Astrocytic BDNF Modulates Sensitivity to Stress-Induced Anxiety-Like Behaviors by Wei-Peng Li, Gui-Yu Liu, Shi-Yun Wang, Jiao Hu, Wen-Juan Ji, Jun-Ming Zhu, Qing-Yu Chang, Tian-Yi Li, Guo-Rong Wei, Jian-Qing Shang, Hong-Zhan Li, Fu-Hua Peng, Yun-Yan Zhao, Xiao-Hong Su, Wei Xie

“…Pharmacological manipulation confirms the involvement of BDNF/TrkB signaling, while knockdown of astrocytic BDNF further impairs synaptic function and exacerbates stress-induced anxiety. …”
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Respiratory transmission potential of severe fever with thrombocytopenia syndrome bunyavirus: evidence from intranasal exposure in a humanized mouse model by Dafeng Lu, Yifang Han, Ruowei Xu, Chunfang Wang, Mingke Qin, Jianwei Shi, Fuqiang Ye, Jinhai Zhang, Zhenghan Luo, Yuhe Wang, Hong Lin, Peiqi Jia, Jin Zhu, Chunhui Wang

“…Severe Fever with Thrombocytopenia Syndrome Bunyavirus (SFTSV) is a highly lethal pathogen with expanding endemic regions in Asia. While primarily transmitted by ticks, recent evidence suggests potential airborne transmission, raising significant public health concerns. …”
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Cellular imbalance in proximal and distal lung of CFTR −/− sheep in utero and at birth by Shih-Hsing Leir, Svyatoslav Tkachenko, Alekh Paranjapye, Arnaud J. Van Wettere, Jenny L. Kerschner, Iuri Viotti Perisse, Cheyenne M. Marriott, Tayler Patrick, Ying Liu, Kenneth L. White, Irina A. Polejaeva, Ann Harris

“…Results At term, FOXJ1-expressing ciliated cells are overrepresented in both lung regions from CFTR −/− lambs, while secretory epithelial and basal cells are underrepresented in proximal lung, as are T cells and monocytes in distal lung. …”
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Molecular Adaptations and Quality Enhancements in a Hybrid (<i>Erythroculter ilishaeformis</i> ♀ × <i>Ancherythroculter nigrocauda</i> ♂) Cultured in Saline–Alkali Water by Lang Zhang, Qiuying Qin, Qing Li, Yali Yu, Ziwei Song, Li He, Yanhong Sun, Liting Ye, Guiying Wang, Jing Xu

“…These findings suggest that SA stress enhances antioxidant capacity, activates immune pathways, and modulates ion transport, enabling adaptation while improving meat quality. This study elucidates molecular mechanisms of fish acclimation to SA environments, providing insights for sustainable aquaculture development and breeding of stress-tolerant species in SA regions.…”
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Loss of CTRP10 results in female obesity with preserved metabolic health by Fangluo Chen, Dylan C Sarver, Muzna Saqib, Leandro M Velez, Susan Aja, Marcus M Seldin, G William Wong

“…Female, but not male, mice lacking CTRP10 develop obesity with age on a low-fat diet while maintaining an otherwise healthy metabolic profile. …”
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Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice by Pranay Ramteke, Bahiyah Watson, Mallory Toci, Victoria A. Tran, Shira Johnston, Maria Tsingas, Ruteja A. Barve, Ramkrishna Mitra, Richard F. Loeser, John A. Collins, Makarand V. Risbud

“…Abstract Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. …”
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Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research by Tian Tian, Guie Lai, Ming He, Xiaofang Liu, Yun Luo, You Guo, Guini Hong, Hongdong Li, Kai Song, Hao Cai

“…Low-quality samples served as the case group, while paired high-quality samples constituted the control group. …”
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Lactobacillus johnsonii HL79 mitigate plateau environment-induced hippocampal dysfunction in mice by Baoxing Gan, Xufei Zhang, Jinge Xin, Lixiao Duan, Ning Sun, Yu Chen, Junqi Zeng, Yueying Lian, Hao Li, Hesong Wang, Xueqin Ni, Hailin Ma

“…Combined hippocampal transcriptomic analyses suggested that HL79’s beneficial effects primarily involved modulation of lipid-related gene expression in the hippocampus, consistent with prior reports of plateau environmental impacts on gene expression. …”
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Assessment and Monitoring of the Wound Micro-Environment in Chronic Wounds Using Standardized Wound Swabbing for Individualized Diagnostics and Targeted Interventions by Julian-Dario Rembe, Waseem Garabet, Jan-Wilm Lackmann, Sadaf Alizadehrahrouei, Matthias Augustin, Joachim Dissemond, Wiebke Ibing, Karl Köhrer, Klaus Pfeffer, Anna Rommerskirchen, Sebastian Alexander Scharf, Tobias Wienemann, Thorsten Wachtmeister, Hubert Schelzig, Ewa Klara Stuermer

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Caffeic acid and chlorogenic acid mediate the ADPN-AMPK-PPARα pathway to improve fatty liver and production performance in laying hens by Wenjie Tian, Gerard Bryan Gonzales, Hao Wang, Youyou Yang, Chaohua Tang, Qingyu Zhao, Junmin Zhang, Huiyan Zhang, Yuchang Qin

