Evaluation of Risk Factors and a Gene Panel as a Tool for Unexplained Infertility Diagnosis by Next-Generation Sequencing by Eglė Jašinskienė, Ieva Sniečkutė, Ignas Galminas, Lukas Žemaitis, Mantas Simutis, Marija Čaplinskienė

“…<i>Results:</i> In the female group, controls had a higher mean age, while in the male patients, both groups were similar in terms of age. …”
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Extract of <i>Curculigo capitulata</i> Ameliorates Postmenopausal Osteoporosis by Promoting Osteoblast Proliferation and Differentiation by Ying Wang, Xueru Wang, Kaijin Wang, Weiwei Qin, Ning Li

“…The major components of the extract were identified using HPLC. Transcriptomics was employed to predict potential targets. …”
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Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis by Rong-Chao He, Haibo Wang, Jun He, Hou-Dong Wang, Zhong Shen

“…Enrichment analysis linked high-risk groups to extracellular matrix remodeling, PI3K-Akt signaling, and immune evasion, while low-risk groups exhibited metabolic and immune activation pathways. …”
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Prognostic analysis of bladder cancer with neddylation-related genes by Huang Xiaolong, Deng Min, Zhang Sizhou, Hu Daorong, Pan Juncheng, Wang Yanjian, Li Jie Gu Hong, Zheng Ji, Wu Qingjian

“…LASSO and Cox regression analyses subsequently identified six key genes: CUL1, PUM2, UBE2D3, HIF3A, COPS2, and DDB1. Transcriptomic data and RT-qPCR findings indicated that PUM2 and HIF3A exhibited high expression levels in normal tissues, while DDB1 showed increased expression in tumor tissues; no significant changes were observed for CUL1, COPS2, and UBE2D3. …”
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Multi-omics network toxicology reveals the role of benzo[a]pyrene in ovarian cancer: Integrating gut microbiota dynamics and Mendelian randomization by Jinfa Huang, Qian Yang, Lingling Zeng, Kaixian Deng

“…Protein-protein interaction networks and functional enrichment analyses were conducted utilizing Cytoscape, while molecular docking (CB-Dock 2) confirmed a strong binding affinity between BaP and core targets (e.g., HSP90AA1: −11.7; AHR: −10.0). …”
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PANoptosis-Relevant Subgroups Predicts Prognosis and Characterizes the Tumour Microenvironment in Ovarian Cancer by Chen Y, Deng Z, Chen J, Lin J, Zou J, Li S, Sun Y

“…However, its prognostic relevance in OC remains unclear.Methods: Utilizing data from The Cancer Genome Atlas (TCGA), we analyzed transcriptomic and clinical signatures of OC patients. …”
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Expression and prognostic value of SEC13 across multiple tumour types and its association with the regulation by Pulsatilla chinensis: a multi-omics and Mendelian Randomization Stu... by Huaqing Leng, Xin Luan, Ming Li

“…Methods In this study, we conducted a comprehensive analysis of SEC13 expression using data from TCGA and GTEx, and explored associated pathways through gene set enrichment analysis. Single-cell transcriptomic data were integrated to investigate the cell-type-specific expression of SEC13 within the tumour microenvironment. …”
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Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR&amp;ndash;ISG15 Regulatory Networks by Liu S, Zhang Z

“…Non-negative matrix factorization (NMF) was employed to categorize LUAD cases based on TME features, while DESeq2 was used to pinpoint bacterial taxa with differing abundance. …”
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Increased adherence and expression of virulence genes in a lineage of Escherichia coli O157:H7 commonly associated with human infections. by Galeb S Abu-Ali, Lindsey M Ouellette, Scott T Henderson, David W Lacher, James T Riordan, Thomas S Whittam, Shannon D Manning

“…Adherence to epithelial cells was >2-fold higher for EHEC O157:H7 strains belonging to clade 8 versus clade 2, while no difference in invasiveness was observed between the two lineages. …”
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The phytohormone brassinosteroid (BR) promotes early seedling development via auxin signaling pathway in rapeseed by Changrui Ma, Jinfeng Wu, Yaqian Chen, Dawei Zhang, Dinggang Zhou, Jihong Zhang, Mingli Yan

“…A total of 234 significantly DEGs were identified between the mock- and BR-treated groups by transcriptomic analyses. These DEGs were markedly enriched in BR biosynthesis, pentose and glucuronate interconversions and plant hormone signal transduction pathways. …”
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Identification and characterization of Eco-miR 169-EcNF-YA13 gene regulatory network reveal their role in conferring tolerance to dehydration and salinity stress in finger millet by Varsha Rani, Sumi Rana, Mehanathan Muthamilarasan, D. C. Joshi, Ramwant Gupta, Rajesh Singh, Dinesh Yadav

