Transcriptomic dynamics and cell-to-cell communication during the transition of prospermatogonia to spermatogonia revealed at single-cell resolution by Zhen He, Rong-Ge Yan, Qin-Bang Shang, Qi-En Yang

Get full text

Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation Mechanism of Epididymis Sperm Maturation in Tibetan Sheep by Yijian Li, Yanan Yang, Binyan Yu, Rong Gao, Xinrong Wang

“…With increasing altitude, Tibetan sheep showed a decreasing trend in serum reproductive hormones (FSH and T), while the antioxidant enzyme SOD activity was significantly reduced. …”
Get full text

Metabolic and transcriptomic responses of Taxus mairei to nano-pollutants: insights into AgNPs and PsNPs impact by Zhijing Wang, Pengcheng Zhang, Yao Wei, Zijin Fang, Lingxiao Zhang, Yibo Zhang, Ruoyun Ma, Wanting Lin, Yiang Wang, Erxu Pi, Chenjia Shen, Shuling Wang, Chenliang Yu

“…In T. mairei, AgNPs greatly impacted flavonoid metabolism by regulating the expression of the CHI gene, while PsNPs significantly impacted energy metabolism by regulating the expression of FRK genes. …”
Get full text

Single-cell transcriptomic profiling of immune landscape in triple-negative breast cancer during neoadjuvant chemotherapy by M. R. Patysheva, P. S. Iamshchikov, A. A. Fedorenko, O. D. Bragina, M. A. Vostrikova, E. Y. Garbukov, N. V. Cherdyntseva, E. V. Denisov, T. S. Gerashchenko

Get full text

Biomarkers associated with cell-in-cell structure in kidney renal clear cell carcinoma based on transcriptome sequencing by Zehua Wang, Zhongxiao Zhang

Get full text

Effects of Geraniol on Survival, Reproduction, Endophytes, and Transcriptome of Tea Green Leafhoppers (<i>Empoasca onukii</i>) by Junjie Tian, Hainuo Hong, Shiliang Mo, Shiqin Mo, Hongliang Shi, Juan Shi, Ying Zhou

“…In order to investigate whether the release of geraniol is a defensive mechanism of tea plants against infestation by tea green leafhoppers, our study explored the effects of geraniol on tea green leafhoppers, including the selectivity of tea green leafhoppers’ response to geraniol, survival and reproductive parameters, as well as alterations in endophytes and the transcriptome. The findings indicated that while geraniol did not exhibit strong repellent or lethal effects on tea green leafhoppers, it significantly reduced the egg-laying and hatching rates. …”
Get full text

Stacking ensemble learning models diagnose pulmonary infections using host transcriptome data from metatranscriptomics by Tian Zhang, Ying Deng, Wentao Wang, Zhe Zhao, Yiling Wu, Haoqian Wang, Shutao Xia, Weifang Liao, Weijie Liao

Get full text

Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. by Romina Briffa, Inhwa Um, Dana Faratian, Ying Zhou, Arran K Turnbull, Simon P Langdon, David J Harrison

Get full text

Muscle Spatial Transcriptomic Reveals Heterogeneous Profiles in Juvenile Dermatomyositis and Persistence of Abnormal Signature After Remission by Margot Tragin, Séverine A. Degrelle, Baptiste Periou, Brigitte Bader-Meunier, Christine Barnerias, Christine Bodemer, Isabelle Desguerre, Mathieu Paul Rodero, François Jérôme Authier, Cyril Gitiaux

“…The “myofibrillar stress signature” was prominent in the most severe biopsy while the “muscle remodeling” signature was mostly present in the biopsy from the patient with good outcome. …”
Get full text

Analysis of immune infiltration in basal cell carcinoma based on transcriptome sequencing and experimental validation of diagnostic biomarkers by Pengfei Fan, Yun Liu, Tengxiao Ma, Qiaoxing Wang, Lei Li

“…Abstract Background Basal cell carcinoma (BCC) is the most common type of malignant skin tumour, and its incidence is increasing worldwide. While it grows slowly, BCC is locally invasive, causing significant tissue damage. …”
Get full text

Blood-based transcriptomic biomarkers for response to [177Lu]Lu-DOTA-TATE therapy in neuroendocrine tumors by Hyunpil Sung, Sungwoo Bae, Minseok Suh, Hongyoon Choi, Hyung-Jun Im, Gi Jeong Cheon, Keon Wook Kang

“…Abstract Background [177Lu]Lu-DOTA-TATE is an effective treatment for metastatic neuroendocrine tumors (NETs) expressing somatostatin receptors. While the tumor uptake [177Lu]Lu-DOTA-TATE of has shown potential as a predictive biomarker, patient response to the treatment varies significantly. …”
Get full text

Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis by Hongbin Luo, Qunya Zheng, Youzheng Zhou, Weipeng Lai, Nanwen Zhang, Peng Chen

Get full text

Transcriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism in <i>C. elegans</i> by Hong-Jia Zhang, Hai-Quan Lan, Meng-Ying Wang, Cai-Feng Wang, Lu-Gang Wei, Chen Xu

Get full text

Combining Transcriptome and Hormone-Targeted Metabolome Analyses to Dissect the Regulatory Mechanisms Underlying Wheat Peduncle Elongation by Huifang Hao, Lu Chen, Zhiyang Cao, Xiujuan Jin, Feng Guo, Zerui Shi, Jinwen Yang, Juan Lu, Daizhen Sun

“…This was attributed to the considerable elongation of parenchyma cells, while no significant differences were noted in other internodes. …”
Get full text

Transcriptomic profiling and machine learning reveal novel RNA signatures for enhanced molecular characterization of Hashimoto’s thyroiditis by Zefeng Li, Qiuyu Xu, Fengxu Xiao, Yipeng Cui, Jue jiang, Qi Zhou, Jiangwei Yan, Yu Sun, Miao Li

“…Abstract While ultrasonography effectively diagnoses Hashimoto’s thyroiditis (HT), exploring its transcriptomic landscape could reveal valuable insights into disease mechanisms. …”
Get full text

Spatial Transcriptomics Reveals Regional and Temporal Dynamics of Gene Expression in the Mouse Brain Across Development and Aging by Benjamin Conacher, Amanda Moore, Liduo Yin, Yu Lin, Xiguang Xu, Qinwen Mao, Hehuang Xie

“…Investigating transcriptomic changes during healthy development and aging provides insights into the molecular mechanisms that regulate the maturation of brain functions and drive age-related decline. …”
Get full text

Spatial transcriptomic analysis drives PET imaging of tight junction protein expression in pancreatic cancer theranostics by James Wang, Jai Woong Seo, Aris J. Kare, Martin Schneider, Mallesh Pandrala, Spencer K. Tumbale, Marina N. Raie, Gokce Engudar, Nisi Zhang, Yutong Guo, Xiaoxu Zhong, Sofia Ferreira, Bo Wu, Laura D. Attardi, Guillem Pratx, Andrei Iagaru, Ryan L. Brunsing, Gregory W. Charville, Walter G. Park, Katherine W. Ferrara

“…Abstract Molecular imaging using positron emission tomography (PET) provides sensitive detection and mapping of molecular targets. While cancer-associated fibroblasts and integrins have been proposed as targets for imaging of pancreatic ductal adenocarcinoma (PDAC), herein, spatial transcriptomics and proteomics of human surgical samples are applied to select PDAC targets. …”
Get full text

Histological, Transcriptomic, and Functional Analyses Reveal the Role of Gibberellin in Bulbil Development in <i>Lilium lancifolium</i> by Shanshan Du, Mengdi Wang, Jiahui Liang, Wenqiang Pan, Qianzi Sang, Yanfang Ma, Mengzhu Jin, Mingfang Zhang, Xiuhai Zhang, Yunpeng Du

“…Silencing <i>LlGA20ox2</i> in bulblets inhibited development by reducing the cell length, while overexpression increased the bulblet length and width. …”
Get full text

An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis by Ayano Fukushima-Nomura, Hiroshi Kawasaki, Kiyoshi Yashiro, Shoko Obata, Keiji Tanese, Tamotsu Ebihara, Hidehisa Saeki, Takafumi Etoh, Takehiro Hasegawa, Junshi Yazaki, Jun Seita, Osamu Ohara, Aiko Sekita, Tomohiro Miyai, Koichi Ashizaki, Haruhiko Koseki, Kazuhiro Sakurada, Eiryo Kawakami, Masayuki Amagai

Get full text

Transcriptome sequencing revealed the regulation of stem internode length associated with mechanical harvesting in three tea varieties by Xiaozeng Mi, Xiaozeng Mi, Dahe Qiao, Dahe Qiao, Chun Yang, Chun Yang, Juan Chen, Sihui Liang, Sihui Liang, Yan Guo, Yan Guo

“…IntroductionInternode length of tea plant is one of the key traits affecting the mechanical harvesting effect, but there are relatively few reports on their molecular regulatory.MethodsTranscriptome sequencing (RNA-seq) was performed on it in order to explain its molecular mechanism. …”
Get full text