Phylogenetic and expression analysis of terpenoid synthase gene family in Eustoma grandiflorum by LI Xinyuan, LIANG Yuwei, FANG Huiyi, SUN Fuhui, ZHANG Liangsheng

“…Among these clades, only the TPS-a.1 clade exhibited amplification, while most of the other clades presented gene loss. …”
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Gene expression dataset of the blood clam Anadara kagoshimensis in relation to anoxic stressDDBJ by Kaito Hatano, Ryo Orita, Kei Kimura, Yukio Nagano, Nobuo Suzuki

“…This article presents the transcriptome dataset of gill tissues from A. kagoshimensis under anoxic and normoxic conditions. …”
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Genome-wide exonic small interference RNA-mediated gene silencing regulates sexual reproduction in the homothallic fungus Fusarium graminearum. by Hokyoung Son, Ae Ran Park, Jae Yun Lim, Chanseok Shin, Yin-Won Lee

“…Although both Dicers and Argonautes partially share their functions, the sex-specific RNAi pathway is primarily mediated by FgDicer1 and FgAgo2, while the constitutively expressed RNAi components FgDicer2 and FgAgo1 are responsible for hairpin-induced RNAi. …”
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Evolution of canonical circadian clock genes underlies unique sleep strategies of marine mammals for secondary aquatic adaptation. by Daiqing Yin, Zhaomin Zhong, Fan Zeng, Zhikang Xu, Jing Li, Wenhua Ren, Guang Yang, Han Wang, Shixia Xu

“…To satisfy the needs of sleeping underwater, marine mammals, including cetaceans, sirenians, and pinnipeds, have evolved an unusual form of sleep, known as unihemispheric slow-wave sleep (USWS), in which one brain hemisphere is asleep while the other is awake. All aquatic cetaceans have only evolved USWS without rapid eye movement (REM) sleep, whereas aquatic sirenians and amphibious pinnipeds display both bihemispheric slow-wave sleep (BSWS) and USWS, as well as REM sleep. …”
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Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance by Alexander S. Ham, Shuo Lin, Alice Tse, Marco Thürkauf, Timothy J. McGowan, Lena Jörin, Filippo Oliveri, Markus A. Rüegg

“…To elucidate how the NMJ transcriptome is regulated, we also performed snRNA-seq on sciatic nerve transected, botulinum toxin injected, and Musk knockout muscles. …”
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Cuminaldehyde downregulates folate metabolism and membrane proteins to inhibit growth of Penicillium digitatum in citrus fruit by Okwong Oketch Reymick, Dazhao Liu, Xiaoli Tan, Qiuli OuYang, Nengguo Tao

“…The results suggest that cuminaldehyde instigated superoxide anion radicle production initially from mitochondrial complex I, while limiting the ability of the cells to scavenge the accumulating ROS by reducing the expression of glutathione and catalase. …”
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Obesity induced transcriptional changes in skeletal muscle across different species. by Yujie Wang, Jiaman Zhang, Xintong Yang, Fuwen Wang, Long Jin, Jing Li, Xuewei Li, Mingzhou Li

“…This study constructs the skeletal muscle transcriptome of obese pigs and integrates it with publicly available transcriptional profiles from obese humans and mice, and ATAC-seq data from lean individuals across species. …”
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TET3 is a positive regulator of mitochondrial respiration in Neuro2A cells. by Valeria Leon Kropf, Caraugh J Albany, Anna Zoccarato, Hannah L H Green, Youwen Yang, Alison C Brewer

“…We report the results of an unbiased transcriptome analysis of the neuroblastoma-derived cell line; Neuro2A, in which Tet3 was silenced. …”
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miR-21 promotes cervical cancer by regulating NTF3 by Yishan Chen, Caiwu Su, Yuke Cai, Lina Ke, Yaxiong Huang

“…Overexpression of NTF3 inhibited cell proliferation and migration, while promoting apoptosis, as demonstrated by flow cytometry. …”
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A novel mechanism explaining the temperature dependence of marine unicellular nitrogen‐fixing cyanobacteria by Lixia Deng, Jiawei Chen, Jonathan P. Zehr, Jiaxing Liu, Xiaodong Zhang, Shunyan Cheung, Hongbin Liu

“…Abstract The major marine nitrogen‐fixing cyanobacterium, Crocosphaera watsonii, is restricted to warm tropical and subtropical oceans, while the underlying mechanisms remain unclear. C. watsonii fixes nitrogen (oxygen‐sensitive) and carbon (oxygen‐evolving) during night and day, respectively. …”
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GROWTH-REGULATING FACTOR 9 negatively regulates arabidopsis leaf growth by controlling ORG3 and restricting cell proliferation in leaf primordia. by Mohammad Amin Omidbakhshfard, Ushio Fujikura, Justyna Jadwiga Olas, Gang-Ping Xue, Salma Balazadeh, Bernd Mueller-Roeber

