Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL‐AD preclinical testing core study by Kristen D. Onos, Sara K. Quinney, David R. Jones, Andrea R. Masters, Ravi Pandey, Kelly J. Keezer, Carla Biesdorf, Ingrid F. Metzger, Jill A. Meyers, Johnathon Peters, Scott C. Persohn, Brian P. McCarthy, Amanda A. Bedwell, Lucas L. Figueiredo, Zackary A. Cope, Michael Sasner, Gareth R. Howell, Harriet M. Williams, Adrian L. Oblak, Bruce T. Lamb, Gregory W. Carter, Stacey J. Sukoff Rizzo, Paul R. Territo

“…Plasma concentrations of the 10 mg/kg dose in 5XFAD overlapped with human plasma concentrations used for studies of mild cognitive impairment, while the 30 and 56 mg/kg doses were reflective of doses used to treat seizure activity. …”
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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…Surprisingly, our data showed that macrophages exposed to the Delta variant exhibited a transcriptional profile more similar to the naïve control group, while macrophages exposed to the Omicron variant showed intermediate differentially expressed genes (DEGs) between the two groups. …”
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The comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes by Qingyao Zhao, Jiahao Wang, Fuping Ma, Quanzhen Chen, Huatao Liu, Jinyan Yang, Siqian Chen, Yongjie Tang, Siyuan Mi, Lulu Wang, Xini Wang, Guohong Liu, Kai Xing, Ying Yu, Chuduan Wang

“…However, comprehensive systematic studies on transcriptome of porcine immune tissues are still rare. …”
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Analysis of 1,25-dihydroxyvitamin D genomic action in human enteroids and colonoids reveals multiple regulatory effects of vitamin D in human intestinal physiology by Zachary K. Criss, Kali Deans-Fielder, James C. Fleet, Sylvia Christakos, Noah Shroyer

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A Single-Cell Assessment of Intramuscular and Subcutaneous Adipose Tissue in Beef Cattle by Mollie M. Green, Hunter R. Ford, Alexandra P. Tegeler, Oscar J. Benitez, Bradley J. Johnson, Clarissa Strieder-Barboza

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Identification of QTLs associated with grain yield-related traits of spring barley by Yuliya Genievskaya, Saule Abugalieva, Yerlan Turuspekov

“…Integrating genomic and transcriptomic methods suggests a promising strategy for genomic selection and marker-assisted breeding to enhance barley grain yield.…”
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Silver carp muscle hydrolysate ameliorated atherosclerosis and liver injury in apoE-/- mice: the modulator effects on enterohepatic cholesterol metabolism by Kai Wang, Zixin Fu, Yuqing Tan, Hui Hong, Jianping Wu, Yongkang Luo

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The abiotic stress gene (Asg) family member Asg2 as a modulator of plant responses to salt stress by Xiaona Tian, Ziru Chang, Ruigang Wang, Guojing Li, Yang Qi

“…Overexpression of Asg2 enhances primary root elongation, while gene-edited mutants display the opposite effect. …”
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Effects of exogenous insulin supplementation on lipid metabolism in peripartum obese dairy cows by Yuanyin Guo, Yihan Zhao, Ziang Wei, Jie Cao

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Subpopulation-specific gene expression in Lachancea thermotolerans uncovers distinct metabolic adaptations to wine fermentation by Javier Vicente, Santiago Benito, Domingo Marquina, Antonio Santos

“…Understanding the gene expression differences linked to lactic acid production could allow a more rational address of biological acidification while optimizing yeast-specific nutritional requirements during fermentation. …”
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Cell wall modulation by drought and elevated CO2 in sugarcane leaves by Alexandre Junio Borges Araujo, Amanda Pereira de Souza, Débora Pagliuso, Mauro de Medeiros Oliveira, Bruno Viana Navarro, Adriana Grandis, Marcos Silveira Buckeridge

