The regulation of cell homeostasis and antiviral innate immunity by autophagy during classical swine fever virus infection by Xiaowen Li, Yiwan Song, Xinyan Wang, Cheng Fu, Feifan Zhao, Linke Zou, Keke Wu, Wenxian Chen, Zhaoyao Li, Jindai Fan, Yuwan Li, Bingke Li, Sen Zeng, Xiaodi Liu, Mingqiu Zhao, Lin Yi, Jinding Chen, Shuangqi Fan

“…Enhanced autophagy further inhibited CSFV-induced RIG-I-IRF3 signal transduction axis and JAK-STAT signalling pathway and blocked type I interferon production while reducing autophagy inhibition of the NF-κB signalling pathway and apoptosis in CSFV infection cells. …”
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New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels by Huan Zhao, Huan Zhao, Xu Dong, Xu Dong, Dazuo Yang, Dazuo Yang, Qingchao Ge, Qingchao Ge, Peng Lu, Peng Lu, Chang Liu, Chang Liu

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Identification of regulatory loci and candidate genes related to body weight traits in broilers based on different models by Na Luo, Keqi Cai, Limin Wei, Huanxian Cui, Jie Wen, Bingxing An, Guiping Zhao

“…Maximizing body weight (BW) while minimizing feed intake is key to enhancing the efficiency of broiler breeding. …”
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Effects of salicylic acid on the quality of fresh-cut Chinese water chestnuts by Liu Yu, Keyan Lu, Yang Yi, Limei Wang, Wenfu Hou, Youwei Ai, Hongxun Wang, Ting Min

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Exploring the Causal Association Between 91 Circulating Inflammatory Proteins and Neurodegenerative Diseases: A Bidirectional Two‐Sample Mendelian Randomization and Bioinformatics... by Ziwei Gong, Rong Cao, Hong Zhu

“…Single‐GSEA results suggest that CD40 promotes nucleotide metabolism, mitochondrial calcium ion transport, unfolded protein response (UPR), and adaptive immune regulation, while inhibiting androgen response and TGF‐β signaling pathways, thereby influencing the progression of RRMS. …”
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Epigenomic analysis identifies DTP subpopulation using HOPX to develop targeted therapy resistance in lung adenocarcinoma by Yang Tian, Reshmee Bhattacharya, Seungyeul Yoo, Feng Jiang, Eric Park, Genesis Lara Granados, Yudao Shen, Kwang-Su Park, Husnu Umit Kaniskan, Jian Jin, Benjamin D. Hopkins, Jun Zhu, Hideo Watanabe

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Enhancement of body red coloration in juvenile spotted scat (Scatophagus argus) by dietary supplementation with Lianjiang red orange peels as a natural carotenoid source by Tong Han, Yongguan Liao, Lei Yang, Xinyi Li, Gang Shi, Dong-Neng Jiang, Chunhua Zhu, Chunhua Zhu, Guangli Li, Hongjuan Shi

“…In the groups fed diets containing more than 9% Lianjiang red orange peels (9% and 12%), the L* value (lightness) decreased, while the a* value (redness) increased in red skin, and b* value (yellowness) increased in caudal fin (P < 0.05). …”
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A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia by Sandra Viz-Lasheras, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. Pollard, Colin Fink, Taco T. Kuijpers, Suzanne Anderson, Cristina Calvo, María del Carmen Martínez-Padilla, Ana Pérez-Aragón, Esteban Gómez-Sánchez, Juan Valencia-Ramos, Francisco Giménez-Sánchez, Paula Alonso-Quintela, Laura Moreno-Galarraga, Ulrich von Both, Marko Pokorn, Dace Zavadska, María Tsolia, Clementien L. Vermont, Henriëtte A. Moll, Michael Levin, Federico Martinón-Torres, Antonio Salas

“…Our research seeks to address this gap by identifying host transcriptomic biomarkers in the blood of children with definitive viral and bacterial pneumonia. …”
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Transcriptome analysis of H2O2-treated wheat seedlings reveals a H2O2-responsive fatty acid desaturase gene participating in powdery mildew resistance. by Aili Li, Rongzhi Zhang, Lei Pan, Lichuan Tang, Guangyao Zhao, Mingzhu Zhu, Jinfang Chu, Xiaohong Sun, Bo Wei, Xiangqi Zhang, Jizeng Jia, Long Mao

“…MapMan classification showed that, while both up- and down- regulations were observed for auxin, abscisic acid, and brassinolides signaling genes, the jasmonic acid and ethylene signaling pathway genes were all up-regulated, suggesting H(2)O(2)-enhanced JA/Et functions in PmA. …”
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Ginsenoside Rb1 and berberine synergistically protect against type 2 diabetes mellitus via GDF15/HAMP pathway throughout the liver lobules: Insights from spatial transcriptomics an... by Rongfang Guo, Shuying Zhang, Anyao Li, Ping Zhang, Xin Peng, Xiaoyan Lu, Xiaohui Fan

