Comparison Between Worker and Soldier Transcriptomes of Termite <i>Neotermes binovatus</i> Reveals Caste Specialization of Host–Flagellate Symbiotic System by Yu-Hao Huang, Miao Wang, Xiu-Ping Chang, Yun-Ling Ke, Zhi-Qiang Li

“…This research provides insights into the functional specialization of the host–flagellate symbiotic system in the worker and soldier castes of termites, supporting the workers’ roles in nest maintenance, preliminary food processing, and communication, while emphasizing the defensive role of soldiers. …”
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Single-cell transcriptome integrated with genome-wide association study reveals heterogeneity of carotid and femoral plaques and its association with plaque stability by Xinhuang Hou, Zhipeng Li, Jun Lin, Wei Lin, Luyao Li, Xiaoqi Zheng, Xiaoling Lai, Lin Zhu, Pingfan Guo, Fanggang Cai, Jinchi Zhang, Wanglong Li, Changwei Yang, Yiquan Dai

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LC/MS-based lipidomics and transcriptomics reveal lipid diversity and regulatory networks underlying intramuscular fat differences in Xingguo grey geese by Mengyun Zou, Weihong Zhang, Xiaolan Xiong, Linjie Rao, Qipeng Wei, Haiqin Li, Fanfan Zhang, Jinfang Xie, Zhangzhang Wang, Jiangnan Huang

“…Interestingly, the low-IMF group exhibited an increase in GPs, specifically phosphatidylethanolamines (PEs) and phosphatidylcholines (PCs), while the high-IMF group showed elevated levels of triacylglycerols (TAGs). …”
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Integrated Multi-Omics of the Longissimus Dorsal Muscle Transcriptomics and Metabolomics Reveals Intramuscular Fat Accumulation Mechanism with Diet Energy Differences in Yaks by Jingying Deng, Pengjia Bao, Ning Li, Siyuan Kong, Tong Wang, Minghao Zhang, Qinran Yu, Xinyu Cao, Jianlei Jia, Ping Yan

“…This study reveals the energy-dependent epigenetic regulatory mechanism of IMF deposition in plateau ruminants, which provides molecular targets for optimizing yak nutritional strategies and quality meat production, while having important theoretical and practical value for the sustainable development of livestock husbandry on the Tibetan Plateau.…”
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Transcriptomic analysis of two Chinese wheat landraces with contrasting Fusarium head blight resistance reveals miRNA-mediated defense mechanisms by Lijuan Wu, Lijuan Wu, Junqiang Wang, Shian Shen, Zaijun Yang, Xinkun Hu

“…These miRNAs targeted genes involved in immune responses, while lncRNAs and circRNAs played a more limited role in the regulation of defense responses. …”
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Repetitive transcranial magnetic stimulation ameliorates chronic pain behavior and modulates the brain transcriptome in a mouse model of chronic constriction injury by Tianying Li, Guanwen Lin, Tao Zhang, Yani Guo, Yongjin He, Jing Luan, Jin Wang, Dan Lyu, Yiqi Weng, Xin Jin

“…Results and conclusion: rTMS at both 5 Hz and 10 Hz significantly improved PWL and PWT in CCI mice and reduced anxiety-like behaviors. Transcriptomic analysis revealed that CCI induced dysregulation of 66 genes, while rTMS partially normalized gene expression patterns. …”
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Integrative metabolomics and transcriptomics analysis of hippocampus reveals taurine metabolism and sphingolipid metabolism dysregulation associated with sleep deprivation-induced... by Ting Chen, Junke Jia, Chenyi Gao, Qi Zhong, Lijuan Tang, Xiaokai Sui, Shuang Li, Chang Chen, Zongze Zhang

“…The analysis revealed that sleep deprivation caused abnormalities in several metabolic pathways, with particularly pronounced effects observed in glycerophospholipid metabolism, linoieic acid metabolism, alanine, aspartate, glutamate metabolism, taurine and hypotaurine metabolism, and purine metabolism. While transcriptomic analysis releaved 97 differentially expressed genes (DEGs) (51 were down-regulated and 46 were up-regulated DEGs). …”
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Integrated transcriptomics and machine learning reveal REN as a dual regulator of tumor stemness and NK cell evasion in Wilms tumor progression by Qingfei Cao, Junyi Li, Yunfei Zou, Changwen Xu, Huihui Tang, Meixue Chen

“…At spatial and single-cell resolution, REN-expressing tumor cells promoted NK cell exhaustion via PTN-NCL and COL4A1-CD44 ligand-receptor interactions, while showing limited impact on T cell dysfunction. …”
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Integration of Physiological and Comparative Transcriptomic Analyses Reveal the Toxicity Mechanism of <i>p</i>-Coumaric Acid on <i>Morchella importuna</i> by Qi Yin, Wenchang Zhang, Yingli Cai, Xiaofei Shi, Fuqiang Yu, Jianzhuang Guo, Xinhua He, Peixin He, Wei Liu

“…Therefore, we used physiological and comparative transcriptomic analyses to reveal its toxicity mechanism. …”
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New insights into the transcription factor regulatory networks driving peel coloration under hormone induction analyzed by transcriptomics and metabolomics in tangor ‘Murcot’ by Yang Chen, Yang Chen, Lei Yang, Lei Yang, Shuang Li, Min Wang, Jianjun Yu, Wenqin Bai, Wenqin Bai, Wenqin Bai, Lin Hong, Lin Hong