“…The miR169 is one of the most conserved miRNA families, while Eco_N1 is a species-specific miRNA prevalent in finger millet. …”
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Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study by Qiyun Shi, Taotao Tian, Yanfeng Li

“…WNT5A correlated negatively with memory immune cells, while PLCG, ITPR1, and CAMK2A correlated with lymphocyte subpopulations.ConclusionWe identified a conserved molecular signature across cardiac and skeletal muscle IRI, with WNT5A/PLC pathway components as mechanistically validated therapeutic targets. …”
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Genomic adaptations of Vibrio campbellii to thermal and salinity stress: insights into marine pathogen resilience in a changing ocean by Jiranan Pattano, Thitaporn Dechathai, Netnapa Chaichanit, Komwit Surachat, Korakot Wichitsa-nguan Jetwanna, Kanchana Srinitiwarawong, Pimonsri Mittraparp-arthorn

“…While elevated temperature and salinity suppress certain virulence traits (e.g., T6SS, flagellar assembly), they concurrently promote biofilm formation, enabling persistence in marine environments. …”
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Targeting EPAS-1/HIF-2α Pathway to Address Endocrine Resistance in Luminal A Type Breast Cancer by Enzhi Luo, Seongmin Lee, Neeraj manvi agarwal, Junjeong Choi

“…Methods: We performed a comprehensive multi-omics analysis using publicly available transcriptomics and whole-exome sequencing data from tamoxifen-sensitive and tamoxifen-resistant luminal A breast cancer patient samples. …”
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USP5 Promotes Head and Neck Squamous Cell Carcinoma Progression via mTOR Signaling Pathway by Ni Xiong, Yue Wang, Junhong Jiang

“…ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy characterized by limited prognostic markers and treatment options, contributing to high mortality rates. While Ubiquitin‐specific peptidase 5 (USP5) has been implicated in various cancers, its role in HNSCC remains poorly understood. …”
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Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis by Eisa Mahyari, Sean Davin, Kimberly Ogle, Emma Fale-Olsen, Carley Shaut, Tammy M. Martin, Jasvinder S. Ahuja, Eric Suhler, Atul Deodhar, James T. Rosenbaum, James T. Rosenbaum, Tejpal Gill, Tejpal Gill

“…Using cellular indexing of transcriptomes and epitopes (CITE-Seq) in a well-characterized cohort of 25 subjects—including AS (HLA-B27pos), AS+AAU (HLA-B27pos), AAU (HLA-B27pos), HCs (HLA-B27pos), and HCs (HLA-B27neg); N = 5/group—we identified transcriptomic differences at the single-cell level, along with differentially expressed cell surface markers. …”
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Deconvolution of cell types and states in spatial multiomics utilizing TACIT by Khoa L. A. Huynh, Katarzyna M. Tyc, Bruno F. Matuck, Quinn T. Easter, Aditya Pratapa, Nikhil V. Kumar, Paola Pérez, Rachel J. Kulchar, Thomas J. F. Pranzatelli, Deiziane de Souza, Theresa M. Weaver, Xufeng Qu, Luiz Alberto Valente Soares Junior, Marisa Dolhnokoff, David E. Kleiner, Stephen M. Hewitt, Luiz Fernando Ferraz da Silva, Vanderson Geraldo Rocha, Blake M. Warner, Kevin M. Byrd, Jinze Liu

“…Abstract Identifying cell types and states remains a time-consuming, error-prone challenge for spatial biology. While deep learning increasingly plays a role, it is difficult to generalize due to variability at the level of cells, neighborhoods, and niches in health and disease. …”
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Pathological and Molecular Characterization of Grass Carp Co-Infected with Two <i>Aeromonas</i> Species by Wenyao Lv, Zhijie Zhou, Lingli Xie, Xinyue Wang, Yifei Zhou, Lang Gui, Xiaoyan Xu, Yubang Shen, Jiale Li, Junqiang Qiu

“…Notably, metabolic pathways showed substantial suppression while immune responses were significantly activated after infected. …”
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Role of carbohydrate-active enzymes in brown planthopper virulence and adaptability by Fang Liu, Fang Liu, Jing Xiao, Xin-Feng Wang, Ya-Xuan Wang, Hou-Hong Yang, Yu-Biao Cai, Feng-Xiang Lai, Qiang Fu, Pin-Jun Wan

“…These insects employ a variety of strategies to overcome plant defenses, including the secretion of carbohydrate-active enzymes (CAZymes) that degrade plant cell walls. While CAZymes are well-studied in other insect species, their role in BPH virulence remains largely unexplored. …”
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Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP by Lichang Liu, Longbao Feng, Yuanyuan Zhang, Junjie Xu, Le Liu, Lichun Wang, Weihong Hong, Yuyan Jin, Jiahao Zeng, Peihua He, Xusheng Liu

“…Liposomes enhance the solubility and stability of capsaicin, while the SerMA hydrogel provides sustained release of Difelikefalin. …”
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