Metabolome and transcriptome analyses reveal the mechanism underlying the differences in skin development between the two duck breeds during embryonic stage by Zhigang Hu, Yingjie Cai, Chang Cao, Hua He, Shun Guo, Na Li, Aiguo Xin, Xiaolin Liu

“…Black skinned duck, such as Yulin black duck, is more popular in China because they are considered more suitable for making soup, while other skin colors, such as Pekin duck, is used for roasting. …”
Get full text

A Mouse Model of Polycystic Ovary Syndrome Established Through Subcutaneous Administration of Letrozole Sustained-Release Pellets and Hepatic Transcriptome Analysis by XU Qiuyu, YAN Guofeng, FU Li, FAN Wenhua, ZHOU Jing, ZHU Lian, QIU Shuwen, ZHANG Jie, WU Ling

“…However, no significant changes were observed in absolute liver weight (P>0.05), hepatic histomorphology, or lipid deposition. Transcriptome sequencing identified 119 upregulated and 217 downregulated DEGs in the liver tissues of letrozole-treated mice, which were predominantly enriched in pathways related to cholesterol and steroid biosynthesis, steroid hormone metabolism, and inflammatory responses. qPCR validation demonstrated that mRNA expression of HSD3B2 and HMGCR was significantly upregulated in liver (P<0.01), while mRNA expression of IL4, CCL2 and COL1A1 was downregulated (P<0.05) in the model group compared with the control group. …”
Get full text

Comparative transcriptome profiling and co-expression network analysis reveals important genes regulating maize response to Southern corn rust by Jialong Liu, Kailai Wang, Nan Wang, Yuan Zhong, Xiuzhen Zhai, Yinsuo Jia, Zhiying Chu, Qing Miao, Hao Su, Mengyun Kou, Huijun Duan, Xiaocui Yan

“…Phenotypic analysis shows that DTMA-50, R99 and P767 have strong resistance, while DTMA-45, N110 and 15B020F3 are more sensitive. …”
Get full text

Metabolome and Transcriptome Analysis Reveals the Regulatory Effect of Magnesium Treatment on EGCG Biosynthesis in Tea Shoots (<i>Camellia sinensis</i>) by Zixuan Feng, Zhuan Li, Rui Yan, Nan Yang, Meichen Liu, Yueting Bai, Yuyuan Mao, Chengzhe Zhou, Yuqiong Guo, Yulin Zeng, Yuhang Ji, Yangshun Lin, Jiayong Chen, Shuilian Gao

“…Herein, we performed a comprehensive analysis of the metabolomics and transcriptomics of the shoots of ‘Huangdan’ at five magnesium concentrations: L1-L5 (0, 0.15, 0.45, 0.6, and 0.9 mmol/L mg²⁺, respectively). …”
Get full text

Salinity tolerance in resting cysts of colpodid ciliates: Comparative transcriptomics analysis and chemical analysis of cyst walls to investigate their tolerance capability by Ryota Saito, Hiroki Yamanobe, Kazuma Yabuki, Tomohiro Suzuki, Takeru Saito, Shuntaro Hakozaki, Manfred Wanner, Ryota Koizumi, Tatsuya Sakai, Maribet Gamboa, Toshihiko Tanaka, Akiko Ono, Hoa Thanh Nguyen, Yuta Saito, Tetsuya Aoyama, Katsuhiko Kojima, Futoshi Suizu, Kozo Watanabe, Yoichiro Sogame

“…The outer shell-like layer, called the ectocyst, while the inner multiple layers, known as the endocyst. …”
Get full text

Longitudinal transcriptome analysis reveals distinct gene expression patterns in traditional Chinese medicine syndromes of upper respiratory tract infections by Hao Zou, Hao Zou, Changrui Huang, Changrui Huang, Qinqi Feng, Qinqi Feng, Bang Yu, Bang Yu, Jian Liu, Xinyang Shu, Xiaolu Nie, Hongchun Zhang, Xiaohui Zou

“…WC syndrome is marked by mitochondrial dysfunction, while WH syndrome is characterized by downregulated TGF-β and Wnt/β-catenin pathways.…”
Get full text

