Interaction between post-tumor inflammation and vascular smooth muscle cell dysfunction in sepsis-induced cardiomyopathy by Rui Liu, Lina Jia, Lin Yu, Detian Lai, Qingzhu Li, Bingyu Zhang, Enwei Guo, Kailiang Xu, Qiancheng Luo

“…BackgroundSepsis-induced cardiomyopathy (SIC) presents a critical complication in cancer patients, contributing notably to heart failure and elevated mortality rates. While its clinical relevance is well-documented, the intricate molecular mechanisms that link sepsis, tumor-driven inflammation, and cardiac dysfunction remain inadequately explored. …”
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Recombinant serralysin metalloproteases D enhances the intracellular replication of infectious bovine rhinotracheitis virus by Longfei Yan, Yanran Li, Jiancheng Qi, Li Ren, Xueke Zhou, Liping Gou, Zhicai Zuo

“…Quantification of IBRV gB gene copy numbers using fluorescence quantification PCR (FQ-PCR) revealed that rSPD promotes viral replication during the intracellular stage, without affecting viral adsorption, entry, or directly interacting with viral particles. The transcriptomic analysis further demonstrated that rSPD suppresses innate immune responses while amplifying inflammatory pathways in IBRV-infected MDBK cells. …”
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Emerging biomarkers in amyotrophic lateral sclerosis: from pathogenesis to clinical applications by Farah Anjum, Farah Anjum, Maha Bakhuraysah, Maha Bakhuraysah, Abdulaziz Alsharif, Abdulaziz Alsharif, Taj Mohammad, Anas Shamsi, Md. Imtaiyaz Hassan

“…., rapid vs slow progressors), while cryptic exon-derived peptides, such as UNC13A-derived peptides, enable genetic stratification by identifying molecular subtypes linked to TDP-43 pathology (e.g., C9orf72 vs sporadic ALS). …”
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Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development by Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang

“…Abstract Robust development is essential for multicellular organisms. While various mechanisms contributing to developmental robustness are identified at the subcellular level, those at the intercellular and tissue level remain underexplored. …”
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TaTCP6 is required for efficient and balanced utilization of nitrate and phosphorus in wheat by Bin Liu, Weiya Xu, Yanxiao Niu, Qiuyuan Li, Beilu Cao, Jingyi Qi, Yidi Zhao, Yilan Zhou, Long Song, Dongkai Cui, Zhenshan Liu, Mingming Xin, Yingyin Yao, Mingshan You, Zhongfu Ni, Qixin Sun, Jiewen Xing

“…Inhibiting TaTCP6 reduces N and P absorption, negatively impacting yield, while overexpressing TaTCP6 increases grain yield. …”
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LCN2-mediated ferroptosis resistance in tissue homeostasis and early-stage tumorigenesis of the fallopian tube epithelium by Keiyo Imaeda, Tomohiro Tamura, Shimpei Nagai, Eiji Sugihara, Juntaro Yamasaki, Yuji Otsuki, Kohei Nakamura, Takashi Takeda, Kanako Nakamura, Yuya Nogami, Kosuke Tsuji, Tatsuyuki Chiyoda, Iori Kisu, Yusuke Kobayashi, Kouji Banno, Rui Yamaguchi, Kazuhiro Sakurada, Hideyuki Saya, Daisuke Aoki, Ahmed Ashour Ahmed, Osamu Nagano, Kenta Masuda, Wataru Yamagami

“…Summary: While the fallopian tube epithelium (FTE) is known to be composed of various differentiated cells such as secretory and ciliated cells, the upstream regulatory mechanisms of cell differentiation that are essential for tissue homeostasis remain under investigation. …”
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Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways by Sofie Rennen, Victor Bosteels, Clint De Nolf, Sandra Maréchal, Jessica Vetters, Karo Van Lil, Greta Webb, Janne Swinnen, Evelien Van De Velde, Farzaneh Fayazpour, Ria Roelandt, Niels Vandamme, Kevin Verstaen, Stefaan C. De Smedt, Karine Breckpot, Stijn Vanhee, Philippe Gevaert, Eric Hoste, Bruno G. De Geest, Rein Verbeke, Ine Lentacker, Sophie Janssens

“…The data corroborate that uptake of empty (or peptide-containing) LNPs induces homeostatic maturation in DCs, while uptake of Toll-like receptor ligand-adjuvanted (or mRNA-containing) LNPs induces immunogenic maturation, yielding distinct T cell outputs. …”
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Identification and validation of shared biomarkers and drug repurposing in psoriasis and Crohn’s disease: integrating bioinformatics, machine learning, and experimental approaches... by Xiaolong Li, Xiaolong Li, Hui Cao, Mutian Niu, Mutian Niu, Qingbo Liu, Bin Liang, Junfeng Hou, Junfeng Hou, Jian Tu, Jian Tu, Jintao Gao, Jintao Gao

“…Immune infiltration analysis underscored the involvement of hub genes in immune regulation, while single-cell transcriptomic analysis revealed the cellular localization of these hub genes. …”
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Male mouse skeletal muscle lacking HuR shows enhanced glucose disposal at a young age by Robert C. Noland, Robert C. Noland, Sujoy Ghosh, Sujoy Ghosh, Carlos J. Crisanto, Antonio Aleman, McKenna K. Chaney, Maitri K. Chauhan, Layla G. Loftis, Ally C. Goad, Christin F. Rickman, Samuel E. Velasquez, Jaycob D. Warfel, Jaycob D. Warfel

