Integrated analysis of single-cell, spatial and bulk RNA-sequencing identifies a cell-death signature for predicting the outcomes of head and neck cancer by Yue Pan, Lei Fei, Shihua Wang, Hua Chen, Changqing Jiang, Hong Li, Changsong Wang, Yao Yang, Qinggao Zhang, Yongwen Chen

“…Finally, samples from laryngeal squamous cell cancer (LSCC) were conducted by spatial transcriptomics (ST) to further validate the results of CDRscore model.ResultsT cells from HNC patients manifested the highest levels of cell death while HPV infection attenuates malignant cell death based on single-cell atlas. …”
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Therapeutic effects and mechanism analysis of Paeonia lactiflora extract (PLE) in menopausal rats with hot flashes by Weilin Cui, Tingting Song, Dongmei Gao, Xiaoyu Wang, Ya Sun, Liyu Fu, Yichao Han, Jieqiong Wang

“…In terms of pathological manifestations, the model rats had significantly thinner endometrial thickness, looser tissues and reduced integrity, while the rats intervened by PLE treatment had significantly thicker endometrium and more regularly arranged tissue structure. …”
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Exploring transcriptomic databases to identify and experimentally validate tissue-specific consensus reference gene for gene expression normalization in BALB/c mice acutely exposed... by Nour Hammoudeh, Reem Hasan, Mohammad Deeb, Zuher Radwan, Omar Ayoubi, Roaa Alendary, Mouayad Youssef, Abdulfattah Kazan, Rasil Alsahli, Walaa Faiad, Nour Aldeli, Abdulsamie Hanano

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Gene Expression Comparison Between the Injured Tubercule Skin of Turbot (<i>Scophthalmus maximus</i>) and the Scale Skin of Brill (<i>Scophthalmus rhombus</i>) by João Estêvão, Andrés Blanco-Hortas, Juan A. Rubiolo, Óscar Aramburu, Carlos Fernández, Antonio Gómez-Tato, Deborah M. Power, Paulino Martínez

“…Functional annotation of skin transcriptomes was similar in both species, but in turbot, it was enriched on mechanisms related to maintenance of epithelial structure, mannosidase activity, phospholipid binding, and cell membranes, while in brill, it was enriched on biological and gene regulation mechanisms, tissue development, and transferase and catalytic activities. …”
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Effects of combined hypoxia and irradiation on mouse bone marrow hematopoietic cells by YANG Xinhai, CHEN Fang, QUAN Yong

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Genomic Features of <i>Taiwanofungus gaoligongensis</i> and the Transcriptional Regulation of Secondary Metabolite Biosynthesis by Yadong Zhang, Yi Wang, Xiaolong Yuan, Hongling Zhang, Yuan Zheng

“…The <i>TgPKS1</i> gene is hypothesized to be involved in the biosynthesis of orsellinic acid or its derivatives, while <i>TgPKS2</i> might catalyze the synthesis of 6-methylsalicylic acid (6MSA) and its derivatives. …”
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The molecular mechanism and utilization of ZmMs7-mediated dominant nuclear sterility in Oryza sativa L by Yusheng Xu, Yusheng Xu, Dingyang Yuan, Meijuan Duan

“…In the hybrid offspring, approximately 50% of the seeds are genetically modified fluorescent seeds, while the remaining seeds are non-genetically modified and non-fluorescent. …”
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Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

“…Increased expression was observed with higher tumor stages, especially in renal and skin cancer, while applying therapeutic modalities targeting these genes dampened this effect in breast, prostate and skin cancer. …”
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Adaptation to Nighttime Light via Gene Expression Regulation in Drosophila suzukii by Natsumi Takenaka, Yuma Takahashi

“…ALAN elevated overall activity, especially in the early night, while urban females displayed reduced sensitivity regarding activity and sleep. …”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

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Impact of Arsenic Stress on the Antioxidant System and Photosystem of <i>Arthrospira platensis</i> by Jiawei Liu, Jie Du, Di Wu, Xiang Ji, Xiujuan Zhao

