ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity by Yiming Liu, Xingyu Jiang, Dongquan Jing, Yanting Lin, Rui Gao, Qixiang Zhao, Huijuan Da, Yiming Ren, Qiuhua Cao, Ning Liu, Xiaoyun Han, Juan Du, Xinghua Gao

“…The effect of ACSL4 silencing on PD-L1 blockade efficacy was also examined.Results: ACSL4 levels were markedly increased in CRC and linked to unfavorable patient outcomes. While ACSL4 knockdown had no direct effect on CRC cell proliferation, it significantly suppressed tumor growth in immunocompetent mice. …”
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Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Additionally, rs4883263 in CD163 was related to low PLT count at diagnosis, while rs2272022 in CD200 was protective against low PLT count. rs4780335 in CIITA was associated with high WBC count at diagnosis and worse OS. …”
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Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells by Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Clémence Rives, Jules Imler, Sofiane Safi-Stibler, Lara Gales, Floriant Bellvert, Julien Dairou, Auriane Hagimont, Agnès Burel, Dominique Lagadic-Gossmann, Robert Barouki, Jerry W. Shay, Jean Bastin, Sophie Mouillet-Richard, Anthony Lemarié, Fatima Djouadi, Sandrine Ellero-Simatos, Xavier Coumoul, Judith Favier, Sylvie Bortoli

“…SDHi exposure also induces a Warburg-like metabolic reprogramming typical of cancer cells, associated with transcriptomic and morphological changes promoting cell migration and invasion. …”
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Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution by Chunliang Liu, Xiang Wang, Erdong Liu, Yali Zong, Wenlong Yu, Youhai Jiang, Jianan Chen, Mingye Gu, Zhengyuan Meng, Jingfeng Li, Yang Liu, Yongjie Zhang, Jing Tang, Hongyang Wang, Jing Fu

“…Specifically, iCCAs were associated with a senescent program, while eCCAs were enriched in an IFN-responsive program linked to adverse clinical outcomes and increased drug resistance. …”
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Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells by Ye Yang, Ye Yang, Jieyun Zhou, Qiaoying Lv, Qicheng Ni, Qicheng Ni, Baichun Hu, Yulong Wang, Shuning Qu, Guoting Li, Wenjie Yang, Ruihua Zhong, Xiaojun Chen, Yan Zhu

“…In vivo, nude mouse xenograft models were used to evaluate the efficacy of CANA and MPA. Transcriptomic and proteomic analyses were performed to identify pathways associated with progestin resistance. …”
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NIR-responsive tissue-adaptive hydrogel for accelerating healing of seawater-immersed wounds by Rui Ma, Li Xu, Ze Li, Sicheng Li, Ye Liu, Guiwen Qu, Kang Chen, Canwen Chen, Luqiao Huang, Yitian Teng, Xinxin Huang, Shuanghong Yang, Qingchuan Li, Jinjian Huang, Jianan Ren, Xiuwen Wu

“…This study presented the first transcriptomic profiling of V. vulnificus following photothermal treatment (PTT). …”
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Single-cell landscape of immunological responses in patients with juvenile idiopathic arthritis by Yun Liu, Xiwen Luo, Liuqing Yang, Qiang Luo, Xiya Luo, Li Xu, Yating Wang, Yunfei An, Yupeng Cun, Xuemei Tang

“…The study aimed to analyze the single-cell transcriptomes of immune cells in juvenile idiopathic arthritis (JIA) patients to understand the cellular heterogeneity within the immune system. …”
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RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer by Jing Zhu, Chun Yu, Xin Xu, Chu Zou, Jiaqi Li, Rui Wang, Xinchao Li, Aijun Sun, Shiyan Wang, Chao Jiang

“…The TISCH database identified primary cell types expressing RAB5B within the tumor microenvironment, while univariate Cox regression modeling evaluated its prognostic significance in cancer outcomes. …”
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Mesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis by Alexandra C. Bayer, Natalia Pinzón, Axel You, Cinthia Bergman, Nadine Dragin, Aurélien Corneau, Frédérique Truffault, Danièle Noël, Christophe Martinaud, Rozen Le Panse, Sonia Berrih-Aknin, Jean-Thomas Vilquin

“…In contrast, IFN-γ activation predominantly increased HLA-related markers while also enhancing the homogeneity of the populations. …”
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Regulatory role of lncRNA MSTRG.11540.1 on the novel-m1192-3p/CYP2C70 axis in modulating albendazole resistance in Haemonchus contortus by Xindi Chen, Tengyu Wang, Xu Yan, Ya Su, Wa Gao, Chunxia Liu, Huilin Kou, Yu Yu, Xianran Meng, Wenlong Wang, Wenrui Guo

“…Starting with significantly upregulated lncRNAs and incorporating functional enrichment analysis of predicted target genes, a potential regulatory axis—MSTRG.11540.1/novel-m1192-3p/HCON_00073890 (CYP2C70)—was identified from the ceRNA network. Transcriptomic analysis revealed that MSTRG.11540.1 and CYP2C70 were significantly upregulated (fold changes of 1.20 and 4.01, respectively; P < 0.01), while novel-m1192-3p was significantly downregulated (fold change: 5.91; P < 0.05) in resistant strains. …”
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S100A8/A9 high-expression macrophages mediate renal tubular epithelial cell damage in acute kidney injury following acute type A aortic dissection surgery by Xiujuan Cai, Xin Li, Jian Shi, Lu Tang, Jie Yang, Ronghuang Yu, Zhigang Wang, Dongjin Wang, Dongjin Wang