“…In this study, we focus on the functional characterization of the Arabidopsis thaliana TF GROWTH-REGULATING FACTOR9 (GRF9) and demonstrate that it exerts its negative effect on leaf growth by activating expression of the bZIP TF OBP3-RESPONSIVE GENE 3 (ORG3). While grf9 knockout mutants produce bigger incipient leaf primordia at the shoot apex, rosette leaves and petals than the wild type, the sizes of those organs are reduced in plants overexpressing GRF9 (GRF9ox). …”
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HMGCL activates autophagy in osteosarcoma through β-HB mediated inhibition of the PI3K/AKT/mTOR signaling pathway by Wenda Liu, Kezhou Xia, Xinghan Huang, Zhun Wei, Zicheng Wei, Xingyu Wang, Chen Xiong, Weichun Guo

“…Abstract Background 3-hydroxy-3-methylglutaryl-coenzymOHBe A(HMG-CoA) lyase (HMGCL) catalyzes the cleavage of HMG-CoA into acetyl-CoA and acetoacetic acid and serves as a rate-limiting enzyme in the metabolism of ketone bodies. While HMGCL is involved in various biological processes, its specific role in osteosarcoma remains unclear. …”
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Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis by Le Xu, Jian Xu, Wanting Shi, Sa Zhang, Ting Guo, Shien Zou

“…In vitro, 17β-estradiol (E2) upregulated PRKRA expression, while follicle-stimulating hormone (FSH) downregulated it in HepG2 and HuH7 cells. …”
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Optimizing rabies mRNA vaccine efficacy via RABV-G structural domain screening and heterologous prime-boost immunization by Dongdong Li, Xuan Wang, Gaotian Li, Jingying Zhou, Lijun Bian, Xiaoyan Zhao, Liao Xing, Juanmei Zeng, Jiaxing Cui, Lili Cui, Yong Zhang, Yan Chen

“…Heterologous immunization results revealed that mRNA-primed strategies yielded higher long-lasting VNTs, but lower early VNTs than inactivated rabies virus (IRV)-primed strategies. 2×RABV-Full and IRV > RABV-Full provided 100% protection, while that of RABV-Full>IRV was 90%. Transcriptome analysis showed that rabies mRNA vaccine induced both MHCI and MHCII antigen presentation, as well as B/T cell activation. …”
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A reliable prognostic model for hepatocellular carcinoma using neutrophil extracellular traps and immune related genes by Defeng Yuan, Feng Zhang, Pengfei Lv, Jun Zhu, Haiwei Zhang, Zhengcong Zhang

“…Drug sensitivity analysis identified 74 drugs with differential sensitivity between risk groups; axitinib showed lower sensitivity in high-risk patients, while ABT-888 showed higher sensitivity. RT-qPCR confirmed reduced HMOX1 and FLT3 expression in LIHC tissues, while MMP9 and TNFRSF4 were upregulated. …”
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The toxicity and mechanisms of pyrotinib on male reproductive system by Xiao Hu, Zhongjian Pan, Jie Yang, Peng Zheng, Jian Tan, Zhipeng Xu, Huaming Tang, Jianpeng Hu

“…Clonogenic assays, flow cytometry, Western blotting and transcriptome sequencing were employed. Results: Pyrotinib treatment for 24 hours significantly reduced cell viability and colony formation while increasing apoptosis. …”
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Effects of Tannin Supplementation in Diet on the Resistance to Ammonia Stress of Pacific White Shrimp Litopenaeus vannamei by Xiuhong Zhang, Han Gong, Ping Chen, Jiajia Wang, Zhao Chen, Zhiqiang Chang, Jitao Li

“…In this study, we fed a diet containing 800 mg/kg of tannin on Litopenaeus vannamei for 56 days and then subjected to acute ammonia stress for 48 hr to investigate the effect of dietary tannin on the ammonia stress response of L. vannamei through transcriptomic and metabolomic analysis. The transcriptome analysis indicated that ammonia stress-induced differential expression of 4,185 genes, while tannin-fed shrimp only had 964 differentially expressed genes. …”
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Repression of CADM1 transcription by HPV type 18 is mediated by three-dimensional rearrangement of promoter-enhancer interactions. by Karen Campos-León, Jack Ferguson, Thomas Günther, C David Wood, Steven W Wingett, Selin Pekel, Christy S Varghese, Leanne S Jones, Joanne D Stockton, Csilla Várnai, Michelle J West, Andrew Beggs, Adam Grundhoff, Boris Noyvert, Sally Roberts, Joanna L Parish

“…The virus-induced changes to the host cell's transcriptome are thought to contribute to carcinogenesis. …”
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Cucurbitacin Profile and Metalloid Stress Response in Cucurbita pepo L. Upon Arsenic Exposure by Gerardo Flores‐Iga, Carlos Lopez‐Ortiz, Purushothaman Natarajan, Padma Nimmakayala, Umesh K. Reddy, Nagamani Balagurusamy, Aldo Almeida

“…To comprehend the effects of As on the root system of C. pepo, we assessed phenotype, cucurbitacin content, and transcriptome under low and high As concentrations. We report that at low dosages, cucurbitacins are decreased, while growth is not significantly affected. …”
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Integrative bioinformatics analysis and experimental validation reveals key genes and regulatory mechanisms in the development of gout by Ye Yuan, Zhiqiang Gao, Jianhong Chen, Yuejing Liu, Jingguo Zhou

“…CeRNA network identified KCNQ1OT1 and hsa-mir-98-5p as regulatory elements, while CEBPB, STAT3, RELA, and NFKB1 were key transcription factors. …”
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