Overexpression of plasma membrane SUT1 in poplar alters lateral sucrose partitioning in stem and promotes leaf necrosis by Liang‐Jiao Xue, Moh'd I. Hozain, Christopher J. Frost, Afraz Talebi, Batbayar Nyamdari, Kavita B. Aulakh, Ran Zhou, Scott A. Harding, Chung‐Jui Tsai

“…However, plasma membrane sucrose transporters (SUT1 and SUT3) orthologous to those associated with apoplastic phloem loading are expressed in vascular tissues of poplar. While SUT3 functions in sucrose import into developing xylem, the role of SUT1 remains unclear. …”
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Long Noncoding RNA–Messenger RNA (lncRNA–mRNA) Network in Resistance to Gummy Stem Blight (<i>Stagonosporopsis cucurbitacearum</i>) of Melon Plant Introduction (PI) 420145 by Rui Zhang, Jing Chen, Yongbing Zhang, Xiumei Lu, Chunyan Cheng, Ji Li, Qunfeng Lou, Yuhui Wang, Chuntao Qian

“…Specifically, phenylpropanoid biosynthesis, cyanoamino acid metabolism, and MAPK signaling–plant and plant–pathogen interactions were enriched in PI 420145, while ‘Baipicui’ displayed enrichment in metabolism and autophagy. …”
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Promotion of HIV clearance by sensitization of HIV reservoirs to cell death by Min Li, Baichao Sun, Jing Dong, Jian-Rong Li, Laurie J. Minze, Min Chen, Chao Cheng, Chao Cheng, Chao Cheng, Jin Wang, Jin Wang

“…Moreover, these resistant reservoirs expressed more epigenetic modifiers that repress HIV gene expression, while targeting such epigenetic repression promoted cell death in HIV-infected cells.DiscussionOur results indicate that T cell reservoirs refractory to depletion maintain a delicate balance between low levels of HIV gene expression and evasion of cell death. …”
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Functional roles of folic acid in alleviating dexamethasone‐induced fatty liver syndrome in laying hens by Xi Sun, Junjie Ma, Chaohui Wang, Zhouzheng Ren, Xin Yang, Xiaojun Yang, Yanli Liu

“…FA significantly reversed hepatic lipid deposition, and 57 differentially expressed genes affected by FA were identified in the transcriptome analysis. Their transcriptional and translational levels indicate that in the early FLS, insulin‐like growth factor 2/phosphatidylinositol‐3‐kinase/protein kinase B pathway related to lipid metabolism was activated; folate cycling was inhibited, while endoplasmic reticulum (ER) stress and apoptosis‐related protein abundance were elevated. …”
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Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025) by Jay M. Yarbro, Him K. Shrestha, Zhen Wang, Xue Zhang, Masihuz Zaman, Mengqi Chu, Xusheng Wang, Gang Yu, Junmin Peng

“…Discrepancies between proteome and transcriptome suggest altered protein turnover in AD. …”
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Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype. by Fanping Kong, Omar A Saldarriaga, Heidi Spratt, E Yaneth Osorio, Bruno L Travi, Bruce A Luxon, Peter C Melby

“…We used RNA sequencing coupled with de novo transcriptome assembly, because the Syrian hamster does not have a fully sequenced and annotated reference genome. …”
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Precise metabolic dependencies of cancer through deep learning and validations by Tao Wu, Xiangyu Zhao, Yu Zhang, Die Qiu, Kaixuan Diao, Dongliang Xu, Weiliang Wang, Xiaopeng Xiong, Xinxiang Li, Xue-Song Liu

“…Summary: Cancer cells exhibit metabolic reprogramming to sustain proliferation, creating metabolic vulnerabilities absent in normal cells. While prior studies identified specific metabolic dependencies, systematic insights remain limited. …”
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The impact of genomic variation on protein phosphorylation states and regulatory networks by Jan Grossbach, Ludovic Gillet, Mathieu Clément‐Ziza, Corinna L Schmalohr, Olga T Schubert, Maximilian Schütter, Julia S P Mawer, Christopher A Barnes, Isabell Bludau, Matthias Weith, Peter Tessarz, Martin Graef, Ruedi Aebersold, Andreas Beyer

“…Previous work has focused on the former, while in this context, the functional states of proteins have largely remained neglected. …”
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Molecular characterization of Echinocandin resistance and the CHS3-mediated adaptive response in Candida glabrata bloodstream infections in Eastern China by Peishan Cong, Biao Wang, Hong He, Xiaoying Li, Lijing Peng, Ji Liu, Hui Guo, Guirong Sun

“…Drug susceptibility testing revealed a fluconazole resistance rate of 21.7%, while non-wild-type rates for voriconazole, itraconazole, and posaconazole were 23.6%, 7.5%, and 6.6%, respectively. …”
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Expression Analysis of the Extensive Regulation of Mitogen-Activated Protein Kinase (MAPK) Family Genes in Buckwheat (<i>Fagopyrum tataricum</i>) During Organ Differentiation and S... by Guoqing Dong, Zihao Gui, Yi Yuan, Yun Li, Dengxiang Du