“…None of these differences were noted in females. Transcriptomics showed far more differences between male and female mice than between control and HuR knockout mice. …”
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Strike at the root: exploring the transferability of heat stress tolerance in tomatoes by reciprocal grafting by Robin T. Biermann, Robin T. Biermann, Linh T. Bach, Christian M. Steuer, Christian M. Steuer, Julia J. Reimer, Dietmar Schwarz, Frederik Börnke, Frederik Börnke

“…This study aims to test whether a priori knowledge of tolerance levels can be used to facilitate the identification of suitable grafting combinations, while simultaneously exploring molecular and physiological changes caused by grafting that further our understanding of the transferability of HS tolerance by grafting. …”
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GPD1L downregulation in colorectal cancer: a novel obesity-related biomarker linking metabolic dysregulation to tumor progression by Feng Zhu, Feng Zhu, Huiyuan Li, Huiyuan Li, Hongzhang Liu, Hongzhang Liu, Yusheng Wang, Yusheng Wang

“…ObjectiveTo delineate the expression profile and tumor-suppressive function of the metabolism-associated gene GPD1L in colorectal carcinogenesis. Methods: Transcriptomic datasets from TCGA and GEO repositories (GSE74602, GSE113513, GSE164191) were computationally analyzed. …”
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DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal Lobar degeneration genetic risk-associated loci by Naiomi Rambarack, Katherine Fodder, Megha Murthy, Christina Toomey, Rohan de Silva, Peter Heutink, Jack Humphrey, Towfique Raj, Tammaryn Lashley, Conceição Bettencourt

“…We then leveraged FTLD transcriptomic and proteomic datasets to investigate possible downstream effects of DNA methylation changes. …”
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Potential physiological mechanisms behind variation in rainbow trout (Oncorhynchus mykiss) to biosynthesize EPA and DHA when reared on plant oil replacement feeds by Ken Overturf, Jason Abernathy, Dietmar Kültz, Jacob Bledsoe, Shawn Narum, Thomas Welker

“…No genes or proteins were identified in the muscle that were linked to lipid synthesis or deposition. However, while in the liver a few genes with notable association to lipid synthesis were detected across individual group comparisons, there were no potential proteins linked to lipid processing that were found to be significantly upregulated in fish across all comparisons that presented with increased EPA and DHA muscle values. …”
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Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s disease by Junshi Zhang, Tingting Liu, Haojie Wu, Jianshe Wei, Qiumin Qu

“…In the MPTP-induced PD mice model, the expression of ACO2, HSPA9, and SDHA was decreased while the expression of CYCS, SNCA, and VDAC1 was increased, and the expression of the 5 DED-ORGs was decreased. …”
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CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer by Xiao Ma, Baojian Zhang, Xuezhe Yin, ShiPeng Yang, Zhenhua Lin, Yang Yang, Xianchun Zhou

“…Interestingly, LAA affects ROS homeostasis through the Nrf2/NQO1 pathway, specifically influencing angiogenesis in BC and HUVECs, while having no significant effect on their proliferation or EMT process. …”
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Bile acids enhance fat metabolism and skeletal muscle development in Zhijiang duck by modulating gut microbiota by Liang Chen, Zhizhong Zhang, Wei Deng, Guitao Jiang, Deming Xie, Aizhi Cao

“…Slaughter data showed that BA significantly enhanced (P < 0.05) breast muscle weight and percentage while decreasing (P < 0.05) abdominal fat weight. …”
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Establishment of a Novel in vitro Model of Sepsis-Induced Myocardial Injury Using Septic Serum: A Comprehensive Comparative Study by Yang H, Feng L, Jiang Z, Deng R, Wu X, Zeng K

“…The diagnostic utility of each model was assessed using receiver operating characteristic (ROC) analysis.Results: While LPS and TNF-α-treated cardiomyocytes exhibited similar injury features, both only partially captured the complexity of the sepsis-induced myocardial injury phenotype. …”
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Molecular analysis highlights TREM2 as a discriminating biomarker for patients suffering from pancreatic ductal adenocarcinoma by Dimitrios Papakonstantinou, Haiding Wang, Mohamed-Amine Bani, Kevin Mulder, Garett Dunsmore, Alice Boilève, Gérôme Jules-Clément, Leonardo Panunzi, Leslie Robert de Sousa, Carlos de la Calle Fabregat, Marc Deloger, Nicolas Signolle, Grégoire Gessain, Sergey I Nikolaev, Michel Ducreux, Antoine Hollebecque, Florent Ginhoux, Camille Blériot

“…In this study, we applied established molecular signatures to our in-house transcriptomic data from a cohort of pancreatic cancer patients. …”
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Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury by Yu Yang, Xudan Dou, Yongzhan Sun, Mengyao Wang, Jing Wang, Xinyi Cao, Haijie Xie, Linguo Xie, Weiping Tian, Jing Nie, Yupeng Chen, Chunyu Liu, Lirong Zhang

“…Importantly, the animal studies revealed that RXRα deletion promoted the CaOx crystal deposition, while its activation by Bexarotene (Bex), an FDA‐approved drug, mitigated this progression. …”
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Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids by Thomas A. Kluiver, Yuyan Lu, Stephanie A. Schubert, Lianne J. Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L. Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W. de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C. van den Heuvel, Vincent E. de Meijer, Ruben H. de Kleine, Jan J. Molenaar, Thanasis Margaritis, Hendrik G. Stunnenberg, Ronald R. de Krijger, József Zsiros, Hans Clevers, Weng Chuan Peng

“…The fetal group is enriched for liver-specific WNT targets, while the embryonal group is enriched in canonical WNT target genes. …”
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