Host taxonomy and environment shapes insectivore viromes and viral spillover risks in Southwestern China by Ji-Hu Yang, Chun-Feng Luo, Rong Xiang, Jiu-Meng Min, Zong-Ti Shao, Yi-Lin Zhao, Lu Chen, Lin Huang, Yun Zhang, Shun-Shuai Liu, Yu-Qiong Li, En-Nian Pu, Wen-Qiang Shi, Hai-Feng Pan, Wei-Jun Chen, Chun-Hong Du, Jia-Fu Jiang

“…Cross-species transmission was predominantly observed in viruses carried by shrews, while moles may play a pivotal role in facilitating viral transmission among insectivores. …”
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Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances by Jian Qiu, Margaritis Voliotis, Martha A Bosch, Xiao Feng Li, Larry S Zweifel, Krasimira Tsaneva-Atanasova, Kevin T O'Byrne, Oline K Rønnekleiv, Martin J Kelly

“…To investigate this shift, we combined transcriptomics, electrophysiology, and mathematical modeling. …”
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Time-restricted feeding protects against septic liver injury by reshaping gut microbiota and metabolite 3-hydroxybutyrate by Jing-Juan Hu, Fan Deng, Qi-Shun Sun, Qing-Ming Xiong, Yue Min, Si-Yuan Feng, Ze-Bin Lin, Peng-Han Chen, Zhen Hu, Ling Wu, Xiao-Feng Chen, Sun Xie, Wei-Feng Liu, Cai Li, Ke-Xuan Liu

“…Further study revealed that live L. murinus could markedly elevate serum levels of metabolite 3-hydroxybutyrate (3-HB) and alleviate sepsis-related injury, while the knockout of the key enzyme for 3-HB synthesis (3-hydroxy-3-methylglutaryl-CoA synthase 2, Hmgcs2) in the liver negated this protective effect. …”
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A donor PD-1+CD8+ TSCM-like regulatory subset mobilized by G-CSF alleviates recipient acute graft-versus-host-disease by Dan Liu, Xue Wang, Yuheng Han, Jing Wang, Yidan Sun, Yafei Hou, Qian Wu, Cong Zeng, Xuping Ding, Yingjun Chang, Jiong Hu, Xiaojun Huang, Liming Lu

“…In summary, we, for the first time, identified a novel donor peripheral T cell subset suppressing aGVHD while promoting the immune reconstitution of recipients. …”
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Polystyrene microplastics induce nephrotoxicity through DDIT4-mediated autophagy and apoptosis by Yujiao Wang, Anxiu Zhang, Ting Liang, Long Chen, Shuqi Feng, Zhuoyuan Zhao, Ziye Jing, Jieping Lv, Jun Xie, Bingrui Zhou

“…Microplastics (MPs), plastic particles smaller than 5 mm, have garnered increasing attention due to their pervasive presence in the environment and potential health risks. While their accumulation in various organs, including the liver, kidneys, and intestines, is well-documented, the specific mechanisms they affect kidney development remain unclear. …”
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Brassica napus BnaWIP2 transcription factor promotes seed germination under salinity stress by repressing ABA biosynthesis and signaling by Shuangcheng He, Saiqi Yang, Yuanchang Min, Ankang Ge, Junjin Liu, Zijin Liu, Yuan Guo, Mingxun Chen

“…Under NaCl treatment, knocking out all six BnaWIP2 paralogs in B. napus led to significantly reduced germination, while overexpression of BnaC06.WIP2 promoted germination. …”
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The developmental toxicity of bisphenol F exposure on the zebrafish larvae by Biyu Wu, Zirui Cheng, Xiang Li, Minxing Liang, Xue Wang, Duan Pi, Jiayi Liu, Huiling Li, Jun Zhao, Junjie Wang, Fang Liang, Xuegeng Wang

“…To explore the underlying mechanisms, transcriptomic analysis was performed to identify differentially expressed genes (DEGs). …”
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Integrative multi-omics analysis reveals the interaction mechanisms between gut microbiota metabolites and ferroptosis in rheumatoid arthritis by Lifang Liang, Lifang Liang, Lifang Liang, Huaguo Liang, Min He, Min He, Min He, Huiling Zhang, Huiling Zhang, Huiling Zhang, Peifeng Ke, Peifeng Ke, Peifeng Ke

“…GSVA and GSEA analyses revealed that high expression of GPX3 and MYC was enriched in interferon response and TNFA signaling pathways, while their low expression was associated with fatty acid metabolism and oxidative phosphorylation pathways. …”
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SNRPB/CCNB1 axis promotes hepatocellular carcinoma progression and cisplatin resistance through enhancing lipid metabolism reprogramming by Xin Jin, Xigan He, Runze Huang, Qinyu Liu, Lei Wang, Xuanci Bai, Yibin Wu, Yixiu Wang, Ziting Jiang, Yi Shi, Gautam Sethi, Lu Wang, Weiping Zhu

“…Knockdown of SNRPB suppressed HCC cell proliferation and migration, while promoting apoptosis. Mechanistically, SNRPB regulated CCNB1 expression via FOXM1-mediated transcription, and SNRPB overexpression enhanced lipid metabolism and cisplatin resistance. …”
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Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep by Zhaohua He, Fangfang Zhao, Hongxian Sun, Jiang Hu, Jiqing Wang, Xiu Liu, Mingna Li, Zhiyun Hao, Zhidong Zhao, Bingang Shi, Feiyan Liu, Shaobin Li

