KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML by Junhui Lv, Zhinang Yin, Conghui Li, Honglin Wen, Jian Ni, Peiyuan Yang, Zemin Song, Ying Xiang, Honghong Wang, Rui Lu, Li Huang, Ying Zhou, Hai-Bing Zhou, Ruijing Xiao, Pingping Fang, Kaiwei Liang

“…Results We employ a domain-focused truncation strategy to generate de novo murine models of K/C and K/P fusions, which faithfully recapitulate the morphological, immunophenotypic, and transcriptomic features of KAT6A-rearranged AML. Genomic profiling reveals that KAT6A fusions preferentially localize to H3K4me2/3-marked regions, while biochemical analyses uncover that KAT6A interacts with the Nucleosome Remodeling Factor (NURF), a key H3K4me2/3 reader. …”
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Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFκB1/CXCL9-mediated tumor growth and metastasis by Kai-Di Ni, Xian Fu, Ying Luo, Xin He, Hou-Hua Yin, Dong-Ping Mo, Jing-Xian Wu, Ming-Jun Wu, Xiao Zheng, Ya-Nan Liu, Qing Jiang, Ling-Tong Zhang, Ai-Zhi Lin, Ling Huang, Qing-Jin Pan, Xue-Dong Yin, Huan-Yu Zhang, Yi-Wen Meng, Xue Zhou, Jianbo Pan, Zufeng Guo, Jun-Yan Liu

“…Both overexpression of CYP2J2 and EpOME treatment upregulate PLEC, while PLEC upregulates NFκB1, which is a transcription regulator of CXCL9. …”
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UBC9 overexpression promotes proliferation and metastasis in gastric cancer via ATF2 by QingShui Wang, ShengZhao Li, YiNing Xu, Yuluo Chen, Chao Xu, QiuYan He, Yan Ye, YiMin Huang, Yue Wu, KeJia Guo, YaJuan Wei, Yide Huang, Yan Liu, Qing Lin, Shanshan Wang, Feng Li, Minghan Huang, FangQin Xue, Yao Lin

“…Abstract Gastric cancer remains a leading cause of cancer-related mortality worldwide, characterized by poor prognosis due to its aggressive nature and high metastatic potential. While the E2-conjugating enzyme UBE2I (UBC9), essential for SUMOylation, has been implicated in various cancers, its precise role in gastric cancer remains poorly understood. …”
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A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage by YuYa Wang, Wei Yang, YuanSong Yang, HuiHui Cheng, Rui Xiong, Xi Wu, Nan Xu, ShuNan Liu, Zhe Qu, Chen Ling, Yuan Cao, Yanwei Yang, HaoYang Zhao, WenDa Gu, Yong Wu, SuSu Liu, Yining Wang, Yu Wang, SanLong Wang, Rui Fu, WeiJin Huang, Hongning Zhou, Wei Wei, Jing An, YouChun Wang, ChangFa Fan

“…Dengue virus (DENV) infection remains a critical global health threat, with DENV-2 being the most virulent serotype capable of causing lethal dengue hemorrhagic fever (DHF), a severe complication characterized by plasma leakage and hemorrhagic manifestations. While the search for viral receptors and immunocompetent animal models has persisted since the first recorded outbreak in 1779, significant gaps remain. …”
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hCCL19-expressing recombinant Newcastle disease virus boosts CAR T cell infiltration and efficacy in solid tumor by Qian Li, Ling Wang, Man Liu, Ze-kun Liu, Wen Yin, Can Li, Lan-Ting Feng, Ren-Yu Zhang, Wen-Liang Li, Hai-Jiao Yang, Yu-Le Yong, Xiang-Min Yang, Hong-Yong Cui, Ling-Min Kong, Zhi-Nan Chen, Huijie Bian, Ding Wei

