Enhanced hierarchical attention networks for predictive interactome analysis of LncRNA and CircRNA in oral herpes virus by Pradeep Kumar Yadalam, Carlos M. Ardila

“…Node embedding statistics showed a mean of 0.005110 and a standard deviation of 0.013370, while attention weights had a high mean of 0.997178, emphasizing model robustness. …”
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Bojungikki-Tang Augments Pembrolizumab Efficacy in Human PBMC-Injected H460 Tumor-Bearing Mice by Se Won Na, Jin-Mu Yi, Heerim Yeo, Sang-Min Park, Mibae Jeong, Jaemoo Chun, Mi-Kyung Jeong

“…The results confirmed that BJIKT improved T cell function and tumor necrosis factor signaling while suppressing transforming growth factor-β signaling. …”
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…RTS iPSC-derived osteoblasts showed defective osteogenic differentiation and gain of in vitro tumorigenic ability. Transcriptome analysis of RTS osteoblasts validated decreased bone morphogenesis while revealing aberrantly upregulated mitochondrial respiratory complex I gene expression. …”
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Strigolactones optimise plant water usage by modulating vessel formation by Jiao Zhao, Dongbo Shi, Kiara Kaeufer, Changzheng Song, Dominik Both, Anna Lea Thier, Hui Cao, Linus Lassen, Xiaocai Xu, Yuki Hamamura, Laura Luzzietti, Tom Bennett, Kerstin Kaufmann, Thomas Greb

“…While SL signalling is generally active in differentiating vascular tissues, it is low in developing vessels and CSCs, where it modulates cell fate decisions and drought response. …”
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PADI4 expression in baseline circulating tumour cells acts as a prognostic biomarker in oral squamous cell carcinoma by Anshika Chauhan, Geeta S. Boora, Arindam Maitra, Rijuneeta Gupta, Jaimanti Bakshi, Sushmita Ghoshal, Arnab Pal

“…Though CTC enumeration has been associated with disease outcome, in-depth molecular analysis of CTCs remained minimal as the techniques for CTC isolation and analysis are challenging. While exploring gene expression in CTCs, we performed whole transcriptome analysis of paired primary tumour and CTCs isolated from Oral Squamous Cell Carcinoma (OSCC) patients. …”
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Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure by Jung Gyu Park, Minseok Kim, Sungje Yoo, Sun Wook Hwang, Jongsoo Mok, Joonghoon Park, Keon Wook Kang

“…However, their clinical efficacy is hindered by the risk of severe hypoglycemia and secondary sulfonylurea failure. While the mechanisms underlying sulfonylurea-induced hypoglycemia are well-documented, the precise factors contributing to sulfonylurea resistance (SR) remain poorly understood. …”
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Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior. by N Sören Häfker, Laurenz Holcik, Audrey M Mat, Aida Ćorić, Karim Vadiwala, Isabel Beets, Alexander W Stockinger, Carolina E Atria, Stefan Hammer, Roger Revilla-I-Domingo, Liliane Schoofs, Florian Raible, Kristin Tessmar-Raible

“…While behaviorally arrhythmic worms showed a similar total number of cycling transcripts compared to their behaviorally rhythmic counterparts, the annotation categories of their transcripts, however, differed substantially. …”
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Enhancement of carrimycin production in Streptomyces spiramyceticus 54-IA by the reporter-guided selection method with traditional mutagenesis by Kemeng Li, Jianlu Dai, Yue Chang, Tianyi Hao, Weiqing He

“…A comparative analysis of the transcriptome profiles between the F2R-15 mutant and 54-IA strains revealed 158 significantly differentially expressed genes. …”
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Cytokine Signaling in Diabetic Neuropathy: A Key Player in Peripheral Nerve Damage by Zahra Nashtahosseini, Majid Eslami, Elham Paraandavaji, Alireza Haraj, Bahram Fadaee Dowlat, Ehsan Hosseinzadeh, Valentyn Oksenych, Ramtin Naderian

“…Additionally, crucial molecular targets have been found using proteomic and transcriptome techniques, enabling precision medicine for the treatment of DPN. …”
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24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. by Andrew S P Lim, Gyan P Srivastava, Lei Yu, Lori B Chibnik, Jishu Xu, Aron S Buchman, Julie A Schneider, Amanda J Myers, David A Bennett, Philip L De Jager

“…These rhythms are paralleled by 24-hour rhythms of large portions of the transcriptome. The role of dynamic DNA methylation in influencing these rhythms is uncertain. …”
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Reproductive tract microbiome dysbiosis associated with gynecological diseases by Qingyue Zheng, Qingyue Zheng, Tianshu Sun, Xiaochuan Li, Xiaochuan Li, Lan Zhu, Lan Zhu

