Seed Priming with 2,4-Epibrassionolide Enhances Seed Germination and Heat Tolerance in Rice by Regulating the Antioxidant System and Plant Hormone Signaling Pathways by Jingya Qian, Xu Mo, Yue Wang, Qiang Li

“…Additionally, exogenous EBR increases the levels of GA and IAA while decreasing the ABA content. According to a transcriptomic analysis, exogenous EBR can induce the expression of key genes involved in GA, IAA, and ABA hormone biosynthesis and metabolism, regulating GA-, IAA-, ABA-, and H₂O₂-mediated signaling pathways to promote the germination of rice seeds under heat stress. …”
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Porcine β-defensin 5 (pBD-5) modulates the inflammatory and metabolic host intestinal response to infection by Arthur Nery Finatto, Christine Yang, Matheus de Oliveira Costa

“…Conversely, metabolic pathways such as ribosome, protein digestion and absorption, and renin-angiotensin system were upregulated by pBD-5 treatment, hinting at a role in producing and conserving energy during the challenge. While this study offers insights into the immunomodulatory effects of pBD-5, further research is necessary to elucidate its precise mechanisms and potential applications as an alternative treatment for infectious diseases.…”
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Identification of Gene Modules Associated with Low Temperatures Response in Bambara Groundnut by Network-Based Analysis. by Venkata Suresh Bonthala, Katie Mayes, Joanna Moreton, Martin Blythe, Victoria Wright, Sean Tobias May, Festo Massawe, Sean Mayes, Jamie Twycross

“…Modules of sub-optimal temperature stress are principally enriched with carbohydrate and lipid metabolic processes, while most of the modules of very sub-optimal temperature stress are significantly enriched with responses to stimuli and various metabolic processes. …”
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Sideroflexin family genes were dysregulated and associated with tumor progression in prostate cancers by Hua Huang, Huibo Lian, Wang Liu, Benyi Li, Runzhi Zhu, Haiyan Shao

“…SFXN2/4 genes were significantly upregulated while the SFXN3 expression was significantly downregulated in malignant tissues compared to benign tissues. …”
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Dietary exposure of the water flea Daphnia galeata to microcystin-LR by Eun-jeong Kim, Donggu Jeon, Yeon-jeong Park, Hyunmin Woo, Seong-il Eyun

“…Furthermore, functional protein classification revealed an upregulation of lipid and inorganic ion transport processes, while amino acid and carbohydrate transport processes were found to be downregulated. …”
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Pheromone‐binding proteins based phylogenetics and phylogeography of Maruca spp. from Asia, Africa, Oceania, and South America by Periasamy Malini, Srinivasan Ramasamy, Roland Schafleitner, Krishnan Muthukalingan

“…The genetic differences among Maruca populations should be carefully considered while using sex pheromone lures and bio‐control agents.…”
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Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells by Jiahao Jiang, Thomas K. Hiron, Anil Chalisey, Yashaswat Malhotra, Thomas Agbaedeng, Chris A. O’Callaghan

“…Abstract Oxidised low-density lipoprotein cholesterol (ox-LDL) is critical in the initiation and progression of atherosclerosis. While excessive atherogenic lipids in the arterial intima can trigger endothelial dysfunction in advanced lesions, the response of endothelial cells to ox-LDL in the early stages of atherogenesis remains unclear. …”
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Pseudomonas plecoglossicida infection induces neutrophil autophagy-driven NETosis in large yellow croaker Larimichthys crocea by Jia-Feng Cao, Jia-Feng Cao, Jia-Feng Cao, Jiong Chen, Jiong Chen, Jiong Chen

“…Neutrophil extracellular traps (NETs) are crucial for the immune defense of many organisms, serving as a potent mechanism for neutrophils to capture and eliminate extracellular pathogens. While NETosis and its antimicrobial mechanisms have been well studied in mammals, research on NETs formation in teleost fish remains limited. …”
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New perspectives on YTHDF2 O-GlcNAc modification in the pathogenesis of intervertebral disc degeneration by Liangjie Lu, Lijun Wang, Minjie Yang, Huihan Wang

“…Further, in vivo animal experiments confirmed a decrease in YTHDF2 expression and O-GlcNAcylation in IDD mice, while overexpression or increased O-GlcNAcylation of YTHDF2 promoted CCNE1 protein expression, thereby alleviating IDD pathology. …”
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Molecular insights into Solanum sisymbriifolium’s resistance against Globodera pallida via RNA-seq by Raquel Varandas, Cristina Barroso, Isabel Luci Conceição, Conceição Egas

