Integrated mRNA and miRNA Analysis Reveals Layer-Specific Mechanisms of Antler Yield Variation in Sika Deer by Derui Zhao, Zhen Zhang, Qianghui Wang, Heping Li

“…In particular, genes such as <i>FBP2</i>, <i>TPT1</i>, <i>TFRC</i>, <i>ZEB1</i>, and <i>PHOSPHO1</i> were upregulated in high-yield deer across specific tissue layers, while <i>NFATC2</i> was downregulated in these high-yield deer. …”
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Differential regulation of apoptosis-related genes during long-term culture and differentiation of canine adipose-derived stem cells - a functional bioinformatical analysis by Maurycy Jankowski, Maurycy Jankowski, Maurycy Jankowski, Katarzyna Stefańska, Michał Suchodolski, Claudia Dompe, Claudia Dompe, Grzegorz Wąsiatycz, Bartosz Kempisty, Bartosz Kempisty, Bartosz Kempisty, Bartosz Kempisty, Michał Nowicki, Magdalena Roszak

“…RNA sequencing (RNA-seq) and bioinformatical analysis were performed to obtain comprehensive transcriptomic data. A total of 17793 genes were detected and GO enrichment analysis was performed on the differentially expressed genes to identify significantly up- and downregulated Biological Process (BP) GO terms across each comparison.ResultsThe upregulation of apoptosis-regulating genes and genes related to circulatory system development suggest an induction of these processes, while the downregulation of neurogenesis and gliogenesis genes points to reciprocal regulation during osteogenic differentiation of canine ADSCs.DiscussionThese findings underscore the potential of ADSCs in bone regeneration and offer valuable insights for advancing tissue engineering, however further studies, including proteomic analyses, are needed to confirm these patterns and their biological significance.…”
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Molecular profiling of bladder cancer xenografts defines relevant molecular subtypes and provides a resource for biomarker discovery. by Sharada Mokkapati, Ganiraju Manyam, Alexis R. Steinmetz, Côme Tholomier, Alberto Martini, Woonyoung Choi, Bogdon Czerniak, Byron H Lee, Colin P Dinney, David J McConkey

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A CC‐NB‐ARC‐LRR Gene Regulates Bract Morphology in Cotton by Sunyi Yan, Zhanfeng Si, Guoan Qi, Yihao Zang, Lisha Xuan, Lu He, Yiwen Cao, Xiaoran Li, Tianzhen Zhang, Yan Hu

“…They serve multiple functions such as attracting pollinators, aiding tolerance of abiotic stressors, and conducting photosynthesis. While previous studies extensively examine bract function, the molecular mechanisms underlying bract growth remain unknown. …”
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Effects of β-1,3-glucan feed supplementation on the growth, liver biochemistry, transcript levels and intestinal microorganisms of swamp eel (Monopterus albus) by Mengyu Bao, Wenzong Zhou, Tian Zhu, Weiwei Huang, Quan Yuan, Hang Yang, Yuning Zhang, Weiwei Lv, Qichen Jiang

“…Monopterus albus were reared for 56 days, the final body weight, weight gain rate, survival rate, and specific growth rate were significantly increased, while the feed conversion rate was reduced considerably, in EG-2, EG-3, and EG-4 compared with the CT (P < 0.05). …”
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Transcriptional profiles of Microcystis reveal gene expression shifts that promote bloom persistence in in situ mesocosms by Lauren E. Krausfeldt, Paisley S. Samuel, Robert P. Smith, Hidetoshi Urakawa, Barry H. Rosen, Rita R. Colwell, Jose V. Lopez

“…Overall, our results show the stepwise transcriptional response of a Microcystis bloom to the introduction of nutrients, specifically urea, as it is sustained in a natural setting. The transcriptomic shifts observed herein may serve as markers of the longevity of blooms while providing insight into why Microcystis blooms over other cyanobacteria.IMPORTANCEHarmful algal blooms represent a threat to human health and ecosystems. …”
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Identification of functional pathways and hub genes associated with the heterochronic development of sugarcane axillary buds and sett roots through multi-omics analysis by Jiabao Zheng, Xiaoyu Huang, Yanli Wei, Wenyan Li, Baoshan Chen, Baoshan Chen, Wenlan Li, Wenlan Li

“…In addition, we identified differentially expressed genes through transcriptomic analysis and discovered, via GO and KEGG enrichment analyses, that negative regulation of external stimulus response is a key to the preference of ZZ2 for early bud sprouting. …”
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High soybean dietary supplementation with quercetin improves antioxidant capacity of spotted sea bass Lateolabrax maculatus by Longhui Liu, Yanbo Zhao, Zhangfan Huang, Zhongying Long, Huihui Qin, Hao Lin, Sishun Zhou, Lumin Kong, Jianrong Ma, Yi Lin, Zhongbao Li

“…This was evidenced by the notable rise in glutathione (GSH) levels in the intestine and liver, as well as the elevated levels of catalase (CAT) and total antioxidant capacity (T-AOC) in the liver. Furthermore, transcriptome results showed that the S-transferase (GST) gene in the glutathione metabolism pathway was significantly down-regulated by high soybean meal, while with the addition of QUE, noteworthy alterations in genes associated with the PI3K-Akt signaling pathway, Foxo signaling pathway, and AMPK signaling pathway. …”
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Metabolic, transcriptional, and hormonal responses of Panax ginseng C. A. Meyer to nitrogen deficiency by Hao Liang, Hai Sun, Cai Shao, Bochen Lv, Jiapeng Zhu, Weiyu Cao, Jixin Zhou, Yayu Zhang

