Transcriptome approach to understand the potential mechanisms of resistant and susceptible alfalfa (Medicago sativa L.) cultivars in response to aphid feeding by Xiong-bing TU, Hai-long ZHAO, Ze-hua ZHANG

“…In this pilot study, we conducted a transcriptomic analysis of a resistant (R) and susceptible (S) variety of alfalfa, with (+A) or without (–A) aphids (totally four treatments). …”
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Time-course transcriptome analysis reveals gene co-expression networks and transposable element responses to cold stress in cotton by Yan Dai, Jialiang Zhou, Baohong Zhang, Dewei Zheng, Kai Wang, Jinlei Han

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Transcriptomic and metabolomic analyses for the mechanism underlying anthocyanin synthesis during the growth and development of purple eggplant (Solanum melongena L) by Ting Yang, Wanping Lv, Runjie Zhuang, Shiyu Wang, Shuqi Fan, Yongxian Wen, Yongxian Wen

“…Metabolomic profiling identified anthocyanin types, while transcriptomic data highlighted differentially expressed genes. …”
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Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation by Marie Sémon, Marion Mouginot, Manon Peltier, Claudine Corneloup, Philippe Veber, Laurent Guéguen, Sophie Pantalacci

“…Abstract Mice have evolved a new dental plan with two additional cusps on the upper molar, while hamsters were retaining the ancestral plan. …”
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Decoding the impact of MMP1+ malignant subsets on tumor-immune interactions: insights from single-cell and spatial transcriptomics by Da-Ming Xu, Ling-Xiao Chen, Ting Xue, Xiao-Yu Zhuang, Li-Chao Wei, Hui Han, Miao Mo

“…Inhibition of MMP1 in vitro demonstrated reduced cell invasion, stemness, and proliferation, while increasing reactive oxygen species levels and promoting apoptosis. …”
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Decoding the Tissue-Specific Profiles of Bioactive Compounds in <i>Helvella leucopus</i> Using Combined Transcriptomic and Metabolomic Approaches by Qian Zhou, Xusheng Gao, Junxia Ma, Haoran Zhao, Dan Gao, Huixin Zhao

“…To investigate the molecular basis of these tissue-specific variations, we conducted integrative transcriptomic and metabolomic analyses. Metabolomic profiling showed that the cap is particularly rich in bioactive compounds, including sterols and alkaloids, while the stipe is abundant in essential nutrients, such as glycerophospholipids and amino acids. …”
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Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation in the Qinghai Toad-Headed Lizard <i>Phrynocephalus vlangalii</i> by Jun Zhong, Jian Chen, Yu-Hong Lu, Yu-Fei Huang, Ming-Sheng Hong, Xiang Ji

“…In conclusion, the glycogen utilization-related genes and metabolites experienced broad down-regulation, while lipid-related genes and metabolites had a clear trend of up-regulation. …”
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Mobiluncus mulieris alters the transcriptomic profile of cervicovaginal epithelial cells, shedding light on molecular drivers of adverse reproductive outcomes by Yu Hasegawa, Olivia Swain, Urvija Rajpal, Michael T. France, Liqhwa Ncube, Haocheng Yu, Ilaria Mogno, Amir Horowitz, Jacques Ravel, Michal A. Elovitz

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Biomarkers and potential therapeutic targets driving progression of non-alcoholic steatohepatitis to hepatocellular carcinoma predicted through transcriptomic analysis by Hui Fan, Rong Wang, Bin Wen, Jing Xiong

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Transcriptome Analysis Reveals the Molecular Mechanism of <i>Pseudomonas</i> with Different Adhesion Abilities on <i>Tilapia</i> Decay by Liumin Zhuang, Chen Song, Yunru Wei, Jinzhi Han, Li Ni, Chengxu Ruan, Wen Zhang

“…After being exposed to 3.5% NaCl stress, the PS01 strain with low adhesion showed an enhancement in adhesion ability, while the LP-3 strain with high adhesion exhibited a decrease. …”
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Transcriptome Analysis Reveals Immune and Antioxidant Defense Mechanisms in the <i>Eriocheir japonica sinensis</i> after Exposure to Ammonia by Xi-Rong Zhu, Ye Jin, Xue Zhang, Qiu-Ning Liu, Bo-Ping Tang