“…Both CA and CGA improved production performance and egg quality, while reducing markers of hepatic damage and lipid accumulation. …”
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Artesunate Mitigates Sepsis-Induced Acute Kidney Injury via Lactate/AMPK/mTOR-Regulated Autophagy Based on Multi-Omics by Chen H, Du P, Guo R, Li X, Zhang L, Duan J, Chen M, Guo J, Li Y, Jiang T

“…Integrative analysis of metabolomics and transcriptomics reveals that ART intervention markedly decreases lactate levels, inhibits excessive AMPK activation, relieves mTOR pathway suppression, and suppresses excessive autophagy, thereby attenuating inflammation and oxidative stress, and mitigating renal cell injury.Conclusion: The findings suggest that ART may mitigate inflammation and oxidative stress while improving renal function in S-AKI by modulating the lactate/AMPK/mTOR pathway and inhibiting excessive autophagy.Keywords: acute kidney injury, artesunate, multi-omics, lactate/AMPK/mTOR pathway, autophagy…”
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Microbiome-driven gene dysregulation in oesophageal cancer: a multi-omics analysis by Chaitali Nath

“…Introduction: Oesophageal cancer is increasingly recognised as a disease influenced by both host genetics and microbial dysbiosis.1,2 While chronic inflammation and immune evasion are established hallmarks of tumor progression,3 the specific interactions between microbial species and host gene expression remain poorly defined. …”
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Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease by Rezwanul Islam, Hadi Hasan Choudhary, Feng Zhang, Hritik Mehta, Jun Yoshida, Ajith J. Thomas, Khalid Hanafy

“…Microglial Toll-like receptor 4 (TLR4) is instrumental in the binding of fibrillary amyloid proteins, while Lyn kinase (Lyn) is a member of the Src family of non-receptor tyrosine kinases involved in immune signaling. …”
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Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells by Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee, Ju-Hee Kang

“…Methods We performed transcriptomic analysis to identify genes related to aging-induced sarcopenia using 21 month-old Sprague–Dawley rats. …”
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High levels of histone acetylation modifications promote the formation of PGCs by Ziduo Zhao, Yuhui Wu, Fufu Cheng, Zhe Wang, Qingqing Geng, Yingjie Niu, Qisheng Zuo, Yani Zhang

“…To explore the role of acetylation, acetate and an acetyltransferase inhibitor (ANAC) were added to the ESCs induction medium. Transcriptomic analysis revealed that during ESCs differentiation into PGCs, genes involved in histone acetyltransferase activity were upregulated, while those associated with histone deacetylase activity were downregulated. …”
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Neuro-immune communication at the core of craving-associated brain structural network reconfiguration in methamphetamine users by Yanyao Du, Jiaqi Zhang, Dan Cao, Wenhan Yang, Jin Li, Deying Li, Ming Song, Zhengyi Yang, Jun Zhang, Tianzi Jiang, Jun Liu

“…Additionally, transcriptomic, chemical compounds, cell-type analyses, and molecular imaging collectively highlight the influence of neuro-immune communication on human craving modulation. …”
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Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis by Siqi Zhu, Jingyi Ren, Yadong Zhang, Xiaoya Sun, Huanting Pei, Bowen Yin, Ziyi Wang, Zhenao Zhang, Shenghe Li, Ruonan Zhang, Ziqian Zeng, Yuxia Ma

“…In the Ses-treated group, ferroptosis and apoptosis were significantly inhibited, while HMOX1 was effectively restored. In cell experiments, both the HMOX1 agonist hemin and Ses attenuated ferroptosis and apoptosis. …”
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EGR1 regulates oxidative stress and aldosterone production in adrenal cells and aldosterone-producing adenomas by Yingxian Pang, Siyuan Gong, Martina Tetti, Zhuolun Sun, Sanas Mir-Bashiri, Martin Bidlingmaier, Thomas Knösel, Eckhard Wolf, Martin Reincke, Elisabeth Kemter, Tracy Ann Williams

“…We show that EGR1 silencing decreases oxidative stress and increases CYP11B2 gene expression and aldosterone production in adrenal cells, while its overexpression has the opposite effects. …”
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Peroxiredoxin 4 Ameliorates T-2 Toxin-Induced Growth Retardation in GH3 Cells by Inhibiting Oxidative Stress and Apoptosis by Qirong Lu, Yi Zhu, Luyao Wang, Meng Mei, Yinsheng Qiu, Yu Liu, Shulin Fu, Jianglin Xiong, Pu Guo, Zhongyuan Wu, Xu Wang

“…The experiments demonstrated that T-2 toxin significantly increased reactive oxygen species’ production, apoptosis, and cell cycle arrest while reducing the activity of antioxidant enzymes (superoxide dismutase and glutathione peroxidase) and PRDX4 expression in GH3 cells. …”
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FLOWERING LOCUS T (FT) gene regulates short-day flowering in low latitude Xishuangbanna cucumber (Cucumis sativus var. xishuangbannanesis) by Shan-Shan Song, Qian Hao, Li-Hong Su, Shi-Wei Xia, Rui-Jing Zhang, Yan-Jun Liu, Yu Li, Yuan-Ying Zhu, Qiu-Yu Luo, Yun-Song Lai

“…XIS cucumbers are strictly short-day plants, while cultivated cucumbers are day-neutral plants. …”
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