The Impact of Dissolved Biochar on Oxidative Stress and Its Effect on the Virulence of <i>Steinernema feltiae</i>: Implications for Biocontrol Efficiency by Xinrui Wang, Jie Li, Jing Li, Lan Luo, Gang Li, Weibin Ruan, Guilong Zhang

“…The nematodes treated with DBC700 exhibited 64.34% higher ROS levels, while those treated with DBC400 had 51.13% higher levels compared to the control. …”
Get full text

Comparison of the effects and mechanisms of astaxanthin, astaxanthin esters and astacene on high-fat diet-induced NAFLD by Chunhao Gao, Fangtian Chen, Nengyun Gong, Shiran Hu, Mengjia Zhu, Qingxin Zhou, Xiang Gao

“…While AXE displayed notable efficacy in modulating transcriptional profiles across both tissues. …”
Get full text

Detection of Different Patterns of Genome-Wide Gene Expression Disturbance in Three Nullisomy Lines in Allotetraploid <i>Brassica napus</i> by Shaolin Lei, Bo Wei, Qi Hu, Lang Liu, Feng Yu, Tuo Zeng, Xuye Du, Lei Gu, Hongcheng Wang

“…Specifically, in the C1-deleted variant, the average gene expression of the A1 chromosome increased, while the number of expressed genes on other chromosomes decreased. …”
Get full text

Differential expression of sex regulatory genes in gonads of Astyanax mexicanus surface fish and cavefish by Kaitlyn A. Webster, Bethany Ponte, Hans Vasquez-Gross, Juli Petereit, John Hutchinson, Misty R. Riddle

“…Results We compared the ovary and testis transcriptome of surface fish and cavefish at juvenile and adult stages. …”
Get full text

Integrated ultrasensitive metabolomics and single-cell transcriptomics identify crucial regulators of sheep oocyte maturation and early embryo development in vitro by Bo Pan, JianPeng Qin, KunLin Du, LuYao Zhang, GongXue Jia, JiangFeng Ye, QiuXia Liang, QiEn Yang, GuangBin Zhou

Get full text

Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study by Vanessa Kiyomi Ota, Vanessa Kiyomi Ota, Vanessa Kiyomi Ota, Vanessa Kiyomi Ota, Adrielle Martins Oliveira, Adrielle Martins Oliveira, Adrielle Martins Oliveira, Amanda Victória Gomes Bugiga, Amanda Victória Gomes Bugiga, Amanda Victória Gomes Bugiga, Helena B. Conceição, Pedro Alexandre Favoretto Galante, Paula Fontes Asprino, Julia Luiza Schäfer, Julia Luiza Schäfer, Mauricio Scopel Hoffmann, Mauricio Scopel Hoffmann, Mauricio Scopel Hoffmann, Mauricio Scopel Hoffmann, Mauricio Scopel Hoffmann, Rodrigo Bressan, Rodrigo Bressan, Rodrigo Bressan, Elisa Brietzke, Gisele Gus Manfro, Gisele Gus Manfro, Rodrigo Grassi-Oliveira, Ary Gadelha, Ary Gadelha, Luis Augusto Rohde, Luis Augusto Rohde, Luis Augusto Rohde, Luis Augusto Rohde, Euripedes Constantino Miguel, Euripedes Constantino Miguel, Pedro Mario Pan, Pedro Mario Pan, Pedro Mario Pan, Marcos Leite Santoro, Marcos Leite Santoro, Marcos Leite Santoro, Giovanni Abrahao Salum, Giovanni Abrahao Salum, Giovanni Abrahao Salum, Carolina Muniz Carvalho, Carolina Muniz Carvalho, Carolina Muniz Carvalho, Sintia Iole Belangero, Sintia Iole Belangero, Sintia Iole Belangero, Sintia Iole Belangero

Get full text

Molecular Mechanisms Underlying Sweet Potato (<i>Ipomoea batatas</i> L.) Responses to Phosphorus Deficiency by Zhufang Yao, Zhongxia Luo, Hongda Zou, Yiling Yang, Bingzhi Jiang, Lifei Huang, Zhangying Wang

