MicroRNA transcriptome of skeletal muscle during yak development reveals that miR-652 regulates myoblasts differentiation and survival by targeting ISL1 by Xue-lan ZHOU, Xian GUO, Chun-nian LIANG, Min CHU, Xiao-yun WU, Ping YAN

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MAVS signaling of long-lived brain-resident myeloid cells is needed during viral encephalitis to adjust the transcriptome of CNS infiltrating CD8+ T cells by Andreas Pavlou, Luca Ghita, Felix Mulenge, Inken Waltl, Olivia Luise Gern, Pia-Katharina Larsen, Bibiana Costa, Veronica Duran, Lena Mareike Busker, Shelly J. Robertson, Yvonne Lueder, Stephan Halle, Reinhold Förster, Sonja M. Best, Martin Stangel, Ulrich Kalinke

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Integrated proteomics and transcriptomics analysis reveals key regulatory genes between ER-positive/PR-positive and ER-positive/PR-negative breast cancer by Zhengjia Lu, Jiao Yang, Yang Feng, Jia Ming

“…Drug sensitivity analysis indicated that the low-risk patients may be more sensitive to endocrine drug like fulvestrant, while high-risk patients may be more sensitive to chemotherapy drugs like docetaxel, paclitaxel, and vinorelbine. …”
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Mechanistic Exploration of Yiqi Zengmian in Regulating the Microenvironment as an Immunopotentiator with the Beijing Bio-Institute of Biological Products Coronavirus Vaccine Based... by Zeyue Yu, Yudong Wang, Jianhui Sun, Xiaotong Zheng, Liyu Hao, Yurong Deng, Jianliang Li, Zongyuan Li, Zhongchao Shan, Weidong Li, Yuling Qiao, Ruili Huo, Yibai Xiong, Hairu Huo, Hui Li, Longfei Lin, Hanhui Huang, Guimin Liu, Aoao Wang, Hongmei Li, Luqi Huang

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Genetic and transcriptomic analyses of early-onset colon cancer (EOCC): a post hoc analysis of 2973 patients from two adjuvant randomized trials by A. Gandini, C. Gallois, H. Blons, C. Mulot, N. Agueeff, C. Lepage, R. Guimbaud, L. Mineur, J. Desramé, B. Chibaudel, A. de Reyniès, T. André, P. Laurent-Puig, J. Taieb

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CD9, a novel potential biomarker of sarcopenia by Lin Yin, Na Li, Peirong Bai, Shasha Wu, Xuena Wang, Bin Lu

“…The combined omics analysis identified 8 key genes, while the experiments verified that only CD9 significantly decreased in sarcopenia. …”
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Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways by Lijun Chen, Wei Han, Wenwen Jing, Meng Feng, Qingtong Zhou, Xunjia Cheng

“…Nitroxoline treatment upregulated genes involved in DNA repair and oxidative stress response while regulating genes in the methionine and cysteine cycles. …”
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Transcriptional Signatures of the Right Ventricle in End‐Stage Heart Failure by Jonah D. Garry, Giovanni E. Davogustto, Vineet Agrawal, Fei Ye, Kelsey Tomasek, Yan Ru Su, Tarek Absi, James D. West, Anna Hemnes, Evan L. Brittain

“…Additionally, we compared transcriptomic changes between right and left ventricular (LV) failure. …”
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The Effects of FR and UVA Irradiation Timing on Multi-Omics of Purple Lettuce in Plant Factories by Yubin Zhang, Zhaoxin Li, Ning Zhang, Xiujuan Chai

“…Metabolomic analysis corroborated the transcriptomic findings, with particular emphasis on antioxidant activity, photoprotection, and defense mechanisms. …”
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Prediction of hub genes in pulpal inflammation and regeneration using autoencoders and a generative AI approach by Pradeep K. Yadalam, Jogikalmat Krithikadatta, Prabhu M. Natarajan, Carlos M. Ardila

“…Abstract Pulpal inflammation and regeneration are crucial for enhancing endodontic treatment outcomes. Transcriptomic studies highlight the involvement of proinflammatory cytokines, NF-κB signaling, and stem cell activity. …”
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Decoding aging in the heart via single cell dual omics of non-cardiomyocytes by Yiran Song, Li Wang, Haofei Wang, Hong Ma, Jun Xu, Jiandong Liu, Li Qian

