Insights into growth retardation and dwarfism caused by goose parvovirus in goslings: a transcriptomic profiling study by Keshan Zhang, Guangliang Gao, Zhuping Chen, Hongyuan Zhang, Xianzhi Zhao, Qin Li, Lin Ma, Lecheng Wang, Yi Luo, Qigui Wang

“…Serum analysis revealed a marked increase in the levels of immunosuppressive factors such as TGF-β and IL-10 (p < 0.01 or p < 0.05), while the levels of pro-inflammatory cytokines such as IL-4, IFN-γ, TNF-α, and IgG remained unaffected. …”
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Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period by Xiaoxia Zhang, Wenxuan Zhu, Zirui Liu, Xiangling Ren, Yingao Li, Guomin Li, Jingzhuo Wang, Xiaoyan Zhu, Yinghua Shi, Chengzhang Wang, Defeng Li, Hao Sun

“…Additionally, there was a reduction in the levels of malondialdehyde (MDA) and superoxide anion (O2 −), while the activity and concentration of superoxide dismutase (SOD), peroxidase (POD), and glutathione (GSH) were enhanced to varying extents. …”
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Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver by Lijuan Chen, Guoyuan Sui, Jin Wu, Ning Li, Zhe Zhang, Ying Du, Meijun Lü, Xiaorui Yan, Guowei Pan, Lianqun Jia

“…Additionally, transcriptomics reveals that differentially expressed genes (DEGs) triggered by NPs exposure are predominantly involved in metabolic routes including lipid metabolism and cytochrome P450 (CYP). …”
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Physiological and Transcriptomic Mechanisms Underlying Vitamin C-Mediated Cold Stress Tolerance in Grafted Cucumber by Panpan Yu, Junkai Wang, Xuyang Zhang, Zhenglong Weng, Kaisen Huo, Qiuxia Yi, Chenxi Wu, Sunjeet Kumar, Hao Gao, Lin Fu, Yanli Chen, Guopeng Zhu

“…Results showed that 150 mg L⁻¹ Vc treatment was most impactive, significantly reducing the cold damage index while increasing the root-to-shoot ratio, root vitality, chlorophyll content, and activities of antioxidant enzymes (SOD, POD, CAT). …”
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Transcriptomic response of the picoalga Pelagomonas calceolata to nitrogen availability: new insights into cyanate lyase function by Nina Guérin, Chloé Seyman, Céline Orvain, Laurie Bertrand, Priscillia Gourvil, Ian Probert, Benoit Vacherie, Élodie Brun, Ghislaine Magdelenat, Karine Labadie, Patrick Wincker, Adrien Thurotte, Quentin Carradec

“…By utilizing both global scale in situ metatranscriptomes and laboratory-based transcriptomics, we uncover how P. calceolata adapts to low-nitrate conditions. …”
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Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implications by Xiaoxiao Wang, David Venet, Frédéric Lifrange, Denis Larsimont, Mattia Rediti, Linnea Stenbeck, Floriane Dupont, Ghizlane Rouas, Andrea Joaquin Garcia, Ligia Craciun, Laurence Buisseret, Michail Ignatiadis, Marcela Carausu, Nayanika Bhalla, Yuvarani Masarapu, Eva Gracia Villacampa, Lovisa Franzén, Sami Saarenpää, Linda Kvastad, Kim Thrane, Joakim Lundeberg, Françoise Rothé, Christos Sotiriou

“…Abstract While triple-negative breast cancer (TNBC) is known to be heterogeneous at the genomic and transcriptomic levels, spatial information on tumor organization and cell composition is still lacking. …”
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Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics by Binbin Gong, Binbin Gong, Binbin Gong, Feixiang Yang, Feixiang Yang, Feixiang Yang, Ning Zhang, Zhengyang Wu, Tianrui Liu, Kun Wang, Xiangyu Zhang, Yangyang Zhang, Zhengyao Song, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

“…BackgroundProstatic diseases, consisting of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa), pose significant health challenges. While single-omics studies have provided valuable insights into the role of mitochondrial dysfunction in prostatic diseases, integrating multi-omics approaches is essential for uncovering disease mechanisms and identifying therapeutic targets.MethodsA genome-wide meta-analysis was conducted for prostatic diseases using the genome-wide association studies (GWAS) data from FinnGen and UK Biobank. …”
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The alteration of IL-17 signaling pathway in bipolar disorder: a preliminary study with transcriptomic perspective by Xiaobo Wang, Xiaobo Wang, Su Yu, Zhen Gao, Fangming Xu, Yumei Wang, Yumei Wang, Yumei Wang, Tianle Zhang, Tingting Xie, Xihua Jia

“…Validation of differentially expressed genes within the IL-17 pathway was conducted through qRT-PCR, while ELISA measured specific protein levels. GO and KEGG pathway enrichment analyses were performed, alongside PPI analysis and Gene Set Variation Analysis (GSVA) to assess immune cell infiltration.ResultsIn the comparison between BD and HC, a total of 304 differentially expressed genes (DEGs) were identified, of which 217 genes were upregulated and 87 genes were downregulated. …”
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Proteomic and transcriptomic analyses identify apo-transcobalamin-II as a biomarker of overall survival in osteosarcoma by Ryan A. Lacinski, Ryan A. Lacinski, Sebastian A. Dziadowicz, Sebastian A. Dziadowicz, Clark A. Roth, Li Ma, Li Ma, Vincent K. Melemai, Brody Fitzpatrick, Edwin Chaharbakhshi, Tanya Heim, Ines Lohse, Karen E. Schoedel, Gangqing Hu, Gangqing Hu, Nicolas J. Llosa, Kurt R. Weiss, Brock A. Lindsey