“…Furthermore, genes associated with IAA and CTK signaling pathways were downregulated, while genes related to GA and JA signaling were upregulated. …”
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Global changes in gene expression of mRNA and miRNA in liver tissues of Micropterus salmoides after infection with Aeromonas hydrophila by Zhi Lei Yao, Ming Yu, Xiao Wang, Hong Ju Chen, Xiang Shan Ji, Yan Zhao

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Effects of dietary protein levels on genes related to subcutaneous fat deposition and lipid metabolism in Tibetan sheep by Xianhua Zhang, Zhenling Wu, Jiacheng Gan, Rengeerli Sa, Wei Gao, Yu Zhang, Shengzhen Hou, Linsheng Gui

“…Correlation analysis showed that NR4A1, FOS, JUN, and JUNB positively correlated with catalase (CAT) activity, while FOS, JUN, and JUNB were linked to fatty acid metabolism and adipocyte development. …”
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Gene expression analysis of primary graft dysfunction in adult heart transplant recipients: A cohort study by Samuel Padovani Steffen, MD, Alvaro Monteiro Perazzo, MD, MSc, Shirlyne Fabianni Dias Gaspar, MD, Ronaldo Honorato Barros Santos, MD, Domingos Dias Lourenço Filho, MD, PhD, Alexandre da Costa Pereira, MD, PhD, Luis Fernando B. da Costa Seguro, MD, PhD, Fabiana G. Marcondes-Braga, MD, PhD, Fernando Bacal, MD, PhD, Jose Eduardo Krieger, MD, PhD, Fabio Antonio Gaiotto, MD, PhD, Fabio Biscegli Jatene, MD, PhD

“…Background: Cardiac transplantation remains the primary treatment for advanced heart failure, with primary graft dysfunction (PGD) being the leading cause of early mortality. While PGD’s exact pathogenesis is unclear, ischemia/reperfusion injury is a key factor. …”
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Phytotoxic Effects of Bisphenol A on Growth and Physiology of <i>Capsicum annuum</i> L. by Zilin Zhang, Rong Lu, Longxue Li, Yishui Chen, Jin Lan, Rongrong Chen, Yong Zhou, Huibin Han

“…The exogenous application of 5 mg/kg of BPA prominently inhibited pepper growth, while 0.5 mg/kg of BPA had no obvious effects on pepper growth. …”
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Bioinformatic Analysis of C1GALT1 in Cancer: Insights Into Prognosis, Metastasis and Therapeutic Potential by Ecem Kalemoglu, Ayse Caner

“…Gene expression, DNA methylation, and survival analyses were performed, along with correlation analyses between C1GALT1 and proliferation‐ or metastasis‐related genes, Cosmc expression, and immune cell infiltration (specifically, regulatory T‐cells [Tregs] and myeloid‐derived suppressor cells [MDSCs]), using transcriptomic web platforms. Results C1GALT1 expression was significantly upregulated in gastrointestinal and genitourinary cancers compared to normal tissues, while downregulated in thyroid, breast, and prostate cancers. …”
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Synchronous bacterial barrier and exudate absorption: A novel dual-function dressing strategy for pin-site infection prevention by Bing Liang, Sha Zhou, Linyuan Xue, Qizun Wang, Qianqian Li, Zihan Zheng, Xinyue Ma, Jiyixuan Li, Li Sun, Kunyue Xing, Xiaobo Wen, Xiaolin Wu, Miao Zhang, Dongming Xing

“…This study introduces PINSHIELD, a dual-functional dressing that externally seals wounds while efficiently managing exudate to mitigate pin-site infections (PSI). …”
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Multi-omics profiling reveals distinct pathogenic mechanisms in Hunner and non-Hunner interstitial cystitis subtypes by Lin Zhu, Hanwei Ke, Qi Wang, Kexin Xu, Xiaofang Chen

“…Genomic, metabolomic, and transcriptomic data were obtained using high-throughput sequencing techniques. …”
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Electron-beam FLASH whole brain irradiation induced a unique changes of intestinal flora by Feifei Gao, Wei Cheng, Yanxi Ma, Boyi Yu, Xinle Lang, Xiaodong Jin, Jianxin Wang, Xianhong Liu, Cuixia Di, Hui Wang, Fei Ye, Ting Zhao, Weiqiang Chen, Qiang Li

“…The up-regulated microbiota after eFLASH irradiation was significantly positively correlated with genes related to neuronal development and regeneration, while significantly negatively correlated with genes related to inhibitory synapses. …”
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Multiomics-based analysis of the mechanism of ammonia reduction in Sphingomonas by Wang Mingcheng, Wang Mingcheng, Wang Mingcheng, Wang Mingcheng, Liu Daoqi, Xia Huili, Wang Gailing, Liu Chaoying, Guo Yanan, Guo Aizhen, Guo Aizhen, Guo Aizhen

“…To explore the mechanisms of ammonia reduction by Sphingomonas sp. Z392, the transcriptome and metabolome analysis of Sphingomonas sp. …”
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Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines by Alexandra Razumovskaya, Mariia Silkina, Mariia Silkina, Mariia Silkina, Andrey Poloznikov, Timur Kulagin, Maria Raigorodskaya, Nina Gorban, Anna Kudryavtseva, Maria Fedorova, Boris Alekseev, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky, Sergey Nikulin, Sergey Nikulin, Sergey Nikulin

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Rapid reprogramming and stabilization of homoeolog expression bias in hexaploid wheat biparental populations by Marek Glombik, Ramesh Arunkumar, Samuel Burrows, Sophie Louise Mogg, Xiaoming Wang, Philippa Borrill

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