Impact of aging on gene expression in human oocytes: a comparative analysis of young and older patients by Raoul Orvieto, Omri Nayshool, Louisa Cohen, Yuval Yung, Adva Aizer, Efrat Glick Saar, Dan Dominissini

“…Moreover, among these genes, LINC02087 was the most downregulated (log2FC = -7.66), while CITED2 showed the strongest upregulation (log2FC = 3.43) in young versus old oocytes. …”
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Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc by Changli Zhang, Martha Elena Diaz-Hernandez, Takanori Fukunaga, Sreekala Shenoy, Sangwook Tim Yoon, Lisbet Haglund, Hicham Drissi

“…Specifically, rhPDGF-AB/BB treatment downregulated genes related to neurogenesis and mechanical stimulus response in AF cells, while in NP cells, metabolic pathways were predominantly suppressed. …”
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Characterization, Expression Profile Analysis, and Functional Prediction of <i>UGP</i> Gene Family in <i>Dendrocalamus brandisii</i> by He Li, Chongyang Wu, Xiangyi Li, Junlei Xu, Zhanchao Cheng, Jian Gao

“…Expression profiling revealed <i>DbUGP1</i>/<i>5</i> were highly expressed in flowers, while others were enriched in shoots, buds, and culms. …”
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A common mechanism of detoxification for lambda-cyhalothrin and abamectin in Cydia pomonella by Di Ju, Chao Hu, Peirong Li, Ping Gao, Yuting Li, Xueqing Yang

“…A total of 72 P450 genes and 75 CarE genes were identified in the C. pomonella transcriptome, with 43 of these genes (including 11 P450, 3 GST, 10 CarE, 11 ABC transporters, and 8 UDP-glycosyl transferases) being over-expressed in response to both insecticides Interestingly, ABC transporters were predominantly induced by AM treatment, while GST showed higher induction levels with LCT treatment. …”
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Separate, separated, and together: the transcriptional program of the Clostridium acetobutylicum-Clostridium ljungdahlii syntrophy leading to interspecies cell fusion by Noah B. Willis, Eleftherios T. Papoutsakis

“…The second type compared membrane-separated versus -unseparated cocultures, isolating the impact of interspecies physical contact. While we could not firmly identify specific genes that might drive cell fusion, consistent with our hypothesized model for this interspecies microbial cell fusion, we observed differential regulation of genes involved in C. ljungdahlii’s autotrophic Wood-Ljungdahl pathway metabolism and genes of the motility machinery. …”
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Revitalizing the Epigenome of Adult Jaw Periosteal Cells: Enhancing Diversity in iPSC-Derived Mesenchymal Stem Cells (iMSCs) by Felix Umrath, Valerie Wendt, Gilles Gasparoni, Yasser Narknava, Jörn Walter, Bernd Lethaus, Josefin Weber, Victor Carriel, Meltem Avci-Adali, Dorothea Alexander

“…Using an optimized protocol, we generated iMSCs with a remarkable osteogenic potential while exhibiting lower expression levels of the senescence markers p16 and p21 compared to the original JPCs. …”
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A Fragment Insertion of <i>AgDFR</i> Results in a White Flower Phenotype in <i>Arundina graminifolia</i> (Orchidaceae) by Jie Li, Yonglu Wei, Jianpeng Jin, Jie Gao, Qi Xie, Fengxi Yang, Genfa Zhu

“…Histological examination revealed anthocyanin accumulation restricted to two to three upper epidermal cell layers in purple petals, while white petals showed complete pigment absence. …”
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Leptin receptor signaling mediates the distinct tendon–bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears by Dongxu Zhu, Xinrui Zhu, Yingze Zhang, Xiaohong Huang

“…Results RC rats exhibited better functional recovery during the proliferative phase of TBI reconstruction, i.e., 2-week, compared to OVX + RC rats, while both RC and OVX + RC rats showed a lower grip strength in the upper limbs during the remodeling phase, i.e., 8-week. …”
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Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus by Jingyi Yang, Yingdong Wang, Yuzhe Xu, Xinqi Jia, Fangping Lu

“…Concurrently, sustained ER stress suppresses Akt activity while upregulating the muscle-specific E3 ubiquitin ligase Atrogin1, thereby accelerating proteolysis and inducing indirect muscle wasting. …”
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Genetic Variation and Gene Expression of the Antimicrobial Peptide Macins in Asian Buffalo Leech (<i>Hirudinaria manillensis</i>) by Yunfei Yu, Lizhou Tang, Mingkang Xiao, Jingjing Yin, Tianyu Ye, Rujiao Sun, Rui Ai, Fang Zhao, Zuhao Huang, Gonghua Lin

“…All <i>Hman1</i> sequences were translatable, while four <i>Hman2</i> and 28 <i>Hman3</i> sequences had degenerated into pseudogenes. …”
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Transcriptional profiling of Chlamydia trachomatis and its host in an ex vivo endocervical primary cell culture system using dual RNA sequencing by Olusola Olagoke, Siddharth Chittaranjan, Deborah Dean, Deborah Dean, Deborah Dean, Deborah Dean, Deborah Dean

