AMF30a promotes survival and function of human corneal endothelial cells by regulating TGF-β/ROCK/HIPPO pathway by Yunkyoung Ryu, Hye-Jin Son, Jin Sun Hwang, Kyung Bo Noh, Sun-Hee Oh, Eun-Kyoung Choi, Young Joo Shin

“…AMF30a modulated the HIPPO signaling pathway by increasing YAP phosphorylation and reducing its nuclear translocation, while downregulating ERK1/2 activation. Transcriptome analysis identified differentially expressed genes (DEGs) associated with AMF30a treatment, highlighting pathways related to GPCR signaling and protein targeting. …”
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Identification of biomarkers associated with energy metabolism in hypertrophic cardiomyopathy and exploration of potential mechanisms of roles by Songyan Cai, Tianying Jin, Mintong Liu, Qingyuan Dai

“…Utilizing ssGSEA, it was unveiled that the HCM cohort exhibited elevated ratings of effector memory CD4T cells while displaying diminished scores across 22 other immune cell categories. …”
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LMOD2 interaction with ACTC1 regulates myogenic differentiation by Kaiming Wang, Caihong Liu, Lei Yi, Sui Liufu, Wenwu Chen, Xiaolin Liu, Bohe Chen, Xin Xu, Jingwen Liu, Xibing Liu, Yulong Yin, Haiming Ma

“…MyoG is a transcription factor for LMOD2, while miR-335-3p can negatively regulate LMOD2 expression. …”
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Genome-wide identification and expression of the HB gene family during overwintering in Korla pear (Pyrus sinkiangensis) by LIU Xiaoyan, WANG Lijuan, YANG Shenghui, LUO Guanghong, ZHU Jianbo

“…On chromosome 15, the highest number of HB members was distributed, totaling 12, while the other chromosomes contained 2 to 9 members each. …”
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Biocontrol Potential of Entomopathogenic Fungi Against Plant-Parasitic Nematodes: A <i>Caenorhabditis elegans</i>-Based Screening and Mechanistic Study by Cheng Cheng, Renjun Zhang, Yanzhen Wang, Shuo Yang, Wenhao Yu, Yuxian Xia

“…This was accompanied by a transcriptome-wide modulation of genes involved in detoxification and immune defense pathways. …”
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Intragenomic conflict associated with extreme phenotypic plasticity in queen-worker caste determination in honey bees (Apis mellifera) by Sean T. Bresnahan, Shaun Mahony, Kate Anton, Brock Harpur, Christina M. Grozinger

“…Although parent-of-origin effects have been reported in honey bees, the associated gene regulatory mechanisms remain unknown. While DNA methylation underlies parent-biased transcription in eutherians, angiosperms, and some insects, it is not operating in honey bees or other social insects. …”
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Comparison of stromal vascular fraction cell composition between Coleman fat and extracellular matrix/stromal vascular fraction gel by Xiaoyun Li, Guohong Zhang, Mengmeng Wang, Changhao Lu, Guangping Zhang, Zhehui Chen, Yingchang Ji

“…Our findings reveal ECM/SVF-gels share the same dominant immune cells beneficial to fat graft survival with Coleman fat, but exhibiting obvious losses of immune cells (especially macrophages), while non-immune cells necessary for adipose regeneration might have no significant loss in ECM/SVF-gels and their biological effects could be markedly enhanced by the ECM/SVF-gel’s condensed nature.…”
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Identification and Validation of NK Marker Genes in Ovarian Cancer by scRNA-seq Combined with WGCNA Algorithm by Xin He, Weiwei Feng

“…The WGCNA algorithm screens NK cell marker genes based on bulk RNA transcriptome patterns. Finally, a total of 42 NK cell marker genes were included in our investigation. …”
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Detoxification of coumarins by rumen anaerobic fungi: insights into microbial degradation pathways and agricultural applications by Yuqi Li, Jian Gao, Yaxiong Cao, Xinming Cheng, Zhanying Sun, Jiyu Zhang, Weiyun Zhu, Martin Gierus, Yanfen Cheng

“…Abstract Background Coumarins are toxic phytochemicals found in a variety of plants and are known to limit microbial degradation and interfere with nutrient cycling. While the degradation of coumarins by fungi has been studied in an environmental context, little is known about their degradation in the gastrointestinal system of herbivores after ingestion. …”
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Genome‑wide identification of the cotton FAR gene family reveals GhFAR3 as a positive regulator of Verticillium dahliae resistance by Wenhan Cheng, Siqi Gao, Zhaojie He, Nurimanguli Aini, Zengqiang Zhao, Xianpeng Xiong, Ning Wang, Rui Chen, Keyun Feng

