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Transcriptomic and biochemical insights into key gene networks driving bulbil development of Pinellia ternata (Thunb.) Breit.
Published 2025-01-01“…Based on physiological and biochemical reactions as well as transcriptome technology, this study determined the content of endogenous metabolites and related enzyme activities during the five growth stages of the bulbils, obtained the transcriptome information of all samples. …”
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342
Transcriptome profiling of two rice varieties reveals their molecular responses under high night-time temperature.
Published 2024-01-01“…In this study, we employed a transcriptome approach to investigate the effects of HNT, 1-MCP, and their interaction on two Texas rice varieties, Antonio and Colorado. …”
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Transcriptomic and network toxicology approaches reveal potential mechanisms of DEHP induced intrahepatic cholestasis during pregnancy
Published 2025-07-01“…In conclusion, this study offers novel insights into the molecular mechanisms of DEHP-induced hepatotoxicity during pregnancy while providing a systematic framework for assessing risks associated with DEHP exposure; thus contributing to the prevention and treatment of ICP.…”
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345
Spatial transcriptomics and scRNA-seq: decoding tumor complexity and constructing prognostic models in colorectal cancer
Published 2025-08-01“…Abstract Introduction Recent advancements in transcriptomic analysis, combined with single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics, have deepened our understanding of the tumor microenvironment and cellular heterogeneity, laying the groundwork for personalized therapies. …”
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346
Winnow-KAN: single-cell RNA-seq location recovery with small-gene-set spatial transcriptomics
Published 2025-08-01“…While these state-of-the-art methods demonstrate excellent performance in cell location recovery, their effectiveness is often specific to the particular pair of scRNA-seq and spatial transcriptomics datasets used, limiting their scalability to larger datasets and generalizability to external query scRNA-seq data. …”
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347
Orthologous marker groups reveal broad cell identity conservation across plant single-cell transcriptomes
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348
Differential Gene Expression Analysis of Whole Blood Transcriptome Between Young and Old Border Collie Dogs
Published 2025-01-01“…However, studies on other species, such as wolves, have identified more significant age-related genes. In conclusion, while some of our findings are promising, further research is needed to standardize environmental factors affecting blood gene expression levels in dogs. …”
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349
Spatial transcriptomics reveals tumor microenvironment heterogeneity in EBV positive diffuse large B cell lymphoma
Published 2025-05-01“…Here, we integrated 10X Visium spatial transcriptomics (ST) with single-cell RNA sequencing (scRNA-seq) to map TME heterogeneity in EBV+DLBCL. …”
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350
De Novo Assembly, Characterization and Comparative Transcriptome Analysis of the Mature Gonads in <i>Megalobrama terminalis</i>
Published 2025-07-01“…This paper presents the first comparative transcriptome analysis of the gonads of female and male <i>M. terminalis</i>. …”
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351
Transcriptome Analysis of Resistant and Susceptible Sorghum Lines to the Sorghum Aphid (<i>Melanaphis sacchari</i> (Zehntner))
Published 2025-07-01“…Moench) cultivars, revealing that HX133 significantly suppressed aphid proliferation through repellent and antibiotic effects, while aphid populations increased continuously in HX37. …”
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DLX4 regulates rheumatoid arthritis fibroblast-like synoviocytes invasiveness and a cancer transcriptomic signature
Published 2025-07-01“…HMOX1 and SOD2 were among the genes with the most significantly increased expression, while CPNE3 and HADHA were among those with the most significantly decreased expression in FLS knocked down for DLX4 compared with controls. …”
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XModNN: Explainable Modular Neural Network to Identify Clinical Parameters and Disease Biomarkers in Transcriptomic Datasets
Published 2024-11-01“…Two crucial genes and three pathways were identified for sex classification, while 26 genes and six pathways are highly important to discriminate adrenergic–mesenchymal cell states in neuroblastoma cancer.…”
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Transcriptome analysis of Bombyx mori larval midgut during persistent and pathogenic cytoplasmic polyhedrosis virus infection.
Published 2015-01-01“…Collectively, our data provide an initial assessment of the relative significance of persistent infection of silkworm larvae on the host response following pathogenic infection with CPV, while they also highlight the relative importance of RNAi as an antiviral mechanism.…”
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359
A Review of Genomic, Transcriptomic, and Proteomic Applications in Edible Fungi Biology: Current Status and Future Directions
Published 2025-05-01“…It discusses how these technologies, independently and in preliminary integration, uncover critical steps and regulatory mechanisms within endogenous metabolic pathways. While acknowledging the importance of metabolomics and epigenomics as cutting-edge areas, this review focuses on the “classical triad” of genomics, transcriptomics, and proteomics due to their technological maturity, data accessibility, and established application base in elucidating core metabolic mechanisms in edible fungi. …”
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In-Depth Exploration of the Coloration Mechanism of <i>Iris dichotoma</i> Pall. via Transcriptomic and Metabolomic Analyses
Published 2025-05-01“…A comprehensive integrative analysis of the transcriptome and metabolome of the two petal types was carried out. …”
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