TCMD: A High‐Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio‐Based Resources by Yongdong Xu, Yueyao Wang, Yongming Chen, Yunxia Wang, Shicheng Zhang, Gang Luo, Fuhao Cui, Taisheng Du, Zhidan Liu

“…Compared to conventional approaches, TCMD is estimated to be 3–20 times faster and ≈10 times more cost‐effective, while maintaining high‐throughput capacity for analyzing thousands of compounds simultaneously. …”
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Human skeletal muscle fiber heterogeneity beyond myosin heavy chains by Roger Moreno-Justicia, Thibaux Van der Stede, Ben Stocks, Jenni Laitila, Robert A. Seaborne, Alexia Van de Loock, Eline Lievens, Diana Samodova, Leyre Marín-Arraiza, Oksana Dmytriyeva, Robin Browaeys, Kim Van Vossel, Lukas Moesgaard, Nurten Yigit, Jasper Anckaert, Anneleen Weyns, Ruud Van Thienen, Ronni E. Sahl, Edmar Zanoteli, Michael W. Lawlor, Michael Wierer, Pieter Mestdagh, Jo Vandesompele, Julien Ochala, Morten Hostrup, Wim Derave, Atul S. Deshmukh

“…Proteomics was conducted in males, while transcriptomics included ten males and two females. …”
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Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa by Dorota Kuc-Ciepluch, Karol Ciepluch, Daria Augustyniak, Grzegorz Guła, Barbara Maciejewska, Artur Kowalik, Ewelina Jop, Zuzanna Drulis-Kawa, Michał Arabski

“…Transcriptomic analyses revealed the activation of the immune system pathways in response to LPS, mainly in monocytic cells, in contrast to epithelial A549 or HeLa cell lines. …”
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The Venom Proteome of the Ecologically Divergent Australian Elapid, Southern Death Adder <i>Acanthophis antarcticus</i> by Theo Tasoulis, C. Ruth Wang, Shaun Ellis, Tara L. Pukala, Joanna Sumner, Kate Murphy, Nathan Dunstan, Geoffrey K. Isbister

“…The fact that <i>A. antarcticus</i> has a venom composition similar to cobra venom while having a viper-like ecology illustrates that similar venom expressions can evolve independently of ecology. …”
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Genomic insights reveal community structure and phylogenetic associations of endohyphal bacteria and viruses in fungal endophytes by Efraín Escudero-Leyva, Michal Belle, Abolfazl DadkhahTehrani, James N. Culver, Marcelo Araya-Salas, Joseph P. Kutza, Natasha Goldson, Max Chavarría, Priscila Chaverri

“…Abstract Background Endohyphal microbial communities, composed of bacteria and viruses residing within fungal hyphae, play important roles in shaping fungal phenotypes, host interactions, and ecological functions. While endohyphal bacteria have been shown to influence fungal pathogenicity, secondary metabolism, and adaptability, much remains unknown about their diversity and host specificity. …”
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GADD45GIP1 promotes osteosarcoma progression by modulating RPL35 ubiquitination and alleviating endoplasmic reticulum stress via the PERK/eIF2α pathway by Zhiqiang Li, Xiao Yu, Renjie Xu, Xiangxin Zhang, Jun Shen, Wei Xu

“…Functional tests have demonstrated that the silencing of GADD45GIP1 significantly reduces the migration and proliferation of osteosarcoma cells in vitro and in vivo, while its overexpression has the opposite effect. …”
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CXCL12/CXCR4 axis mediates CD8 + T cell overactivation in the progression of viral myocarditis by Li Zhang, Keyu Liu, Xiuyun Duan, Shan Zhou, Hailin Jia, Yingnan You, Bo Han

“…The transcriptomic analysis reveals elevated CXCR4 expression in CD8+T cells in acute FM. …”
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Lake Baikal amphipods and their genomes, great and small by P. B. Drozdova, E. V. Madyarova, A. N. Gurkov, A. E. Saranchina, E. V. Romanova, J. V. Petunina, T. E. Peretolchina, D. Y. Sherbakov, M. A. Timofeyev

“…For about one­tenth of the Baikal amphipod species, nuclear genome sizes and chromosome numbers are known. While genome sizes vary within one order of magnitude, the karyotypes are relatively stable (2n = 52 for most species studied). …”
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Antioxidant and Anti-Inflammatory Effects of Crude <i>Gastrodia elata</i> Polysaccharides in UVB-Induced Acute Skin Damage by Jiajia Liu, Xiaoqi Yang, Xing Huang, Yuan Luo, Qilin Zhang, Feng Wang, Yicen Lin, Lianbing Lin