“…Leaf biomass, cell wall composition, and global transcriptome sequencing were analyzed. eCO2 (780 ppm) significantly increased leaf biomass by 64%, attributed to enhanced photosynthesis and water-use efficiency. …”
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Combined metabolic phenotypes and gene expression profiles revealed the formation of terpene and ester volatiles during white tea withering process by Xuming Deng, Jun Wu, Tao Wang, Haomin Dai, Jiajia Chen, Bo Song, Shaoling Wu, Chenxi Gao, Yan Huang, Weilong Kong, Weijiang Sun

“…To study the mechanism underlying aroma changes during the white withering, we herein conducted volatile metabolomics and transcriptomics of the young leaves from the 'Fuding Dahaocha' tea cultivar. …”
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Immune Dysregulation and Trophoblastic Dysfunction as a Potential Cause of Idiopathic Recurrent Pregnancy Loss by Sara Vasconcelos, Ana Costa Braga, Ioannis Moustakas, Bruno Cavadas, Mariana Santos, Carla Caniçais, Carla Ramalho, Susana M. Chuva de Sousa Lopes, Cristina Joana Marques, Sofia Dória

“…This study investigates the transcriptomic profiles of first-trimester products of conception (POC) from iPLs to uncover underlying molecular pathways. …”
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Synergistic Response Mechanisms in Rice Seedlings Exposed to Brown Planthopper Infestation and High-Temperature Stress by Danyun Cao, Yuchen Ping, Yiru Lin, Jinyan Hu, Zimeng Wang, Wei Yuan, Tongtong Li, Linxin Liu, Bo Zhang, Shijiao Xiong, Cong Dang, Dawei Xue

“…In the present study, we found that pre-treatment with high temperature can enhance rice seeding resistance to BPH, while BPH feeding did not alter the high-temperature tolerance of rice. …”
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Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

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Unveiling the mechanisms driving the rapid growth of Malania oleifera seedlings, a high-value root hemiparasitic plant by Si-Hai Wang, Si-Hai Wang, Chuan-Guang Zhang, Chuan-Guang Zhang, Wei Yang, Wei Yang, Jian Chen, Jian Chen, Ming Shi

“…We then analyzed the transcriptomic differences between non-parasitic and parasitic plants that exhibited significant growth disparities. …”
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Effects of High Temperature at Grain Filling Stage on Grain Quality and Gene Transcription in Heat-Sensitive Versus Heat-Tolerant Rice Cultivars by Yujian Guo, Hui Luo, Jiajie Yi, Yuqi Zhu, Xiaojie Ma, Yubing Jiang, Yanjiao Peng, Yunhua Xiao, Guilian Zhang, Xiong Liu, Huabing Deng

“…The DEGs of 8XR274 were mainly enriched in pathways related to carbohydrates, while 5W0076 was mainly enriched in pathways related to photosynthesis. …”
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Combined Effects of Magnetized Irrigation and Water Source on Italian Lettuce (<i>Lactuca sativa</i> L. var. <i>ramosa</i> Hort.) Growth and Gene Expression by Xueying Yao, Xiaofan Wang, Mingshan Qu, Yibo Wei, Feifei Shan, Youli Li

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Integrative RNA-seq and ATAC-seq analysis unveils antioxidant defense mechanisms in salt-tolerant rice variety Pokkali by Qiaoyu Yang, Yutong Zheng, Xitao Li

“…Abstract Background Salt stress is one of the most significant environmental challenges, severely impacting rice growth and yield. While different rice varieties exhibit varying levels of tolerance to salinity, Pokkali, a traditional salt-tolerant variety, stands out for its ability to thrive in saline conditions. …”
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Integration of volatile and non-volatile metabolites and the transcriptome reveals the formation mechanisms of differential aroma compounds between Pyrus communis and Pyrus pyrifol... by Jiao Wang, Jiao Wang, Xianping Guo, Xianping Guo, Zhongying Wu, Zhongying Wu, Dongsheng Wang, Dongsheng Wang, Peng Guo, Yongping Han, Hui Jiang, Zhenzhen Lü

“…Among cultivated pears, fruits from Pyrus communis (hereafter referred to as P. communis) cultivars are famous for their abundant aroma, while the fruits of most Pyrus pyrifolia (hereafter referred to as P. pyrifolia) cultivars lack aroma compounds. …”
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