“…Abstract Background The presence of potato cyst nematodes (PCN) causes a significant risk to potato crops globally, leading to reduced yields and economic losses. While the plant Solanum sisymbriifolium is known for its resistance to PCN and can be used as a trap crop, the molecular mechanisms behind this resistance remain poorly understood. …”
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Purification and identification of anti-inflammatory peptides from sturgeon (Acipenser schrenckii) cartilage by Li Yuan, Qian Chu, Bei Yang, Wei Zhang, Quancai Sun, Ruichang Gao

“…Among these five peptides, LTGP, LLLE, LLEL and VGPAGPAGP reduced the production of nitric oxide (NO) and interleukin-6 (IL-6) while increasing interleukin-10 (IL-10) excretion. …”
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Epithelial and macrophage cell interaction in cervical cancer through single-cell RNA-sequencing and spatial analysis by Zhichao Wang, Long Cheng, Guanghui Li, Huiyan Cheng

“…Triptolide was effective in epithelial cell subgroup 1, while memantine was more effective in macrophages.ConclusionEpithelial-macrophage interactions in the TME are crucial for CC progression and treatment, offering a potential immunotherapeutic strategy.…”
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Epigenetic signature of human vitamin D3 and IL-10 conditioned regulatory DCs by Silvia Liu, Alan F. Zahorchak, Steven F. Dobrowolski, Diana M. Metes, Angus W. Thomson, Hossam A. Abdelsamed

“…Further, DCreg differentially-methylated regions (DMRs) were enriched in binding motifs specific to the immunomodulatory transcription factor Krueppel-like factor 11 (KLF11), while activator protein-1 (AP-1) (Fos:Jun) transcription factor-binding motifs were enriched in sDC DMRs. …”
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Two-sample bi-directional causality between two traits with some invalid IVs in both directions using GWAS summary statistics by Siyi Chen

“…Summary: Mendelian randomization (MR) is a widely used method for assessing causal relationships between risk factors and outcomes using genetic variants as instrumental variables (IVs). While traditional MR assumes uni-directional causality, bi-directional MR aims to identify the true causal direction. …”
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Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows by Sevda Hosseinzadeh, Seyed Abbas Rafat, Lingzhao Fang

“…RPL12 plays a role in protein synthesis, essential for gametogenesis and embryo development, while FKBP1B regulates calcium signaling, particularly in oocyte aging and fertility decline, and FZD10 is crucial in Wnt signaling. …”
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The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. by Mauro Savino, Daniela Annibali, Nicoletta Carucci, Emilia Favuzzi, Michael D Cole, Gerard I Evan, Laura Soucek, Sergio Nasi

“…Specifically, it prevents Myc binding to promoter E-boxes and transactivation of target genes while retaining Miz-1 dependent binding to promoters and transrepression. …”
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Spatio-Temporal Regulation of Gibberellin Biosynthesis Contributes to Optimal Rhizome Bud Development by Kanako Bessho-Uehara, Tomoki Omori, Stefan Reuscher, Keisuke Nagai, Ayumi Agata, Mikiko Kojima, Yumiko Takebayashi, Takamasa Suzuki, Hitoshi Sakakibara, Motoyuki Ashikari, Tokunori Hobo

“…Our study revealed that rhizome buds initiate between the third and fifth nodes of seedlings beyond the 6-leaf stage, while the buds above the sixth node develop into tillers. …”
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Renal oncocytoma with liver metastasis: a case report with genetic analysis and literature review by Issa Al-kharouf, Carmen Miller, Ameer Hamza, Benyi Li, Da Zhang

“…Oncocytomas are clinically benign tumors composed of cells with abundant granular eosinophilic cytoplasm due to a high mitochondrial content. While typically non-metastatic, rare cases of metastatic oncocytomas have been documented. …”
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Comparison of Nucleosome Landscapes Between Porcine Embryonic Fibroblasts and GV Oocytes by Minjun Zhao, Shunran Zhao, Zhaoqi Pang, Chunhui Jia, Chenyu Tao

“…Next, we reanalyzed the currently published transcriptome of fully grown GV oocytes and PEF, and a total of 51 genes in BF and 80 genes in PEF were identified as being uniquely expressed. …”
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Intermittent Supplemental Irradiation With Blue Light Promotes Leafy Heads in Lettuce by Yanke Liu, Yiqun Chen, Rongcheng Lin, Ep Heuvelink, Yang Li

“…In this study, we examined the impacts of varying blue light photon intensity and durations at 5‐, 15‐, 30‐, and 45‐min intervals of intermittent exposure on the growth and development of lettuce (Lactuca sativa) in plant factories while maintaining a constant red light photon flux and daily light integral (DLI). …”
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