Reference genome provide insights into sex determination of silver aworana (Osteoglossum bicirrhosum) by Yi Liu, Chao Bian, Ka Yan Ma, Yexin Yang, Yuanyuan Wang, Chao Liu, Guochang Ouyang, Meng Xu, Jinhui Sun, Changwei Shao, Jiehu Chen, Qiong Shi, Xidong Mu

“…Abstract Background Silver arowana (Osteoglossum bicirrhosum) is a basal fish species with sexual monomorphism, while its sex determination mechanism has been poorly understood, posing a significant challenge to its captive breeding efforts. …”
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Torreya grandis nut peptides regulate lipid-II inhibitors in high-fat diet-fed mice by Rabia Durrani, Sun Yutian, Hou Bowen, Hammad Ullah, Erwann Durand, Yang Meiyun, Long Yiyang, André Delavault, Muhammad Yasir, Huan Weiwei, Gao Fei, Song Lili

“…T. grandis supplementation in HFD mice reduced body weight, TC, TG, LDL, and decreased inflammation, while reducing oxidative stress and increasing HDL in the model group fed a high-fat diet. …”
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Enterobacterales use capsules, transporters, mobile genetic elements, and other evolutionary adaptations to survive antibiotics exposure in the absence of resistance genes by Masego Mmatli, Nontombi Marylucy Mbelle, Bernard Fourie, John Osei Sekyere

“…Phenotypic assays were used to evaluate the effects of various inhibitors on antibiotic susceptibility, while bioinformatic pipelines were used to characterize resistance determinants, virulence factors, and mobile genetic elements (MGEs).Results Phylogenetic analysis revealed widespread carriage of diverse resistance genes, particularly on plasmids of K. pneumoniae, while Enterobacter species possessed fewer known ARGs. …”
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Disease-resistant watermelon variety against Fusarium wilt by remodeling rhizosphere soil microenvironment by Bingye Yang, Caipeng Yue, Chunhui Guo, Mingzi Zheng, Xiefeng Yao, Jinhua Xu, Sijie Huang, Mengmeng Yang

“…Specifically, fungal changes were primarily observed in Ascomycota and Chytridiomycota, while bacterial changes were mainly observed in Cyanobacteria and Gemmatimonadetes. …”
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Characterization of Mucosal Immune-Related lncRNAs and mRNAs in a Mouse Model of Allergic Conjunctivitis by Zhang H, Zhang H, Leng Q, Zheng YJ

“…Transcriptomic analysis revealed significant differences in mRNAs and lncRNAs expression between AC and control groups. …”
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Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella by Ti Lu, Skyler T. Kramer, Mary A. York, Mst Nusrat Zahan, Debaki R. Howlader, Zackary K. Dietz, Sean K. Whittier, Nathan J. Bivens, Alexander Jurkevich, Lyndon M. Coghill, Lyndon M. Coghill, William D. Picking, Wendy L. Picking

“…Our analysis also revealed significant reprogramming of fibroblasts and cardiomyocytes, showing that fibroblasts are shifted from extracellular matrix production to immune modulation, while cardiomyocytes enhanced the signaling for immune cell recruitment and vascular stability. …”
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Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in Pseudomonas aeruginosa clinical isolates by Bartosz J. Bartmanski, Anja Bösch, Steven Schmitt, Niranjan R. Ireddy, Qun Ren, Jacqueline Findlay, Adrian Egli, Maria Zimmermann-Kogadeeva, Baharak Babouee Flury

“…The rate of resistance evolution to CZA was substantially lower (21%, 5/24), while 38% (9/24) acquired cross-resistance to MEM. …”
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Multiomics-based analysis of key genes, metabolites and pathways unveils mechanism associated with social rank in Chickens by Mengqiao Zhao, Limin Xing, Yushan Li, Jiaxin Zhang, Yinghui Liu, Fei Ye, Siyu Chen

“…We found that the pro-inflammatory genes were significantly lower while anti-inflammatory factor in spleen was higher in HSR chickens than in LSR chickens (P<0.05). …”
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Time-dependent cortical responses to siesta disruption in male mice by Jingwei Ding, Shigenobu Shibata, Shigenobu Shibata, Tatsuhiko Kubo, Yu Tahara

“…However, the effects of siesta disruption remain largely unexplored.MethodsIn this study, we disrupted the natural siesta period (ZT20–23) through daily bedding changes for 2 weeks and examined its effects on overall stress levels, sleep architecture, behavior, and transcriptional responses in the frontal cortex.ResultsSiesta disruption during the late dark phase led to increased core body temperature, locomotor activity, and wakefulness, while having minimal effects on subsequent light phase sleep patterns, behavioral performance, or serum stress markers. …”
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Shifts in sex-specific immune gene expression in a beetle with parental care by Nikoletta A. Nagy, José O. Valdebenito, Johanna Lévai-Kiss, Zoltán Rádai, András Kosztolányi, Tamás Székely, Zoltán Barta