“…Tumor burden, immune cell infiltration, and mouse survival were analyzed.Results rNDV19 retained potent oncolytic activity, significantly reducing tumor cell viability while achieving stable expression of human CCL19. rNDV19 triggered significant recruitment of CAR T cells into tumors and promoted their activity. …”
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Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations by Yiyue Jiang, Zheng Zhang, Kangkang Ren, Shujuan Zhou, Yang Qiao, Weilu Huang, Nanyang Zhang, Hanyan Xu, Xinping Xu, Bing Wen, Wei Zhang, Lu Yin

“…The large- and medium-sized subpopulation upregulates genes involved in immune responses, calcium signaling, and ECM-receptor interaction, while the small-sized subpopulation downregulates genes associated with immune response pathways, cell cycle, and growth factor activities. …”
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Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis by Liang Chen, Yuanqing Liu, Chenhao Yu, Pei Cao, Yiming Ma, Yiran Geng, Yu Cai, Yong Zhang, Jia Liu, Yang Li, Qingxian Luan

“…Additionally, iMSCs reduce the production of pro-inflammatory cytokines (IL-1β, IL-17) and reactive oxygen species (ROS), while enhancing the secretion of anti-inflammatory cytokines (IL-10) and growth factors (VEGF), thereby improving the inflammatory microenvironment. …”
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Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysisResearch in context by Wanqing Dong, Jie Bai, Qibin Yuan, Yingyu Zhang, Yongjiang Zhang, Ziyue Zhang, Maoxing Yang, Hanxiao Li, Ziyue Zhao, Hongwei Jiang

“…Mazdutide, a dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR), has been shown to simultaneously reduce body weight, blood glucose levels, and other comorbidities associated with obesity in patients with T2DM. While its insulinotropic and glucose-lowering effects through the GLP-1 pathway are well-established, mazdutide may also enhance energy expenditure via activation of the GCGR pathway. …”
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Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell mali... by Xiaoyu Chen, Yuqing Wang, Ziqi Liu, Yujie He, Huan Gao, Xinchao Guan, Liping Chen, Shen Chen, Xiumei Xing, Wen Chen, Daochuan Li, Qing Wang

“…Among them, USP7 was upregulated, while ATM, S1PR1, and PLK2 were downregulated in cancer tissues. …”
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Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study by Dimitrii Pogorelov, Sebastian Felix Nepomuk Bode, Xin He, Javier Ramiro-Garcia, Fanny Hedin, Wim Ammerlaan, Maria Konstantinou, Christophe M. Capelle, Ni Zeng, Aurélie Poli, Olivia Domingues, Guillem Montamat, Oliver Hunewald, Séverine Ciré, Alexandre Baron, Joseph Longworth, Agnieszka Demczuk, Murilo Luiz Bazon, Ingrid Casper, Ludger Klimek, Lorie Neuberger-Castillo, Dominique Revets, Lea Guyonnet, Sylvie Delhalle, Jacques Zimmer, Vladimir Benes, Françoise Codreanu-Morel, Christiane Lehners-Weber, Ilse Weets, Pinar Alper, Dirk Brenner, Jan Gutermuth, Coralie Guerin, Martine Morisset, François Hentges, Reinhard Schneider, Mohamed H. Shamji, Fay Betsou, Paul Wilmes, Enrico Glaab, Antonio Cosma, Jorge Goncalves, Feng Q. Hefeng, Markus Ollert

“…Abstract Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen allergy. However, the molecular switches leading to successful durable tolerance restoration remain elusive. …”
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Improving the therapeutic profile of MSCs: Cytokine priming reduces donor-dependent heterogeneity and enhances their immunomodulatory capacity by Jaris Valencia, Jaris Valencia, Jaris Valencia, Rosa M. Yáñez, Rosa M. Yáñez, Rosa M. Yáñez, Sandra Muntión, Sandra Muntión, Sandra Muntión, María Fernández-García, María Fernández-García, María Fernández-García, Jorge Diego Martín-Rufino, Jorge Diego Martín-Rufino, Agustín G. Zapata, Agustín G. Zapata, Agustín G. Zapata, Juan A. Bueren, Juan A. Bueren, Juan A. Bueren, Ángeles Vicente, Ángeles Vicente, Ángeles Vicente, Fermín Sánchez-Guijo, Fermín Sánchez-Guijo, Fermín Sánchez-Guijo