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Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata by Jesus Gay-Mimbrera, Pedro Jesús Gómez-Arias, Pedro Jesús Gómez-Arias, Pablo Álvarez-Heredia, Alexander Batista-Duharte, Irene Rivera-Ruiz, Macarena Aguilar-Luque, Miguel Juan-Cencerrado, Miguel Juan-Cencerrado, Carmen Mochón-Jiménez, Carmen Mochón-Jiménez, Álvaro Cebrián-García, Eloísa Andújar-Pulido, Mónica Pérez-Alegre, Alejandra Pera, Alejandra Pera, Juan Ruano, Juan Ruano, Juan Ruano

“…IntroductionAlopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss ranging from mild, self-limiting episodes to severe and chronic forms. While prior research has primarily focused on lesional skin, the contribution of systemic immune cells remains underexplored.MethodsWe performed integrated single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) on peripheral blood mononuclear cells (PBMCs) from patients with mild and severe AA, as well as healthy controls. …”
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Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics by Chaonan Wang, Yuyao Feng, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Keqiang Shu, Deqiang Kong, Jiaxian Wang, Yiran Li, Xiangling Lei, Chen Li, Bao Liu, Wei Sun, Zhichao Lai

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Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas by Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding

“…Background While the prognostic role of tertiary lymphoid structures (TLS) has been well studied in solid cancers, the prevalence and impact of immature precursor lymphoid structures known as lymphoid aggregates (LA) remain unresolved in relation to the disease process. …”
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Transcriptome and hormonal analyses reveal an important role of auxin and cytokinin in regulating rice ratooning ability by Can Hu, Chenfan Zheng, Bo Liu, Like Sun, Jiaxi Yin, Yuanyuan Tan, Pedro García-Caparros, Qingyao Shu, Meng Jiang

“…RRA3 has been shown to inhibit RA of rice by suppressing cytokinin signal transduction, while qRA2 promotes RA. In the present study, the RA trait was evaluated in 23 rice varieties cultivated across three different locations in Hainan Province, showing substantial phenotypic variation. …”
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Integrated metabolomic and transcriptomic analysis reveals the biosynthesis mechanism of dihydrochalcones in sweet tea (Lithocarpus litseifolius) by Shaojun Ling, Shaojun Ling, Shaojun Ling, Qiongqiong Lin, Qiongqiong Lin, Qiongqiong Lin, Biaofeng Zhou, Biaofeng Zhou, Biaofeng Zhou, Yiye Liang, Yiye Liang, Yiye Liang, Wenji Luo, Wenji Luo, Wenji Luo, Zhao Shen, Zhao Shen, Zhao Shen, Jingshu Wang, Jingshu Wang, Jingshu Wang, Jingwei Niu, Jingwei Niu, Jingwei Niu, Liangjing Qiao, Liangjing Qiao, Liangjing Qiao, Baosheng Wang, Baosheng Wang, Baosheng Wang, Hui Liu, Hui Liu, Hui Liu

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Changes of endogenous hormone concentrations and transcriptome analysis during the healing process of greenwood grafting in grape by DENG Jiayi, WEI Jiayan, CHEN Aisai, HE Fei, YU Keji, WANG Jun

“…From the analysis of plant hormone levels, the concentration of IAA increased, while the concentrations of IP, ABA and JAs decreased during healing. …”
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Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment by Wilanee Dechkhajorn, Yaowapa Maneerat, Kriengchai Prasongsukarn, Panan Kanchanaphum, Ratchanok Kumsiri

“…This cross-sectional study investigates the association of the IL-8 expression in hyperlipidemia (H) and CHD patients who have been treated with statin cholesterol-lowering drugs while undergoing coronary artery bypass grafting treatment. …”
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Transcriptome and Cellular Evidence of Depot-Specific Function in Beef Cattle Intramuscular, Subcutaneous, and Visceral Adipose Tissues by Alexandra P. Tegeler, Hunter R. Ford, Jean Franco Fiallo-Diez, Tainara C. Michelotti, Bradley J. Johnson, Oscar J. Benitez, Dale R. Woerner, Clarissa Strieder-Barboza

“…Approaches to increase marbling while limiting subcutaneous and visceral adiposity are limited. …”
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Temporal transcriptome and WGCNA analysis unveils divergent drought response strategies in wild and cultivated Solanum varieties by Athira C. Rajeev, Athira C. Rajeev, Rajesh Raju, Archana Pan

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Characterization of canine tumor-infiltrating leukocyte transcriptomic signatures reveals conserved expression patterns with human osteosarcoma by Dylan T. Ammons, R. Adam Harris, Lyndah Chow, Steven Dow

“…Comparisons to human literature and analysis of human scRNA-seq data revealed conserved transcriptomic responses to tumor infiltration, while also identifying species differences. …”
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A cross‐tissue transcriptome‐wide association study identifies novel susceptibility genes for atrial fibrillation by Yalin Yuan, Xin Zheng, Wenjing Zhang, Zhaoyu Ren, Bin Liang

“…MR analysis further revealed that the gene expression levels of FKBP7, CEP68, and CAMK2D were positively associated with AF risk, while SPATS2L exhibited a significant protective effect. …”
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