“…Our findings demonstrated that the combined use of Rb1 and BBR at a 1:4 ratio had more pronounced effects than the first-line anti-diabetic drug metformin on reducing the weight ratio of white adipose tissue, ameliorating insulin resistance, and improving glucose and lipid metabolism. Using spatial transcriptomics, we revealed that metformin treatment improved gluconeogenesis and lipogenesis only in the periportal zone, while the combination treatment induced improvements throughout the liver lobule, with distinct key targets across different zones, thus underscoring a more comprehensive modulation of hepatic metabolism. …”
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Transcriptome Analysis Reveals the Pivotal Genes and Regulation Pathways Under Cold Stress and Identifies <i>SbERF027</i>, an AP2/ERF Gene That Confers Cold Tolerance in Sorghum by Qijin Lou, Peifeng Wang, Miao Yu, Zhigan Xie, Chen Xu, Shengyu Chen, Hao Yu, Rui Zhang, Guangling Tian, Di Hao, Xianshi Ke, Shuai Yu, Jiajia Zhou, Yao Zhao, Chao Ye, Jiyuan Guo, Haiyan Zhang, Mo Chen, Xingbei Liu

“…In addition, the cold tolerance of <i>SbERF027</i>-overexpressing lines was higher than that of wild-type plants; while the cold tolerance of lines with <i>SbERF027</i> silenced via virus-induced gene silencing (VIGS) was significantly lower than that of wild-type plants. …”
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Biological Mechanisms of Aflatoxin B₁-Induced Bile Metabolism Abnormalities in Ducklings by Yihong Chu, Aimei Yu, Huanbin Wang, Shahid Ali Rajput, Qianqian Yu, Desheng Qi

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Integrating brain proteomes and genetics to identify novel risk genes in chronic widespread musculoskeletal pain by Zhisen Dai, Yanlin Wu, Huaqing Huang, Huizhe Zheng

“…Four of these genes were confirmed through a subsequent PWAS, while three showed associations with cis-regulated mRNA expression. …”
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Human brain single-cell data reveal shared synaptic dysfunction and immune abnormality in epilepsy and Alzheimer′s disease by YU Xiaolin, ZHANG Erning, SHA Longze

“…The vEEG recordings of APP/PS1 mouse model of AD showed 30% of mice exhibited high-frequency epileptic seizures, while 70% showed low-frequency seizure activity. …”
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Comparative physiological and co-expression network analysis reveals potential hub genes and adaptive mechanisms responsive to NaCl stress in peanut (Arachis hypogaea L.) by Nan Zhang, Baiyi Bai, Shiyu Zuo, He Zhang, Jingyao Ren, Zhenghao Lv, Dongying Zhou, Haiqiu Yu

“…Transcriptome analysis revealed the presence of 12,612 differentially expressed genes (DEGs) in response to salt stress, with FH23 exhibiting a greater number than NH5. …”
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Toxicity of Flonicamid to <i>Diaphorina citri</i> (Hemiptera: Liviidae) and Its Identification and Expression of Kir Channel Genes by Jiangyue Zhu, Xinjing Wang, Yunfei Mo, Beibei Wu, Tuyong Yi, Zhongxia Yang

“…The analysis of the transcriptomes revealed 345 differentially expressed genes (DEGs) in <i>D. citri</i> adults subjected to different treatments. …”
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Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses by Ziang Meng, Chumeng Zhang, Shuai Liu, Wen Li, Yue Wang, Qingyi Zhang, Bichen Peng, Weiyi Ye, Yue Jiang, Yingchao Song, Miao Guo, Xiao Chang, Lei Shao

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Genetic and molecular insights into tiller development and approaches for crop yield improvement by Zaid Chachar, Xiaoming Xue, Junteng Fang, Ming Chen, Weiwei Chen, Xuhui Li, Nazir Ahmed, Sadaruddin Chachar, Aamir Ali, Zhong liang Chen, Lina Fan, Ruiqiang Lai, Yongwen Qi

“…QTL mapping has pinpointed specific genomic regions associated with tiller development, while genome-wide association studies (GWAS) have provided deeper insights into natural genetic variations within populations. …”
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Natural ligand 3,3’-diindolylmethane functions as an AHR agonist to modulate angiogenesis and organ development in chicken embryos by Gee-yea Lim, Hao Chen, Woo-seon Song, Dong-hee Koh, Dong-ha Kim, Hisato Iwata, Eun-Young Kim

“…These results suggest that DIM activates the AHR signaling pathway, promoting hepatic cell proliferation and angiogenesis while modulating inflammatory responses during chicken development. …”
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Identification of key modules and genes in response to high-temperature stress in Platostoma palustre based on WGCNA by Xiufang Li, Fan Wei, Changqian Quan, Meihua Xu, Danfeng Tang

“…Under HTS, 8352 DEGs were up-regulated and 9201 DEGs were down-regulated in HT_LSL_vs_CK_LSL, while 5433 DEGs were up-regulated and 6325 DEGs were down-regulated in HT_MDG_vs_CK_MDG, suggesting a significant difference in gene expression levels between LSL and MDG under HTS. …”
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