“…The results showed that fine type wool fiber scales were more regularly distributed in rings with large scale spacing and smooth edges, while coarse type wool fiber scales were more irregularly arranged in tiles with relatively rougher edges, and the density of wool scales was greater than that of fine type wool. …”
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Genome-wide identification of the regulatory network of mitogen-activated protein kinase signaling cascades gene families in Hevea Brasiliensis by Xiaojuan Huang, Manman Sun, Xiaoyu Du, Lin Quan, Jinquan Chao, Xiaomin Deng, Hongze Liao

“…Through phylogenetic analysis and compared to Arabidopsis MPK cascade genes, HbMPKs and HbMPKKs were categorized into categorized four subgroups with no significant expansion or contraction, while the notably expanded HbMAPKKKs were divided into three subgroups: Raf, ZIK, and MEKK. …”
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The Mkx- TGF-β pathway induced the development of the myodural bridge complex in SD rats by Ji-Hang Li, Ji-Hang Li, Wen-Bin Jiang, Lu Zhang, Yun-Feng Liu, Yi-Tong Sun, Hua-Xun Lai, M. Adeel Alam Shah, Wei Ma, Chan Li, Campbell Gilmore, Jian-Fei Zhang, Hong-Jin Sui

“…At the molecular level, Mkx coordinates differentiation processes through dynamic equilibrium of Scx/Egr1/Myod expression profiles while constructing regulatory networks that couple biomechanical-chemical signals via TGF-β pathway activation.…”
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Shared and specific competing endogenous RNAs network mining in four digestive system tumors by Yulai Tang, Aamir Fahira, Siying Lin, Yiming Shao, Zunnan Huang

“…Methods: Clinical and transcriptomic data from The Cancer Genome Atlas (TCGA) were analyzed to predict differentially expressed RNAs using the edgeR package. …”
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Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes. by Wipawee Wongchana, Pornrat Kongkavitoon, Pattarin Tangtanatakul, Chutamath Sittplangkoon, Patcharavadee Butta, Supatta Chawalitpong, Thitiporn Pattarakankul, Barbara A Osborne, Tanapat Palaga

“…LPS/IC stimulation increased the level of cleaved Notch1 in murine macrophages, while IC stimulation alone did not. Delta-like 4, but not Jagged1, was responsible for generating cleaved Notch1. …”
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Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst by Lu Pan, Bufu Tang, Xuan Zhang, Paolo Parini, Roman Tremmel, Joseph Loscalzo, Volker M. Lauschke, Bradley A. Maron, Paola Paci, Ingemar Ernberg, Nguan Soon Tan, Ákos Végvári, Zehuan Liao, Sundararaman Rengarajan, Roman Zubarev, Yuxuan Fan, Xu Zheng, Xinyue Jian, Ren Sheng, Zhenning Wang, Xuexin Li

“…It automates critical analysis steps, such as quality control, data processing, and phenotype‐specific analyses, while also offering interactive, publication‐ready visualizations. …”
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Molecular mechanism of PANoptosis and programmed cell death in neurological diseases by Ketian Hou, Wenhan Pan, Lianhui Liu, Qianqian Yu, Jiahao Ou, Yueqi Li, Xi Yang, Zhenlang Lin, Jun Hui Yuan, Mingchu Fang

“…Emerging PANoptosis-targeted therapies show preclinical promise in alleviating neurovascular dysfunction while preserving physiological microglial surveillance functions. …”
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Three-stage sequential targeted nasal drops for correcting abnormal mitochondrial division in microglia by Miaomiao Fei, Qidong Liu, Hui Zhang, Yawei Du, Liang Chen, Juan Wang, Wenguo Cui, Cheng Li

“…Firstly, dehydroepiandrosterone (DHEA), identified from clinical data and transcriptomic analyses as a key neurosteroid regulating mitochondrial fission, was selected. …”
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Unraveling resistance mechanisms to the novel nucleoside analog RX-3117 in lung cancer: insights into DNA repair, cell cycle dysregulation and targeting PKMYT1 for improved therapy by Mahrou Vahabi, Geng Xu, Dzjemma Sarkisjan, Btissame El Hassouni, Giulia Mantini, Valentina Donati, Bing Wang, Giulia Lencioni, Richard J. Honeywell, Dongmei Deng, Sabrina Strano, Godefridus J. Peters, Giovanni Blandino, Elisa Giovannetti

“…A CRISPR-Cas9 screen identified genes whose loss increased RX-3117 sensitivity, while RNA-sequencing with differential expression analyses revealed resistance-related pathways, further investigated through cell cycle distribution, knock-out, and ELISA assays. …”
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Induced collagen type‐I secretion by hepatocytes of the melanoma liver metastasis is associated with a reduction in tumour‐infiltrating lymphocytes by Shodai Mizuno, Matias A. Bustos, Yoshinori Hayashi, Kodai Abe, Satoru Furuhashi, Yalda Naeini, Xiaowei Xu, Anton J Bilchik, Dave S. B. Hoon

“…Methods Hepatocytes and melanoma tumour cells of MLiM were assessed using transcriptomic NanoString GeoMx digital spatial profiling (NGDSP) assay. …”
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Machine learning-driven multi-omics analysis identifies a prognostic gene signature associated with programmed cell death and metabolism in hepatocellular carcinoma by Xiang Li, Donghao Yin, Jiahao Geng, Yanyu Xu, Zijing Xu, Xuemeng Yang, Quanwei Li, Zimeng Shang, Zhiyun Yang, Zhong Xu, Jiabo Wang, Enxiang Zhang, Xinhua Song

“…Methods We utilized single-cell and bulk transcriptomic datasets to identify differentially expressed genes (DEGs) strongly associated with PCD and metabolism in HCC. …”
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