A Zeolitic Imidazolate Framework-Based Antimicrobial Peptide Delivery System with Enhanced Anticancer Activity and Low Systemic Toxicity by Jingwen Jiang, Kaderya Kaysar, Yanzhu Pan, Lijie Xia, Jinyao Li

“…Flow cytometry also revealed that CEC@ZIF-8 NPs induced greater apoptosis rates than CEC, while unloaded ZIF-8 had little inherent pro-apoptotic activity. …”
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Microglia in the aged brain develop a hypoactive molecular phenotype after surgery by Zhuoran Yin, Anna K. Leonard, Carl M. Porto, Zhongcong Xie, Sebastian Silveira, Deborah J. Culley, Oleg Butovsky, Gregory Crosby

“…We investigated the impact of surgery on the microglial transcriptome to test the hypothesis that surgery produces an age-dependent pro-inflammatory phenotype in these cells. …”
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Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration by Ya-Jun Gong, Zhi-Lin Zou, Kai-Rui Qiu, Qiang Wang, Xiao-Lai Zhou

“…Furthermore, METTL3 and NSUN6 were found to have a protective effect, while MRM1 was associated with an increased risk of AMD. …”
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The E3 ubiquitin ligase RNF6 facilitates the progression of cervical cancer by inhibiting the Hippo/Yap pathway by Yawen Liu, Juanjuan Zhou, Weiqi Liu, Yi Le, Lingling Zhang, Ziyu Zhang, Ling Zhou, Ling Li

“…Cellular functional experiments demonstrate that RNF6 promotes the proliferation, invasion, and migration of CC cells, while knockdown of RNF6 yields the opposite effect. …”
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Preliminary Analysis of the Salt-Tolerance Mechanisms of Different Varieties of Dandelion (<i>Taraxacum mongolicum</i> Hand.-Mazz.) Under Salt Stress by Wei Feng, Ran Meng, Yue Chen, Zhaojia Li, Xuelin Lu, Xiuping Wang, Zhe Wu

“…Here, we compared the transcriptome and metabolome responses of 0.7% NaCl-stressed dandelion ‘BINPU2’ (variety A) and ‘TANGHAI’ (variety B). …”
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Effect of Spinetoram Stress on Midgut Detoxification Enzyme and Gene Expression of <i>Apis cerana cerana</i> Fabricius by Lin Chen, Tianjun He, Linglong Ding, Xinyan Lan, Jiahao Sun, Xiaoheng Xu, Huafen Wu, Dayun Zhou, Zhichu Huang, Tianxing Zhou, Xiaoling Su, Limin Chen

“…Transcriptome analysis revealed 32 differentially expressed genes (DEGs) that were common to both the LC₂₀ vs. control (CK) and LC₅₀ vs. …”
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Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microglia by Chenyang Wang, Xiaolu Bu, Mengyao Cao, Yunyu Lian, Haocong Ling, Mo You, Junfei Yi, Xiaoya Gao, Duobin Wu, Yang Li

“…In LPS treated BV2 cells, miR-199a-3p mimics promoted M1 polarization, while inhibitors reversed this effect. Transcriptome analysis revealed that miR-199a-3p downregulated WDR76, subsequently suppressing cell cycle-associated pathways, IL-17 signaling, and FOXO pathways, resulting in an increase in the proportion of M1 type microglia. …”
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Genome of the invasive North American Haemaphysalis longicornis tick as a template for bovine anti-tick vaccine discovery by Mohamed Abdallah Mohamed Moustafa, Miranda M. Barnes, Nicole E. Wagner, Deanna Bodine, Kylie Bendele, Pete D. Teel, Perot Saelao, Dana C. Price

“…To further such research, here we sequence and assemble a high-quality H. longicornis genome and robust gene catalog from invasive North American ticks while also providing an organ-specific transcriptomic expression catalog and in-depth informatic screening of the tick proteome for potential bovine antigenic molecules with potential utility as vaccine candidates. …”
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Damage effect of combined noise and CO exposure on spermatogenesis in male rats by GUO Lulu, ZHANG Zhonghao, LIU Chang

“…Conclusion‍　‍Noise and CO exposure induce spermatogenic damage in rats, which may be related with energy metabolism and hormonal regulation, while PTE demonstrates significant protective effects against such reproductive impairments. …”
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LRRFIP1 enhances the Wnt/β-catenin pathway by binding to DVLs in myelodysplastic syndrome by Xiaoli Zhao, Yutian Lei, Han Zhu, Wenyi Shen, Sixuan Qian, Jianyong Li, Yu Zhu