“…Notably, integrated transcriptomic and metabolomic analyses identified 33 transcription factors associated with pigment metabolism. …”
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Transcriptome Analysis Reveals Hyperglycemic Hormone and Excitatory Amino Acid Transporter 3 Are Involved in the Thermal Adaptation of <i>Eriocheir sinensis</i> by Xi Li, Runlin Zhou, Ruiqi Zhang, Zhen He, Mingzhi Zhang, Ran Li, Tong Hao, Jinsheng Sun

“…These findings suggest that temperature may influence sex regulation in <i>E. sinensis</i>, while the dopamine receptor and neuropeptide signaling pathways may play a role in its thermal adaptation. …”
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Transcriptomic Profiling of Heat-Treated Oriental Lily Reveals <i>LhERF109</i> as a Positive Regulator of Anthocyanin Accumulation by Mei Zhou, Lijia Zeng, Fan Li, Chunlian Jin, Jungang Zhu, Xue Yong, Mengxi Wu, Beibei Jiang, Yin Jia, Huijuan Yuan, Jihua Wang, Yuanzhi Pan

“…We subjected ‘Souvenir’ Oriental lily plants to temperature treatments (20 °C and 35 °C) and performed transcriptome sequencing and weighted gene co-expression network analysis (WGCNA). …”
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Dynamic metabolomic and transcriptomic profiling reveals yellow flower development in Camellia perpetua, a rare continuously flowering golden Camellia species by Xianliang Zhu, Haidu Jiang, Xinfeng Pan, Jiaxin Fu, Lihui Peng, Jin Zhang, Jianmin Tang, Rong Zou, Bo Zhao, Xiao Wei, Shengfeng Chai

“…This analysis identified 1,160 metabolites, with flavonoids constituting the largest proportion at 21.6%. Comparative transcriptomic profiling indicated that differentially expressed genes (DEGs) associated with photosynthesis were predominantly active during the early stages of flower development, while DEGs involved in the flavonoid biosynthesis pathway showed a marked increase as the flowers matured. …”
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Impact of dietary protein levels on growth, immune response, digestibility, intestinal microbiota, and transcriptome in Litopenaeus vannamei fed cottonseed protein concentrate by Hongming Wang, Xin Hu, Jian Chen, Yudong Zheng, Beiping Tan, Lili Shi, Shuang Zhang

“…Analysis of hepatopancreatic tissues revealed that activities of superoxide dismutase (SOD), peroxidase (PO), lysozyme (LZM), and catalase (CAT) were significantly reduced, while malondialdehyde (MDA) levels increased in the CPC48 group compared to the CPC40 group. …”
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Transcriptomic profiling reveals SARS-CoV-2-infected humanized MHC mice recapitulate human post vaccination immune responses by Siyue Li, Siyue Li, Xuelian Han, Ruolan Hu, Ruolan Hu, Keyu Sun, Min Li, Yuan Wang, Guangyu Zhao, Mengzhe Li, Huahao Fan, Huahao Fan, Huahao Fan, Huahao Fan, Qi Yin

“…BackgroundThe ongoing COVID-19 pandemic caused by SARS-CoV-2 remains a critical global health priority, with persistent socioeconomic ramifications despite its reclassification from Public Health Emergency of International Concern (PHEIC) status. While humanized major histocompatibility complex (hMHC) murine models have been extensively utilized in oncological research, their application in virological studies-particularly for coronavirus pathogenesis-remains underexplored. …”
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Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction by Sandrine Cabantous, Belco Poudiougou, Aurélie Bergon, Abdoulaye Barry, Aboubacar A. Oumar, Abdoulaye M. Traore, Christophe Chevillard, Ogobara Doumbo, Alain Dessein, Sandrine Marquet

“…We have performed a whole transcriptomic analysis of blood samples from Malian children with CM or uncomplicated malaria (UM). …”
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No detectable impact of chronic oral lactic acid exposure on honey bee health: Insights from survival, lactate accumulation and head transcriptome by Caroline Vilarem, Vincent Piou, Lucie Bouly, Frédéric Julien, Rachel Fourdin, Nathalie Vialaneix, Matthias Zytnicki, Angélique Vétillard

“…While further research on sublethal effects is still needed, this work provides one of the first reports on the off-target effects of lactic acid on honey bee health.…”
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GC-MS metabolite and transcriptome analyses reveal the differences of volatile synthesis and gene expression profiling between two Chinese rose cultivars by Kaiqing Luo, Chao Song, Tingting Bao, Rui Huang, Shengnan Lin, Yingxue Yang, Luhong Leng, Xuezhu Liao, Cuihua Gu, Zhiqiang Wu, Xiaoni Zhang

“…The main VOCs emitted from 'OB' petals was 1,3,5-trimethoxybenzene (TMB), while that from 'CH' petals was 2-phenylethanol (2-PE). …”
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Integrated Physiological, Transcriptomic, and Metabolomic Analysis Reveals Mechanism Underlying the <i>Serendipita indica</i>-Enhanced Drought Tolerance in Tea Plants by Gaojian Shen, Hongli Cao, Qin Zeng, Xiaoyu Guo, Huixin Shao, Huiyi Wang, Liyong Luo, Chuan Yue, Liang Zeng

“…Particularly, the flavonoid biosynthesis pathway was identified from the metabolomic and transcriptomic analysis using Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. …”
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Transcriptomic Analysis of Menstrual Blood-Derived Stem Cells Transplantation Combined with Exercise Training in Promoting Spinal Cord Injury Recovery in Rats by QI Longju, CHEN Shiyuan, LIAO Zehua, SHI Yuanhu, SUN Yuyu, WANG Qinghua

“…Motor function recovery was assessed using the Basso, Beattie, and Bresnahan (BBB) score, while histopathological changes at the injury site were evaluated through hematoxylin-eosin (HE) staining. …”
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