“…Moreover, cytokine priming enhances the anti-inflammatory and immunomodulatory properties of MSCs against NK and dendritic cells, while maintaining the same T cell immunomodulatory capacity as unstimulated MSCs. …”
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Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease by Henna Martiskainen, Roosa-Maria Willman, Päivi Harju, Sami Heikkinen, Mette Heiskanen, Stephan A. Müller, Rosa Sinisalo, Mari Takalo, Petra Mäkinen, Teemu Kuulasmaa, Viivi Pekkala, Ana Galván del Rey, Sini-Pauliina Juopperi, Heli Jeskanen, Inka Kervinen, Kirsi Saastamoinen, FinnGen, Marja Niiranen, Sami V. Heikkinen, Mitja I. Kurki, Jarkko Marttila, Petri I. Mäkinen, Hannah Rostalski, Tomi Hietanen, Tiia Ngandu, Jenni Lehtisalo, Céline Bellenguez, Jean-Charles Lambert, Christian Haass, Juha Rinne, Juhana Hakumäki, Tuomas Rauramaa, Johanna Krüger, Hilkka Soininen, Annakaisa Haapasalo, Stefan F. Lichtenthaler, Ville Leinonen, Eino Solje, Mikko Hiltunen

“…Some other TREM2 variants contribute to the risk of Alzheimer’s disease (AD) and frontotemporal dementia, while deleterious TYROBP variants are globally extremely rare and their role in neurodegenerative diseases remains unclear. …”
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JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction by Dewei Peng, Xiaoli He, Bowen Ren, Qian Wang, Lulu Peng, Yue Jiang, Shengqi Huo, Lintong Men, Wei Shi, Pengcheng Luo, Mengyin Zhu, Cuntai Zhang, Jiagao Lv, Li Lin, Sheng Li

“…Methods A hyperuricemic mouse model was established, and transcriptomic analysis of myocardial tissue was conducted using RNA sequencing. …”
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<i>ZmNLR</i><i>-7</i>-Mediated Synergistic Regulation of ROS, Hormonal Signaling, and Defense Gene Networks Drives Maize Immunity to Southern Corn Leaf Blight by Bo Su, Xiaolan Yang, Rui Zhang, Shijie Dong, Ying Liu, Hubiao Jiang, Guichun Wu, Ting Ding

“…Moreover, H₂O₂ content decreased, while lipid peroxide MDA accumulation increased. …”
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Transitional CXCL14+ cancer‐associated fibroblasts enhance tumour metastasis and confer resistance to EGFR‐TKIs, revealing therapeutic vulnerability to filgotinib in lung adenocarc... by Weijiao Xu, Haitang Yang, Ke Xu, Anshun Zhu, Sean R. R. Hall, Yunxuan Jia, Baicheng Zhao, Enshuo Zhang, Gang Liu, Jianlin Xu, Thomas M. Marti, Ren‐Wang Peng, Patrick Dorn, Yongliang Niu, Xufeng Pan, Yajuan Zhang, Feng Yao

“…Among standard treatment regimens, transitional CXCL14+ myCAFs specifically confer resistance to EGFR‐TKIs, while showing no significant impact on chemotherapy or immunotherapy outcomes. …”
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Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments by Bowen Yin, Jingyi Ren, Xuanyi Liu, Yadong Zhang, Jinshi Zuo, Rui Wen, Huanting Pei, Miaomiao Lu, Siqi Zhu, Zhenao Zhang, Ziyi Wang, Yanyi Zhai, Yuxia Ma