“…For example, Fusobacterium may exacerbate endometriosis, while treatments that target microbiota, such as antibiotics, probiotics, and flora transplantation, showed some efficacy in the experiment. …”
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Subcellular localization and expression analysis of MlSOC1 genes during flower bud differentiation period in Magnolia liliflora by XUAN Lingjuan, CHENG Shaoyu, DAI Mengyi, WANG Zhuowei, SHEN Yamei

“…Phylogenetic tree analysis showed that MlSOC1-1 was closely related to SOC1 homologous gene of M. praecocissima, while MlSOC1-2 was closely related to SOC1 homologous gene of M. virginiana. …”
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Hypoxic transcriptional phenotype and cellular ultrastructural changes of tumor-associated macrophages in gliomas by FAN Haizhen, FAN Haizhen, WANG Lixia, CHENG Yue

“…RT-qPCR and transcriptome sequencing were employed to analyze transcriptional changes in TAMs under normoxic and hypoxic conditions. …”
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Nrf2 controls homeostatic transcriptional signatures and inflammatory responses in a cell-type specific manner in the adult mouse brain by Xin He, Owen Dando, Jing Qiu

“…Summary: Nrf2 is a promising therapeutic target for neurological disorders, but its mechanisms of action remain unclear. While often linked to anti-inflammatory effects, this is mostly based on studies involving pharmacological activation. …”
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Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fe... by Wilson Santos Molari, Mohamed Amine Jmel, Mohamed Amine Jmel, Josiane Betim Assis, Alan Frazão-Silva, Júlia Moura Bernardi, Gretta Huamanrayme, José María Medina, Eliane Esteves, Solange Cristina Antão, Gabriel Cerqueira Alves Costa, Aparecida Sadae Tanaka, Aparecida Sadae Tanaka, Andréa Cristina Fogaça, Andréa Cristina Fogaça, Zdenek Franta, Lucas Tirloni, Michalis Kotsyfakis, Michalis Kotsyfakis, Anderson Sá-Nunes, Anderson Sá-Nunes

“…A comprehensive evaluation of the salivary gland transcriptome database reveals that protease inhibitors are abundantly expressed molecules in tick saliva during feeding. …”
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Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability by Wolfgang Sadee, Ian H. Cheeseman, Audrey Papp, Maciej Pietrzak, Michal Seweryn, Xiaofei Zhou, Shili Lin, Amanda M. Williams, Mark D. Wewers, Heather M. Curry, Hao Zhang, Hong Cai, Carine Kunsevi-Kilola, Happy Tshivhula, Gerhard Walzl, Blanca I. Restrepo, Léanie Kleynhans, Katharina Ronacher, Yufeng Wang, Eusondia Arnett, Abul K. Azad, Larry S. Schlesinger

“…The HAM RNA transcriptome following infection revealed thousands of differentially expressed (DE) genes and differential secretion of 25/27 proteins. …”
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m6A-lncRNA landscape highlights reduced levels of m6A modification in glioblastoma as compared to low-grade glioma by Giedrius Steponaitis, Rugile Dragunaite, Rytis Stakaitis, Amit Sharma, Arimantas Tamasauskas, Daina Skiriute

“…Results Our analysis demonstrated that, 1) 98.5% of m6A-modified RRACH motifs were present within mRNA transcripts, while only 1.16% were conspicuous within lncRNAs. …”
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Potential radiosensitive germline biomarkers in the testes of wild mice after the Fukushima accident by Syun Tokita, Ryo Nakayama, Yohei Fujishima, Valerie Swee Ting Goh, Donovan Anderson, Ippei Uemura, Hikari Ikema, Jin Shibata, Yoh Kinoshita, Yoshinaka Shimizu, Hisashi Shinoda, Jun Goto, Maria Grazia Palmerini, Abdulla Mohamed Hatha, Takashi Satoh, Akifumi Nakata, Manabu Fukumoto, Tomisato Miura, Hideaki Yamashiro

“…Results revealed significant changes during the breeding season, with Lsp1 showing a considerable upregulation, while Ptprk and Tspear exhibited significant reductions. …”
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Assessment of Genetic Diversity by Morphological, Biochemical, and Molecular Markers in <i>Gloriosa superba</i> Ecotypes Collected from Different Agro-Climatic Zones in India by Moumita Majumdar, Rakesh Arya, Soumya Prakash Sahu, Archana Tiwari, Jong-Joo Kim

“…Intermediate CV values (10.05% to 18.75%) were observed in eight traits, while three traits (days to flowering, days to 50% flowering, and colchicine content) had low variation (<5%). …”
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The Glutamatergic System Regulates Feather Pecking Behaviors in Laying Hens Through the Gut–Brain Axis by Xiliang Yan, Chao Wang, Yaling Li, Yating Lin, Yinbao Wu, Yan Wang

“…Feather pecking (FP) is a significant welfare and economic problem in laying hen husbandry. While there is growing evidence that the glutamatergic system plays a crucial role in regulating FP behavior, the biological mechanisms remain unclear, largely due to the limited uptake of peripheral glutamate across the blood–brain barrier (BBB). …”
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