tang, Cheng Chen, Xixian Ke

“…Expression of AC007128.1 and HNRNPUP1 were higher in tumor tissues compared to normal tissue, while the other lncRNAs showed the opposite state, supporting the model’s signature. …”
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A Rare Frameshift Mutation of in <i>CmACS7</i> Alters Ethylene Biosynthesis and Determines Fruit Morphology in Melon (<i>Cucumis melo</i> L.) by Jiyang Zhou, Xiaobing Ma, Qianqian Deng, Zhicong Zhong, Xuefei Ning, Li Zhong, Xianliang Zhang, Xianlei Wang

“…A genetic diversity analysis of public melon germplasm resources indicated that while the CmACS7^{A57V/frameshift} mutation accounts for only 0.5% of the germplasm, it is strongly correlated with the round fruit phenotype and is important for breeding in Xinjiang. …”
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Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head by Han Longfei, Fang Weihua, Han Mingli, Zhuang Zhikun, He Mincong, Wei Qiushi

“…In the co-culture system, fibroblasts intervened with lipopolysaccharide significantly promoted chondrocyte apoptosis, the rate of cartilage matrix degradation, while inhibiting the level of chondrocyte proliferation, and this result was significantly reversed in Irf7 knockout fibroblasts. …”
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Decreased expression of cell adhesion genes in cancer stem-like cells isolated from primary oral squamous cell carcinomas by Amrendra Mishra, Harshini Sriram, Pinal Chandarana, Vivek Tanavde, Rekha V Kumar, Ashok Gopinath, Raman Govindarajan, S. Ramaswamy, Subhashini Sadasivam

“…The upregulated genes included those involved in immune regulation, while the downregulated genes were enriched for genes involved in cell adhesion. …”
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Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1C71G ALS mouse model by Zachary C. E. Hawley, Xueying Li, Dora Bodnar, Yuanzheng Gu, Yi Luo, Daniel Ferretti, Adam Sheehy, Rachelle Driscoll, Maria I. Zavodszky, Shaolong Cao, Isabel Isaza, Luke Jandreski, Yuqing Liu, Thomas Carlile, Shih-Ching Lo, Anna Grimard, Shawn Bourque, Aditya Utturkar, Samantha Desmarais, H. Moore Arnold, Dann Huh, Edward Guilmette, Deborah Y. Kwon

“…Notably, impaired regulation of the PFN1C71G skeletal muscle transcriptome exceeds that of the spinal cord and is also improved by Atxn2 reduction in the CNS. …”
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Silicon and iron co-application modulates cadmium accumulation and cell wall composition in tomato seedlings by Xiaoting Zhou, Ruihan Xia, Jiayi Zhong, Xiaoru Liu, Tian Xia, Yunxin Tang, Qianke Yang, Encai Bao, Kai Cao, Qiang Chen, Zhongqun He

“…However, the application of silicon alone resulted in higher cadmium accumulation in pectin and hemicellulose in the root cell wall, while the combined application of Silicon and Iron reduced cadmium content in the cell wall components and resulted in the highest expression of HMA5, which reduced the accumulation of cadmium in roots and its translocation to the aboveground parts. …”
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Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity by Xuyu Gu, Chanchan Gao, Xiangyu Su, Yaoyao Zhu, Qiyu Fang, Jia Yu, Ziming Wang, Deping Zhao, Wentian Zhang

“…In BATF2−/− mice, the populations of immune active CD8+ T cells were increased, while exhausted T cells were reduced, leading to improved anti-tumor immune responses. …”
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Branched-chain amino acids induce hyperammonemia via gut-liver axis-mediated ammonia overproduction in laying hens by Huafeng Jian, Mengru Xu, Fang Liu, Libo Zhang, Qiuming Huang, Jiangang Ma, Xiaoting Zou, Xinyang Dong

“…Gut microbiota not only biosynthesizes branched-chain amino acids (BCAA) but also catabolizes and utilizes them, while the effects of dietary BCAA supplementation on intestinal microbiota and metabolism remain largely elusive. …”
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SSL5-AnxA5 Fusion Protein Constructed Based on Human Atherosclerotic Plaque scRNA-Seq Data Preventing the Binding of Apoptotic Endothelial Cells, Platelets, and Inflammatory Cells by Yifei Zhao, Xingyu He, Teng Hu, Tianli Xia, Fangyang Huang, Changming Li, Yiming Li, Fei Chen, Mao Chen, Jun Ma, Yong Peng

“…Staphylococcal superantigen-like 5 (SSL5) is an optimal antagonist P-selectin glycoprotein ligand 1 (PSGL1), while annexin V (AnxA5) can precisely detect dead cells in vivo. …”
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Construction of a stromal cell-related prognostic signature based on a 101-combination machine learning framework for predicting prognosis and immunotherapy response in triple-nega... by Fanrong Li, Congnan Jin, Yacheng Pan, Zheng Zhang, Liying Wang, Jieqiong Deng, Yifeng Zhou, Yifeng Zhou, Binbin Guo, Shenghua Zhang, Shenghua Zhang