“…Specifically, ASX upregulates solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), while downregulating the expression of transferrin receptor 1 (TFRC), ferritin heavy chain (FTH1) and ferritin light chain (FTL). …”
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Inflammatory markers after supplementation with marine n-3 or plant n-6 PUFAs: A randomized double-blind crossover study by Elise Grytten, Johnny Laupsa-Borge, Kaya Cetin, Pavol Bohov, Jan Erik Nordrehaug, Jon Skorve, Rolf K. Berge, Elin Strand, Bodil Bjørndal, Ottar K. Nygård, Espen Rostrup, Gunnar Mellgren, Simon N. Dankel

“…Cytokines and chemokines (multiplex assay), acute-phase proteins (MALDI-TOF mass spectrometry), endothelial function (vascular reaction index), blood pressure, FA composition (red blood cell membranes/serum/adipose tissue, GC-MS/MS), and adipose gene expression (microarrays, quantitative PCR) were measured. While significant differences between treatments in relative change scores were found for systolic blood pressure (n-3 vs. n-6: −1.81% vs. 2.61%, P = 0.003), no differences between n-3 and n-6 were found for any circulatory inflammatory markers. …”
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Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates by Pierre Gaudeaux, Pierre Gaudeaux, Juliette Paillet, Juliette Paillet, Monah Abou Alezz, Ranjita Devi Moirangthem, Ranjita Devi Moirangthem, Sara Cascione, Marta Martin Corredera, Marta Martin Corredera, Anne-Catherine Dolens, Anne-Catherine Dolens, Katrien De Mulder, Katrien De Mulder, Imke Velghe, Imke Velghe, Bart Vandekerckhove, Bart Vandekerckhove, Marieke Lavaert, Marieke Lavaert, Noémie Robil, Aurélien Corneau, Aurélien Corneau, Hanem Sadek, Pauline Rault, Akshay Joshi, Pierre de la Grange, Frank J. T. Staal, Frank J. T. Staal, Tom Taghon, Tom Taghon, Olivier Negre, Andrea Ditadi, Isabelle André, Tayebeh-Shabi Soheili

“…Using integrated transcriptomic analyses to compare these ex vivo-generated progenitors to in vivo human thymocytes, we revealed strong similarities with early stages of T cell development, underscoring the physiological relevance of our system. …”
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Proteogenomic characterization of invasive breast tumors in young women by Praveen-Kumar Raj-Kumar, Jianfang Liu, Anthony R. Soltis, Nicholas W. Bateman, Qingrong Chen, Lori A. Sturtz, Brenda Deyarmin, Mariaelena Pierobon, Tamara A. Abulez, Anupama Praveen-Kumar, Xijun Zhang, Trinh Nguyen, Chunhua Yan, Ying Hu, Kate Guion, Jeffrey A. Hooke, Albert J. Kovatich, Leigh Fantacone-Campbell, Brad Mostoller, Leonid Kvecher, Stella Somiari, Patricia S. Steeg, Padma Sheila Rajagopal, Kathleen M. Darcy, Jerry S. H. Lee, Clifton L. Dalgard, Thomas P. Conrads, Emanuel F. Petricoin, Daoud Meerzaman, Matthew D. Wilkerson, APOLLO Research Network, Xiaoying Lin, Craig D. Shriver, Stanley Lipkowitz, Hai Hu

“…Notably, GATA3 mutations were enriched in luminal tumors from young women while TP53 and PIK3CA mutations were more common in luminal tumors from older women. …”
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LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy f... by Yanjun Wang, Xin Zhang, Mengmeng Ren, Shu He, Hengjie Bie, Mengyang Duan, Zhiyuan Chen, Qiaowei Jia, Boyu Chi, Xiongkang Gan, Chengcheng Li, Yahong Fu, Hanxiao Zhou, Sheng Zhang, Qian Zhang, Fenghui An, Xiumei Chen, Enzhi Jia

“…Conclusions Our results delineated the dynamic disruption of the autophagy landscape during the progression of human coronary atherosclerosis and identified the lncRNA LUCAT1/hsa-miR-6776-5p/LRRC25 axis, uncovered through transcriptomic profiling, as a protective mechanism against endothelial cell injury through autophagy activation. …”
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