“…Results In MDS cell lines, proliferation was notably higher in LRRFIP1-overexpressing cells compared to silenced ones, while cell apoptosis was lower in the former. mRNA transcriptome sequencing revealed LRRFIP1's involvement in modulating the Wnt/β-catenin signaling pathway. …”
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Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis by Qiuting Deng, Pengfei Cai, Yingjie Luo, Zhongjin Zhang, Wen Ma, Zijie Huang, Xiaoya Chen, Shijie Hao, Weiguang Ma, Jiangshan Xu, Chunqing Wang, Mengnan Cheng, Xiumei Lin, Ru Zhou, Shanshan Duan, Junjie Chen, Ronghai Li, Xuyang Shi, Chang Liu, Liang Wu, Peng Gao, Jianting Li, Xiao Yang, Xiangdong Wang, Jun Xie, Longqi Liu, Yue Yuan, Chuanyu Liu

“…Here, we present high-throughput single-cell chromatin accessibility and transcriptome sequencing (HT-scCAT-seq), a method that simultaneously profiles transcriptome and chromatin accessibility. …”
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Effects of sun shading on anthocyanin components and the expression of genes related to anthocyanin synthesis in Marselan grape by FU Dongyan, WANG Lei, ZHANG Longsheng

“…During the complete veraison stage and shading during the harvesting stage, the expression levels of PAL, CHS3, F3’H, F3’5’H, UFGT, GST4 and MYB90 genes were upregulated compared to other treatments during the harvesting stage. qRT-PCR analysis revealed that among the 15 screened genes, the expression levels of CHI, F3H, F3’5’H, F3’H, DFR, LDOX, UFGT and OMT showed inconsistent trends with transcriptome sequencing in each treatment, while the changes in other genes were consistent with transcriptome sequencing results. …”
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Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak by Xue-Mei Chen, Ming-Xiu Wang, Peng Zhang, Ke-Min Jing, Bing-Lin Yue, Zhi-Juan Wu, Zhi-Xin Chai, Xin-Rui Liu, Jin-Cheng Zhong, Xin Cai

“…Abstract Background To study the problem of male sterility of cattle-yak and improve the yak crossbreeding, this study obtained the testicular Sertoli cells of yak and cattle-yak and compared the differences in transcriptome levels between the two bovine species. …”
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Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage‐specific XBP1 regulation of the unfolded protein response by Niño Posadas, Cecilia Conaco

“…Abstract Marine sponges are predicted to be winners in the future ocean due to their exemplary adaptive capacity. However, while many sponge groups exhibit tolerance to a wide range of environmental insults, calcifying sponges may be more susceptible to thermo‐acidic stress. …”
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Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish by Michiel van der Vaart, Herman P. Spaink, Annemarie H. Meijer

“…Furthermore, we use transcriptome analysis of zebrafish infected with E. tarda, S. typhimurium, and M. marinum to visualize the gene expression profiles resulting from these infections. …”
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Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects by Yihe Yang, Noah Lorincz-Comi, Xiaofeng Zhu

“…Abstract Transcriptome-wide association studies (TWAS) are commonly used to prioritize causal genes underlying associations found in genome-wide association studies (GWAS) and have been extended to identify causal genes through multivariate TWAS methods. …”
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Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development. by Judith Habicher, Gaurav K Varshney, Laura Waldmann, Daniel Snitting, Amin Allalou, Hanqing Zhang, Abdurrahman Ghanem, Caroline Öhman Mägi, Tabea Dierker, Lena Kjellén, Shawn M Burgess, Johan Ledin

“…However, csgalnact1a-/- fish develop distinct craniofacial defects while the chsy1-/- skeletal phenotype is milder and the remaining mutants display no gross morphological abnormalities. …”
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Acanthamoeba castellanii as a model for unveiling Campylobacter jejuni host–pathogen dynamics by Fauzy Nasher, Burhan Lehri, Richard A. Stabler, Brendan W. Wren

“…We analyzed the whole transcriptome of A. castellanii infected with C. jejuni 11168H. …”
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ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. by Seungjae Lee, Lu Wei, Binglong Zhang, Raeann Goering, Sonali Majumdar, Jiayu Wen, J Matthew Taliaferro, Eric C Lai

“…Nevertheless, little was known about its impacts on the transcriptome, and potential functional overlap with its paralogs. …”
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Large-scale CRISPRi screens link metabolic stress to glioblastoma chemoresistance by Xing Li, Wansong Zhang, Yitong Fang, Tianhu Sun, Jian Chen, Ruilin Tian

“…Abstract Background Glioblastoma (GBM) patients frequently develop resistance to temozolomide (TMZ), the standard chemotherapy. While targeting cancer metabolism shows promise, the relationship between metabolic perturbation and drug resistance remains poorly understood. …”
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