Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution by Tianyuan Zhao, Qing Zhong, Zewen Sun, Xiaoyi Yu, Tianmeng Sun, Zhengwen An

“…Abstract Background Single-cell transcriptomics has revolutionized tooth biology by uncovering previously unexplored areas. …”
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Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular Senescence by Barbora Belakova, José Basílio, Manuel Campos-Medina, Anna F. P. Sommer, Adrianna Gielecińska, Ulrike Resch, Johannes A. Schmid

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Host cellular transcriptional response to respiratory syncytial virus infection in HEp-2 cells: insights from cDNA microarray and quantitative PCR analyses by Manoj K. Pastey, Christopher Lupfer

“…Anti-apoptotic MCL1 increased ~11-fold, while pro-apoptotic caspase-4 showed a more modest 1.6-fold rise, indicating a complex regulation of cell death pathways. …”
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Transcriptional regulation of hormone signalling genes in black pepper in response to Phytophthora capsici by Chidambareswaren Mahadevan, K. Mohamed Shafi, B Nagarathnam, Manjula Sakuntala, Ramanathan Sowdhamini

“…This study employs RNA sequencing and transcriptome analysis to explore the defense mechanisms of P. nigrum against P. capsici. …”
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Multi-omics profiling reveals elevated CO2-enhanced tolerance of Trifolium repens L. to lead stress through environment-plant-microbiome interactions by Lei Wang, Sui Wang, Haifeng Su, Hongguang Cai, Yankun Song, Xiang Gong, Zhihui Sun, Jianhua Qu, Ying Zhang

“…These insights shed light on the plant stress responses under elevated CO2 and while contributing to a broader comprehension of plant-environment interactions.…”
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Predicting cellular responses to complex perturbations in high‐throughput screens by Mohammad Lotfollahi, Anna Klimovskaia Susmelj, Carlo De Donno, Leon Hetzel, Yuge Ji, Ignacio L Ibarra, Sanjay R Srivatsan, Mohsen Naghipourfar, Riza M Daza, Beth Martin, Jay Shendure, Jose L McFaline‐Figueroa, Pierre Boyeau, F Alexander Wolf, Nafissa Yakubova, Stephan Günnemann, Cole Trapnell, David Lopez‐Paz, Fabian J Theis

“…Abstract Recent advances in multiplexed single‐cell transcriptomics experiments facilitate the high‐throughput study of drug and genetic perturbations. …”
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Integrative Identification of Chloroplast Metabolism-Related RETICULATA-RELATED Genes in Soybean by Qianli Dong, Lu Niu, Xiyu Gong, Qianlong Xing, Jie Liang, Jun Lang, Tianya Wang, Xiangdong Yang

“…RNA secondary structures spanning the coding sequences (CDSs), the 5′- and 3′- untranslated regions (UTRs) of <i>GmRERs</i>, displayed exceptional structural plasticity in CDSs, while exhibiting limited conservation in UTRs. In contrast, protein structures retained conserved folds, underscoring evolutionary constraints on functional domains despite transcriptional plasticity. …”
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CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy by Pengchao Zhang, Xuejia Feng, Xiangyun Niu, Zhongming Liu, Minghui Li, Maoxuan Liu, Dehong Yan, Guizhong Zhang, Xiaochun Wan

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Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway by Shengnan Shi, Jiaming Gao, Yehao Zhang, Min Zhan, Zhanfei Tan, Peili Wang, Jianhua Fu, Jianxun Liu

“…BackgroundWhile platelet hyperreactivity constitutes an independent risk factor for major adverse cardiovascular events (MACEs) in coronary artery disease, its molecular underpinnings remain poorly characterized. …”
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Identification and comparative analysis of genes in response to cold stress between two mainly cultivated tetraploid cottons by QI Bowen, GUO Menglan, LU Hejun, MEI Huan, ZHAO Ting, FANG Lei

