Reveal the mechanism of hepatic oxidative stress in mice induced by photo-oxidation milk using multi-omics analysis techniques by Sijia Tan, Qiangqiang Li, Can Guo, Sumeng Chen, Afaf Kamal-Eldin, Gang Chen

“…Gene set enrichment and interaction analyses revealed that photo-oxidized milk inhibited the cytochrome P450 pathway in mice, while also affecting other pathways associated with cellular stress response and lipid biosynthesis. …”
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Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells by Rapeepat Sangsuwan, Bhasirie Thuamsang, Noah Pacifici, Phum Tachachartvanich, Devan Murphy, Abhineet Ram, John Albeck, Jamal S. Lewis

“…The results indicated that lactate differentially impacted the biochemical networks of DCs and MΦs. While lactate mainly altered STAT3, ERK, and p38 MAPK signaling cascades in DCs, the STAT1 and GSK-3β signaling in MΦs were the major pathways significantly impacted by lactate. …”
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Epigenetic dynamics in meniscus cell migration and its zonal dependency in response to inflammatory conditions by Yize Zhang, Ellen Y. Zhang, Catherine Cheung, Yuna Heo, Bat-Ider Tumenbayar, Se-Hwan Lee, Yongho Bae, Su Chin Heo

“…Furthermore, tumor necrosis factor alpha (TNF-α), a proinflammatory cytokine, slows inner meniscus cell migration, while outer cells remain unaffected, indicating a zonal response. …”
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Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development. by Kira Orlovsky, Elena Appel, Shay Hantisteanu, Tsviya Olender, Joseph Lotem, Ditsa Levanon, Yoram Groner

“…The distribution of ATAC and H3K27Ac marked regions in Runx3 peaks containing at least one RUNX binding site (Runx3_RBS) revealed that while most promoter regions were marked by ATAC, a prominent fraction of intron/intergenic regions occupied by Runx3, Brn3a or Isl1 were unmarked by ATAC and/or H3K27Ac.…”
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Esculetin inhibits the PI3K/Akt/mTOR pathway and enhances anti-colorectal cancer activity via binding to ENO1 by Jianing Ma, Miaomiao Zhang, Shulipan Mulati, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Weiyi Zhang, Weiyi Zhang, Weiyi Zhang, Weiyi Zhang

“…The molecular mechanisms of Esc’s antitumor properties were elucidated through network pharmacology, transcriptome sequencing technology, drug affinity responsive target stability (DARTS), and molecular docking. …”
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Icarisid Ⅱ modulates mitochondrial dynamics for anti-HBV activity by Zhengyun Liu, Haiyan Yang, Juan Wen, Dongyan Xiao, Dongyan Xiao, Wan Yu, Guo Luo, Qihai Gong, Huan Wang

“…Cytotoxicity was determined with CCK-8 assay, while ELISA and qPCR were employed to measure HBsAg, HBeAg, and HBV DNA levels. …”
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Alternative Splicing of BnABF4L Mediates Response to Abiotic Stresses in Rapeseed (Brassica napus L.) by Ruijia Zhu, Chu Yue, Shifan Wu, Mingting Wu, Ziyue Xu, Xiaoqun Liu, Rui Wang, Maolin Wang

“…BnABF4L undergoes alternative 3' splice site (A3SS) selection to produce three transcripts (V1-V3) with divergent 5'UTRs. While V1 translation is suppressed by upstream ORFs (uORFs), V2/V3 exhibit enhanced translational efficiency. …”
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ALDH18A1 has carcinogenic functions and regulates alternative splicing events of DNA repair-related genes in esophageal carcinoma cells by Wang Yongkang, Maimaiti Yisireyili, Kelimu Abudureyimu, Atsushi Enomoto

“…ALDH18A1, a potential RNA binding protein (RBP), is significantly overexpressed as in ESCA, while its functions and mechanism is unclear. In this study, we silenced ALDH18A1 in KYSE150 cells using small interfering RNA (siALDH18A1), and evaluated its effect on cell characteristics. …”
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The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis by Mervin V. Loi, MBBS, MSc, FRCPCH, Rehena Sultana, MSc, MBA, Tuong Minh Nguyen, MSc, Shi Ting Tia, Jan Hau Lee, MBBS, MCI, MRCPCH, Daniel O’Connor, DPhil

“…Data including population demographics, sample size, study design, tissue specimen, type of transcriptome, health status of comparator group, and performance of transcriptomic biomarkers were independently extracted by at least two reviewers. …”
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Unraveling the role of HIF2α in melanoma progression and epithelial–mesenchymal transition by Zhao Han, Yanling Gao, Zhifeng Li, Zhao Liu, Jianzhong Zhang, Tingting Jing, Yanyan Xv, Guoying Miao, Xiaojing Li, Aijun Chen