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The promising role of nanopore sequencing in cancer diagnostics and treatment by Xinming Su, Qingyuan Lin, Bin Liu, Chuntao Zhou, Liuyi Lu, Zihao Lin, Jiahua Si, Yuemin Ding, Shiwei Duan

“…In essence, this technology stands poised to unearth novel mechanisms underlying tumorigenesis while providing dependable support for the diagnosis and treatment of cancer.…”
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In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders by Stephen Tunmise Akanbi, Joshua Ayodele Yusuf, Thompson Oluwaferanmi Ayandele, Dayo Samson Oladipupo, Darasimi Racheal Olorunlowu, Blessing Dorcas Olawuyi, Joshua Oluwafisayo Adepoju, Dolapo Emmanuel Opasina, Elizabeth Kehinde Opoola, Uchenna Victor Ugwuanyi, Olufunto Omodele Adeleye

“…Notable miRNAs included hsa-mir-34a-5p, hsa-mir-15a-5p, hsa-mir-424-5p, and hsa-mir-19b-3p, while key transcription factors include GATA2, CREB1, FOXC1, FOXL1, TID1, NFKB1, YY1, SPIB, GATA3, and STAT3. …”
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Impact on the Leishmania mexicana transcriptome due to knockout of genes encoding orthologs of methyltransferases involved in m1A and m5C mRNA modifications by Angela Moreira Bezerra, Ariely Barbosa Leite, Christian Robson de Souza Reis, João Luiz de Lemos Padilha Pitta, Suellen Rodrigues Maran, Nilmar Silvio Moretti, Danielle Maria Nascimento Moura, Antonio Mauro Rezende

“…Abstract Background Chemical modifications of mRNAs constitute an alternative mechanism for gene expression regulation, which involves proteins responsible for adding, recognizing and removing these modifications. While orthologs of enzymes involved in adding m1A (TRMT6/TRMT61A) and m5C (NSUN2) modifications are present in trypanosomatid species, a clear understanding of their biological role in these parasites is necessary. …”
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Transcriptome Analysis of the <i>CML</i> Gene Family in <i>Bletilla striata</i> and Regulation of Militarine Synthesis Under Sodium Acetate and Salicylic Acid Treatments by Kunqian Li, Mengwei Xu, Qingqing Li, Hongwei Li, Ya Xu, Delin Xu

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Trophoblast cell response to periodontal pathogens unveils oxidative stress networks between periodontitis and pre-eclampsia: Mendelian randomization, transcriptomic analysis, and... by Lihua Hu, Shuqin Liu

“…Methods We employed a multi-faceted approach combining Mendelian Randomization (MR) analysis, transcriptomic data mining, and in vitro experiments. …”
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Histological and transcriptome analysis provides new insights into the hematopoietic and immune functions of head kidney, trunk kidney and spleen of adult large yellow croaker, Lar... by Aihua Zhong, Yingbin Wang, Haiqi Zhang, Xiaojun Yan, Shuo Jia

“…This study provides a comprehensive histological and transcriptomic analysis of these organs in adult large yellow croaker, revealing their normal physiological roles in hematopoiesis and immunity. …”
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Multi-tissue transcriptomic analysis reveals that L-methionine supplementation maintains the physiological homeostasis of broiler chickens than D-methionine under acute heat stress... by Mingyung Lee, Hyesun Park, Jung Min Heo, Ho Jun Choi, Seongwon Seo

“…The objective of this study was to compare the effects of supplementation with two methionine isoforms, L-methionine (L-Met) or D-methionine (D-Met), on transcriptome expression in broiler chickens under acute heat stress. …”
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Comparison of the effects and mechanisms of Alismatis Rhizoma with and without salt processing in ameliorating edema due to kidney Yin deficiency based on UPLC-Q-TOF-MS and transcr... by Lin Yan, Zemin Ou, Yi Cheng, Yan Tong, Javed Iqbal, Jinyu Wang, Dewen Liu

“…Additionally, this study compared the effects of AR and SAR on the gene expression in the kidneys of the rat model of edema (syndrome of kidney Yin deficiency) by transcriptomics to decipher the mechanism of salt processing. …”
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Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and... by Xuechen Cao, Yongkai Yu, Hang Yao, Yujie Zheng, Jiawei Lu, Yifei Feng, Tongxin Pei, Ziyu Li, Ming Lu, Yan Lu

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