“…The algae mitigated arsenic-induced oxidative stress by increasing cellular metabolic rates, enhancing cell wall stability, and reducing membrane lipid peroxidation. Transcriptome analysis revealed that pathways related to oxidative phosphorylation and chlorophyll degradation were upregulated under arsenic stress, while the expression of membrane transporters was significantly downregulated. …”
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Immunization induces inflammation in the mouse heart during spaceflight by Alicia L. Veliz, Lorelei Hughes, Delia Carrillo, Michael J. Pecaut, Mary Kearns-Jonker

“…In this study, the cardiovascular response to immunization in space was studied in mice which were housed and immunized while on the International Space Station (ISS). Mice were immunized with tetanus toxoid combined with the adjuvant CpG (TT + CpG) and the effects of vaccination in space were studied using transcriptomics. …”
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Genome-wide analysis of the CML gene family and its response to cold stress in Curcuma alismatifolia by D. Ying, R. Jintong, W. Yang, F. Zuhong, T. Tian, Z. Hong

“…Most homologous gene pairs were subjected to strong purifying selection during evolution, while CACML86 underwent positive selection in both C. alismatifolia and A. viiosum. …”
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Current state and future prospects of spatial biology in colorectal cancer by Francisco G. Carranza, Fernando C. Diaz, Maria Ninova, Enrique Velazquez-Villarreal, Enrique Velazquez-Villarreal

“…Spatial transcriptomics enables high-resolution mapping of the whole transcriptome. …”
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CPN2 alleviates cryptorchidism by inhibiting the NF-κB pathway and regulating immune responses by Lei Wang, Lu Lu, Xia Guo, Feng Shao, Hai-Jun Ma, Yun Zhou

“…Cryptorchidism, a common male reproductive disorder characterized by undescended testes, is associated with infertility and increased cancer risk. While its etiology remains incompletely understood, accumulating evidence suggests that immune-inflammatory responses contribute to disease progression. …”
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Matrine Attenuates <i>Streptococcus agalactiae</i> Virulence by Suppressing Capsular Polysaccharide Synthesis and Host Adhesion Pathways by Shijiao Guo, Kaiming Wang, Hua Zhang, Chaochao Luo, Zixuan Zhao, Jinjin Tong

“…<i>Streptococcus agalactiae</i> (GBS) is a major pathogen causing mastitis in dairy cows while causing oxidative stress. Matrine is an alkaloid compound extracted from the roots of <i>Sophora flavescens</i>, a plant used in traditional Chinese medicine. …”
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Analysis of the Differences Among <i>Camellia oleifera</i> Grafting Combinations in Its Healing Process by Zhilong He, Ying Zhang, Chengfeng Xun, Zhen Zhang, Yushen Ma, Xin Wei, Zhentao Wan, Rui Wang

“…The results demonstrated that Comb. 4 (Xianglin 27 rootstock) exhibited superior compatibility, characterized by systemic antioxidant activation (peaking at 4–8 DPG), rapid auxin accumulation (4 DPG), and efficient sugar allocation. Transcriptome sequencing and WGCNA analysis identified 3781 differentially expressed genes, with notable enrichment in stress response pathways (Hsp70, DnaJ) and auxin biosynthesis (YUCCA), while also revealing key hub genes (FKBP19) associated with graft-healing efficiency. …”
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Insights of Phaseolus vulgaris’ response to infection by Uromyces appendiculatus using an RNA-seq approach by Penny Makhumbila, Molemi Rauwane, Hangwani Muedi, Sandiswa Figlan

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Integration of bioaccumulations, chemical forms and gene expression responses to understand the transformation and detoxification of inorganic arsenic, cadmium and lead in the brow... by Yanfang Zhao, Yingying Guo, Jifa Wu, Xuming Kang, Xiaofeng Sheng, Zhijun Tan

“…Chemical speciation analysis indicated that S. fusiforme primarily detoxified Cd through organic ligand binding, while Pb was predominantly immobilized as insoluble compounds. …”
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Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues by Basak Eraslan, Dongxue Wang, Mirjana Gusic, Holger Prokisch, Björn M Hallström, Mathias Uhlén, Anna Asplund, Frederik Pontén, Thomas Wieland, Thomas Hopf, Hannes Hahne, Bernhard Kuster, Julien Gagneur

“…While PTR ratios span more than 2 orders of magnitude, our integrative model predicts PTR ratios at a median precision of 3.2‐fold. …”
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