“…In vitro, hypoxia increased HIF-2α, N-cadherin, and Vimentin mRNA levels, while decreasing E-cadherin. HIF-2α knockdown reversed these effects, promoting E-cadherin and suppressing N-cadherin and Vimentin under hypoxia. …”
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Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…Interestingly, HED also exerts regulatory effects on gut dysbiosis by cumulative the plenteous of beneficial probiotics like Lactobacillus and Bacteroides, while inhibiting the overgrowth of opportunistic pathogens such as Helicobacter.Conclusion: The regulation of Th2/Th1 and Tregs/Th17 cell balance, as well as the modulation of gut microbiota by HED, provides further experimental evidence for the feasibility of its treatment of UC.Keywords: HED, ulcerative colitis, Th2/Th1, Treg/Th17, gut microbiota…”
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Identification of potential molecular markers for detection of lengthy chilled storage of Prunus persica L. fruit by Giulia Franzoni, Antonella Muto, Leonardo Bruno, Maria Letizia Madeo, Tiziana Maria Sirangelo, Adriana Ada Ceverista Chiappetta, Maria Beatrice Bitonti, Carsten T. Müller, Antonio Ferrante, Hilary J. Rogers, Natasha Damiana Spadafora

“…Maximum damage occurs at 5 °C while at 1 °C damage is reduced. Therefore, rapid early detection methods for the distribution chain to monitor length and temperature of fruit storage are needed. …”
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RETRACTED ARTICLE: NR3C2 affects the proliferation and invasiveness of colon cancer cells through the Wnt/β-Catenin signaling pathway by Ke Nie, Zhong-Jiang He, Ling-Jun Kong

“…Functional experiments show that downregulation of NR3C2 resultsed in the activation of the Wnt/β-catenin signaling pathway, and promotesd the proliferation and invasion of colon cancer cells while suppressing cell autophagy and apoptosis. Conclusion NR3C2 may regulate Wnt/β-catenin to affect the proliferation, invasion apoptosis and autophagy of colon cancer, and this axis is a potential target for the treatment of colon cancer.…”
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SSR42 is a novel regulator of cytolytic activity in Staphylococcus aureus by Mary-Elizabeth Jobson, Brooke R. Tomlinson, Emilee M. Mustor, Emily A. Felton, Andy Weiss, Clayton C. Caswell, Lindsey N. Shaw

“…Herein, we used transcriptomic and proteomic approaches to probe the role of SSR42, revealing that it is a powerful, novel activator of the primary leukocidin LukAB. …”
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Integrative pigGTEx resource with GWAS reveals genetic mechanism underlying semen quality in boars by Xuehua Li, Qing Lin, Zhanwei Zhuang, Kai Rao, Zhili Li, Xiuguo Shang, Panjie Xia, Lin Zhu, Zhe Zhang, Yunxiang Zhao

“…In the past, boar breeding has mostly emphasized characteristics such as lean meat percentage, feed conversion efficiency, and growth rate, while overlooking the genetic improvement of reproductive traits. …”
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Understanding the defense mechanism of Allium plants through the onion isoallicin-omics study by Heejung Cho, Ji Yeon Park, Duck Hyun Kim, JiWon Han, Karthi Natesan, Min-Seon Choi, Seon-Kyeong Lee, Jiseon Kim, Kun Cho, Byoung Ohg Ahn

“…This novel observation suggests that the isoallicin system in onions functions as a dual-defense mechanism: cytosolic alliinases maintain a constant level of defense against biotic stress in undamaged tissues, while vacuolar alliinases enhance isoallicin production in response to tissue damage by herbivory and insects. …”
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The Porphyromonas gingivalis RNA-binding protein is required for growth in high levels of zinc and persistence with host cells by Sai Yanamandra, Holly Marsh, Romana Cvitkovic, Qin Gui, Benjamin R. Belvin, Janina P. Lewis, Janina P. Lewis, Janina P. Lewis

“…We have determined that both the transcriptome and proteome are affected by the deletion of RbpPg1 and found that the major group of proteins with elevated expression were the ones associated with response to environmental stress changes, while proteins mediating metabolic processes were downregulated. …”
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VdPAT1 encoding a pantothenate transporter protein is required for fungal growth, mycelial penetration and pathogenicity of Verticillium dahliae by Stephen Mwangi Kamau, Yongtai Li, Tiange Sun, Feng Liu, Qian-Hao Zhu, Xinyu Zhang, Jie Sun, Yanjun Li

“…Chitin and β-1,3-glucan content determination found that the chitin content in VdPAT1 deletion mutants was significantly lower, while β-1,3-glucan content was higher than that of wild-type and complementary strains. …”
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Role of Bifidobacterium animalis subsp. lactis BB-12 in mice with acute pancreatitis by Bingbing Du, Ren Yan, Xiaoxiang Hu, Jing Lou, Yixin Zhu, Yini Shao, Huiyong Jiang, Yingying Hao, Longxian Lv

“…Microbiome analysis showed that BB-12 treatment significantly increased the relative abundance of Ligilactobacillus and decreased that of Bilophila in the gut microbiota of mice with AP. Transcriptome analysis revealed that BB-12 mitigated the AP-induced dysregulation of several pathways, specifically attenuating the upregulation of the pancreatic secretion and ascorbate and aldarate metabolism pathways while reversing the downregulation of the ribosome, oxidative phosphorylation, and thermogenesis pathways. …”
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Identification of the trail-following pheromone receptor in termites by Souleymane Diallo, Kateřina Kašparová, Josef Šulc, Jibin Johny, Jan Křivánek, Jana Nebesářová, David Sillam-Dussès, Pavlína Kyjaková, Jiří Vondrášek, Aleš Machara, Ondřej Lukšan, Ewald Grosse-Wilde, Robert Hanus

“…The current knowledge on molecular mechanisms of social insect pheromone detection by odorant receptors (ORs) is limited to bees and ants, while no OR was yet functionally characterized in termites, the oldest eusocial insect clade. …”
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