“…Marker genes of M1-type macrophages, like Nos2 and Il1b, were upregulated in S100A8/A9 overexpressed M1-type macrophages, while the opposite was observed in the downregulated group. …”
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Subcutaneous checkpoint inhibition is equivalent to systemic delivery when combined with nelitolimod delivered via pressure-enabled drug delivery for depletion of intrahepatic myel... by Diwakar Davar, Yujia Liu, Jason Laporte, Prajna Guha, Steven C Katz, Chandra C Ghosh, Lauren Cournoyer, Alizee Ballarin, Ilan B Layman, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha

“…Tissues were harvested on Day 3 (D3) or Day 10 (D10) post-PEDD to enrich CD45+ cells and were analyzed via NanoString targeted transcriptomics (D3) or flow cytometry (FC, D10) to interrogate immune cell populations (D10). …”
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Differential gene expression of tumor-infiltrating CD8+ T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis by Reem Saleh, Varun Sasidharan Nair, Salman M Toor, Rowaida Z Taha, Khaled Murshed, Mahmood Al-Dhaheri, Mahwish Khawar, Mahir Abdulla Petkar, Mohamed Abu Nada, Fares Al-Ejeh, Eyad Elkord

“…Densities of CD3+ and CD8+ T cell infiltration in tumors from patients with high and low ppCD8sig scores were assessed by flow cytometry and immunostaining.Results Genes related to epigenetic regulation and response to hypoxia were upregulated in CD8+ TILs from patients with advanced stages, while genes related to T cell activation, cell proliferation and cell cycle were downregulated. …”
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A myeloid IFN gamma response gene signature correlates with cancer prognosis by Yuchao Zhang, Asma Khanniche, Yizhe Li, Zhenchuan Wu, Hailong Wang, Hongyu Zhang, Xiaoxue Li, Landian Hu, Xiangyin Kong

“…Abstract Background The IFN‐γ cytokine plays a dual role in anti‐tumor immunity, enhancing immune defense against cancer cells while promoting tumor survival and progression. Its influence on prognosis and therapeutic responses across cancer types remains unclear. …”
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CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation by Juan Juan Chen, Zhang Ze Lu, Yu Xin Jing, Xing Mei Nong, Yi Qin, Jin Yang Huang, Na Lin, Jie Wei

“…CD79A was significantly downregulated in severe cases, correlating with impaired B-cell responses and cytotoxic immunity, while GADD45A, upregulated in severe infections, linked to oxidative stress and neutrophil-driven inflammation. …”
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Integrated promoter-capture Hi-C and Hi-C analysis reveals fine-tuned regulation of the 3D chromatin architecture in colorectal cancer by Ajay Kumar Saw, Ayush Madhok, Anupam Bhattacharya, Anupam Bhattacharya, Soumyadeep Nandi, Sanjeev Galande, Sanjeev Galande

“…The analysis focused on identifying fine-scale interactions within topologically associated domains (TADs) while incorporating histone modification landscapes (H3K27ac, H3K4me3) and transcriptomic signatures from CRC cell lines and the TCGA database. …”
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Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in Aspergillus by Heungyun Moon, Mi-Kyung Lee, Junha Shin, Sung Chul Park, Julio C. Rivera Vazquez, Daniel Amador-Noguez, Nancy P. Keller, Hee-Soo Park, Kap-Hoon Han, Jae-Hyuk Yu

“…To address this gap, we have conducted network-based multiomics analyses in two distantly related species, Aspergillus nidulans and Aspergillus flavus. Transcriptomic profiling reveals that NsdD regulates gene expression in a cell type- and species-specific manner. …”
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FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…FNDC5 promotes tumor growth, while ACOX1 appears protective, offering potential targets for therapeutic intervention.…”
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Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways by Shi Qiu, Zhibo Wang, Sifan Guo, Dandan Xie, Ying Cai, Xian Wang, Chunsheng Lin, Songqi Tang, Yiqiang Xie, Aihua Zhang

“…Spatial metabolomics revealed distinct anatomical clustering of ten clinically associated metabolites, while spatial proteomic profiling uncovered sixty-four region-enriched proteins linked to these pathways. …”
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Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective... by Xue Zhang, Xin Dai, Aina Liu, Meili Sun, Lei Cong, Jing Liang, Zimin Liu, Zhen Li, Jinling Zhang, Jing Lv, Fangli Cao, Linli Qu, Haiyan Liu, Lu Yue, Yi Zhai, Fujun Yang, Jiahui Chu, Shuang Wang, Qian Xu, Jianyuan Zhou, Shulun Nie, Miao Huang, Ruitao Xu, Qiushi Wang, Xinyu Song, Di Zhang, Zhaodi Nan, Song Li, Lian Liu

“…SMARCA4 and BRCA2 mutations were more frequent in patients with responses, while CCNE1 and ZFHX3 alternation, alongside high “ABC transporters” signatures, were more common in non-responsive patients. …”
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