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Exploring and analyzing two aging related genes FPR1 and UCHL1 and their potential molecular mechanisms in aggravating lumbar disc herniation by Di Zhao, Bang-xin Sha, Ling-feng Zeng, Gui-hong Liang, He-tao Huang, Jian-ke Pan, Jun Liu, Shuai Zhao

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Assessing the Tolerance of Spotted Longbarbel Catfish as a Candidate Species for Aquaculture to Ammonia Nitrogen Exposure by Song Guo, Linwei Yang, Xiaopeng Xu

“…We demonstrate that ammonia-N stress significantly decreases the survival rate of spotted longbarbel catfish and induces tissue damage, including gill lamella proliferation, hepatocyte blurring, and renal necrosis. Transcriptomic analysis revealed that ammonia-N stress promotes the expression of genes related to endoplasmic reticulum stress, heat-shock proteins, immune response, and apoptosis, while inhibiting antioxidant-related genes and Wnt-related genes. …”
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QS molecules change the planktonic/mineral subpopulations distribution of moderately thermophilic leaching bacteria in pyrite and decrease leaching in chalcopyrite by Beatriz Salas, Beatriz Salas, Sören Bellenberg, Emelie Nilsson, Luna López-Tomasovic, Mark Dopson, Mario Vera, Mario Vera

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Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis by Yanwei Cheng, Haoran Peng, Qiao Chen, Lijun Xu, Lijie Qin

“…This study leverages transcriptomics and machine learning (ML) to identify critical biomarkers and therapeutic targets in sepsis. …”
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Comprehensive multi-omics and biochemical analysis to elucidate the molecular response mechanisms of gill and kidney tissues under acute salinity stress in Pseudobagras ussuriensis by Yu Liu, Libo Gu, Jun Zhao, Mengzhu Liu, Ke Wang, Qingbo Zhou, Yang Cao, Ruyi Hu, Weiwei Wang, Qing Liu

“…This study investigated the molecular adaptation mechanisms of Pseudobagrus ussuriensis exposed to 10 ppt NaCl for 96 h, integrating transcriptomic and metabolomic analyses of gill and kidney tissues. …”
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Topical transdermal administration of lenalidomide nanosuspensions-based hydrogels against melanoma: In vitro and in vivo studies by Mengdi Zhang, Haiying Qiu, Zheyi Han, Yazhong Ma, Jingjing Hou, Jingwei Yuan, Haiyan Jia, Menglu Zhou, Hongjie Lu, Yan Wu

“…Network pharmacology and transcriptomic analyses identified key targets and signaling pathways. …”
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Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy by Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng

“…It is primarily caused by damage to hair cells, degeneration of spiral ganglion neurons, and atrophy of the stria vascularis, which are integral components of the cochlea. While extensive research has been devoted to hair cells and spiral ganglion neurons, this review focuses on the critical role of the stria vascularis in ARHL. …”
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Multi-omics exploration of the factors influencing feather coverage in laying hens by Xin Li, Xiaohui Shen, Xiaoliang Wang, Yao Yan, Wei Liu, Kai Zhan, Daqian He, Changsuo Yang, Huaxiang Yan, Junfeng Yao

“…By integrating multi-omics approaches, we sought to identify key genetic and microbial determinants of feather morphology and their synergistic effects on host physiology.MethodsA retrospective analysis was conducted on 400 laying hens classified into high (H) and low (L) feather coverage groups using a standardized 4-point scoring system. Transcriptomic profiling of cecal tissue was performed via RNA sequencing, while gut microbiota composition was analyzed using 16S rRNA amplicon sequencing. …”
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Multi-omics analysis of Iris sanguinea with distinctive flower colors provides insights into petal coloration by Guiling Liu, Huijun Liu, Gongfa Shi, Nuo Xu, Zhaoqian Niu, Lei Wang, Ruiyang Zhao, Ling Wang, Lijuan Fan

“…In this study, integrative analyses of metabolomics and transcriptomics data were performed on five cultivars of I. sanguinea with varying petal colors to elucidate the molecular basis underlying petal pigmentation. …”
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Research on the Degradation Efficacy and Mechanism of Zearalenone by Tibetan Yeast Meyerozyma caribbica by Zhiliang XU, Yingbo CHEN, Keliang MENG, Chenxiaoye YANG, Dandan JIANG, Disha JIANG, Yulin WANG, Hao HU

“…Experimental treatments included viable cells, heat-killed cells, cell-free supernatant, and intracellular extracts.Samples were collected at 48 h for transcriptomic sequencing to predict degradation-related pathways and genes.…”
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