“…Advances in single-cell transcriptomics have highlighted the impact of stromal cells on tumor progression, immune suppression, and immunotherapy. …”
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Selenium exposure on breast cancer risk and progression: Comprehensive analysis identifies MSRB1 as a novel therapeutic target by Jingsong Cheng, Diyuan Zhang, Ningxi Wang, Ziheng Zheng, Cong Zhang, Nanting Chen, Yuanyuan Wan, Xue Chen, Qingyao Yin, Xinyi Zhu, Yu Zhao, Liming Yi, Na Sun

“…The CMap database identified potential BRCA drugs, while random forests pinpointed critical selenoproteins. …”
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Synthesis of biosafe spirulina-derived carbon dots and their fluorescence imaging in zebrafish by Yue Wang, Zhizhi Gu, Jingyi Dong, Cunguang Liu, Jie Zhu, Zixu Wang, Jiaying Li, Meichen Lu, Jian Han, Shengnan Cao, Zhuang Xue, Yan Chen, Liyong Chen, Wei Wang

“…In embryos, CDs preferentially accumulate in the yolk sac while preserving normal developmental progression. …”
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Integration of Bulk and Single-Cell RNA Sequencing to Identify RNA Modifications-Related Prognostic Signature in Ovarian Cancer by Wang S, Zheng Q, Chen L

“…In this study, we aimed to identify and verify RNA modifications-related prognostic genes in OC by integrating bulk and single-cell RNA sequencing (scRNA-seq) data.Methods: Transcriptome data came from public databases and RNA modifications-related genes (RMRGs) were obtained from literature. …”
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Chloroplast positioning affects Hexokinase 1-mediated plant immunity under combined low temperature and high light by Sophia Bianca Bagshaw, Anastasia Kitashova, Beyza Özmen, Chun Kwan Yip, Bianca Emily Süling, Laura Schröder, Tatjana Kleine, Thomas Nägele

“…Plants were exposed to a treatment of combined cold and elevated light. While mutants with deficiencies in sucrose or starch metabolism showed affected metabolic pathway regulation under abiotic stress, Hexokinase 1 mutants (hxk1) showed a severe growth phenotype with lesions and pale areas on leaf tissue. …”
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Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission by Sun Y, Jin S, Chen J, Zhang J, Lu Y, Gu Q, Yan Z, Chen W, Chen A, Fang Y, Geng W, Xu X, Song N

“…Fibrosis markers and mitochondrial dynamics-related proteins were evaluated using Western blotting, while differential gene expression and pathway enrichment were analyzed by RNA-seq. …”
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Knockout of bcas3 gene causes neurodevelopment defects in zebrafish by Huihui Liu, Nianyi Sun, Zhenxing Liu, Jinze Li, Xianqin Zhang

“…Mutations in BCAS3 gene are associated with syndromic neurodevelopmental disorders in humans, while the detailed pathological mechanism is still unknown. …”
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Response of different cotton genotypes to salt stress and re-watering by Kang Zhao, Tao Yang, Bo Pang, Honggang Wang, Zhining Yang, Weiwei Liang, Cun Rui, Wengwei Gao

“…After re-watering, ST recovered fully, while SS sustained permanent oxidative and structural damage, indicating distinct salt tolerance. …”
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Genetic variants influencing liver fat in normal-weight individuals of European ancestry by Ignazio S. Piras, Janith Don, Nicholas J. Schork, Johanna K. DiStefano

“…Leveraging large-scale genomic and imaging data from the UK Biobank, we identified both known and novel variants associated with liver fat accumulation, emphasizing that genetic predisposition can drive hepatic steatosis independently of excess adiposity. While the study is based on individuals of European ancestry, future research should assess the relevance of these findings in more diverse populations to ensure broader clinical applicability. …”
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<i>Tn</i>P and AHR-CYP1A1 Signaling Crosstalk in an Injury-Induced Zebrafish Inflammation Model by Geonildo Rodrigo Disner, Thales Alves de Melo Fernandes, Milton Yutaka Nishiyama-Jr, Carla Lima, Emma Wincent, Monica Lopes-Ferreira

“…This study aimed to elucidate <i>Tn</i>P’s molecular mechanisms on the AHR–cytochrome P450, family 1 (CYP1) pathway upon injury-induced inflammation in wild-type (WT) and <i>Ahr2</i>-knockdown (KD) zebrafish larvae through transcriptomic analysis and <i>Cyp1a</i> reporters. <i>Tn</i>P, while unable to directly activate AHR, potentiated AHR activation by the high-affinity ligand 6-Formylindolo [3,2-b]carbazole (FICZ), implying a role as a CYP1A inhibitor, confirmed by in vitro studies. …”
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Lipophilic Resazurin in Bioelectrochemical Systems: Role in Regulating Carbon Metabolic Pathways by Siyu Tan, Xiao Zhu, Xinxin Wang, Huangsheng Su, Zongqiang Zhu, Xiaobo Luo, John R. Reinfelder, Yundang Wu, Fangbai Li

“…Transcriptome analysis reveals significant upregulation of genes involved in the NADH‐dependent metabolic pathway (e.g., nuoHIJKLMN) and ATP synthesis (atpABDEFGH) under resazurin conditions. …”
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