Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for Endometriosis by Mingrui Zou, Mingmei Lin, Kai-Lun Hu, Rong Li

“…Endometriosis (EMT) is a common gynecological disease with a strong genetic component, while its precise etiology remains elusive. This study aims to integrate transcriptome-wide association study (TWAS), Mendelian randomization (MR), and bioinformatics analyses to reveal novel putatively causal genes and potential mechanisms. …”
Get full text

Screening of ferroptosis genes related to the prognosis of cervical cancer and construction of a prognostic model by Yue CHEN, Wenxin CHEN, Yi JIANG, Dong ZHANG, Boqun XU

“…Two prognostic models were conducted, Model 1 included age and tumor stage, while Model 2 incorporated age, tumor stage, and prognostic genes. …”
Get full text

Arabidopsis P4-ATPases ALA1 and ALA7 Enhance Resistance to <i>Verticillium dahliae</i> via Detoxifying Vd-Toxins by Fanlong Wang, Mingliang Qiu, Xiaoxia Yao, Jiancong Li, Hui Ren, Mei Su, Jiaohuan Shen, Caiwang Li, Qian Jiang, Zixuan Zhang, Yundi Li, Jiyu Tang, Xianbi Li, Yanhua Fan, Yan Pei

“…Overexpression of <i>AtALA1</i> improved the resistance of Arabidopsis to 4MBA, 3ICD, and indazole, while <i>AtALA7</i> enhanced resistance to 4MBA, 3ICD, and CIA. …”
Get full text

Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells by Rongfeng Dai, Yu Qian, Siqi Liu, Xi Zou, Shanshan Sun, Zhuo Sun

“…HG treatment also upregulated GAS1, Keap1, and total Nrf2 expressions while downregulating nuclear Nrf2 in Müller cells (p < 0.001). …”
Get full text

Lnc MSTRG 4701.7 targets miR-1786/RORa to competitively regulate proliferation and apoptosis in chicken follicular granulosa cells by Chang Ma, Chang Ma, Hengsong Wu, Hengsong Wu, Chunchi Yan, Chunchi Yan, Simushi Liswaniso, Simushi Liswaniso, Xue Sun, Xue Sun, Ning Qin, Ning Qin, Rifu Xu, Rifu Xu

“…BackgroundFollicular development in chickens is a highly coordinated and complex process. While the hypothalamic–pituitary-gonadal axis plays a central regulatory role in this process, the role of long noncoding RNAs (LncRNAs) remains unclear. …”
Get full text

TGF-β3 Restrains Osteoclastic Resorption Through Autophagy by Hui Liao, Yiqin Pan, Yiming Liu, Yuxiao Li, Shiyi Huang, Shan Ding, Qi Xiang

“…While TGF-β3 promoted defect healing in a primate baboon skull defect model and patients, it remains unclear whether TGF-β3 affects the formation of osteoclasts and bone resorption between osteogenesis and osteolysis. …”
Get full text

Histological morphology and gene expression in the digestive system of Procambarus clarkii by Zonglin Yang, Jingjing Hao, Yufei Liu, Xugan Wu, Xiaowu Chen

“…To unravel the intricate morphological structure and functional aspects of the digestive system in Procambarus clarkii, this study employed histology and transcriptome sequencing techniques for a comprehensive analysis of its digestive system. …”
Get full text

Therapeutic Target Discovery for Multiple Myeloma: Identifying Druggable Genes via Mendelian Randomization by Shijun Jiang, Fengjuan Fan, Qun Li, Liping Zuo, Aoshuang Xu, Chunyan Sun

“…Pregnenolone and irinotecan, identified as agonists of ORM1 and OVGP1, respectively, significantly inhibited MM cell viability, while upregulating their expression (<i>p</i> < 0.05). …”
Get full text

Identification and Expression Pattern Analysis of Odorant Receptor Family Genes of Tuta absoluta by Zhonglin ZHOU, Gang LIAO, Tingting XIANG, Zhongxiang SUN

“…Phylogenetic analysis revealed that four genes (TabsOR01, TabsOR28, TabsOR34, and TabsOR38) clustered in a well-defined branch, while the remaining genes were distributed across other branches. …”
Get full text

Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC) by Shafiq Shaikh, Xia Zhao, Ryan T. Wagner, Xiaoyu Pan, Ryan A. Hlady, Liguo Wang, Thai H. Ho, Keith D. Robertson

“…Mutations in SETD2, a histone H3 lysine 36 trimethylase (H3K36me3), are associated with reduced survival, greater metastatic propensity, and metabolic reprogramming. While m6A and H3K36me3 deregulation are separately implicated in renal tumorigenesis, H3K36me3 may participate directly in m6A targeting, but the m6A-H3K36me3 interplay has not been investigated in the context of ccRCC. …”
Get full text

Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum by Qian Xiu, Xiaoru Yin, Yuanyuan Chen, Ziyang Zhang, Yushuai Mao, Tianshi Wang, Jie Zhang, Mingguo Zhou, Yabing Duan

“…Collectively, these findings provide compelling evidence for the involvement of de novo uracil biosynthesis as a mechanism of action for quinofumelin while identifying FgDHODHII as its specific target.…”
Get full text

Adequate post-ischemic reperfusion of the mouse brain requires endothelial NFAT5 by Reiner Kunze, Paul Wacker, Paula Breuer, Emil Nasyrov, Ivan M. Kur, Andreas Weigert, Andreas H. Wagner, Hugo H. Marti, Thomas Korff

“…Cerebral ischemia was induced by transient middle cerebral artery occlusion (MCAO) followed reperfusion up to 28 days. While loss of endothelial Nfat5 did not evoke any phenotypic abnormalities in mice under control conditions, infarct volumes, neurological deficits and the degree of brain atrophy were significantly pronounced following MCAO as compared to control animals (Nfat5 fl/fl ). …”
Get full text

Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5 by Hankun Wang, Chunling Zhang, Moran Li, Wangchun Zhao, Jialin Wang, Yanhong Ran, Xiaoping Yang, Zemin Deng, Jun Chen, Hongjian Li

“…Viruses have also evolved multiple strategies to resist the host’s immune system while coexisting with the host. In this study, based on RNA sequencing transcriptome differential analysis, we found that HCMV encoded UL23 May specifically down-regulate chemokines Chemokine ligand 2 (CCL2) and Chemokine ligand 5 (CCL5). …”
Get full text

The Spatial‐Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis by Wei Wang, Xinhao Fan, Weiwei Liu, Yuxin Huang, Shuhong Zhao, Yalan Yang, Zhonglin Tang

“…Transcriptome analysis suggests that specifically knocking‐down Fxr1E15+ isoform in myoblasts modulates differentiation by influencing gene expression and splicing of specific targets. …”
Get full text

Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus by Akanksha Bafna, Gareth Banks, Vadim Vasilyev, Robert Dallmann, Michael H Hastings, Patrick M Nolan

“…Correspondingly, we show that the conditional loss of ZFHX3 in the adult has a dramatic effect on the SCN transcriptome, including changes in the levels of transcripts encoding elements of numerous neuropeptide neurotransmitter systems while attenuating the daily oscillation of the clock TF Bmal1. …”
Get full text

The induction effect of hydroxyurea and metformin on fetal globin in the K562 cell line by Mohammad Eini, Hossain Safarpour, Ebrahim Miri-Moghddam

“…Leveraging this information, we aimed to predict the transcriptome network and elucidate the mechanism of action of HU and Metformin (Met) on this network comprehensively. …”
Get full text

Overexpression of MYB transcription factor LrAN2 from Lycium ruthenicum activated the anthocyanin biosynthesis in the leaf and fruit of Lycium barbarum by Yunlong Liang, Wenyan Ma, Jinglei Hu, Yanyan Jiang, Shiming Li, Yun Li, Xuemei Bao, Dong Cao, Baolong Liu

“…The structural genes involved in the anthocyanin pathway, such as 4CL, CHS, F3H, F3’5’H, DFR, ANS, and UFGT, were up-regulated in transgenic lines, while the expression of transcription factors bHLH and WD40 were remained unchanged. …”
Get full text

Megakaryocyte phenotyping in response to SARS-CoV-2 variants by Marcin A Sowa, Michael Tuen, Florencia Schlamp, Yuhe Xia, Marie I Samanovic, Mark J Mulligan, Tessa J Barrett

“…In conclusion, WA1, Delta, and Omicron similarly induce classical MK activation responses while mediating distinct transcriptomic changes. …”
Get full text

Multi-omics analysis of the mechanism of alfalfa and wheat-induced rumen flatulence in Xizang sheep by Jing Wu, Xiaoming Zhang, Khan Ayesha, Shahzad Khuram, Jianzhao Cui, Gaofu Wang, Zhaxi Yangzong, Mingyan Shi, Xunping Jiang, Long Li, Guiqiong Liu, Wangsheng Zhao, Tianzeng Song

“…Versus LRF, MRF had 201 upregulated and 185 downregulated DEGs, while HRF had 128 upregulated and 238 downregulated DEGs. …”
Get full text

Multi-omics reveals effects of diet FNDF/starch level on growth performance and rumen development of Hu sheep by Haibi Zhao, Jiqing Wang, Zhiyun Hao, Pengfei Yin, Shanglong Wang, Yanli Guo, Chunyan Ren

“…Notably, during histidine metabolism, thiamine in the rumen decreased with increasing FNDF/starch levels, while the expression level of the TPK1 in the rumen epithelium increased with rising FNDF/starch levels. …”
Get full text