“…Biochemical assays showed that GP significantly reduced the activities of MPO and MDA following UVB exposure while restoring the enzymatic activities of SOD and GSH, thereby mitigating oxidative stress. …”
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TNFα activation of the PLEKHA5-FCRLA axis disturbs lipid metabolism, leading to the progression of cutaneous malignant melanoma by Kexin Yan, Wei Zhang, Wenqi Chu, Jinliang Qi, Hao Song, Xiulian Xu

“…Lipid metabolomics showed that PLEKHA5 knockdown increased ceramide and sphingosine levels while decreasing cholesterol ester and triglyceride levels in CMM cells, possibly related to disease progression. …”
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CCDC138 overexpression predicts poor prognosis and highlights ciliopathy-linked mechanisms in uterine corpus endometrial carcinoma by Aiping Wang, Fang Yang, Chunhua Zhang, Shi Li, Han Fu

“…IntroductionUterine corpus endometrial carcinoma (UCEC) is a prevalent malignancy of the female reproductive system with increasing incidence, necessitating the identification of molecular mechanisms and biomarkers. While coiled-coil domain-containing protein 138 (CCDC138) is implicated in ciliopathies and cancer, its role in UCEC remains underexplored.MethodsWe integrated transcriptomic and proteomic data from the Cancer Genome Atlas (TCGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and Genotype-Tissue Expression (GTEx). …”
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Dissecting the connection between volatile organic compounds and cardiovascular disease: immune cell-mediated mechanism by Qi Cao, Jiajing Liu, Daiyao Lu, Junhuai Song, Qiming Yu, Jinkun Wen, Bin Zheng

“…Objective: This study aims to investigate the association between urinary VOC metabolites and cardiovascular disease risk, while evaluating whether monocytes may partially explain. …”
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Integrated Multi-Omics Profiling Reveals That Highly Pyroptotic MDMs Contribute to Psoriasis Progression Through CXCL16 by Liping Jin, Xiaowen Xie, Mi Zhang, Wu Zhu, Guanxiong Zhang, Wangqing Chen

“…Immune cell infiltration profiles were evaluated via CIBERSORT, while cell-cell communication networks were analyzed by CellChat. …”
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Behçet syndrome: The disturbed balance between anti‐ (CLEC12A, CLC) and proinflammatory (IFI27) gene expressions by Ali Kemal Oğuz, Çağdaş Şahap Oygür, Seda Taşır, Hilal Özdağ, Mehmet Nejat Akar

“…A microarray‐based comparative transcriptomic analysis was performed to elucidate the molecular mechanisms of BS and identify any potential therapeutic targets. …”
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Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma by Jiafen Xie, Xiaoming Wang

“…Notably, G6PD was predominantly expressed in early and mid-stages, while KPNA2, PFKP, and TPX2 were upregulated in advanced tumor states. …”
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Generation of IL-8 and IL-9 Producing CD4+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands by Michaela Gasch, Tina Goroll, Mario Bauer, Denise Hinz, Nicole Schütze, Tobias Polte, Dörthe Kesper, Jan C. Simon, Jörg Hackermüller, Irina Lehmann, Gunda Herberth

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Dietary geniposide supplementation alleviates hepatic lipid deposition and oxidative stress induced by high-fat diet in juvenile tiger puffer, Takifugu rubripes by Haoran Sun, Yonghui Wang, Yinghui Liu, Yi Liu, Junjie Zhang

“…H&E staining revealed hepatocyte enlargement and cytoplasmic vacuolization in the HFD group, while HFD supplemented with geniposide ameliorated these conditions. …”
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Construction and validation of a chemokine-related gene signature associated with prognosis, clinical significance, and immune microenvironment characteristics in cervical cancer by Tianjiao Huang, Renshuang Cao, Cong Gao, Jie Luo, Zhiyu Zhou, Kun Ma

“…Abstract Background Cervical cancer (CC) remains a prevalent malignancy with significant mortality among women, highlighting the urgent need for reliable prognostic tools. While chemokines have emerged as pivotal regulators in tumor progression, their potential in constructing prognostic models for CC remains underexplored. …”
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In ovo delivery of carvacrol triggers expression of chemotactic factors, antimicrobial peptides and pro-inflammatory pathways in the yolk sac of broiler chicken embryos by Mila M. Y. Meijer, Henry van den Brand, Shahram Niknafs, Eugeni Roura

“…Yolk sac tissue samples were collected at E19.5, and transcriptomic analyses using RNA sequencing were performed, following functional enrichment analyses comparing the control (saline) and carvacrol-injected groups. …”
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Comprehensive analysis of housekeeping genes, tissue-specific genes, and dynamic regulation across developmental stages in pearl millet by Wei Luo, Min Sun, Ailing Zhang, Chuang Lin, Yarong Jin, Xiaoshan Wang, Linkai Huang

“…It serves as a staple food for millions, while also being utilized as forage and an energy crop. …”
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