“…This study investigates the effects of phosphorus deficiency on the growth, endogenous phytohormones, metabolome, and transcriptome of sweet potato (<i>Ipomoea batatas</i> L.) over a growth period from 30 to 120 days. …”
Get full text

Decoding Flavonoid Metabolism for Nutritional Enhancement: A Transcriptome–Metabolome Integration Study of Biosynthesis in Edible <i>Chrysanthemum indicum</i> L. by Chengxiang Wang, Yong Su, Min Wei, Qiaosheng Guo, Qingjun Zou, Tao Wang

“…This study compared flavonoid metabolism in white mutant (BHYJ) and yellow (HJ06) varieties through integrated metabolomic and transcriptomic analyses. Metabolomics identified 491 flavonoids, revealing distinct accumulation patterns: BHYJ accumulated dihydroflavones/chalcones (eriodictyol, hesperetin-8-<i>C</i>-glucoside-3′-<i>O</i>-glucoside, naringenin chalcone), while HJ06 showed higher flavones/flavonols (linarin, rhoiflolin, vitexin, rutin, nicotiflorin). …”
Get full text

Refining the resolution of the yeast genotype–phenotype map using single-cell RNA-sequencing by Arnaud N'Guessan, Wen Yuan Tong, Hamed Heydari, Alex N Nguyen Ba

“…Due to the larger scale of our dataset and its multidimensionality, we could recapitulate results from decades of work in GPM from yeast bulk assays while revealing new associations between phenotypic and transcriptomic variations at a broad scale. …”
Get full text

Novel metabolic subtypes in IDH-mutant gliomas: implications for prognosis and therapy by Peng Wang, Jiayi Wang, Zheng Fang, Qiaodong Chen, Ying Zhang, Xiaoguang Qiu, Zhaoshi Bao

“…Current study has primarily focused on the different IDH statuses or grades, while the metabolic heterogeneity within IDH-mutant gliomas remains insufficiently characterized. …”
Get full text

Identification and validation of reference genes for qRT-PCR analyses under different experimental conditions in Dendrobium nobile by Kaijie Li, Xianfen Deng, Yao Wu, Jinling Li, Mingjin Huang, Chunli Luo, Hualei Wang, Hongchang Liu, Dandan Li

“…In this study, eight genes were selected as the candidate RGs based on the transcriptome data from different tissues of D. nobile. …”
Get full text

An environmental isolate of Pseudomonas, 20EI1, reduces Aspergillus flavus growth in an iron-dependent manner and alters secondary metabolism by Elizabeth M. Wyman, W. Scott Grayburn, Matthew K. Gilbert, Matthew D. Lebar, Jessica M. Lohmar, Jeffrey W. Cary, Thomas J. C. Sauters, Antonis Rokas, Ana M. Calvo

“…Expression of other secondary metabolite (SM) genes was also reduced by the bacteria, including genes of clusters involved in cyclopiazonic acid, kojic acid and imizoquin biosynthesis, while genes of the cluster corresponding to aspergillicin, a siderophore, were upregulated. …”
Get full text

Multi-Omics Investigation of Fatty Acid Content Variations in Common Carp (<i>Cyprinus carpio</i>) Muscle: Integrating Genome, Transcriptome, and Lipid Profiling Data by Kaikuo Wang, Qi Wang, Yingjie Chen, Yiming Cao, Ran Zhao, Shuangting Yu, Xiaoqing Sun, Yan Zhang, Jiongtang Li

“…The genetic variation at genes participating in oxidation, ubiquitination, and transcriptional factors was associated with the content of multiple FAs, while few variants were observed in the FA-synthesis genes. …”
Get full text

Oligochitosan Mitigates <i>Vibrio harveyi</i> Infection in Hybrid Groupers (<i>Epinephelus lanceolatus</i> ♂ × <i>Epinephelus fuscoguttatus</i> ♀) by Modulating Immune Responses an... by Fei Shi, Lixin Ma, Zhilong Chen, Hao Zhao, Cuiyun Zou, Li Lin, Zhendong Qin

“…Transcriptome analysis was used to identify differentially expressed genes in the disease-related and immune system pathways that significantly accumulated in the treatment groups. …”
Get full text