“…During the whole cold stress treatment, TM-1 had 11 up-regulated genes, while Hai7124 had 10 down-regulated genes. The real time quantitative reverse polymerase chain reaction (RT-qPCR) was used to verify expression levels of five response genes. …”
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Mitigating Cd stress in alfalfa: the role of melatonin and nano-calcium oxide in enhancing photosynthesis and antioxidant defense by Maqsood Ul Hussan, Umer Mahmood, Saeedeh Zarbakhsh, Sadam Hussain, Muhammad Bilal Hafeez, Noreen Zahra, Munib Ahmed, Quanzhen Wang, Mingke Yan

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Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers by Maria Teresa De Angelis, Antonia Rizzuto, Angela Amaddeo, Carlo Sagnelli, Niccolò Vono, Michela Reda, Valentina Lise, Luca Parrillo, Carmela De Marco, Donatella Malanga, Gianluca Santamaria, Giuseppe Viglietto

“…Results Chromosomal analyses revealed that 43% of focal and 77% of large-scale CNAs were specific of CC, while 10.5% and 57% were specific of RC with 8% of mutant genes unique to CC and 0.18% to RC. …”
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Single-dose VSV-based vaccine protects cynomolgus macaques from disease after Taï Forest virus infection by Paige Fletcher, Kyle L. O’Donnell, Brianna M. Doratt, Delphine C. Malherbe, Chad S. Clancy, Joseph F. Rhoderick, Friederike Feldmann, Patrick W. Hanley, Thomas G. Ksiazek, Thomas W. Geisbert, Ilhem Messaoudi, Andrea Marzi

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Membrane transporter genes predict chemoradiotherapy response in patients with cervical cancer by Natália Gregório Custódio, Fábio Ribeiro Queiroz, Angelo Borges de Melo Neto, Brenda Martins Cavalcante, Laurence Rodrigues do Amaral, Telma Maria Rossi de Figueiredo Franco, Matheus de Souza Gomes, Vasco Ariston de Carvalho Azevedo, Letícia da Conceição Braga, Paulo Guilherme de Oliveira Salles, Wander de Jesus Jeremias

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Advancing precision antibody-drug conjugate therapy: unique proteogenomic profiles of tumor subsets in non-small cell lung cancer by Edwin Lin, Ying-Chun Lo, Vivek Subbiah, Rajat Thawani, Aakash Desai

“…This study utilized transcriptomics and proteomics to characterize NSCLC subtypes with distinct ADC target expression profiles. …”
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PerturbNet predicts single-cell responses to unseen chemical and genetic perturbations by Hengshi Yu, Weizhou Qian, Yuxuan Song, Joshua D Welch

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Organizational Principles of the Primate Cerebral Cortex at the Single‐Cell Level by Renrui Chen, Pengxing Nie, Liangxiao Ma, Guang‐Zhong Wang

“…Typically, excitatory neuron clusters mainly consist of excitatory‐excitatory combinations, while inhibitory clusters primarily contain excitatory‐inhibitory combinations. …”
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Untargeted metabolomics-based study of extracts from Simarouba glauca plant parts for insecticidal effects against Spodoptera frugiperda by Komala G, Shanthi Mookiah, Murugan Marimuthu, Sujayanand G. K, Vellaikumar Sampathrajan, Preetha Gnanadhas, Kavitha Govindasamy, Prakash Kolanchi

“…Bioactive compounds were extracted from different plant parts using various solvents, with seeds yielding the highest recovery in n-hexane, while the bark extracted with ethyl acetate exhibited the lowest median lethal concentration (LC₅₀) of 4.80%. …”
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The Dysregulation of Tuning Receptors and Transcription Factors in the Antennae of <i>Orco</i> and <i>Ir8a</i> Mutants in <i>Aedes aegypti</i> Suggests a Chemoreceptor Regulatory M... by Matthew M. Cooke, Michael S. Chembars, Ronald Jason Pitts

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Fenaminosulf Promotes Growth and Gall Formation in <i>Zizania latifolia</i> Through Modulation of Physiological and Molecular Pathways by Chaohong Ding, Ruifang Ma, Liqiu Wang, Xinyan Lan, Limin Chen, Jinxing Zhu, Lailiang Wang

“…Physiological measurements showed that a moderate FM concentration (1.25 g/L) promoted key vegetative growth parameters, including plant height and leaf length, while maintaining chlorophyll content, suggesting a potential bio-stimulant effect. …”
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