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Comparative transcriptome analysis of emerging young and mature leaves of Bienertia sinuspersici, a single-cell C4 plant by Richard M. Sharpe, Seanna Hewitt, Gerald Edwards, Amit Dhingra

“…Results In the emergent leaf, differentially expressed genes and enrichment of ontologies associated with the cell cycle and cytoskeletal dynamics were observed, while the mature leaf displayed enrichment of processes associated with photosynthesis and cellular energetics. …”
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Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles by Rong Du, Ajay Kumar, Enzhi Yang, Jingxue Zhang, Ningli Wang, Yiqin Du

“…In this study, we performed a comprehensive transcriptomic comparison of human TMSCs and human TM cells (TMCs) using RNA sequencing and microarray analyses, followed by qPCR validation. …”
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Effects of defined voluntary running distances coupled with high‐fat diet consumption on the skeletal muscle transcriptome of male mice by Afrina Brishti, Sarah J. Johnson, Daniel G. Palmer, Md Obayed Raihan, Lin Yan, Shanon L. Casperson

“…However, complex molecular changes that occur in skeletal muscle in response to exercising while consuming a HFD are not yet known. We investigated the interplay between diverse exercise regimes and HFD consumption on the adaptation of skeletal muscle transcriptome. …”
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Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells by Sasi Kumar Jagadeesan, Ahmad Galuta, Ryan Vimukthi Sandarage, Eve Chung Tsai

“…Functional assays corroborated the transcriptomic findings, demonstrating superior neurogenic potential in iPSC-Br NSPCs. …”
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Multi-omics integrated analysis to generate transcriptome and protome profiles of resveratrol improving Paraquat-induced acute lung injury by Ziying Xu, Lijuan Huang, Zihui Yu, Yagang Gao, Ruikun Wang, Bing Du, Xiaohu Cui, Jing Yuan

“…In the in vitro experiment using A549 cells, Resveratrol effectively alleviated Paraquat-induced oxidative stress and iron ion deposition, significantly increasing cell viability (P < 0.05). Through transcriptomic and proteomic analysis, Resveratrol was found to upregulate genes and proteins associated with inflammation, cell death, and lipid peroxidation, while downregulating those related to lipid peroxidation and iron. …”
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Genomics and Transcriptomics of 3ANX (NX-2) and NX (NX-3) Producing Isolates of <i>Fusarium graminearum</i> by Philip L. Walker, Sean Walkowiak, Srinivas Sura, E. RoTimi Ojo, Maria A. Henriquez

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A cross-tissue transcriptome-wide association study identifies WDPCP as a potential susceptibility gene for coronary atherosclerosis by Xinyue Hu, Guanglei Chen, Xiaofang Yang, Jin Cui, Ning Zhang

“…Background: Coronary atherosclerosis (CAS) is a complex chronic inflammatory disease with significant genetic and environmental contributions. While genome-wide association studies (GWAS) have pinpointed many risk loci, over 75 % are in non-coding regions, complicating functional analysis and understanding gene-disease mechanisms. …”
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Single-cell transcriptomic and m6A methylation analyses reveal platelet-mediated immune regulatory mechanisms in sepsis by Weiwei Qian, Yuanyuan Liu, Xinyang Zhao, Yuxin Dong, Jian Zhou, Songtao Shou

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Ferulic acid and N-Feruloylserotonin ameliorate LPS-induced intestinal inflammation via modulation of gut microbiota, metabolome, and transcriptome by Xiangdong Hu, Xiangdong Hu, Xiangdong Hu, Xuebing Han, Xuebing Han, Gang Liu, Guiping Guan, Chenmei Xia

“…This work establishes a mechanistic foundation for deploying ferulic acid and N-Feruloylserotonin in intestinal health preservation and inflammatory disease prevention, while providing novel insights into microbiota-homeostasis crosstalk.…”
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