“…The mitogen-activated protein kinase (MAPK) signaling cascade is a unique and relatively conserved signaling pathway in eukaryotes, transmitting extracellular signals into cells through successive phosphorylation and eliciting appropriate responses from the organism. While its mechanism in plant immune response has been partially elucidated in <i>Arabidopsis</i>, it has been rarely examined in Tartary buckwheat (<i>Fagopyrum tataricum</i>). …”
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Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS meta-analysis, biological network construction, and structural modeling by Pakorn Sagulkoo, Hathaichanok Chuntakaruk, Apichat Suratanee, Kitiporn Plaimas, Nuttinee Teerakulkittipong

“…Drug repurposing and molecular docking suggested abciximab and paclitaxel as potential therapeutic agents targeting CD40, while ivermectin emerged as a strong candidate for LRP1 binding. …”
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Bacterial communities associated with ambrosia beetles: current knowledge and existing gaps by Juan Carlos Cambronero-Heinrichs, Juan Carlos Cambronero-Heinrichs, Peter H. W. Biedermann, Laura Besana, Andrea Battisti, Davide Rassati

“…Ambrosia beetles (Curculionidae: Scolytinae and Platypodinae) are wood-boring insects studied as examples of fungus-insect symbiosis and for their success as invasive species. While most research on their microbiota has focused on fungal associates, their bacterial communities remain largely understudied. …”
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WGCNA analysis and identification of key genes in tobacco in response to different nitrogen levels by Xinwang Zhang, Shouhui Pan, Dong Chen, Yuqi Pan, Deepak Bhanot, Tianju Xu, Sachin Gupta, Jinling Zhang, Yin Huang

“…NtGDSL may enhance nitrogen use efficiency (NUE) through stress-responsive mechanisms, while NtDFC could integrate N signaling with developmental processes. …”
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Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk. by Joshua D Hoffman, Rebecca E Graff, Nima C Emami, Caroline G Tai, Michael N Passarelli, Donglei Hu, Scott Huntsman, Dexter Hadley, Lancelote Leong, Arunabha Majumdar, Noah Zaitlen, Elad Ziv, John S Witte

“…In summary, we used a transcriptome-based approach to investigate the genetic underpinnings of breast carcinogenesis. …”
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Assessing Bias and Reproducibility of Viral Metagenomics Methods for the Combined Detection of Faecal RNA and DNA Viruses by Rik Haagmans, Oliver J. Charity, Dave Baker, Andrea Telatin, George M. Savva, Evelien M. Adriaenssens, Penny P. Powell, Simon R. Carding

“…Whole transcriptome amplification (WTA2) and sequence-independent single primer amplification (SISPA) are two widely used methods for combined metagenomic sequencing of RNA and DNA viruses. …”
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Establishment of rat model for aspiration pneumonia and potential mechanisms by Hanbing Hu, Junfeng Chen, Yiru Shao, Yuedong Tang, Yu Dun, Obulkasim Memet, Xuanrong Bao, Jie Shen

“…Current animal models fail to fully replicate the condition, focusing solely on chemical lung injury from gastric acid while neglecting pathogen‐induced inflammation. This gap hinders research on pathogenesis and treatment, creating an urgent need for a clinically relevant model. …”
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Lung Tissue Extracellular Vesicles-Mediated Delivery of miR-128-3p as a Novel Mechanism of Acute Lung Inflammation by Deng W, Zhu X, Li H, Hu P, Qian K, Liu F

“…This study combines transcriptomic profiling and functional validation to reveal how Lung Ti-EVs mediate macrophage polarization through miRNA-dependent NLRP3 inflammasome activation.Methods: We established a sepsis mouse model, extracted and characterized lung tissue-derived EVs, performed high-throughput transcriptome sequencing and bioinformatics analysis. …”
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Application of root exudates derived from peanut/maize intercropping system promotes peanut growth and yield via modulating nitrogen turnover processes by Tong Si, Lijian Yang, Jinhao Lu, Yimin Lin, Xiaona Yu, Xiaojun Zhang, Xiaoxia Zou

“…Sucrose (SUC) and myo-inositol (MI) were significantly declined while oxalic acid (OA) was dramatically enriched compared with peanut monoculture. …”
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MSI expresso: a software for determining MSI status and detecting MSI-related transcription events from RNA sequencing data by Emmanuel Tubacher, Alexandre How-Kit, Mourad Sahbatou, Alex Duval, Victor Renault, Jean-François Deleuze, Jean-François Deleuze

“…Thus, MSI Expresso is a new tool for MSI detection from RNA-sequencing data complementary to genomic and genetic approaches allowing to explore the consequence of MSI events on transcripts/transcriptome.…”
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Identification of a novel chemotherapy benefit index for patients with advanced ovarian cancer based on Bayesian network analysis. by Shuxiao Ma, Lu Zhou, Yi Liu, Hui Jie, Min Yi, Chenglin Guo, Jiandong Mei, Chuan Li, Lei Zhu, Senyi Deng

“…<h4>Methods</h4>Based on The Cancer Genome Atlas (TCGA) transcriptome data, we conducted correlation and Bayesian network analyses to identify key genes strongly associated with chemotherapy prognosis. …”
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