“…Promoter cis-element analysis and transcriptome profiling revealed that while most FAR genes were downregulated under abiotic stress, many were notably upregulated in response to hormone treatments and Verticillium dahliae infection. …”
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The combination of polystyrene microplastics and di (2-ethylhexyl) phthalate promotes the conjugative transfer of antibiotic resistance genes between bacteria by Yu Li, Xiaomei Liu, Saisai Guo, Lan Wang, Jingchun Tang

“…This indicated that the effects of DEHP and microplastics on ARGs transfer might be antagonistic. Transcriptome analysis indicated that the transfer of ARGs affects bacterial ion binding, oxidative stress, and energy metabolism processes, while the expression of genes related to cell membrane permeability, DNA repair, bacterial drug resistance, and quorum sensing also increase. …”
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Identification and Expression Analysis of miR166 Gene Family in Response to Salt Stress in <i>Chrysanthemum</i> by Di Wang, Shuheng Wang, Dongyang Zhang, Yuan Meng, Ying Qian, Siyu Feng, Yun Bai, Yunwei Zhou

“…The expression level of miR166 was upregulated in root under salt stress, while the expression level of the target gene HD-ZipIII was downregulated. …”
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Integrative Proteomics and Genomics Identify Novel Biomarkers and Therapeutic Targets in Vitiligo via Mendelian Randomization by Chenjue Yan, Ling Jiang, Yibo Hu, Ting You, Jing Chen, Songjiang Wu

“…Results Four proteins (KLF4, MYL4, TNFRSF13C, TNFSF13B) were associated with lower vitiligo risk, while five proteins (ALPI, CDH1, ITGB1, SERPINH1, TNFSF10) were linked to higher risk. …”
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RNF138 contributes to cisplatin resistance in nasopharyngeal carcinoma cells by Hangyu Xu, Qing Yin, Linna Fan, Yating Zhao, Biying Song, Qifan Xu, Jie Zhu, Meifen Xu

“…Additionally, in nude mice, RNF138 overexpression attenuated the suppressive effects of cisplatin on the growth of xenograft tumor, while RNF138 silencing further enhanced the inhibiting role of cisplatin. …”
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Identification of cell adhesion-related subtypes and construction of risk model to predict breast cancer prognostic and immunological properties by De-Ming Lv, Li Yang, Chen Fan, Ling-Hui Fang, Su-Fen Cheng

“…The study aims to identify breast cancer subtypes related to cell adhesion and develop prognostic models that are essential for evaluating the prognostic risk and immunological profile of breast cancer. Methods Transcriptome and clinical data were obtained from The Cancer Genome Atlas (TCGA) database, while cell adhesion-related genes (CARGs) from the MSigDB database. …”
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Metabolomics analysis of extracellular vesicles derived from bovine colostrum and mature milk by Sitong Zhang, Xipeng Sun, Yameng Zhang, Rong Huang, Wenyou Situ, Huaxi Yi, Lingjun Tong

“…However, most research on mEVs has focused on their proteomics, lipidomics, and transcriptome, while metabolome analysis are still lacking. …”
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Sex-biased gene expression across tissues reveals unexpected differentiation in the gills of the threespine stickleback by Sylvestre, Florent, Aubin-Horth, Nadia, Bernatchez, Louis

“…Using the high multiplexing capability of 3′ QuantSeq to sequence the sex-biased transcriptome of the liver, gills, and brain, we provide the first characterization of sex-specific transcriptomes from ~80 sticklebacks (40 males and 40 females) collected from a natural population during the reproductive period. …”
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Differential Effects of Two Herbivore-Induced Plant Volatiles on the Oviposition of <i>Chilo suppressalis</i> by Xiaowei Yang, Chang Liu, Xixi Jia, Chen Zhang, Lanzhi Han, Wanlun Cai, Yunhe Li

“…To examine these effects, we conducted oviposition assays, preoviposition and longevity tests, combined with qPCR and transcriptome analyses to explore underlying molecular responses. …”
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XMU-MP-1, Inhibitor of STE20-like MST1/2 Kinases of the Hippo Signaling Pathway, Suppresses the Cell Cycle, Activates Apoptosis and Autophagy, and Induces Death of Hematopoietic Tu... by Alexander G. Stepchenko, Sofia G. Georgieva, Elizaveta V. Pankratova

“…Levels of the LC3-II protein were also shown to be increased, while the level of p62 decreased. These changes are associated with apoptosis and autophagy, respectively. …”
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The BES1/BZR1 transcriptional factor SlBES2 regulates photosynthetic apparatus in tomato fruit by Ming Huang, Wenjing Liu, Deding Su, Ghassen Abid, Baowen Huang, Zhengguo Li

“…Notably, chlorophyll content and number of thylakoids per chloroplast in fruit was substantially increased in SlBES2-overexpressing lines, while markedly decreased in SlBES2-suppressing lines. …”
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