“…Inclusion-membrane genes peaked at 1hpi, while hemolysin-like and polymorphic membrane protein genes were upregulated at 24hpi. …”
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Insights into the Underlying Mechanism of the <i>Piriformospora indica</i>-Enhanced Drought Tolerance in Blueberry by Yongyan Zhang, Pengyan Qu, Junke Zhang, Ruide Li, Rui Liu, Chunzhen Cheng

“…To explore the underlying mechanism, comparative root transcriptome analysis of well-watered (WW) and DS-treated CK and PI blueberry plants was conducted. …”
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A novel cardiomyopathy phenotype linked to a CHD7 missense variant by In Young Park, Chih-Wei Hsu, Karim Bouazoune, Christina E. Espindola, Madeline Hannah McLaughlin Armond, Cristian Coarfa, Sandra L. Grimm, James F. Martin, Donna M. Martin, Cheryl Lyn Walker

“…Micro-CT analysis at E18.5 revealed that heterozygous mice primarily exhibited hypertrophic cardiomyopathy (HCM), while homozygous mice developed both HCM and dilated cardiomyopathy (DCM). …”
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Deubiquitinase OTUD7B stabilizes HNF4α to alleviate pressure overload-induced cardiac hypertrophy by regulating fatty acid oxidation and inhibiting ferroptosis by Rujie Zheng, Wenjuan Song, Che Wang, Xiaoyu Du, Chunlei Liu, Xiaotong Sun, Chengzhi Lu

“…Cardiac-specific OTUD7B deficiency exacerbated, while OTUD7B overexpression mitigated, pressure overload-induced hypertrophy and cardiac dysfunction both in vivo and in vitro. …”
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Antecedent viral immunization and efficacy of immune checkpoint blockade: an extensive serum antibody profile to predict outcomes in non-small cell lung cancer by Francois-Xavier Danlos, Aurélien Marabelle, Tyler Hulett, Fabrice Barlesi, Benjamin Besse, David Planchard, Nathalie Chaput-Gras, Mihaela Aldea, Filippo G Dall’Olio, Paul-Henry Cournède, Quentin Blampey, Wael Salem Zrafi, Matthieu Roulleaux-Dugage, Gabriel Roman, Charles Naltet, Daniel Gautheret

“…Of them, 129 were treated with ICBs alone, 66 with CT-ICBs and 195 with CT alone. 90 out of 129 patients treated with ICBs alone received ICBs as a subsequent line of treatment, while CT-ICBs and CT were administered as upfront therapies.A higher tUP was correlated with improved overall survival in patients treated with ICBs, and confirmed in the multivariate model (HR 0.43, 95% CI 0.24, 0.79, p=0.006), while it was not in those treated with CT-ICBs (p=0.8) and CT alone (p=0.1).tUP was not correlated with programmed death-ligand 1 (PD-L1) expression, while at the transcriptome level it was correlated with several immune-related pathways, particularly involving B cells.Conclusion A higher number of viral peptides recognized by serum antibodies might reflect increased immune fitness, resulting in improved outcomes in ICBs treated patients with NSCLC.…”
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Intermittent Supplementation with Far-Red Light Accelerates Leaf and Bud Development and Increases Yield in Lettuce by Yanke Liu, Rong Ye, Xinying Gao, Rongcheng Lin, Yang Li

“…In this study, the effects are explored of varying far-red light photon intensities and intermittent exposure durations—specifically at 5, 15, 30, and 45 min intervals—on the growth and development of lettuce (<i>Lactuca sativa</i>) in plant factories, while maintaining a constant red light photon flux and daily light integral. …”
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Identification of Yellow Pigmentation Genes in Brassica rapa ssp. pekinensis Using Br300 Microarray by Hee-Jeong Jung, Ranjith Kumar Manoharan, Jong-In Park, Mi-Young Chung, Jeongyeo Lee, Yong-Pyo Lim, Yoonkang Hur, Ill-Sup Nou

“…To identify responsible genes for yellow pigmentation in leaves, the transcriptome profiles of white (Kenshin) and yellow leaves (Wheessen) were examined using the Br300K oligomeric chip in Chinese cabbage. …”
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Identification and experimental validation of prognostic genes related to cytochrome c in breast cancer by Huimin Yu, Shihong Li, Jian Wu, Haobin Wang, Haobin Wang

“…Bioinformatics and RT-qPCR analyses confirmed that CETP and HGF are upregulated in normal tissues, while CLEC11A and PLAU showed higher expression in BC tissues. …”
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Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression by F. N. U. Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey

“…Low levels of A1AT in the lung contributes to chronic obstructive pulmonary disease, while misfolding of A1AT in the liver contributes to liver cirrhosis. …”
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RNA-seq analysis identifies key genes and signaling pathways involved in androgen promotion of sebaceous gland proliferation in Hetian sheep by Zhiya Feng, Zhigang Li, Wanwan Peng, Jianping Zhang, Chunyang Li, Ruijun Shi, Shuwei Li

“…The upregulated genes were predominantly enriched in lipid metabolism pathways, while the downregulated genes were mainly associated with keratin filament structures. …”
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